AU2001294354A1 - Process for making amlodipine, derivatives thereof, and precursors therefor - Google Patents
Process for making amlodipine, derivatives thereof, and precursors thereforInfo
- Publication number
- AU2001294354A1 AU2001294354A1 AU2001294354A AU2001294354A AU2001294354A1 AU 2001294354 A1 AU2001294354 A1 AU 2001294354A1 AU 2001294354 A AU2001294354 A AU 2001294354A AU 2001294354 A AU2001294354 A AU 2001294354A AU 2001294354 A1 AU2001294354 A1 AU 2001294354A1
- Authority
- AU
- Australia
- Prior art keywords
- derivatives
- precursors therefor
- making amlodipine
- amlodipine
- making
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25861300P | 2000-12-29 | 2000-12-29 | |
US60/258,613 | 2000-12-29 | ||
US80935101A | 2001-03-16 | 2001-03-16 | |
US09/809,351 | 2001-03-16 | ||
PCT/NL2001/000601 WO2002053535A2 (en) | 2000-12-29 | 2001-08-15 | Process for making amlodipine, derivatives thereof, and precursors therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2001294354A1 true AU2001294354A1 (en) | 2002-07-16 |
AU2001294354A8 AU2001294354A8 (hr) | 2005-10-06 |
Family
ID=26946752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001294354A Abandoned AU2001294354A1 (en) | 2000-12-29 | 2001-08-15 | Process for making amlodipine, derivatives thereof, and precursors therefor |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1345901A2 (hr) |
AU (1) | AU2001294354A1 (hr) |
BR (1) | BR0116558A (hr) |
CA (1) | CA2433366C (hr) |
CZ (1) | CZ20031779A3 (hr) |
DE (2) | DE20116723U1 (hr) |
ES (1) | ES2277960T3 (hr) |
MX (1) | MXPA03005888A (hr) |
WO (2) | WO2002053535A2 (hr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1014450A6 (nl) * | 2000-12-29 | 2003-10-07 | Bioorg Bv | Werkwijze voor het maken van amlodipine, derivaten daarvan en voorlopers daarvoor. |
GB2371862B (en) | 2000-12-29 | 2004-07-14 | Bioorg Bv | Reference standards for determining the purity or stability of amlodipine maleate and processes therefor |
US6828339B2 (en) * | 2001-11-21 | 2004-12-07 | Synthon Bv | Amlodipine salt forms and processes for preparing them |
NL1019882C2 (nl) * | 2002-02-01 | 2003-08-04 | Synthon Licensing | Amlodipine vrije base. |
ES2211317B1 (es) * | 2002-11-18 | 2005-10-16 | Finaf 92, S.A. | Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes. |
EP1587792B1 (en) * | 2003-01-27 | 2014-08-27 | Hanmi Science Co., Ltd. | Stable amorphous amlodipine camsylate, process for preparing same and composition for oral administration thereof |
US20060270715A1 (en) * | 2003-02-28 | 2006-11-30 | Singh Romi B | Dosage forms of amlodipine and processes for their preparation |
CH697952B1 (de) * | 2003-07-25 | 2009-03-31 | Siegfried Generics Int Ag | Verfahren zur Reinigung der freien Amlodipinbase. |
WO2005023769A1 (en) * | 2003-09-04 | 2005-03-17 | Cipla Limited | Process for the preparation of amlodipine salts |
KR100604034B1 (ko) * | 2003-10-08 | 2006-07-24 | 주식회사유한양행 | 암로디핀 유리염기를 함유한 구강 속붕해정 및 그의 조성물 |
WO2007131759A1 (en) * | 2006-05-15 | 2007-11-22 | Lek Pharmaceuticals D.D. | A process for the preparation of amlodipine benzenesulfonate |
EP1975167A1 (en) | 2007-03-30 | 2008-10-01 | Esteve Quimica, S.A. | Acetone solvate of phthaloyl amlodipine |
WO2011117876A1 (en) | 2010-03-26 | 2011-09-29 | Fdc Limited | An improved process for the preparation of amlodipine free base and acid addition salts thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
US4572908A (en) | 1982-12-21 | 1986-02-25 | Pfizer Inc. | Dihydropyridines |
DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE4305454A1 (de) * | 1993-02-23 | 1994-08-25 | Bayer Ag | Klotzverfahren mit einer Phthalocyaninmischung |
GB9317773D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
GB0008332D0 (en) * | 2000-04-04 | 2000-05-24 | Pfizer Ltd | Treament |
GB0020842D0 (en) * | 2000-08-23 | 2000-10-11 | Pfizer Ltd | Therapeutic compositions |
-
2001
- 2001-08-15 CZ CZ20031779A patent/CZ20031779A3/cs unknown
- 2001-08-15 AU AU2001294354A patent/AU2001294354A1/en not_active Abandoned
- 2001-08-15 EP EP01974983A patent/EP1345901A2/en not_active Withdrawn
- 2001-08-15 WO PCT/NL2001/000601 patent/WO2002053535A2/en not_active Application Discontinuation
- 2001-10-04 DE DE20116723U patent/DE20116723U1/de not_active Ceased
- 2001-12-31 ES ES01995820T patent/ES2277960T3/es not_active Expired - Lifetime
- 2001-12-31 MX MXPA03005888A patent/MXPA03005888A/es active IP Right Grant
- 2001-12-31 DE DE60125981T patent/DE60125981T2/de not_active Expired - Fee Related
- 2001-12-31 WO PCT/NL2001/000947 patent/WO2002053135A1/en active IP Right Grant
- 2001-12-31 CA CA002433366A patent/CA2433366C/en not_active Expired - Fee Related
- 2001-12-31 BR BR0116558-5A patent/BR0116558A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA03005888A (es) | 2005-04-19 |
CA2433366C (en) | 2006-01-24 |
AU2001294354A8 (hr) | 2005-10-06 |
BR0116558A (pt) | 2003-10-28 |
DE60125981T2 (de) | 2007-10-18 |
WO2002053135A1 (en) | 2002-07-11 |
WO2002053535A2 (en) | 2002-07-11 |
DE20116723U1 (de) | 2002-01-17 |
CZ20031779A3 (cs) | 2004-10-13 |
DE60125981D1 (de) | 2007-02-22 |
ES2277960T3 (es) | 2007-08-01 |
EP1345901A2 (en) | 2003-09-24 |
WO2002053535A3 (en) | 2003-01-23 |
CA2433366A1 (en) | 2002-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2001227573A1 (en) | Ceramics and process for producing | |
AU2001269531A1 (en) | Sulfone derivatives, process for their production and use thereof | |
TWI319764B (en) | Mercaptoacetylamide derivatives, a process for their preparation and their use | |
AU6397301A (en) | Synchronization method | |
AU2002210409A1 (en) | Ethanol process | |
HUP0302295A3 (en) | Thienodibenzoazulene derivatives, process for their preparation and use thereof | |
AU2002231135A1 (en) | Method for forming complex ceramic shapes | |
AU2001294354A1 (en) | Process for making amlodipine, derivatives thereof, and precursors therefor | |
AU2001264411A1 (en) | A method for manufacturing a susceptor, a susceptor thus obtained and its application | |
AU2001291313A1 (en) | Process for making 3-amino-2-chloro-4-methylpyridine | |
AU2000254308A1 (en) | Pyrazolopyrimidinone derivatives, process for their preparation and their use | |
AU2002218440A1 (en) | New process | |
AU2001291864A1 (en) | Silicoboroncarbonitride ceramics and precursor compounds, method for the production and use thereof | |
AU2001272757A1 (en) | Process for producing 5-fluorooxyindole and for producing intermediate therefor | |
AU3734301A (en) | Method for producing 2-chloro-benzimidazole derivatives | |
AU2001262229A1 (en) | Cyclipostins, a method for their production and the use of the same | |
AU2002227966A1 (en) | Coniosetin and derivatives thereof, method for producing the same and use thereof | |
AU2002222604A1 (en) | Process for preparing substance GM-95 | |
AU2002229149A1 (en) | Process for producing hydrazinomonosaccharide derivatives and use thereof | |
AU2001283030A1 (en) | Process for making 3-hydroxyalkanenitriles and hydroxyaminoalkanes | |
AU6730001A (en) | Component, method for production and use thereof | |
AU2002228593A1 (en) | Process for preparing alpha-(3-arylthio)-acetophenones | |
AU4480201A (en) | Azetidinone derivatives, a process for their preparation and a method for producing 1-beta-alkyl azetidinone using the same | |
AU2001284442A1 (en) | Process for producing fluoroalkanol | |
AU2002227952A1 (en) | Klainetin and derivatives thereof, method for their production and the use of the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |