CA2447779C - Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists - Google Patents

Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Download PDF

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Publication number
CA2447779C
CA2447779C CA2447779A CA2447779A CA2447779C CA 2447779 C CA2447779 C CA 2447779C CA 2447779 A CA2447779 A CA 2447779A CA 2447779 A CA2447779 A CA 2447779A CA 2447779 C CA2447779 C CA 2447779C
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CA
Canada
Prior art keywords
ch3s
halogen
optionally substituted
compound
phe
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2447779A
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English (en)
French (fr)
Other versions
CA2447779A1 (en
Inventor
Zhaoyin Wang
Christian Beaulieu
Claude Dufresne
Daniel Guay
Yves Leblanc
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Merck Canada Inc
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Merck Frosst Canada Ltd
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Publication date
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Publication of CA2447779A1 publication Critical patent/CA2447779A1/en
Application granted granted Critical
Publication of CA2447779C publication Critical patent/CA2447779C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CA2447779A 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Expired - Fee Related CA2447779C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29307701P 2001-05-23 2001-05-23
US60/293,077 2001-05-23
PCT/CA2002/000745 WO2002094830A2 (en) 2001-05-23 2002-05-22 DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
CA2447779A1 CA2447779A1 (en) 2002-11-28
CA2447779C true CA2447779C (en) 2010-08-31

Family

ID=23127559

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2447779A Expired - Fee Related CA2447779C (en) 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists

Country Status (9)

Country Link
US (1) US7144913B2 (enExample)
EP (1) EP1395590B1 (enExample)
JP (1) JP4279561B2 (enExample)
AT (1) ATE340796T1 (enExample)
AU (1) AU2002302248B2 (enExample)
CA (1) CA2447779C (enExample)
DE (1) DE60215000T2 (enExample)
ES (1) ES2272712T3 (enExample)
WO (1) WO2002094830A2 (enExample)

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US8426449B2 (en) * 2008-04-02 2013-04-23 Panmira Pharmaceuticals, Llc Aminoalkylphenyl antagonists of prostaglandin D2 receptors
US20110112134A1 (en) * 2008-05-16 2011-05-12 Amira Pharmaceuticals, Inc. Tricyclic Antagonists of Prostaglandin D2 Receptors
WO2010008864A2 (en) * 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors
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Also Published As

Publication number Publication date
WO2002094830A2 (en) 2002-11-28
JP4279561B2 (ja) 2009-06-17
AU2002302248B2 (en) 2008-03-06
ATE340796T1 (de) 2006-10-15
ES2272712T3 (es) 2007-05-01
WO2002094830A8 (en) 2003-04-10
WO2002094830A3 (en) 2003-03-06
US20040180934A1 (en) 2004-09-16
US7144913B2 (en) 2006-12-05
EP1395590A2 (en) 2004-03-10
DE60215000T2 (de) 2007-08-09
CA2447779A1 (en) 2002-11-28
EP1395590B1 (en) 2006-09-27
DE60215000D1 (de) 2006-11-09
JP2004534774A (ja) 2004-11-18

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