AU2001247212B2 - Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof - Google Patents

Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof Download PDF

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Publication number
AU2001247212B2
AU2001247212B2 AU2001247212A AU2001247212A AU2001247212B2 AU 2001247212 B2 AU2001247212 B2 AU 2001247212B2 AU 2001247212 A AU2001247212 A AU 2001247212A AU 2001247212 A AU2001247212 A AU 2001247212A AU 2001247212 B2 AU2001247212 B2 AU 2001247212B2
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AU
Australia
Prior art keywords
cel
sequence
nucleic acid
endonuclease
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2001247212A
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English (en)
Other versions
AU2001247212A1 (en
Inventor
Anthony T. Yeung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Fox Chase Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/510,322 external-priority patent/US6391557B1/en
Priority claimed from US09/514,768 external-priority patent/US6699980B1/en
Application filed by Fox Chase Cancer Center filed Critical Fox Chase Cancer Center
Publication of AU2001247212A1 publication Critical patent/AU2001247212A1/en
Application granted granted Critical
Publication of AU2001247212B2 publication Critical patent/AU2001247212B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2001247212A 2000-02-22 2001-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof Ceased AU2001247212B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/510,322 2000-02-22
US09/510,322 US6391557B1 (en) 2000-02-22 2000-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof
US09/514,768 US6699980B1 (en) 2000-02-28 2000-02-28 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof
US09/514,768 2000-02-28
PCT/US2001/005502 WO2001062974A1 (en) 2000-02-22 2001-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2001247212A1 AU2001247212A1 (en) 2001-11-15
AU2001247212B2 true AU2001247212B2 (en) 2005-12-22

Family

ID=27056866

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001247212A Ceased AU2001247212B2 (en) 2000-02-22 2001-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof
AU4721201A Pending AU4721201A (en) 2000-02-22 2001-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU4721201A Pending AU4721201A (en) 2000-02-22 2001-02-22 Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof

Country Status (5)

Country Link
EP (1) EP1257671B1 (https=)
JP (1) JP4986358B2 (https=)
AU (2) AU2001247212B2 (https=)
CA (1) CA2400441C (https=)
WO (1) WO2001062974A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7582423B2 (en) 2001-02-02 2009-09-01 Novici Biotech Llc Population of polynucleotide sequence variants
CA2436214C (en) 2001-02-02 2012-12-04 Large Scale Biology Corporation A method of increasing complementarity in a heteroduplex polynucleotide
US7838219B2 (en) 2001-02-02 2010-11-23 Novici Biotech Llc Method of increasing complementarity in a heteroduplex
US7078211B2 (en) 2002-02-01 2006-07-18 Large Scale Biology Corporation Nucleic acid molecules encoding endonucleases and methods of use thereof
DE10248258A1 (de) * 2002-10-16 2004-05-06 Biopsytec Analytik Gmbh Mutierte Nukleinsäure einer Cel I-Endonuklease und Verfahren zur Herstellung des rekombinanten vollständigen Cel I-Proteins
CA2575276A1 (en) * 2004-07-30 2006-02-02 Institut National De La Recherche Agronomique Method for producing highly sensitive endonucleases, novel preparations of endonucleases and uses thereof
CN101538561B (zh) * 2009-04-17 2010-09-29 广州大学 一种提取芹菜中celⅰ核酸酶的方法
JP6009649B2 (ja) 2013-03-14 2016-10-19 タカラバイオ株式会社 耐熱性のミスマッチエンドヌクレアーゼの利用方法
KR20170053636A (ko) * 2014-09-11 2017-05-16 다카라 바이오 가부시키가이샤 내열성의 미스매치 엔도뉴클레아제의 이용방법
WO2016178207A1 (en) 2015-05-04 2016-11-10 Ramot At Tel-Aviv University Ltd. Methods and kits for fragmenting dna
CN119242611A (zh) 2020-03-19 2025-01-03 宝生物工程株式会社 耐热的错配核酸内切酶变体
CN112301020B (zh) * 2020-10-19 2024-04-12 复旦大学附属肿瘤医院 Iii类脱氧核酶突变体及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869245A (en) * 1996-06-05 1999-02-09 Fox Chase Cancer Center Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0964929B1 (en) * 1996-06-05 2004-10-20 Fox Chase Cancer Center Mismatch endonucleases and uses thereof in identifying mutations in targeted polynucleotide strands

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869245A (en) * 1996-06-05 1999-02-09 Fox Chase Cancer Center Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nucleic Acids Research (1998) 26(20): 4597-4602, "Mutation detection using a novel plant endonuclease", Oleykowski et al, 15 October 1998. *

Also Published As

Publication number Publication date
CA2400441C (en) 2013-08-27
EP1257671B1 (en) 2015-01-14
EP1257671A4 (en) 2005-08-17
EP1257671A1 (en) 2002-11-20
JP4986358B2 (ja) 2012-07-25
JP2004529602A (ja) 2004-09-30
CA2400441A1 (en) 2001-08-30
AU4721201A (en) 2001-09-03
WO2001062974A1 (en) 2001-08-30

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired