CA2447732A1 - Antineoplastic combinations - Google Patents
Antineoplastic combinations Download PDFInfo
- Publication number
- CA2447732A1 CA2447732A1 CA002447732A CA2447732A CA2447732A1 CA 2447732 A1 CA2447732 A1 CA 2447732A1 CA 002447732 A CA002447732 A CA 002447732A CA 2447732 A CA2447732 A CA 2447732A CA 2447732 A1 CA2447732 A1 CA 2447732A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- neoplasm
- rapamycin
- mtor inhibitor
- alkylating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29519001P | 2001-06-01 | 2001-06-01 | |
| US29523601P | 2001-06-01 | 2001-06-01 | |
| US60/295,236 | 2001-06-01 | ||
| US60/295,190 | 2001-06-01 | ||
| PCT/US2002/016737 WO2002098416A2 (en) | 2001-06-01 | 2002-05-29 | Antineoplastic combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2447732A1 true CA2447732A1 (en) | 2002-12-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002447732A Abandoned CA2447732A1 (en) | 2001-06-01 | 2002-05-29 | Antineoplastic combinations |
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| Country | Link |
|---|---|
| EP (1) | EP1392286A2 (enExample) |
| JP (1) | JP2004532883A (enExample) |
| KR (1) | KR100875611B1 (enExample) |
| CN (1) | CN100496485C (enExample) |
| AU (2) | AU2002259309B2 (enExample) |
| BR (1) | BR0210101A (enExample) |
| CA (1) | CA2447732A1 (enExample) |
| CO (1) | CO5540294A2 (enExample) |
| EA (1) | EA007530B1 (enExample) |
| HU (1) | HUP0400006A2 (enExample) |
| IL (1) | IL158800A0 (enExample) |
| MX (1) | MXPA03010907A (enExample) |
| NO (1) | NO20035317L (enExample) |
| NZ (1) | NZ529877A (enExample) |
| PL (1) | PL367267A1 (enExample) |
| SG (1) | SG153647A1 (enExample) |
| WO (1) | WO2002098416A2 (enExample) |
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| LT3351246T (lt) * | 2001-02-19 | 2019-07-10 | Novartis Pharma Ag | Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| AR046194A1 (es) | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
| DK1848414T3 (da) | 2005-02-03 | 2011-07-25 | Gen Hospital Corp | Fremgangsmåde til behandling af gefitinib-resistent cancer |
| AU2006311877A1 (en) * | 2005-11-04 | 2007-05-18 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272 |
| US9006224B2 (en) * | 2005-11-21 | 2015-04-14 | Novartis Ag | Neuroendocrine tumor treatment |
| GB0523658D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| US20090023768A1 (en) * | 2006-02-24 | 2009-01-22 | Novartis Ag | Rapamycin derivatives for treating neuroblastoma |
| EP2591775A1 (en) | 2006-04-05 | 2013-05-15 | Novartis AG | Combinations comprising mtor inhibitors for treating cancer |
| LT2481409T (lt) * | 2007-03-07 | 2018-10-25 | Abraxis Bioscience, Llc | Nanodalelės, apimančios rapamiciną ir albuminą, kaip priešvėžinį agentą |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| SI2310011T1 (sl) | 2008-06-17 | 2013-10-30 | Wyeth Llc | Antineoplastične kombinacije, ki vsebujejo HKI-272 in vinorelbin |
| BRPI0916694B1 (pt) | 2008-08-04 | 2021-06-08 | Wyeth Llc | uso de neratinibe em combinação com capecitabina para tratar câncer de mama metastático de erbb-2 positivo, kit e produto compreendendo os mesmos |
| CA2755789C (en) | 2009-04-06 | 2016-01-19 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
| CN103721189A (zh) * | 2013-12-27 | 2014-04-16 | 刘玉含 | 一种脑膜瘤护理药物及其制备方法 |
| CN105168204A (zh) * | 2015-09-06 | 2015-12-23 | 江志鑫 | 一种含有丝裂霉素的抗结肠癌药物组合物 |
| CN119732959A (zh) * | 2024-12-31 | 2025-04-01 | 吉林大学 | 具有mTOR抑制能力的制剂在制备抗肿瘤联合用药物组合物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| DE69209183T2 (de) * | 1991-06-18 | 1996-08-08 | American Home Prod | Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen |
| TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| LT3351246T (lt) * | 2001-02-19 | 2019-07-10 | Novartis Pharma Ag | Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui |
-
2002
- 2002-05-29 JP JP2003501455A patent/JP2004532883A/ja not_active Withdrawn
- 2002-05-29 NZ NZ529877A patent/NZ529877A/en unknown
- 2002-05-29 PL PL02367267A patent/PL367267A1/xx not_active Application Discontinuation
- 2002-05-29 SG SG200507698-9A patent/SG153647A1/en unknown
- 2002-05-29 EA EA200301319A patent/EA007530B1/ru not_active IP Right Cessation
- 2002-05-29 CN CNB02811048XA patent/CN100496485C/zh not_active Expired - Fee Related
- 2002-05-29 EP EP02729310A patent/EP1392286A2/en not_active Ceased
- 2002-05-29 IL IL15880002A patent/IL158800A0/xx unknown
- 2002-05-29 AU AU2002259309A patent/AU2002259309B2/en not_active Ceased
- 2002-05-29 KR KR1020037015721A patent/KR100875611B1/ko not_active Expired - Fee Related
- 2002-05-29 BR BR0210101-7A patent/BR0210101A/pt not_active Application Discontinuation
- 2002-05-29 MX MXPA03010907A patent/MXPA03010907A/es not_active Application Discontinuation
- 2002-05-29 HU HU0400006A patent/HUP0400006A2/hu unknown
- 2002-05-29 CA CA002447732A patent/CA2447732A1/en not_active Abandoned
- 2002-05-29 WO PCT/US2002/016737 patent/WO2002098416A2/en not_active Ceased
-
2003
- 2003-11-26 CO CO03104435A patent/CO5540294A2/es not_active Application Discontinuation
- 2003-11-28 NO NO20035317A patent/NO20035317L/no not_active Application Discontinuation
-
2008
- 2008-06-18 AU AU2008202690A patent/AU2008202690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004532883A (ja) | 2004-10-28 |
| EP1392286A2 (en) | 2004-03-03 |
| IL158800A0 (en) | 2004-05-12 |
| WO2002098416A2 (en) | 2002-12-12 |
| KR20040025923A (ko) | 2004-03-26 |
| HUP0400006A2 (hu) | 2004-04-28 |
| EA200301319A1 (ru) | 2004-04-29 |
| CN100496485C (zh) | 2009-06-10 |
| SG153647A1 (en) | 2009-07-29 |
| MXPA03010907A (es) | 2004-02-17 |
| BR0210101A (pt) | 2004-06-08 |
| CO5540294A2 (es) | 2005-07-29 |
| NO20035317D0 (no) | 2003-11-28 |
| NZ529877A (en) | 2006-08-31 |
| WO2002098416A3 (en) | 2003-03-13 |
| PL367267A1 (en) | 2005-02-21 |
| KR100875611B1 (ko) | 2008-12-24 |
| EA007530B1 (ru) | 2006-10-27 |
| NO20035317L (no) | 2003-12-22 |
| AU2008202690A1 (en) | 2008-07-10 |
| CN1646120A (zh) | 2005-07-27 |
| AU2002259309B2 (en) | 2008-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |