AU2001245637A1 - Methods of improving homologous recombination - Google Patents

Methods of improving homologous recombination

Info

Publication number
AU2001245637A1
AU2001245637A1 AU2001245637A AU4563701A AU2001245637A1 AU 2001245637 A1 AU2001245637 A1 AU 2001245637A1 AU 2001245637 A AU2001245637 A AU 2001245637A AU 4563701 A AU4563701 A AU 4563701A AU 2001245637 A1 AU2001245637 A1 AU 2001245637A1
Authority
AU
Australia
Prior art keywords
agent
homologous recombination
methods
alteration
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001245637A
Other languages
English (en)
Inventor
Evguenii Ivanov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Human Genetics Therapies Inc
Original Assignee
Transkaryotic Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transkaryotic Therapies Inc filed Critical Transkaryotic Therapies Inc
Publication of AU2001245637A1 publication Critical patent/AU2001245637A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4712—Cystic fibrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Led Devices (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
AU2001245637A 2000-03-14 2001-03-13 Methods of improving homologous recombination Abandoned AU2001245637A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/525,160 US6569681B1 (en) 2000-03-14 2000-03-14 Methods of improving homologous recombination
US09525160 2000-03-14
PCT/US2001/007870 WO2001068882A2 (en) 2000-03-14 2001-03-13 Methods for homologous recombination

Publications (1)

Publication Number Publication Date
AU2001245637A1 true AU2001245637A1 (en) 2001-09-24

Family

ID=24092175

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001245637A Abandoned AU2001245637A1 (en) 2000-03-14 2001-03-13 Methods of improving homologous recombination

Country Status (10)

Country Link
US (1) US6569681B1 (ja)
EP (1) EP1263972B1 (ja)
JP (1) JP2003526376A (ja)
AT (1) ATE525472T1 (ja)
AU (1) AU2001245637A1 (ja)
CA (1) CA2403113A1 (ja)
DK (1) DK1263972T3 (ja)
MX (1) MXPA02009044A (ja)
TR (1) TR200202196T2 (ja)
WO (1) WO2001068882A2 (ja)

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Publication number Priority date Publication date Assignee Title
AU2001279069A1 (en) * 2000-07-27 2002-02-13 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
SG141239A1 (en) * 2001-01-26 2008-04-28 Selexis Sa Matrix attachment regions and methods for use thereof
EP1474522B1 (en) * 2002-01-18 2012-03-07 Morphotek, Inc. A method for generating engineered cells for locus specific gene regulation and analysis
GB0214896D0 (en) * 2002-06-27 2002-08-07 Novartis Forschungsstiftung Gene for increased somatic recombination
FR2846337B1 (fr) 2002-10-28 2007-06-22 Centre Nat Rech Scient Procede pour inserer un acide nucleique d'interet dans une cellule procaryote ou eucaryote par recombinaison homologue
AU2003296438A1 (en) * 2002-12-24 2004-07-29 North Carolina State University Increasing gamete production with a gene switch
JP5396653B2 (ja) 2003-10-24 2014-01-22 セレキス エスアー Ｍａｒ配列の多トランスフェクション手順による高効率の遺伝子導入および哺乳動物細胞における発現
JP4050712B2 (ja) 2004-02-27 2008-02-20 独立行政法人科学技術振興機構 相同組換えを行わせる方法
DE602005023427D1 (de) 2004-04-02 2010-10-21 Dsm Ip Assets Bv Filamentöse pilzmutanten mit verbesserter homologer rekombinationseffizienz
US20060110390A1 (en) * 2004-08-25 2006-05-25 Myogen, Inc. Inhibition of Ku as a treatment for cardiovascular diseases
JP4625318B2 (ja) * 2004-12-06 2011-02-02 財団法人野田産業科学研究所 相同組換え頻度が上昇した形質転換菌
CN101137752B (zh) 2005-03-08 2013-04-03 巴斯福植物科学有限公司 增强表达的内含子序列
EP2305791A1 (en) 2005-04-15 2011-04-06 North Carolina State University Methods and compositions to modulate adhesion and stress tolerance in bacteria
JP2007222055A (ja) * 2006-02-22 2007-09-06 Noda Inst For Scient Res 染色体領域欠失株の作製方法
JP2008263927A (ja) * 2007-04-25 2008-11-06 Noda Inst For Scient Res 染色体大領域の欠失方法
DK2147107T3 (da) * 2007-05-09 2011-10-24 Novozymes As Fremgangsmåde til ekspressionskloning, som er egnet til selektion af bibliotekskloner, der producerer et polypeptid af interesse
ES2466916T3 (es) 2007-06-27 2014-06-11 Admune Therapeutics Llc Complejos de IL-15 e IL-15R alfa y usos de los mismos
DK2462230T3 (en) * 2009-08-03 2015-10-19 Recombinetics Inc METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
EP3381937A3 (en) 2009-08-13 2018-10-31 The Johns Hopkins University Methods of modulating immune function
JP5924773B2 (ja) * 2009-12-21 2016-05-25 キージーン・エン・フェー プロトプラストを形質移入するための改善された技術
WO2011078662A1 (en) * 2009-12-21 2011-06-30 Keygene N.V. Dsrna for improved genetic modification of plant dna
GB201009732D0 (en) * 2010-06-10 2010-07-21 Gene Bridges Gmbh Direct cloning
WO2012168307A2 (en) * 2011-06-07 2012-12-13 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Improved recombination efficiency by inhibition of nhej dna repair
US20150307876A1 (en) * 2012-02-10 2015-10-29 Regents Of The University Of Minnesota Dna assimilation
US20150359853A1 (en) 2012-10-24 2015-12-17 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
WO2015066205A1 (en) * 2013-10-29 2015-05-07 Rutgers, The State University Of New Jersey Fast genetically modified organism and systems for precise genome editing and targeted genetic manipulation through enhanced homologous recombination
ES2811974T3 (es) 2014-07-29 2021-03-15 Novartis Ag Regímenes de aumento escalonado de la dosis del heterodímero de il-15 e il-15ralfa para tratar afecciones
US10413597B2 (en) 2014-09-29 2019-09-17 Alexion Pharmaceuticals, Inc. Methods of treating Mucopolysaccharidosis IIIB (MPSIIIB)
ES2847252T3 (es) * 2016-02-22 2021-08-02 Caribou Biosciences Inc Procedimientos de modulación de resultados de reparación de ADN
JP2020505350A (ja) 2017-01-20 2020-02-20 ノバルティス アーゲー 癌の治療のための組合せ療法
WO2018134784A1 (en) 2017-01-20 2018-07-26 Novartis Ag Combination therapy for the treatment of cancer
JP7084021B2 (ja) * 2018-01-24 2022-06-14 公立大学法人大阪 ターゲティングベクター
US20210244821A1 (en) 2020-02-05 2021-08-12 Novartis Ag Cho cell expressed het il-15

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US6010908A (en) 1992-08-21 2000-01-04 The Regents Of The University Of California Gene therapy by small fragment homologous replacement
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
CA2118513A1 (en) * 1992-04-24 1993-11-11 David A. Zarling In vivo homologous sequence targeting in eukaryotic cells
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
PT966683E (pt) 1997-01-13 2003-08-29 Kudos Pharm Ltd Ensaios agentes terapia e diagnostico relativos a modulacao de actividade de reparacao de adn celular
GB9700574D0 (en) 1997-01-13 1997-03-05 Cancer Res Campaign Tech Methods and means relating to retrotransposon and retroviral integration
AU743305C (en) * 1997-01-17 2006-03-30 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US5986055A (en) 1997-11-13 1999-11-16 Curagen Corporation CDK2 interactions
DE19755952C1 (de) 1997-12-16 1998-12-10 Curt Niebling Dünnwandiges, elektro-magnetisch abschirmendes, tiefgezogenes Formteil, Verfahren zu dessen Herstellung, und ein bei diesem Verfahren einsetzbares Zwischenprodukt
WO1999033971A1 (en) 1997-12-31 1999-07-08 Medical College Of Georgia Research Institute, Inc. Oligomers that bind to ku protein
US6180850B1 (en) 1998-09-02 2001-01-30 Pioneer Hi-Bred International, Inc. Maize Ku70 orthologue and uses thereof
AU771438C (en) 1999-05-05 2004-12-02 Pioneer Hi-Bred International, Inc. Maize Rad50 orthologue and uses thereof

Also Published As

Publication number Publication date
CA2403113A1 (en) 2001-09-20
JP2003526376A (ja) 2003-09-09
TR200202196T2 (tr) 2003-01-21
EP1263972A2 (en) 2002-12-11
ATE525472T1 (de) 2011-10-15
US6569681B1 (en) 2003-05-27
WO2001068882A2 (en) 2001-09-20
DK1263972T3 (da) 2012-01-02
EP1263972B1 (en) 2011-09-21
WO2001068882A3 (en) 2002-03-14
MXPA02009044A (es) 2003-04-25

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