AU2001241798A1 - 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors - Google Patents

3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors

Info

Publication number
AU2001241798A1
AU2001241798A1 AU2001241798A AU4179801A AU2001241798A1 AU 2001241798 A1 AU2001241798 A1 AU 2001241798A1 AU 2001241798 A AU2001241798 A AU 2001241798A AU 4179801 A AU4179801 A AU 4179801A AU 2001241798 A1 AU2001241798 A1 AU 2001241798A1
Authority
AU
Australia
Prior art keywords
indolinone compounds
pyrolyllactone
kinase inhibitors
compounds
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001241798A
Other languages
English (en)
Inventor
Jingrong Cui
Ping Huang
Xiaoyuan Li
Todd A. Miller
Peng Cho Tang
Chung Chen Wei
Ruofei Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Sugen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen LLC filed Critical Sugen LLC
Publication of AU2001241798A1 publication Critical patent/AU2001241798A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2001241798A 2000-02-28 2001-02-28 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors Abandoned AU2001241798A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18553600P 2000-02-28 2000-02-28
US60185536 2000-02-28
PCT/US2001/006214 WO2001064681A2 (en) 2000-02-28 2001-02-28 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
AU2001241798A1 true AU2001241798A1 (en) 2001-09-12

Family

ID=22681392

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001241798A Abandoned AU2001241798A1 (en) 2000-02-28 2001-02-28 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors

Country Status (9)

Country Link
US (1) US6465507B2 (de)
EP (1) EP1259514B9 (de)
JP (1) JP2003525296A (de)
AT (1) ATE297395T1 (de)
AU (1) AU2001241798A1 (de)
CA (1) CA2400649A1 (de)
DE (1) DE60111358T2 (de)
ES (1) ES2243461T3 (de)
WO (1) WO2001064681A2 (de)

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EP1244672B1 (de) * 1999-12-21 2005-07-20 Sugen, Inc. 4-substituierte 7-aza-indolin-2-one und ihre anwendung als protein kinase inhibitoren
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JP2006514101A (ja) * 2002-11-08 2006-04-27 ノボ・ノルデイスク・エー／エス 肥満症の治療のための安全な化学的脱共役剤
US7626031B2 (en) 2002-11-15 2009-12-01 Symphony Evolution, Inc. Substituted 3-(diarylmethylene)indolin-2-ones and methods of their use
US20040266843A1 (en) * 2003-03-07 2004-12-30 Sugen, Inc. Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
US7157577B2 (en) * 2003-03-07 2007-01-02 Sugen Inc. 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
US7640052B2 (en) 2004-05-28 2009-12-29 Ippp, Llc Method of integrated proton beam and therapeutic magnetic resonance therapy
US7801585B1 (en) * 2003-06-02 2010-09-21 Newlife Sciences Llc System for analyzing and treating abnormality of human and animal tissues
WO2005113561A1 (en) * 2004-05-20 2005-12-01 Sugen, Inc. Cyclicsulfonate pyrrole indolinones as kinase inhibitors
WO2007056493A1 (en) * 2005-11-08 2007-05-18 Schumann Daniel H Device and method for the treatment of pain with electrical energy
BRPI0707312B1 (pt) 2006-01-27 2022-06-07 Shanghai Hengrui Pharmacetical Co., Ltd Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase, seu uso e seu processo de fabricação, intermediário e seus processos de fabricação, composição farmacêutica e seu uso
CN101007815B (zh) * 2006-01-27 2010-06-23 江苏恒瑞医药股份有限公司 吡咯并六元杂环化合物及其在医药上的用途
CN101054379A (zh) * 2006-04-11 2007-10-17 上海恒瑞医药有限公司 吡咯取代的嘧啶酮衍生物、其制备方法及其在医药上的用途
US20080109049A1 (en) * 2006-11-08 2008-05-08 Schumann Daniel H Device & method for relieving pain
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
WO2008138232A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co., Ltd. Dérivés pyrrolo-azotés hétérocycliques, leur préparation et leur utilisation pharmaceutique
WO2008138184A1 (fr) * 2007-05-14 2008-11-20 Shanghai Hengrui Pharmaceutical Co.Ltd. Dérivés de pyrrolo-azacycles, leur procédé de fabrication et leur utilisation en tant qu'inhibiteurs de protéine kinases
CN101367801B (zh) * 2007-08-15 2011-01-12 上海恒瑞医药有限公司 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用
EP3037419B1 (de) * 2007-09-06 2019-09-04 Boston Biomedical, Inc. Zusammensetzungen von kinaseinhibitoren und ihre verwendung zur behandlung von krebs und anderen mit kinasen in zusammenhang stehenden krankheiten
US20090149732A1 (en) * 2007-12-08 2009-06-11 Weinstock Ronald J System for use of electrical resonant frequencies in analyzing and treating abnormality of human and animal tissues
US20100324627A1 (en) * 2008-07-28 2010-12-23 Newlife Sciences, Llc Method and apparatus for resistivity measurement, detection and treatment in living tissue
WO2011056985A2 (en) * 2009-11-04 2011-05-12 Gilead Sciences, Inc. Substituted heterocyclic compounds
CN102146082A (zh) * 2010-02-04 2011-08-10 江苏恒瑞医药股份有限公司 吡咯并n杂环类衍生物的可药用的盐、其制备方法及其在医药上的应用
CA2819461A1 (en) 2010-11-30 2012-06-07 Newlife Sciences Llc Apparatus and method for treatment of pain with body impedance analyzer
KR20170124602A (ko) 2015-03-13 2017-11-10 포르마 세라퓨틱스 인크. Hdac8 억제제로서의 알파-신나미드 화합물 및 조성물
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US11358948B2 (en) 2017-09-22 2022-06-14 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
JP2021508703A (ja) 2017-12-26 2021-03-11 カイメラ セラピューティクス， インコーポレイテッド Ｉｒａｋ分解剤およびそれらの使用
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
CA3119773A1 (en) 2018-11-30 2020-06-04 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TW202106676A (zh) 2019-04-05 2021-02-16 美商凱麥拉醫療公司 Stat降解劑及其用途
KR20220019712A (ko) 2019-06-12 2022-02-17 트루릴리프 엘엘씨 펄스화된 전류를 생체 조직에 전달하기 위한 시스템 및 방법
US11779578B2 (en) 2019-12-17 2023-10-10 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
CA3162502A1 (en) 2019-12-23 2021-07-01 Yi Zhang Smarca degraders and uses thereof
JP2023518423A (ja) 2020-03-19 2023-05-01 カイメラ セラピューティクス， インコーポレイテッド Ｍｄｍ２分解剤およびそれらの使用
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
US11911605B2 (en) 2021-03-05 2024-02-27 Truerelief Llc Method and apparatus for injury treatment

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Also Published As

Publication number Publication date
ATE297395T1 (de) 2005-06-15
US6465507B2 (en) 2002-10-15
EP1259514A2 (de) 2002-11-27
WO2001064681A3 (en) 2002-04-18
WO2001064681A2 (en) 2001-09-07
DE60111358T2 (de) 2006-05-11
EP1259514B9 (de) 2005-11-09
DE60111358D1 (de) 2005-07-14
US20020042427A1 (en) 2002-04-11
CA2400649A1 (en) 2001-09-07
JP2003525296A (ja) 2003-08-26
ES2243461T3 (es) 2005-12-01
EP1259514B1 (de) 2005-06-08

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