AU2002242253B2 - Modulation of release from dry powder formulations - Google Patents

Modulation of release from dry powder formulations Download PDF

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Publication number
AU2002242253B2
AU2002242253B2 AU2002242253A AU2002242253A AU2002242253B2 AU 2002242253 B2 AU2002242253 B2 AU 2002242253B2 AU 2002242253 A AU2002242253 A AU 2002242253A AU 2002242253 A AU2002242253 A AU 2002242253A AU 2002242253 B2 AU2002242253 B2 AU 2002242253B2
Authority
AU
Australia
Prior art keywords
particles
bioactive agent
weight percent
microns
dppc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002242253A
Other languages
English (en)
Other versions
AU2002242253A1 (en
Inventor
Sujit K. Basu
Giovanni Caponetti
Daniel R. Deaver
Katharina J. Elbert
Jeffrey S. Hrkach
Michael M. Lipp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Publication of AU2002242253A1 publication Critical patent/AU2002242253A1/en
Application granted granted Critical
Publication of AU2002242253B2 publication Critical patent/AU2002242253B2/en
Assigned to ALKERMES, INC. reassignment ALKERMES, INC. Request for Assignment Assignors: ADVANCED INHALATION RESEARCH, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002242253A 2001-02-23 2002-02-22 Modulation of release from dry powder formulations Ceased AU2002242253B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/792,869 2001-02-23
US09/792,869 US20010036481A1 (en) 1999-08-25 2001-02-23 Modulation of release from dry powder formulations
PCT/US2002/005629 WO2002067902A2 (en) 2001-02-23 2002-02-22 Modulation of release from dry powder formulations

Publications (2)

Publication Number Publication Date
AU2002242253A1 AU2002242253A1 (en) 2003-03-06
AU2002242253B2 true AU2002242253B2 (en) 2005-04-21

Family

ID=25158323

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002242253A Ceased AU2002242253B2 (en) 2001-02-23 2002-02-22 Modulation of release from dry powder formulations

Country Status (6)

Country Link
US (2) US20010036481A1 (enExample)
EP (1) EP1370246A2 (enExample)
JP (1) JP2004520409A (enExample)
AU (1) AU2002242253B2 (enExample)
CA (1) CA2438268A1 (enExample)
WO (1) WO2002067902A2 (enExample)

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Also Published As

Publication number Publication date
EP1370246A2 (en) 2003-12-17
WO2002067902A2 (en) 2002-09-06
JP2004520409A (ja) 2004-07-08
CA2438268A1 (en) 2002-09-06
US20050003003A1 (en) 2005-01-06
WO2002067902A3 (en) 2003-03-13
US20010036481A1 (en) 2001-11-01

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