ATE99936T1 - Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren. - Google Patents

Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.

Info

Publication number
ATE99936T1
ATE99936T1 AT89870154T AT89870154T ATE99936T1 AT E99936 T1 ATE99936 T1 AT E99936T1 AT 89870154 T AT89870154 T AT 89870154T AT 89870154 T AT89870154 T AT 89870154T AT E99936 T1 ATE99936 T1 AT E99936T1
Authority
AT
Austria
Prior art keywords
serum
triglyzeride
mammmals
pharmaceuticals
lowering
Prior art date
Application number
AT89870154T
Other languages
German (de)
English (en)
Inventor
Karl H Beyer Jr
Original Assignee
Karl H Beyer Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl H Beyer Jr filed Critical Karl H Beyer Jr
Application granted granted Critical
Publication of ATE99936T1 publication Critical patent/ATE99936T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89870154T 1988-10-21 1989-10-20 Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren. ATE99936T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/260,947 US4920123A (en) 1988-10-21 1988-10-21 Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
EP89870154A EP0370987B1 (en) 1988-10-21 1989-10-20 Pyrazine derivatives as medicaments for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals

Publications (1)

Publication Number Publication Date
ATE99936T1 true ATE99936T1 (de) 1994-01-15

Family

ID=22991313

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89870154T ATE99936T1 (de) 1988-10-21 1989-10-20 Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.

Country Status (9)

Country Link
US (1) US4920123A (xx)
EP (1) EP0370987B1 (xx)
JP (1) JP2840089B2 (xx)
KR (1) KR900005981A (xx)
AT (1) ATE99936T1 (xx)
AU (1) AU616313B2 (xx)
CA (1) CA2001171C (xx)
DE (2) DE68912284T2 (xx)
ZA (1) ZA897966B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110817A (en) * 1988-10-21 1992-05-05 Beyer Jr Karl H Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
US5268181A (en) * 1989-04-13 1993-12-07 Upsher-Smith Laboratories, Inc. Method of using niacin to control nocturnal cholesterol synthesis
US5622985A (en) * 1990-06-11 1997-04-22 Bristol-Myers Squibb Company Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US20060263428A1 (en) * 1993-09-20 2006-11-23 Eugenio Cefali Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6369103B1 (en) 1994-01-18 2002-04-09 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
US5801177A (en) * 1995-12-14 1998-09-01 Beyer, Jr.; Karl H. Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin-dependent diabetic patients
DE19622222A1 (de) * 1996-06-03 1997-12-04 Hoechst Ag Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.
BRPI0514600A (pt) 2004-08-24 2008-06-17 Uab Research Foundation métodos para a fabricação de um composto, para a purificação de um composto, para o tratamento de um indivìduo tendo uma condição neoplástica, tendo carcinoma de célula escamosa, e tendo carcinoma de célula basal, para a redução ou prevenção da ocorrência de uma condição neoplástica em um indivìduo, e para a redução de triglicerìdeos no soro em um indivìduo, composto, e, composição farmacêutica

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274191A (en) * 1963-11-15 1966-09-20 Merck & Co Inc N-(3-aminopyrazinoyl) benzamidines and process for preparing
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4604394A (en) * 1984-10-01 1986-08-05 Merck & Co., Inc. Antiarrhythmic compositions and method
GB8712368D0 (en) * 1987-05-26 1987-07-01 Erba Farmitalia Pyrazine n-oxide derivatives

Also Published As

Publication number Publication date
EP0370987A3 (en) 1990-12-19
EP0370987B1 (en) 1994-01-12
DE370987T1 (de) 1991-09-05
AU4290989A (en) 1990-04-26
KR900005981A (ko) 1990-05-07
CA2001171C (en) 1999-12-21
CA2001171A1 (en) 1990-04-21
DE68912284T2 (de) 1994-04-28
JP2840089B2 (ja) 1998-12-24
JPH02237923A (ja) 1990-09-20
ZA897966B (en) 1990-08-29
AU616313B2 (en) 1991-10-24
DE68912284D1 (de) 1994-02-24
US4920123A (en) 1990-04-24
EP0370987A2 (en) 1990-05-30

Similar Documents

Publication Publication Date Title
ATE99936T1 (de) Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.
ATE247654T1 (de) Neue heterozyklische verbindungen
OA09334A (fr) "Dérivés d'acides aminés".
NO931529D0 (no) Cykliske fruktopyranosesulfitter og -sulfater med antikonvulsiv effekt
NO933450D0 (no) Antiarrytmiske og kardiobeskyttende substituerte 1(2h)isokinoliner, fremgangsmaater for deres fremstilling, medikament inneholdende disse og anvendelse derav for fremstillingav et medikament for aa bekjempe hjertefeil
DE68917485D1 (de) Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen.
ATE46335T1 (de) Piperazinverbindungen als paf-antagonisten.
DE3855325D1 (de) Oxothiolane und Derivate, diese enthaltende pharmazeutische Zubereitungen und ihre Verwendung als Arzneimittel
EP0285278A3 (en) Method of treating anxiety with tetrahydrobenzûc,d¨indole-6-carboxamides
ZA89389B (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
DK527984D0 (da) 11-substituerede 5h,11h-pyrrolo(2,1-c)(1,4)benzoxazepiner eller farmaceutisk acceptable salte deraf, deres fremstilling og mellemprodukter hertil samt deres anvendelse som antipsychotika og analgetika
DE68919378D1 (de) Thienotriazolodiazepine und ihre pharmazeutische Verwendung.
FI914007A (fi) 4-substituerade dihydropyrido (4,3-d) pyrimidiner som smaertslindrande och lokala inflammationshaemmande medel vid vaord av hudsjukdomar.
IL94592A0 (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
ATE63541T1 (de) N-phenylethylaminoalkyl-benzamide als antiarrhythmische mittel.
EP0231087A3 (en) Heptanoyl-glu-asp-ala-amino acid immunostimulants
ES8505993A1 (es) Un metodo para preparar un derivado de 3-indolcarboxamida
DE69428206D1 (de) Chinolincarbonsäurederivate und ihre salze
DK360388D0 (da) Laegemiddel til behandling af hjerteinsufficiens
ATE140922T1 (de) 3- oder 4-glykosyloxybenzopyranderivat und dieses enthaltende antiallergisches mittel
NO933199L (no) Heteroarenylpiperaziner, fremgangsmåte for deres fremstilling og anvendelse derav som legemidler
ATE95697T1 (de) Uricosuretische zusammensetzung.
EP0447812A3 (en) Use of a dihydropyridine to improve the inner ear blood circulation

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee