AU2001234174A1 - Phosphonate nucleotide compound - Google Patents

Phosphonate nucleotide compound

Info

Publication number
AU2001234174A1
AU2001234174A1 AU2001234174A AU3417401A AU2001234174A1 AU 2001234174 A1 AU2001234174 A1 AU 2001234174A1 AU 2001234174 A AU2001234174 A AU 2001234174A AU 3417401 A AU3417401 A AU 3417401A AU 2001234174 A1 AU2001234174 A1 AU 2001234174A1
Authority
AU
Australia
Prior art keywords
nucleotide compound
phosphonate nucleotide
phosphonate
compound
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001234174A
Other languages
English (en)
Inventor
Kouichi Sekiya
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Mitsubishi Tokyo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tokyo Pharmaceuticals Inc filed Critical Mitsubishi Tokyo Pharmaceuticals Inc
Publication of AU2001234174A1 publication Critical patent/AU2001234174A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001234174A 2000-02-29 2001-02-26 Phosphonate nucleotide compound Abandoned AU2001234174A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000054675 2000-02-29
JP2000-54675 2000-02-29
PCT/JP2001/001412 WO2001064693A1 (fr) 2000-02-29 2001-02-26 Compose de nucleotide de phosphonate

Publications (1)

Publication Number Publication Date
AU2001234174A1 true AU2001234174A1 (en) 2001-09-12

Family

ID=18575897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001234174A Abandoned AU2001234174A1 (en) 2000-02-29 2001-02-26 Phosphonate nucleotide compound

Country Status (5)

Country Link
US (1) US6767900B2 (ko)
KR (1) KR20020093824A (ko)
CN (1) CN1426418A (ko)
AU (1) AU2001234174A1 (ko)
WO (1) WO2001064693A1 (ko)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003028737A1 (en) * 2001-08-30 2003-04-10 Mitsubishi Pharma Corporation Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
US20050239054A1 (en) * 2002-04-26 2005-10-27 Arimilli Murty N Method and compositions for identifying anti-HIV therapeutic compounds
EA008775B1 (ru) 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Ингибиторы протеазы вич для лечения инфекции вич и фармацевтическая композиция
AU2003242428A1 (en) * 2002-05-24 2003-12-12 Mitsubishi Pharma Corporation Drugs improved in tissue selectivity
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
JP2006524710A (ja) * 2003-04-25 2006-11-02 ギリアード サイエンシーズ， インコーポレイテッド キナーゼインヒビターホスホネート抱合体
US7300924B2 (en) * 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
DK1628685T3 (da) * 2003-04-25 2011-03-21 Gilead Sciences Inc Antivirale phosphonatanaloge
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US7432261B2 (en) * 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
WO2005002626A2 (en) * 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7407965B2 (en) * 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
WO2004096287A2 (en) * 2003-04-25 2004-11-11 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
WO2005044279A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
WO2005044308A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
JP2007508843A (ja) 2003-10-24 2007-04-12 ギリアード サイエンシーズ， インコーポレイテッド 治療用化合物の同定のための方法および組成物
MXPA06006899A (es) * 2003-12-22 2006-09-04 Gilead Sciences Inc Derivados de carbovir y abacavir 4'-sustituidos asi como compuestos relacionados con actividad antiviral de virus de inmunodeficiencia humana y virus de la hepatitis c.
US20050153990A1 (en) * 2003-12-22 2005-07-14 Watkins William J. Phosphonate substituted kinase inhibitors
US20070281907A1 (en) * 2003-12-22 2007-12-06 Watkins William J Kinase Inhibitor Phosphonate Conjugates
CN100475825C (zh) * 2004-03-19 2009-04-08 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物
US7871991B2 (en) 2004-07-27 2011-01-18 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds
CA2585353A1 (en) * 2004-10-26 2006-05-04 Gilead Sciences, Inc. Phosphonate derivatives of mycophenolic acid
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
WO2007014491A1 (fr) * 2005-08-03 2007-02-08 Beijing Fu Kang Ren Bio-Pharm Tech.Co.Ltd. Phosphonates de nucléotides acycliques et leur utilisation dans des agents antiviraux
CN1935817B (zh) * 2005-09-19 2011-05-11 北京阜康仁生物制药科技有限公司 新的无环核苷膦酸酯及其医药用途
CN101940571A (zh) 2007-04-13 2011-01-12 南方研究所 抗血管生成剂和使用方法
US8787221B2 (en) * 2007-10-23 2014-07-22 La Crosse Technology, Ltd. Method of transmitting, receiving, recording, playing and displaying weather radio
MX2011000306A (es) * 2008-07-08 2011-03-15 Gilead Sciences Inc Sales de compuestos inhibidores de hiv.
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
KR101115041B1 (ko) 2011-01-07 2012-03-06 경남과학기술대학교 산학협력단 계육 가수분해물을 포함하는 기능성 조성물 및 이의 제조방법
DK2794624T3 (da) 2011-12-22 2019-07-22 Geron Corp Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
CN105246902B (zh) 2013-03-15 2018-05-04 加利福尼亚大学董事会 无环核苷膦酸二酯
KR102589658B1 (ko) 2014-09-15 2023-10-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뉴클레오타이드 유사체
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
EP3960740B1 (en) 2017-08-01 2023-11-15 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) vanillate for treating viral infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE199906T1 (de) 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
CA2195262C (en) 1996-01-18 2005-08-09 Masaru Ubasawa Phosphonate nucleotide compounds
KR20020097384A (ko) * 2001-06-20 2002-12-31 미쯔비시 도꾜 세이야꾸 가부시끼가이샤 기존의 약제에 내성변이를 가지는 바이러스에 유효한 약제

Also Published As

Publication number Publication date
KR20020093824A (ko) 2002-12-16
US20030153534A1 (en) 2003-08-14
CN1426418A (zh) 2003-06-25
US6767900B2 (en) 2004-07-27
WO2001064693A1 (fr) 2001-09-07

Similar Documents

Publication Publication Date Title
AU2001234174A1 (en) Phosphonate nucleotide compound
AU2002225730A1 (en) Compounds
AU2002218266A1 (en) Novel indanylidene compounds
AU2001292030A1 (en) Antiparasitic compounds
AU2001292518A1 (en) Novel compounds
AU2001266345A1 (en) Five-membered-ring compound
AU2001265089A1 (en) Rc-timer scheme
AUPQ661800A0 (en) Insulin-potentiating compounds
AU2001239765A1 (en) Novel compounds
AU2001246998A1 (en) Novel compounds
AU2001253362A1 (en) Novel compounds
AU2002231077A1 (en) Novel compounds
EP1277758A4 (en) PHOSPHORUS COMPOUND
AU2001256964A1 (en) Novel compounds
AU2002225724A1 (en) Motilide compounds
AU5935600A (en) Phosphoramide compounds
AU2002220684A1 (en) Fap-alpha-activated anti-tumor compounds
AU2001236065A1 (en) Antiviral compounds
AU2002217285A1 (en) Compounds
AU2001230689A1 (en) Novel compounds
AU2002216060A1 (en) Novel compounds
AU2002221923A1 (en) Novel compounds
AU2001276890A1 (en) Novel compounds
AUPQ575300A0 (en) New compound
AUPR018900A0 (en) Pamidronate solution