AU1593197A - Process for preparing ganciclovir derivatives - Google Patents

Process for preparing ganciclovir derivatives

Info

Publication number
AU1593197A
AU1593197A AU15931/97A AU1593197A AU1593197A AU 1593197 A AU1593197 A AU 1593197A AU 15931/97 A AU15931/97 A AU 15931/97A AU 1593197 A AU1593197 A AU 1593197A AU 1593197 A AU1593197 A AU 1593197A
Authority
AU
Australia
Prior art keywords
derivatives
preparing
preparing ganciclovir
ganciclovir derivatives
ganciclovir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU15931/97A
Other languages
English (en)
Inventor
Humberto B. Arzeno
Eric R Humphreys
Christopher R. Roberts
Jim-Wah Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU1593197A publication Critical patent/AU1593197A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU15931/97A 1996-01-26 1997-01-20 Process for preparing ganciclovir derivatives Abandoned AU1593197A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26
US592282 1996-01-26
PCT/EP1997/000238 WO1997027197A1 (en) 1996-01-26 1997-01-20 Process for preparing ganciclovir derivatives

Publications (1)

Publication Number Publication Date
AU1593197A true AU1593197A (en) 1997-08-20

Family

ID=24370063

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15931/97A Abandoned AU1593197A (en) 1996-01-26 1997-01-20 Process for preparing ganciclovir derivatives

Country Status (7)

Country Link
US (2) US5840890A (https=)
EP (1) EP0885224B1 (https=)
JP (1) JP4094666B2 (https=)
AU (1) AU1593197A (https=)
DE (1) DE69717974T2 (https=)
ES (1) ES2187752T3 (https=)
WO (1) WO1997027197A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
CZ2004446A3 (cs) * 2001-09-07 2005-01-12 Teva Pharmaceutical Industries Ltd. Krystalické formy valaciklovir hydrochloridu
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
BRPI0413331A (pt) * 2003-08-28 2006-10-10 Ranbaxy Lab Ltd cloridrato de valganciclovir amorfo, composição farmacêutica contendo o mesmo e processo para sua preparação
JP2007513074A (ja) * 2004-09-04 2007-05-24 テバ ファーマシューティカル インダストリーズ リミティド 単離されたバラシクロビル不純物、バラシクロビル不純物の調製方法および参照標準としての使用
HRP20110603T1 (hr) * 2005-01-25 2011-09-30 Sigma Coatings B.V. Sastav veziva
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (en) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
MX2009005921A (es) 2006-12-13 2009-06-17 Hoffmann La Roche Formulacion en polvo del valganciclovir.
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
IT1397233B1 (it) * 2010-01-08 2013-01-04 Fidia Farmaceutici Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.
CN101955481B (zh) * 2010-10-09 2016-04-20 广东肇庆星湖生物科技股份有限公司 一种盐酸缬更昔洛韦的制备方法
EP2714691B1 (en) 2011-05-31 2016-09-07 Pharmathen S.A. Process for the preparation of 2-amino-9-((2-phenyl-1,3-dioxan-5-yloxy)methyl)-1h-purin-6(9h)-one compound useful in the preparation of valganciclovir
CN105693722B (zh) * 2016-04-20 2018-07-20 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105732630B (zh) * 2016-04-20 2018-11-30 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105693724B (zh) * 2016-04-20 2017-08-11 安徽海康药业有限责任公司 一种cbz‑缬更昔洛韦的制备方法
CN112409359A (zh) * 2020-11-30 2021-02-26 沃德药业(安徽)股份有限公司 一种盐酸缬更昔洛韦制备方法
CN113880838B (zh) * 2021-11-15 2024-03-19 仁合益康集团有限公司 一种微通道反应器合成盐酸缬更昔洛韦的方法
CN115286632B (zh) * 2022-09-16 2023-05-09 河北医科大学 一种盐酸缬更昔洛韦的制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
DD202717A5 (de) * 1981-08-11 1983-09-28 Wellcome Found Antivirale purinderivate und verfahren zu ihrer herstellung
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
EP0108285B1 (en) * 1982-10-14 1988-04-20 The Wellcome Foundation Limited Antiviral purine derivatives
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
GB8829571D0 (en) 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE68922903T2 (de) * 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
DE69426880T2 (de) * 1993-06-10 2001-10-31 Rolabo S.L., Zaragoza Verfahren zur herstellung von aminosäureester von nukleosid analogen
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives

Also Published As

Publication number Publication date
US6103901A (en) 2000-08-15
WO1997027197A1 (en) 1997-07-31
JP4094666B2 (ja) 2008-06-04
US5840890A (en) 1998-11-24
JP2000505080A (ja) 2000-04-25
EP0885224A1 (en) 1998-12-23
DE69717974D1 (de) 2003-01-30
DE69717974T2 (de) 2003-10-02
EP0885224B1 (en) 2002-12-18
ES2187752T3 (es) 2003-06-16

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