AU2001282922A1 - Novel imidazolidinones as ns3-serine protease inhibitors of hepatitis c virus - Google Patents

Novel imidazolidinones as ns3-serine protease inhibitors of hepatitis c virus

Info

Publication number
AU2001282922A1
AU2001282922A1 AU2001282922A AU8292201A AU2001282922A1 AU 2001282922 A1 AU2001282922 A1 AU 2001282922A1 AU 2001282922 A AU2001282922 A AU 2001282922A AU 8292201 A AU8292201 A AU 8292201A AU 2001282922 A1 AU2001282922 A1 AU 2001282922A1
Authority
AU
Australia
Prior art keywords
imidazolidinones
hepatitis
virus
novel
protease inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001282922A
Other languages
English (en)
Inventor
Ashok Arasappan
Ashit K. Ganguily
Viyyoor Moopil Girijavallabhan
F. George Njoroge
Tejal Parekh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU2001282922A1 publication Critical patent/AU2001282922A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AU2001282922A 2000-07-21 2001-07-19 Novel imidazolidinones as ns3-serine protease inhibitors of hepatitis c virus Abandoned AU2001282922A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22011000P 2000-07-21 2000-07-21
US60/220,110 2000-07-21
US60220110 2000-07-21
PCT/US2001/022828 WO2002008198A2 (fr) 2000-07-21 2001-07-19 Nouveaux imidazolidinones comme inhibiteurs de la protease ns3-serine du virus de l'hepatite c

Publications (1)

Publication Number Publication Date
AU2001282922A1 true AU2001282922A1 (en) 2002-02-05

Family

ID=22822106

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001282922A Abandoned AU2001282922A1 (en) 2000-07-21 2001-07-19 Novel imidazolidinones as ns3-serine protease inhibitors of hepatitis c virus

Country Status (10)

Country Link
US (1) US6838475B2 (fr)
EP (1) EP1301486B1 (fr)
JP (1) JP2004515464A (fr)
AR (1) AR034127A1 (fr)
AT (1) ATE435211T1 (fr)
AU (1) AU2001282922A1 (fr)
CA (1) CA2410766A1 (fr)
DE (1) DE60139127D1 (fr)
ES (1) ES2327819T3 (fr)
WO (1) WO2002008198A2 (fr)

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US6838475B2 (en) 2005-01-04
WO2002008198A2 (fr) 2002-01-31
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ATE435211T1 (de) 2009-07-15

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