AU2002259309B2 - Antineoplastic combinations - Google Patents
Antineoplastic combinations Download PDFInfo
- Publication number
- AU2002259309B2 AU2002259309B2 AU2002259309A AU2002259309A AU2002259309B2 AU 2002259309 B2 AU2002259309 B2 AU 2002259309B2 AU 2002259309 A AU2002259309 A AU 2002259309A AU 2002259309 A AU2002259309 A AU 2002259309A AU 2002259309 B2 AU2002259309 B2 AU 2002259309B2
- Authority
- AU
- Australia
- Prior art keywords
- mtor inhibitor
- cci
- alkylating agent
- rapamycin
- antineoplastic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| AU2008202690A AU2008202690A1 (en) | 2001-06-01 | 2008-06-18 | Antineoplastic combination |
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| US60/295,190 | 2001-06-01 | ||
| PCT/US2002/016737 WO2002098416A2 (en) | 2001-06-01 | 2002-05-29 | Antineoplastic combinations |
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| AU2008202690A Division AU2008202690A1 (en) | 2001-06-01 | 2008-06-18 | Antineoplastic combination |
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| AU2002259309A1 AU2002259309A1 (en) | 2003-05-08 |
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| AU2008202690A Abandoned AU2008202690A1 (en) | 2001-06-01 | 2008-06-18 | Antineoplastic combination |
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| JP (1) | JP2004532883A (enExample) |
| KR (1) | KR100875611B1 (enExample) |
| CN (1) | CN100496485C (enExample) |
| AU (2) | AU2002259309B2 (enExample) |
| BR (1) | BR0210101A (enExample) |
| CA (1) | CA2447732A1 (enExample) |
| CO (1) | CO5540294A2 (enExample) |
| EA (1) | EA007530B1 (enExample) |
| HU (1) | HUP0400006A2 (enExample) |
| IL (1) | IL158800A0 (enExample) |
| MX (1) | MXPA03010907A (enExample) |
| NO (1) | NO20035317L (enExample) |
| NZ (1) | NZ529877A (enExample) |
| PL (1) | PL367267A1 (enExample) |
| SG (1) | SG153647A1 (enExample) |
| WO (1) | WO2002098416A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2762140T (lt) | 2001-02-19 | 2017-06-26 | Novartis Ag | Solidinių smegenų navikų gydymas rapamicino dariniu |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| AR046194A1 (es) | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
| CN113952459B (zh) | 2005-02-03 | 2025-02-11 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
| CN103110948A (zh) * | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
| GB0523658D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| WO2007057457A2 (en) * | 2005-11-21 | 2007-05-24 | Novartis Ag | Neuroendocrine tumor treatment using mtor inhibitors |
| US20090023768A1 (en) * | 2006-02-24 | 2009-01-22 | Novartis Ag | Rapamycin derivatives for treating neuroblastoma |
| RU2447891C2 (ru) * | 2006-04-05 | 2012-04-20 | Новартис Аг | Комбинации терапевтических средств, предназначенные для лечения рака |
| BRPI0808635B1 (pt) * | 2007-03-07 | 2022-06-07 | Abraxis Bioscience, Llc | Uso de uma composição farmacêutica compreendendo nanopartículas que compreendem rapamicina ou um seu derivado e uma proteína veículo, composição para uso em um método de tratamento de câncer em um indivíduo, forma de dosagem unitária para o referido tratamento, e kit |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| CN102641270A (zh) | 2008-06-17 | 2012-08-22 | 惠氏有限责任公司 | 含有hki-272和长春瑞滨的抗肿瘤组合 |
| HUE032958T2 (hu) | 2008-08-04 | 2017-11-28 | Wyeth Llc | 4-Anilino-3-ciano-kinolinok és capecitabin antineoplasztikus kombinációi |
| LT3000467T (lt) | 2009-04-06 | 2023-04-11 | Wyeth Llc | Krūties vėžio gydymo schema naudojant neratinibą |
| CN103721189A (zh) * | 2013-12-27 | 2014-04-16 | 刘玉含 | 一种脑膜瘤护理药物及其制备方法 |
| CN105168204A (zh) * | 2015-09-06 | 2015-12-23 | 江志鑫 | 一种含有丝裂霉素的抗结肠癌药物组合物 |
| CN119732959A (zh) * | 2024-12-31 | 2025-04-01 | 吉林大学 | 具有mTOR抑制能力的制剂在制备抗肿瘤联合用药物组合物中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| ES2084940T3 (es) * | 1991-06-18 | 1996-05-16 | American Home Prod | Uso de la rapamicina para el tratamiento de la leucemia/linfoma de las celulas t adultas. |
| TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| LT2762140T (lt) * | 2001-02-19 | 2017-06-26 | Novartis Ag | Solidinių smegenų navikų gydymas rapamicino dariniu |
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2002
- 2002-05-29 EA EA200301319A patent/EA007530B1/ru not_active IP Right Cessation
- 2002-05-29 CA CA002447732A patent/CA2447732A1/en not_active Abandoned
- 2002-05-29 SG SG200507698-9A patent/SG153647A1/en unknown
- 2002-05-29 CN CNB02811048XA patent/CN100496485C/zh not_active Expired - Fee Related
- 2002-05-29 HU HU0400006A patent/HUP0400006A2/hu unknown
- 2002-05-29 JP JP2003501455A patent/JP2004532883A/ja not_active Withdrawn
- 2002-05-29 WO PCT/US2002/016737 patent/WO2002098416A2/en not_active Ceased
- 2002-05-29 MX MXPA03010907A patent/MXPA03010907A/es not_active Application Discontinuation
- 2002-05-29 EP EP02729310A patent/EP1392286A2/en not_active Ceased
- 2002-05-29 BR BR0210101-7A patent/BR0210101A/pt not_active Application Discontinuation
- 2002-05-29 IL IL15880002A patent/IL158800A0/xx unknown
- 2002-05-29 KR KR1020037015721A patent/KR100875611B1/ko not_active Expired - Fee Related
- 2002-05-29 NZ NZ529877A patent/NZ529877A/en unknown
- 2002-05-29 AU AU2002259309A patent/AU2002259309B2/en not_active Ceased
- 2002-05-29 PL PL02367267A patent/PL367267A1/xx not_active Application Discontinuation
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2003
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
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| Geoerger B et al. Antitumor activity of the rapamycin analogue CCl-199 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Research 2001, Vol 4, No 61, pages 1527-1532. * |
| Shi Y et al. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Research, 1995 Vol 55, No 9, pages 1982-1988. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1646120A (zh) | 2005-07-27 |
| JP2004532883A (ja) | 2004-10-28 |
| KR20040025923A (ko) | 2004-03-26 |
| NZ529877A (en) | 2006-08-31 |
| BR0210101A (pt) | 2004-06-08 |
| HUP0400006A2 (hu) | 2004-04-28 |
| WO2002098416A2 (en) | 2002-12-12 |
| SG153647A1 (en) | 2009-07-29 |
| EA200301319A1 (ru) | 2004-04-29 |
| EP1392286A2 (en) | 2004-03-03 |
| CA2447732A1 (en) | 2002-12-12 |
| CN100496485C (zh) | 2009-06-10 |
| EA007530B1 (ru) | 2006-10-27 |
| MXPA03010907A (es) | 2004-02-17 |
| WO2002098416A3 (en) | 2003-03-13 |
| AU2008202690A1 (en) | 2008-07-10 |
| NO20035317L (no) | 2003-12-22 |
| IL158800A0 (en) | 2004-05-12 |
| PL367267A1 (en) | 2005-02-21 |
| CO5540294A2 (es) | 2005-07-29 |
| NO20035317D0 (no) | 2003-11-28 |
| KR100875611B1 (ko) | 2008-12-24 |
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