AU2001287114A1 - Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor - Google Patents
Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptorInfo
- Publication number
- AU2001287114A1 AU2001287114A1 AU2001287114A AU8711401A AU2001287114A1 AU 2001287114 A1 AU2001287114 A1 AU 2001287114A1 AU 2001287114 A AU2001287114 A AU 2001287114A AU 8711401 A AU8711401 A AU 8711401A AU 2001287114 A1 AU2001287114 A1 AU 2001287114A1
- Authority
- AU
- Australia
- Prior art keywords
- gaba
- ligands
- receptor
- aryl substituted
- tetrahydroindazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23025600P | 2000-09-06 | 2000-09-06 | |
| US60230256 | 2000-09-06 | ||
| PCT/US2001/027676 WO2002020492A1 (en) | 2000-09-06 | 2001-09-06 | Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001287114A1 true AU2001287114A1 (en) | 2002-03-22 |
Family
ID=22864511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001287114A Abandoned AU2001287114A1 (en) | 2000-09-06 | 2001-09-06 | Aryl substituted tetrahydroindazoles and their use as ligands for the gaba-a receptor |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6656941B2 (pt) |
| EP (1) | EP1315703A1 (pt) |
| JP (1) | JP2004508359A (pt) |
| AU (1) | AU2001287114A1 (pt) |
| BR (1) | BR0113697A (pt) |
| CA (1) | CA2419966A1 (pt) |
| MX (1) | MXPA03001945A (pt) |
| WO (1) | WO2002020492A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03008681A (es) | 2001-03-27 | 2004-04-02 | Neurogen Corp | (oxo-pirazol[1,5]pirimidin-2-il)alquil-carboxamidas. |
| MXPA04007606A (es) | 2002-02-07 | 2004-11-10 | Neurogen Corp | Arilamidas de acido pirazolcarboxilico fusionadas substituidas y compuestos relacionados. |
| ATE456558T1 (de) | 2003-08-14 | 2010-02-15 | Hoffmann La Roche | Gabanerge modulatoren |
| US8097654B2 (en) * | 2004-03-18 | 2012-01-17 | Suntory Holdings Limited | Radiolabeled 3-[3-(benzoyl-amido)benzyloxy]aspartic acid derivative and method of producing the same |
| FR2870239B1 (fr) * | 2004-05-11 | 2006-06-16 | Sanofi Synthelabo | Derives de carbamate de 2h- ou 3h-benzo[e]indazol-1-yle, leur preparation et leur application en therapeutique. |
| DK2074123T3 (da) | 2006-10-16 | 2013-01-14 | Bionomics Ltd | Nye anxiolytiske forbindelser |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| GB0808832D0 (en) | 2008-05-15 | 2008-06-18 | Ge Healthcare Ltd | Biomarkers for depression |
| KR101260697B1 (ko) * | 2011-01-03 | 2013-05-10 | 한국식품연구원 | 플로로글루시놀 또는 플로로탄닌을 포함하는 가바 ａ형-벤조다이아제핀 수용체 활성용 조성물 및 불안 완화, 경련 개선, 진정 작용, 및 수면 유도 및 개선용 조성물 |
| US9023848B2 (en) | 2011-03-02 | 2015-05-05 | Bionomics Limited | Small-molecules as therapeutics |
| NZ615466A (en) | 2011-05-12 | 2016-02-26 | Bionomics Ltd | Methods for preparing naphthyridines |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014023258A1 (en) * | 2012-08-10 | 2014-02-13 | F.Hoffmann-La Roche Ag | Pyrazole carboxamide compounds, compositions and methods of use |
| KR101899546B1 (ko) * | 2017-05-11 | 2018-09-17 | 한국식품연구원 | 플로로글루시놀을 유효성분으로 하는 수면 장애 개선, 예방 또는 치료용 조성물, 또는 gaba a 수용체 효능제의 내성 억제 또는 부작용 경감용 조성물 |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| EP4251170A1 (en) | 2020-11-25 | 2023-10-04 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| PE20241335A1 (es) | 2021-06-04 | 2024-07-03 | Vertex Pharma | N-(hidroxialquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio |
| EP4423069A1 (en) | 2021-10-29 | 2024-09-04 | Arcus Biosciences, Inc. | Inhibitors of hif-2alpha and methods of use thereof |
| CN115252749A (zh) * | 2022-03-26 | 2022-11-01 | 吉林大学 | 附子理中制剂作为抗抑郁靶向药物的应用 |
| US12064479B2 (en) | 2022-05-25 | 2024-08-20 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804686A (en) | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| ATE231492T1 (de) | 1997-11-13 | 2003-02-15 | Pfizer Prod Inc | Verfahren zur herstellung von pyrrolamiden |
| GB9900222D0 (en) | 1999-01-06 | 1999-02-24 | Merck Sharp & Dohme | Therapeutic compounds |
| WO2000068691A1 (en) | 1999-05-07 | 2000-11-16 | Neurogen Corporation | Methods for screening gaba-modulatory compounds for specified pharmacological activities |
| GB9911802D0 (en) | 1999-05-20 | 1999-07-21 | Merck Sharp & Dohme | Therapeutic combination |
| MXPA02001709A (es) | 1999-08-31 | 2002-10-23 | Neurogen Corp | Pirrolocarboxamidas fusionadas: ligandos receptores de acido gaba-aminobutirico cerebral. |
-
2001
- 2001-09-06 WO PCT/US2001/027676 patent/WO2002020492A1/en active Application Filing
- 2001-09-06 MX MXPA03001945A patent/MXPA03001945A/es active IP Right Grant
- 2001-09-06 US US09/947,702 patent/US6656941B2/en not_active Expired - Fee Related
- 2001-09-06 AU AU2001287114A patent/AU2001287114A1/en not_active Abandoned
- 2001-09-06 JP JP2002525114A patent/JP2004508359A/ja active Pending
- 2001-09-06 CA CA002419966A patent/CA2419966A1/en not_active Abandoned
- 2001-09-06 BR BR0113697-6A patent/BR0113697A/pt not_active IP Right Cessation
- 2001-09-06 EP EP01966614A patent/EP1315703A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US6656941B2 (en) | 2003-12-02 |
| BR0113697A (pt) | 2003-07-22 |
| WO2002020492A1 (en) | 2002-03-14 |
| EP1315703A1 (en) | 2003-06-04 |
| US20020055524A1 (en) | 2002-05-09 |
| CA2419966A1 (en) | 2002-03-14 |
| MXPA03001945A (es) | 2003-09-10 |
| JP2004508359A (ja) | 2004-03-18 |
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