PE20021085A1 - PIRROLO (2.1-a) DIHIDROISOQUINOLINAS - Google Patents
PIRROLO (2.1-a) DIHIDROISOQUINOLINASInfo
- Publication number
- PE20021085A1 PE20021085A1 PE2002000338A PE2002000338A PE20021085A1 PE 20021085 A1 PE20021085 A1 PE 20021085A1 PE 2002000338 A PE2002000338 A PE 2002000338A PE 2002000338 A PE2002000338 A PE 2002000338A PE 20021085 A1 PE20021085 A1 PE 20021085A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pirrolo
- compounds
- dimetoxy
- isoquinoline
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical class NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-HYDROXY-3,5-DIMETHYLPHENYL Chemical class 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- NRHVLEGHLOHXGQ-UHFFFAOYSA-N C(CC)(=O)O.C1=NC=CC2=CC=CC=C12 Chemical compound C(CC)(=O)O.C1=NC=CC2=CC=CC=C12 NRHVLEGHLOHXGQ-UHFFFAOYSA-N 0.000 abstract 1
- 101001072037 Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100036377 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25520600P | 2000-12-13 | 2000-12-13 | |
| US31031201P | 2001-08-06 | 2001-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20021085A1 true PE20021085A1 (es) | 2003-05-16 |
Family
ID=26944520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000338A PE20021085A1 (es) | 2000-12-13 | 2002-04-23 | PIRROLO (2.1-a) DIHIDROISOQUINOLINAS |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6930114B2 (enExample) |
| EP (1) | EP1347973A1 (enExample) |
| JP (1) | JP2004517843A (enExample) |
| AU (1) | AU2002227985A1 (enExample) |
| CA (1) | CA2431326A1 (enExample) |
| HN (1) | HN2001000277A (enExample) |
| PE (1) | PE20021085A1 (enExample) |
| SV (1) | SV2002000761A (enExample) |
| UY (1) | UY27067A1 (enExample) |
| WO (1) | WO2002048144A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003014116A1 (en) * | 2001-08-06 | 2003-02-20 | Bayer Corporation | Pyrrolo[2.1-a]isoquinoline derivatives |
| WO2003014115A1 (en) * | 2001-08-06 | 2003-02-20 | Bayer Aktiengesellschaft | 3-substituted pyrrolo (2.1-a) isoquinoline derivatives |
| WO2003051877A1 (en) * | 2001-12-18 | 2003-06-26 | Bayer Corporation | 2-substituted pyrrolo[2.1-a]isoquinolines against cancer |
| DE10230604A1 (de) * | 2002-07-08 | 2004-01-29 | Bayer Ag | Heterocyclisch substituierte Imidazotriazine |
| US8338420B1 (en) | 2002-12-04 | 2012-12-25 | Mitsubishi Tanabe Pharma Corporation | Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor |
| EP1578424A4 (en) * | 2002-12-12 | 2007-08-08 | Cytovia Inc | SUBSTITUTED 1-BENZOYL-3-CYANOPYRROLO1,2-A | CHINOLINES AND THEIR ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCTORS OF APOPTOSIS |
| WO2005002579A1 (en) * | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
| WO2005003129A1 (en) * | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolodihydroisoquinolines as pde10 inhibitors |
| WO2006075012A2 (en) * | 2005-01-12 | 2006-07-20 | Nycomed Gmbh | Pyrrolodihydroisoquinolines as antiproliferative agents |
| WO2006089815A1 (en) * | 2005-01-12 | 2006-08-31 | Nycomed Gmbh | Novel pyrrolodihydroisoquinolines as pde10 inhibitors |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2008001182A1 (en) * | 2006-06-26 | 2008-01-03 | Pfizer Products Inc. | Tricyclic heteroaryl compounds as pde10 inhibitors |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011067145A1 (en) | 2009-12-04 | 2011-06-09 | Nerviano Medical Sciences S.R.L. | Tricyclopyrazole derivatives |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| GB202002926D0 (en) * | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE690792A (enExample) * | 1966-12-07 | 1967-05-16 | ||
| FR7348M (enExample) * | 1967-12-07 | 1969-10-13 | ||
| US4719216A (en) * | 1983-06-23 | 1988-01-12 | Mcneilab, Inc. | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants |
| DE3401018A1 (de) * | 1984-01-13 | 1985-07-18 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen |
| GB8718980D0 (en) * | 1987-08-11 | 1987-09-16 | May & Baker Ltd | Compositions of matter |
| IT1292092B1 (it) | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
| US6673564B2 (en) | 1999-10-18 | 2004-01-06 | Millennium Pharmaceuticals, Inc. | Methods for using 22045, a human cyclic nucleotide phosphodiesterase |
-
2001
- 2001-12-04 WO PCT/EP2001/014187 patent/WO2002048144A1/en not_active Ceased
- 2001-12-04 EP EP01989571A patent/EP1347973A1/en not_active Withdrawn
- 2001-12-04 AU AU2002227985A patent/AU2002227985A1/en not_active Abandoned
- 2001-12-04 US US10/451,707 patent/US6930114B2/en not_active Expired - Fee Related
- 2001-12-04 JP JP2002549675A patent/JP2004517843A/ja active Pending
- 2001-12-04 CA CA002431326A patent/CA2431326A1/en not_active Abandoned
- 2001-12-12 HN HN2001000277A patent/HN2001000277A/es unknown
- 2001-12-12 UY UY27067A patent/UY27067A1/es not_active Application Discontinuation
- 2001-12-12 SV SV2001000761A patent/SV2002000761A/es unknown
-
2002
- 2002-04-23 PE PE2002000338A patent/PE20021085A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HN2001000277A (es) | 2002-01-30 |
| CA2431326A1 (en) | 2002-06-20 |
| SV2002000761A (es) | 2002-12-02 |
| WO2002048144A1 (en) | 2002-06-20 |
| EP1347973A1 (en) | 2003-10-01 |
| US20040138249A1 (en) | 2004-07-15 |
| UY27067A1 (es) | 2002-07-31 |
| AU2002227985A1 (en) | 2002-06-24 |
| US6930114B2 (en) | 2005-08-16 |
| JP2004517843A (ja) | 2004-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |