AU2002253045B2 - 6-phenylbenzonaphthyridines - Google Patents
6-phenylbenzonaphthyridines Download PDFInfo
- Publication number
- AU2002253045B2 AU2002253045B2 AU2002253045A AU2002253045A AU2002253045B2 AU 2002253045 B2 AU2002253045 B2 AU 2002253045B2 AU 2002253045 A AU2002253045 A AU 2002253045A AU 2002253045 A AU2002253045 A AU 2002253045A AU 2002253045 B2 AU2002253045 B2 AU 2002253045B2
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- Prior art keywords
- alkyl
- hydrogen
- radical
- salts
- formula
- Prior art date
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- QYQKEEKSROGRBQ-UHFFFAOYSA-N 6-phenylbenzo[b][1,8]naphthyridine Chemical class C1=CC=CC=C1C1=CC=CC2=NC3=NC=CC=C3C=C12 QYQKEEKSROGRBQ-UHFFFAOYSA-N 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 156
- -1 1 -hexahydroazepinyl Chemical group 0.000 claims description 97
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 69
- 229910052757 nitrogen Inorganic materials 0.000 claims description 44
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 36
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 30
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- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 239000002570 phosphodiesterase III inhibitor Substances 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000011533 pre-incubation Methods 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
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- 230000035755 proliferation Effects 0.000 description 1
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- 239000003998 snake venom Substances 0.000 description 1
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
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- 238000003892 spreading Methods 0.000 description 1
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- 239000011975 tartaric acid Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- 230000002588 toxic effect Effects 0.000 description 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Pyridine Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Electroluminescent Light Sources (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01104086 | 2001-02-21 | ||
| EP01104086.2 | 2001-02-21 | ||
| PCT/EP2002/001819 WO2002066476A1 (en) | 2001-02-21 | 2002-02-21 | 6-phenylbenzonaphthyridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002253045A1 AU2002253045A1 (en) | 2003-02-27 |
| AU2002253045B2 true AU2002253045B2 (en) | 2007-07-12 |
Family
ID=8176545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002253045A Ceased AU2002253045B2 (en) | 2001-02-21 | 2002-02-21 | 6-phenylbenzonaphthyridines |
Country Status (12)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1581533A2 (en) * | 2002-08-17 | 2005-10-05 | ALTANA Pharma AG | Novel benzonaphthyridines |
| AU2003253408A1 (en) * | 2002-08-17 | 2004-03-11 | Nycomed Gmbh | Novel phenanthridines |
| WO2004019945A1 (en) | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2286494T3 (es) * | 2002-09-04 | 2007-12-01 | Nycomed Gmbh | Nuevas benzonaftiridinas. |
| HRP20050293A2 (en) * | 2002-09-04 | 2006-07-31 | Altana Pharma Ag | Novel benzonaphthyridines |
| AU2005212857B2 (en) * | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| ME01955B (me) | 2004-03-03 | 2015-05-20 | Takeda Gmbh | Novi hidroksi-6-heteroarilfenantridini i njihova primena kao pde4 inhibitori |
| BRPI0508481A (pt) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4 |
| AU2005223386A1 (en) | 2004-03-17 | 2005-09-29 | Nycomed Gmbh | Novel N- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE3/4 inhibitors |
| HRP20100086T1 (hr) | 2005-03-02 | 2010-04-30 | Nycomed Gmbh | (2R,4aR,10bR)-6-(2,6-DIMETOKSIPIRIDIN-3-IL)-9-ETOKSI-8-METOKSI-1,2,3,4,4a,10b-HEKSAHIDROFENANTRIDIN-2-ol, HCI SOL |
| WO2018069210A1 (en) | 2016-10-10 | 2018-04-19 | Takeda Gmbh | Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9713338B1 (pt) | 1996-11-11 | 2009-12-01 | benzonaftiridinas, medicamento, bem como seu uso como terapêuticos brÈnquicos. | |
| ATE248167T1 (de) | 1997-03-07 | 2003-09-15 | Altana Pharma Ag | Tetrazole derivate |
| DE69811492T2 (de) | 1997-06-03 | 2004-02-05 | Altana Pharma Ag | Benzonaphthyridine |
| ES2195571T3 (es) | 1998-05-05 | 2003-12-01 | Altana Pharma Ag | Nuevos benzonaftiridin-n-oxidos. |
| US6436952B1 (en) | 1998-08-31 | 2002-08-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity |
-
2002
- 2002-02-21 ES ES02722110T patent/ES2236504T3/es not_active Expired - Lifetime
- 2002-02-21 US US10/467,568 patent/US6936622B2/en not_active Expired - Fee Related
- 2002-02-21 EP EP02722110A patent/EP1377574B1/en not_active Expired - Lifetime
- 2002-02-21 AT AT02722110T patent/ATE287403T1/de active
- 2002-02-21 JP JP2002565990A patent/JP4248245B2/ja not_active Expired - Fee Related
- 2002-02-21 AU AU2002253045A patent/AU2002253045B2/en not_active Ceased
- 2002-02-21 PT PT02722110T patent/PT1377574E/pt unknown
- 2002-02-21 CA CA2438717A patent/CA2438717C/en not_active Expired - Fee Related
- 2002-02-21 WO PCT/EP2002/001819 patent/WO2002066476A1/en active IP Right Grant
- 2002-02-21 DK DK02722110T patent/DK1377574T3/da active
- 2002-02-21 DE DE60202669T patent/DE60202669T2/de not_active Expired - Lifetime
- 2002-02-21 SI SI200230083T patent/SI1377574T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6936622B2 (en) | 2005-08-30 |
| CA2438717C (en) | 2011-08-30 |
| SI1377574T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2005-08-31 |
| DE60202669T2 (de) | 2005-09-15 |
| PT1377574E (pt) | 2005-05-31 |
| WO2002066476A1 (en) | 2002-08-29 |
| EP1377574B1 (en) | 2005-01-19 |
| US20040097537A1 (en) | 2004-05-20 |
| JP4248245B2 (ja) | 2009-04-02 |
| ATE287403T1 (de) | 2005-02-15 |
| CA2438717A1 (en) | 2002-08-29 |
| WO2002066476A9 (en) | 2003-10-30 |
| DK1377574T3 (da) | 2005-04-25 |
| DE60202669D1 (de) | 2005-02-24 |
| ES2236504T3 (es) | 2005-07-16 |
| EP1377574A1 (en) | 2004-01-07 |
| JP2004526712A (ja) | 2004-09-02 |
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