AU2001244899A1 - New ccr5 modulators: benzimidazoles or benzotriazoles - Google Patents

New ccr5 modulators: benzimidazoles or benzotriazoles

Info

Publication number
AU2001244899A1
AU2001244899A1 AU2001244899A AU4489901A AU2001244899A1 AU 2001244899 A1 AU2001244899 A1 AU 2001244899A1 AU 2001244899 A AU2001244899 A AU 2001244899A AU 4489901 A AU4489901 A AU 4489901A AU 2001244899 A1 AU2001244899 A1 AU 2001244899A1
Authority
AU
Australia
Prior art keywords
alkyl
phenyl
heteroaryl
optionally substituted
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001244899A
Other languages
English (en)
Inventor
Jeremy Burrows
John Cumming
Thomas Mcinally
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2001244899A1 publication Critical patent/AU2001244899A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001244899A 2000-03-10 2001-03-06 New ccr5 modulators: benzimidazoles or benzotriazoles Abandoned AU2001244899A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0005642.4A GB0005642D0 (en) 2000-03-10 2000-03-10 Chemical compounds
GB0005642 2000-03-10
PCT/SE2001/000470 WO2001066525A1 (fr) 2000-03-10 2001-03-06 Benzimidazoles ou benzotriazoles en tant que nouveaux modulateurs de ccr5

Publications (1)

Publication Number Publication Date
AU2001244899A1 true AU2001244899A1 (en) 2001-09-17

Family

ID=9887252

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001244899A Abandoned AU2001244899A1 (en) 2000-03-10 2001-03-06 New ccr5 modulators: benzimidazoles or benzotriazoles

Country Status (15)

Country Link
US (1) US6989393B2 (fr)
EP (1) EP1265870A1 (fr)
JP (1) JP2003525928A (fr)
KR (1) KR20020080479A (fr)
CN (1) CN1416421A (fr)
AU (1) AU2001244899A1 (fr)
BR (1) BR0109109A (fr)
CA (1) CA2401524A1 (fr)
GB (1) GB0005642D0 (fr)
IL (1) IL151381A0 (fr)
MX (1) MXPA02008656A (fr)
NO (1) NO20024310L (fr)
NZ (1) NZ521113A (fr)
WO (1) WO2001066525A1 (fr)
ZA (1) ZA200207112B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903544D0 (sv) 1999-10-01 1999-10-01 Astra Pharma Prod Novel compounds
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0102716D0 (sv) * 2001-08-14 2001-08-14 Astrazeneca Ab Novel compounds
EP1451173A4 (fr) * 2001-11-01 2005-10-26 Icagen Inc Piperidines
AU2002360561A1 (en) * 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
DE60336576D1 (de) 2002-10-30 2011-05-12 Merck Sharp & Dohme Hemmer der akt aktivität
US7638530B2 (en) 2003-04-24 2009-12-29 Merck & Co., Inc. Inhibitors of Akt activity
SE0301369D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
EP1496058A1 (fr) * 2003-07-09 2005-01-12 Boehringer Ingelheim Pharma GmbH & Co.KG Nouveaux Indoles et heteroderivés N-substitués par heterobicycloalkanes
US7157471B2 (en) 2003-08-25 2007-01-02 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
EP1660476B1 (fr) * 2003-08-25 2006-12-27 Boehringer Ingelheim International GmbH Derives de benzimidazole substitues par haloalkyle et piperidine
EP1685128A1 (fr) 2003-10-16 2006-08-02 Smithkline Beecham Corporation Procede de preparation de thiophenes de benzimidazole
GB0328243D0 (en) 2003-12-05 2004-01-07 Astrazeneca Ab Methods
TW200610761A (en) * 2004-04-23 2006-04-01 Astrazeneca Ab Chemical compounds
US7723360B2 (en) * 2004-08-06 2010-05-25 Boehringer Ingelheim International Gmbh Alkyl-and piperidine-substituted benzimidazole derivatives
CA2621073A1 (fr) * 2005-09-06 2007-03-15 Smithkline Beecham Corporation Procede regioselectif de preparation de benzimidazole thiophenes
WO2007045573A1 (fr) 2005-10-19 2007-04-26 F. Hoffmann-La Roche Ag Phénylacétamides en tant qu'inhibiteurs de nnrt
WO2008071587A2 (fr) 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag Inhibiteurs non nucléosidiques de la transcriptase inverse
GB0625523D0 (en) * 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
MX2010002449A (es) 2007-08-31 2010-09-07 Purdue Pharma Lp Compuestos de piperidina tipo quinoxalina sustituida y uso de los mismsos.
WO2011079087A1 (fr) * 2009-12-23 2011-06-30 Glaxo Group Limited Bloqueurs du canal enac
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
US11452541B2 (en) 2016-12-22 2022-09-27 Scientia Vascular, Inc. Intravascular device having a selectively deflectable tip

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
EG12406A (en) 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
FR2421899A1 (fr) 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4410528A (en) * 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
US5521197A (en) 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
ATE341542T1 (de) 1996-04-19 2006-10-15 Neurosearch As 1-(4-piperidyl)-benzimidazole mit neurotropher aktivität
JP2002510327A (ja) 1997-07-25 2002-04-02 メルク エンド カンパニー インコーポレーテッド 環状アミンケモカイン受容体活性調節剤
AR013669A1 (es) 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
WO1999036421A1 (fr) 1998-01-19 1999-07-22 Pfizer Pharmaceuticals Inc. Composes de 4-(2-ceto-1-benzimidazolinyl)piperidine, utiles comme agonistes du recepteur orl1
AU747508B2 (en) * 1998-03-19 2002-05-16 Nihon Nohyaku Co., Ltd. Arylpiperidine derivatives and use thereof
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6432981B1 (en) * 1999-06-11 2002-08-13 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6340681B1 (en) 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
AR025884A1 (es) 1999-10-01 2002-12-18 Takeda Pharmaceutical Compuestos de amina ciclica, su produccion y su uso
EP1122257B1 (fr) 2000-01-05 2005-10-12 Pfizer Inc. Composés de benzimidazole comme agonistes du récepteur ORL1
EP1277737A4 (fr) * 2000-03-24 2003-05-07 Meiji Seika Kaisha Derives de la diphenylalkylamine utiles comme agonistes du recepteur de l'opioide delta

Also Published As

Publication number Publication date
IL151381A0 (en) 2003-04-10
JP2003525928A (ja) 2003-09-02
KR20020080479A (ko) 2002-10-23
MXPA02008656A (es) 2003-02-24
NO20024310L (no) 2002-10-25
EP1265870A1 (fr) 2002-12-18
US6989393B2 (en) 2006-01-24
BR0109109A (pt) 2003-06-03
CN1416421A (zh) 2003-05-07
GB0005642D0 (en) 2000-05-03
US20030119869A1 (en) 2003-06-26
CA2401524A1 (fr) 2001-09-13
ZA200207112B (en) 2003-12-04
NZ521113A (en) 2004-05-28
NO20024310D0 (no) 2002-09-09
WO2001066525A1 (fr) 2001-09-13

Similar Documents

Publication Publication Date Title
AU2001244899A1 (en) New ccr5 modulators: benzimidazoles or benzotriazoles
JP4988584B2 (ja) Ｖｅｇｆ受容体キナーゼインヒビターとしてのアントラニルアミドピリジンウレア
KR20110133034A (ko) 가용성 구아닐레이트 시클라제 활성화제
ES2392759T3 (es) Piridazina tetrasustituida como antagonistas de la vía Hedgehog.
SK5462003A3 (en) Indolylmaleimide derivatives, method for the preparation thereof and pharmaceutical composition comprising same
JP5498396B2 (ja) ヒスタミンｈ４受容体アンタゴニストとしての４−アミノピリミジン誘導体
HRP940575A2 (en) Piperidine derivatives
EP2663553A2 (fr) Composés quinoléine et isoquinoléine et leurs procédés d&#39;utilisation
KR20080059264A (ko) Ｍｃｈ 수용체 길항제로서의 인단 유도체
US20120053174A1 (en) Quinazoline compounds and methods of use thereof
TW201315727A (zh) 尿嘧啶衍生物及其醫藥用途
RU2345990C2 (ru) Производные пиперидина в качестве модуляторов активности рецептора ccr5, способы и промежуточные соединения для их получения и фармацевтические композиции, содержащие их
JP2008537725A (ja) 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
JP2011513295A (ja) インダゾール誘導体
AU2008293715B2 (en) Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists
WO2012117996A1 (fr) Agoniste de gpr119
JP5291716B2 (ja) ５−ｈｔ７受容体拮抗薬
JP2015034184A (ja) ピリドピラジノン誘導体インスリン分泌刺激剤、それらを得る方法および糖尿病を治療するためのそれらの使用
ES2446307T3 (es) Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
KR101905295B1 (ko) 나프티리딘디온 유도체
JP2012532126A (ja) フラビン誘導体
JP2009501744A (ja) 化合物
CN102149706A (zh) 4-氧代-l,4-二氢-喹啉的抗肿瘤的衍生物、其制备方法和其治疗用途
US10745381B2 (en) Substituted isoquinolines and phthalazines as rock kinase inhibitors
CA2171782A1 (fr) Derives heteroarylaminoalkyliques de naphtylmonazines, antidepresseurs