AU2001269927A1 - Thrombomodulin analogs for pharmaceutical use - Google Patents
Thrombomodulin analogs for pharmaceutical useInfo
- Publication number
- AU2001269927A1 AU2001269927A1 AU2001269927A AU6992701A AU2001269927A1 AU 2001269927 A1 AU2001269927 A1 AU 2001269927A1 AU 2001269927 A AU2001269927 A AU 2001269927A AU 6992701 A AU6992701 A AU 6992701A AU 2001269927 A1 AU2001269927 A1 AU 2001269927A1
- Authority
- AU
- Australia
- Prior art keywords
- analogs
- pharmaceutical use
- thrombomodulin
- thrombin
- thrombomodulin analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000012607 Thrombomodulin Human genes 0.000 title abstract 3
- 108010079274 Thrombomodulin Proteins 0.000 title abstract 3
- 230000004913 activation Effects 0.000 abstract 2
- 102000003847 Carboxypeptidase B2 Human genes 0.000 abstract 1
- 108090000201 Carboxypeptidase B2 Proteins 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21367800P | 2000-06-21 | 2000-06-21 | |
| US60/213,678 | 2000-06-21 | ||
| US09/880,484 | 2001-06-12 | ||
| US09/880,484 US6632791B1 (en) | 2000-06-21 | 2001-06-12 | Thrombomodulin analogs for pharmaceutical use |
| PCT/US2001/019590 WO2001098352A2 (en) | 2000-06-21 | 2001-06-20 | Thrombomodulin analogs for pharmaceutical use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001269927A1 true AU2001269927A1 (en) | 2002-01-02 |
Family
ID=26908302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001269927A Abandoned AU2001269927A1 (en) | 2000-06-21 | 2001-06-20 | Thrombomodulin analogs for pharmaceutical use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6632791B1 (https=) |
| EP (1) | EP1292673B1 (https=) |
| JP (1) | JP4855627B2 (https=) |
| AT (1) | ATE309339T1 (https=) |
| AU (1) | AU2001269927A1 (https=) |
| DE (1) | DE60114819T2 (https=) |
| DK (1) | DK1292673T3 (https=) |
| ES (1) | ES2256266T3 (https=) |
| NO (1) | NO20026147L (https=) |
| WO (1) | WO2001098352A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118580A1 (en) * | 2001-11-09 | 2003-06-26 | Rasmus Rojkjaer | Pharmaceutical composition comprising factor VII polypeptides and thrombomodulin polypeptides |
| US7579000B2 (en) * | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| JP4567437B2 (ja) * | 2002-05-01 | 2010-10-20 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 抗凝固剤としての新規組織因子標的化されたトロンボモジュリン融合タンパク質 |
| US8012693B2 (en) | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
| US7833978B2 (en) | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
| KR20080073293A (ko) | 2005-10-14 | 2008-08-08 | 메디뮨 엘엘씨 | 항체 라이브러리의 세포 디스플레이 |
| EP2120049A1 (de) | 2008-05-14 | 2009-11-18 | PAION Deutschland GmbH | Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern |
| JP2011527992A (ja) * | 2008-07-16 | 2011-11-10 | パイオン ドイチュラント ゲーエムベーハー | 放射線傷害の予防および治療 |
| WO2010006635A1 (en) * | 2008-07-16 | 2010-01-21 | Paion Deutschland Gmbh | Treatment of inflammatory bowel disease |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| EP2440237A1 (en) * | 2009-06-12 | 2012-04-18 | PAION Deutschland GmbH | Treatment of coagulopathy with hyperfibrinolysis |
| US9150844B2 (en) | 2010-08-05 | 2015-10-06 | Neeraj Maheshwari | Protein fusion constructs possessing thrombolytic and anticoagulant properties |
| WO2014020183A1 (de) * | 2012-08-03 | 2014-02-06 | Ici Immunochemical Intelligence Gmbh | In-vitro-assay zur diagnose von störungen der hämostase |
| US9156904B2 (en) * | 2013-07-29 | 2015-10-13 | Blue Blood Biotech Corp. | Thrombomodulin variants and use thereof |
| US11085031B2 (en) * | 2016-04-28 | 2021-08-10 | Saint Louis University | Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466668A (en) | 1989-04-28 | 1995-11-14 | Schering Aktiengesellschaft | Superior thrombomodulin analogs for pharmaceutical use |
| US5256770A (en) | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| US6063763A (en) | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| AU4533093A (en) * | 1992-06-10 | 1994-01-04 | Michael John Morser | Mutants of the epidermal growth factor domains of human thrombomodulin |
-
2001
- 2001-06-12 US US09/880,484 patent/US6632791B1/en not_active Expired - Fee Related
- 2001-06-20 EP EP01948487A patent/EP1292673B1/en not_active Expired - Lifetime
- 2001-06-20 ES ES01948487T patent/ES2256266T3/es not_active Expired - Lifetime
- 2001-06-20 AU AU2001269927A patent/AU2001269927A1/en not_active Abandoned
- 2001-06-20 JP JP2002504307A patent/JP4855627B2/ja not_active Expired - Fee Related
- 2001-06-20 AT AT01948487T patent/ATE309339T1/de active
- 2001-06-20 DK DK01948487T patent/DK1292673T3/da active
- 2001-06-20 DE DE60114819T patent/DE60114819T2/de not_active Expired - Lifetime
- 2001-06-20 WO PCT/US2001/019590 patent/WO2001098352A2/en not_active Ceased
-
2002
- 2002-12-20 NO NO20026147A patent/NO20026147L/no not_active Application Discontinuation
-
2003
- 2003-05-14 US US10/438,648 patent/US6790828B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20026147L (no) | 2003-02-20 |
| DK1292673T3 (da) | 2006-03-27 |
| DE60114819T2 (de) | 2006-08-10 |
| ATE309339T1 (de) | 2005-11-15 |
| US20030186883A1 (en) | 2003-10-02 |
| JP4855627B2 (ja) | 2012-01-18 |
| US6790828B2 (en) | 2004-09-14 |
| EP1292673A2 (en) | 2003-03-19 |
| DE60114819D1 (de) | 2005-12-15 |
| JP2004527452A (ja) | 2004-09-09 |
| ES2256266T3 (es) | 2006-07-16 |
| US6632791B1 (en) | 2003-10-14 |
| WO2001098352A3 (en) | 2002-08-01 |
| EP1292673B1 (en) | 2005-11-09 |
| NO20026147D0 (no) | 2002-12-20 |
| WO2001098352A2 (en) | 2001-12-27 |
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