AU2001289617A1 - Diagnosis of diseases associated with signal transduction - Google Patents

Diagnosis of diseases associated with signal transduction

Info

Publication number
AU2001289617A1
AU2001289617A1 AU2001289617A AU8961701A AU2001289617A1 AU 2001289617 A1 AU2001289617 A1 AU 2001289617A1 AU 2001289617 A AU2001289617 A AU 2001289617A AU 8961701 A AU8961701 A AU 8961701A AU 2001289617 A1 AU2001289617 A1 AU 2001289617A1
Authority
AU
Australia
Prior art keywords
diagnosis
signal transduction
diseases associated
diseases
transduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001289617A
Other languages
English (en)
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001289617A1 publication Critical patent/AU2001289617A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
AU2001289617A 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction Abandoned AU2001289617A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10043826.1 2000-09-01
DE10043826 2000-09-01
PCT/EP2001/007472 WO2002000926A2 (fr) 2000-06-30 2001-06-29 Diagnostic de maladies associees a une transduction de signal

Publications (1)

Publication Number Publication Date
AU2001289617A1 true AU2001289617A1 (en) 2002-01-08

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
AU2001289617A Abandoned AU2001289617A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001287575A Abandoned AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling

Family Applications After (6)

Application Number Title Priority Date Filing Date
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001287575A Abandoned AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas

Country Status (5)

Country Link
US (5) US20040023230A1 (fr)
EP (9) EP1297185A2 (fr)
JP (1) JP2004501666A (fr)
AU (8) AU2001277521A1 (fr)
WO (8) WO2002002806A2 (fr)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
ATE365796T1 (de) 1997-01-14 2007-07-15 Human Genome Sciences Inc Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
WO2001092565A2 (fr) 2000-04-06 2001-12-06 Epigenomics Ag Diagnostic de maladies associees a une transcription adn
WO2002004686A2 (fr) * 2000-07-10 2002-01-17 Epigenx Pharmaceutical, Inc. Detection de la cytosine methylee dans des polynucleotides
JP2002034575A (ja) * 2000-07-28 2002-02-05 Shiseido Co Ltd ヒトＩＩ型５α−レダクターゼのプロモーター遺伝子およびその用途
DE10054974A1 (de) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
DE10061338A1 (de) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnose von mit Angiogenese assoziierten Krankheiten
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
WO2002077895A2 (fr) * 2001-03-26 2002-10-03 Epigenomics Ag Procede de selection d'aspects epigenetiques
EP2280030A3 (fr) 2001-04-10 2011-06-15 Agensys, Inc. Acides nucléiques et protéines correspondantes utiles dans la détection et le traitement des différents cancers
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
WO2003062441A1 (fr) * 2002-01-18 2003-07-31 Genzyme Corporation Procedes de detection d'adn foetal et de quantification d'alleles
WO2003064700A2 (fr) * 2002-01-30 2003-08-07 Epigenomics Ag Identification d'etats de differentiation cellulaire
EP1340818A1 (fr) 2002-02-27 2003-09-03 Epigenomics AG Procédés et acides nucléiques pour l'analyse d'un trouble associé à la prolifération de cellules du colon
WO2003076593A2 (fr) * 2002-03-07 2003-09-18 The Johns Hopkins University School Of Medicine Depistage genomique pour genes lies au cancer rendus epigenetiquement silencieux
JP2005532067A (ja) * 2002-07-03 2005-10-27 コーリー ファーマシューティカル グループ，インコーポレイテッド 刺激性免疫応答用の核酸組成物
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
EP1554407B1 (fr) 2002-10-01 2009-07-29 Epigenomics AG Procede en vue du traitement de troubles de la proliferation de celllules mammaires
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
WO2004087044A2 (fr) * 2002-12-20 2004-10-14 Bioseek, Inc. Cible medicamenteuse
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
EP1692264A2 (fr) * 2003-10-28 2006-08-23 The Johns Hopkins University Pcr quantitative multiplex specifique de la methylation
WO2005054517A2 (fr) * 2003-12-01 2005-06-16 Epigenomics Ag Procedes et acides nucleiques pour l'analyse de l'expression genique associee a la survenue de troubles cellulaires proliferants de la prostate
EP1561821B1 (fr) 2003-12-11 2011-02-16 Epigenomics AG Marqueurs pour le pronostic de la réponse à la thérapie et/ou de la survie chez les patients du cancer du sein
EP2471924A1 (fr) * 2004-05-28 2012-07-04 Asuragen, INC. Procédés et compositions impliquant du microARN
EP2302073A1 (fr) * 2004-07-18 2011-03-30 Epigenomics AG Procédés épigénétiques et acides nucléiques pour la détection de troubles cellulaires proliférables du sein
US20080171318A1 (en) * 2004-09-30 2008-07-17 Epigenomics Ag Epigenetic Methods and Nucleic Acids for the Detection of Lung Cell Proliferative Disorders
EP2302055B1 (fr) 2004-11-12 2014-08-27 Asuragen, Inc. Procédés et compositions impliquant l'ARNmi et des molécules inhibitrices de l'ARNmi
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006088978A1 (fr) 2005-02-16 2006-08-24 Epigenomics, Inc. Procede de determination du modele de methylation d'un acide polynucleique
EP1748080A3 (fr) * 2005-03-11 2007-04-11 Epiontis GmbH L'ADN spécifique pour la caractérisation epigénétique de cellules et tissus
EP2402461B1 (fr) 2005-03-11 2015-08-12 Epiontis GmbH Méthode et kit pour l'identification des chondrocytes par la détection de la deméthylation du gène C15orf27
JP5133238B2 (ja) 2005-04-15 2013-01-30 エピゲノミックス アクチェンゲゼルシャフト 遠隔サンプル由来のｄｎａ断片を提供する方法
WO2006111586A2 (fr) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procede permettant de determiner in vitro le degre de methylation du promoteur de line-1
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (fr) * 2005-07-01 2007-01-11 Epigenomics Ag Procede et acides nucleiques destines a un traitement ameliore des cancers
WO2007032748A1 (fr) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Procede de detection de la methylation de l'adn
AU2006339538A1 (en) * 2005-11-08 2007-09-13 Euclid Diagnostics Llc Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (fr) * 2006-02-09 2007-08-23 Novartis Ag Mutations et polymorphismes du gène ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
US8067168B2 (en) 2006-05-31 2011-11-29 Orion Genomics Llc Gene methylation in cancer diagnosis
ES2599816T3 (es) * 2006-07-21 2017-02-03 Epigenomics Ag Métodos relacionados con el gen GLI3 para la detección de cáncer colorrectal
EP2487240B1 (fr) * 2006-09-19 2016-11-16 Interpace Diagnostics, LLC Micro ARN différemment exprimés dans des maladies pancréatiques et leurs utilisations
WO2008073915A2 (fr) * 2006-12-08 2008-06-19 Asuragen, Inc. Microarn exprimés de manière différentielle en cas de leucémie et leurs utilisations
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
EP2103415B1 (fr) 2007-01-18 2019-03-27 Molecor Tecnología S.l. Système de fabrication d'embouchures intégrées pour des conduites en plastique à orientation biaxiale
US20090170081A1 (en) 2007-02-02 2009-07-02 Orion Genomics Llc Gene methylation in bladder cancer diagnosis
WO2008096146A1 (fr) 2007-02-07 2008-08-14 Solexa Limited Préparation de matrices pour l'analyse de méthylation
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
EP2198050A1 (fr) 2007-09-14 2010-06-23 Asuragen, INC. Microarn exprimés de manière différentielle dans le cancer du col de l'utérus et leurs utilisations
WO2009052386A1 (fr) * 2007-10-18 2009-04-23 Asuragen, Inc. Micro arn exprimés différentiellement dans des maladies pulmonaires et leurs utilisations
WO2009070805A2 (fr) 2007-12-01 2009-06-04 Asuragen, Inc. Gènes régulés par le mir-124 et cheminements servant de cibles pour une intervention thérapeutique
WO2009108917A2 (fr) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Marqueurs pour la détection améliorée du cancer du sein
EP2268832A2 (fr) * 2008-03-06 2011-01-05 Asuragen, INC. Marqueurs microrna pour la récurrence d un cancer colorectal
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
WO2010048337A2 (fr) 2008-10-22 2010-04-29 Illumina, Inc. Préservation d'informations liées à une méthylation d'adn génomique
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
CA2751688A1 (fr) * 2009-02-06 2010-08-12 Biao He Emx2 en diagnostic et pronostic du cancer
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
US20110086925A1 (en) * 2009-06-09 2011-04-14 Diego Mastroeni Method and System to Detect, Diagnose, and Monitor the Progression of Alzheimer's Disease
CA2777906A1 (fr) * 2009-10-28 2011-05-05 Signature Diagnostics Ag Methode pour le pronostic du cancer des ovaires
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
DK2614952T3 (en) 2010-09-06 2016-06-27 Molecor Tecnologia Sl DEVICES AND METHOD FOR PRODUCING mouths of biaxially oriented plastic pipe having INTEGRATED SEAL PACKAGING
EP2630241B1 (fr) * 2010-10-22 2018-10-17 CuRNA, Inc. Traitement de maladies associées à l'alpha-l-iduronidase (idua) par inhibition du transcrit antisens endogène de idua
US10435743B2 (en) 2011-05-20 2019-10-08 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
EP2748333B1 (fr) * 2011-08-25 2017-11-22 Clinical Genomics Pty Ltd Méthylation d'adn dans des procédés de diagnostic du cancer colorectal
WO2013040251A2 (fr) 2011-09-13 2013-03-21 Asurgen, Inc. Méthodes et compositions incluant mir-135b, permettant de faire la distinction entre un cancer du pancréas et une maladie pancréatique bénigne
US9127317B2 (en) 2012-03-02 2015-09-08 Winthrop-University Hospital Method for using probe based PCR detection to measure the levels of circulating demethylated β cell derived DNA as a measure of β cell loss in diabetes
WO2014071281A1 (fr) 2012-11-02 2014-05-08 The Johns Hopkins University Biomarqueurs de méthylation de l'adn pour évaluer le risque de dépression survenant après l'accouchement
ES2859645T3 (es) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Detección de neoplasia
ES2527724B1 (es) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Método para predecir la respuesta al tratamiento con radioterapia combinada con quimioterapia basada en cisplatino
EP4234722A3 (fr) 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Détection de néoplasme colorectal
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US20180230539A1 (en) * 2015-07-21 2018-08-16 Indiana University Research And Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
CA2992790A1 (fr) 2015-08-31 2017-03-09 Mayo Foundation For Medical Education And Research Detection de neoplasme gastrique
KR102380690B1 (ko) 2016-04-14 2022-03-29 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 췌장 고도 이형성증의 검출방법
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
CN105734152B (zh) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 检测人srpk2基因的表达水平的特异引物对及其应用
CN116064795A (zh) * 2016-09-02 2023-05-05 梅约医学教育与研究基金会 确定差异甲基化区域的甲基化状态的方法和试剂盒
US20190284636A1 (en) * 2016-10-26 2019-09-19 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
AU2018229294A1 (en) 2017-02-28 2019-09-26 Exact Sciences Corporation Detecting prostate cancer
KR20200105661A (ko) 2017-11-30 2020-09-08 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 유방암 검출방법
WO2019105090A1 (fr) * 2017-12-01 2019-06-06 博尔诚（北京）科技有限公司 Composition pour détecter le cancer de l'œsophage et utilisation associée
CN108977457B (zh) * 2018-08-31 2021-04-02 长江大学 一种黄鳝抗菌肽的制备方法
JP7320067B2 (ja) 2019-01-18 2023-08-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 保存された遺伝子座に基づく、哺乳動物に関するｄｎａメチル化測定
DE102020111423B4 (de) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 Region als epigenetischer Marker für die Identifizierung von Endothel-Vorläuferzellen (EPCs)
US20240093318A1 (en) * 2020-06-23 2024-03-21 The Regents Of The University Of Colorado, A Body Corporate Method for diagnosing respiratory pathogens and predicting covid-19 related outcomes
EP4196611A1 (fr) 2020-08-15 2023-06-21 Regeneron Pharmaceuticals, Inc. Traitement de l'obésité chez des sujets ayant des molécules d'acide nucléique variantes codant pour le récepteur de la calcitonine (calcr)
WO2023175019A1 (fr) 2022-03-15 2023-09-21 Genknowme S.A. Procédé pour déterminer la différence entre l'âge biologique et l'âge chronologique d'un sujet

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
EP0730663B1 (fr) * 1993-10-26 2003-09-24 Affymetrix, Inc. Reseaux de sondes d'acide nucleique sur des microplaquettes biologiques
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
ATE217028T1 (de) * 1997-12-05 2002-05-15 Max Planck Gesellschaft Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
EP1283905A2 (fr) * 2000-03-15 2003-02-19 Epigenomics AG Diagnostic d'affections associees au cycle cellulaire
WO2001092565A2 (fr) * 2000-04-06 2001-12-06 Epigenomics Ag Diagnostic de maladies associees a une transcription adn
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
EP1502222A2 (fr) * 2001-07-02 2005-02-02 Epigenomics AG Systeme distribue pour prevision a base epigenetique de phenotypes complexes

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AU2001287575A1 (en) 2002-01-08
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WO2002002806A2 (fr) 2002-01-10
US20040023230A1 (en) 2004-02-05
WO2002002806A3 (fr) 2002-05-16
AU2001276371A1 (en) 2002-01-14
EP1355932A2 (fr) 2003-10-29
EP1294947A2 (fr) 2003-03-26
EP1294951A2 (fr) 2003-03-26
EP1297185A2 (fr) 2003-04-02
WO2002000927A2 (fr) 2002-01-03
AU2001279707A1 (en) 2002-01-14
EP1676927A3 (fr) 2006-12-06
AU2001283916A1 (en) 2002-01-14
WO2002000928A3 (fr) 2002-08-01
WO2002002807A2 (fr) 2002-01-10
EP1294948A2 (fr) 2003-03-26
WO2002000926A2 (fr) 2002-01-03
WO2002002809A2 (fr) 2002-01-10
WO2002000927A3 (fr) 2002-07-18
US20040115630A1 (en) 2004-06-17
AU2001283915A1 (en) 2002-01-08
WO2002000926A8 (fr) 2002-07-18
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US20080026396A1 (en) 2008-01-31
WO2002002808A2 (fr) 2002-01-10
US20030143606A1 (en) 2003-07-31
WO2002000926A3 (fr) 2002-11-21
US20080145839A1 (en) 2008-06-19
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AU2001277521A1 (en) 2002-01-14
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