AU2002227985A1 - Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors - Google Patents

Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors

Info

Publication number
AU2002227985A1
AU2002227985A1 AU2002227985A AU2798502A AU2002227985A1 AU 2002227985 A1 AU2002227985 A1 AU 2002227985A1 AU 2002227985 A AU2002227985 A AU 2002227985A AU 2798502 A AU2798502 A AU 2798502A AU 2002227985 A1 AU2002227985 A1 AU 2002227985A1
Authority
AU
Australia
Prior art keywords
dihydroisoquinolines
phosphodiesterase
pyrrolo
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002227985A
Other languages
English (en)
Inventor
Marcus Bauser
Stephen J. Boyer
Nils Burkhardt
Jens-Kerim Erguden
Dietmar Flubacher
Mark Miglarese
Paul Naab
Ulrich Niewohner
Thorsten-Oliver Repp
Michael Schauer
Karl-Heinz Schlemmer
Andrea Sewing
Jurgen Stoltefuss
Olaf Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2002227985A1 publication Critical patent/AU2002227985A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2002227985A 2000-12-13 2001-12-04 Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors Abandoned AU2002227985A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25520600P 2000-12-13 2000-12-13
US60255206 2000-12-13
US31031201P 2001-08-06 2001-08-06
US60310312 2001-08-06
PCT/EP2001/014187 WO2002048144A1 (en) 2000-12-13 2001-12-04 Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors

Publications (1)

Publication Number Publication Date
AU2002227985A1 true AU2002227985A1 (en) 2002-06-24

Family

ID=26944520

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002227985A Abandoned AU2002227985A1 (en) 2000-12-13 2001-12-04 Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors

Country Status (10)

Country Link
US (1) US6930114B2 (enExample)
EP (1) EP1347973A1 (enExample)
JP (1) JP2004517843A (enExample)
AU (1) AU2002227985A1 (enExample)
CA (1) CA2431326A1 (enExample)
HN (1) HN2001000277A (enExample)
PE (1) PE20021085A1 (enExample)
SV (1) SV2002000761A (enExample)
UY (1) UY27067A1 (enExample)
WO (1) WO2002048144A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
US20030236276A1 (en) * 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003051877A1 (en) * 2001-12-18 2003-06-26 Bayer Corporation 2-substituted pyrrolo[2.1-a]isoquinolines against cancer
DE10230604A1 (de) * 2002-07-08 2004-01-29 Bayer Ag Heterocyclisch substituierte Imidazotriazine
US8338420B1 (en) 2002-12-04 2012-12-25 Mitsubishi Tanabe Pharma Corporation Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor
US7135480B2 (en) * 2002-12-12 2006-11-14 Cytovia, Inc. Substituted 1-benzoyl-3-cyano-pyrrolo [1,2-a] quinolines and analogs as activators of caspases and inducers of apoptosis
EP1641457B1 (en) * 2003-06-30 2009-08-05 Nycomed GmbH Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
AU2004253690B2 (en) * 2003-06-30 2010-03-25 Nycomed Gmbh Pyrrolodihydroisoquinolines as PDE10 inhibitors
DE602006006544D1 (de) * 2005-01-12 2009-06-10 Nycomed Gmbh Neue pyrrolodihydroisochinoline als pde10-inhibitoren
EP1838708A2 (en) * 2005-01-12 2007-10-03 Nycomed GmbH Pyrrolodihydroisoquinolines as antiproliferative agents
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008001182A1 (en) * 2006-06-26 2008-01-03 Pfizer Products Inc. Tricyclic heteroaryl compounds as pde10 inhibitors
JP2010502722A (ja) 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
ES2527363T3 (es) 2009-12-04 2015-01-22 Nerviano Medical Sciences S.R.L. Derivados de triciclopirazol
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US10039764B2 (en) 2013-07-12 2018-08-07 University Of South Alabama Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression
GB202002926D0 (en) * 2020-02-28 2020-04-15 Benevolentai Tech Limited Compositions and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE690792A (enExample) * 1966-12-07 1967-05-16
FR7348M (enExample) * 1967-12-07 1969-10-13
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
DE3401018A1 (de) * 1984-01-13 1985-07-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
IT1292092B1 (it) 1997-06-05 1999-01-25 Geange Ltd Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali
US6673564B2 (en) 1999-10-18 2004-01-06 Millennium Pharmaceuticals, Inc. Methods for using 22045, a human cyclic nucleotide phosphodiesterase

Also Published As

Publication number Publication date
JP2004517843A (ja) 2004-06-17
EP1347973A1 (en) 2003-10-01
HN2001000277A (es) 2002-01-30
WO2002048144A1 (en) 2002-06-20
CA2431326A1 (en) 2002-06-20
US20040138249A1 (en) 2004-07-15
US6930114B2 (en) 2005-08-16
UY27067A1 (es) 2002-07-31
SV2002000761A (es) 2002-12-02
PE20021085A1 (es) 2003-05-16

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