ATE98693T1 - Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors. - Google Patents

Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors.

Info

Publication number
ATE98693T1
ATE98693T1 AT89117112T AT89117112T ATE98693T1 AT E98693 T1 ATE98693 T1 AT E98693T1 AT 89117112 T AT89117112 T AT 89117112T AT 89117112 T AT89117112 T AT 89117112T AT E98693 T1 ATE98693 T1 AT E98693T1
Authority
AT
Austria
Prior art keywords
derivatives
bfgf
growth factor
fibroblast growth
basic human
Prior art date
Application number
AT89117112T
Other languages
English (en)
Inventor
Laura Bergonzoni
Antonella Isacchi
Paolo Sarmientos
Gilles Cauet
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Application granted granted Critical
Publication of ATE98693T1 publication Critical patent/ATE98693T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Eye Examination Apparatus (AREA)
AT89117112T 1988-09-16 1989-09-15 Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors. ATE98693T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888821795A GB8821795D0 (en) 1988-09-16 1988-09-16 New derivatives of human/bovine basic fibroplast growth factor
EP89117112A EP0363675B1 (de) 1988-09-16 1989-09-15 Derivate des basischen Mensch-/Rinder-Fibroblastwachstumsfaktors

Publications (1)

Publication Number Publication Date
ATE98693T1 true ATE98693T1 (de) 1994-01-15

Family

ID=10643728

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89117112T ATE98693T1 (de) 1988-09-16 1989-09-15 Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors.

Country Status (21)

Country Link
EP (2) EP0363675B1 (de)
JP (1) JP2888575B2 (de)
KR (1) KR900702027A (de)
CN (1) CN1041181A (de)
AT (1) ATE98693T1 (de)
AU (1) AU620925B2 (de)
CA (1) CA1340834C (de)
DE (1) DE68911461T2 (de)
DK (1) DK120290A (de)
ES (1) ES2061855T3 (de)
FI (1) FI902391A7 (de)
GB (1) GB8821795D0 (de)
HU (1) HUT53937A (de)
IL (1) IL91615A0 (de)
MY (1) MY104910A (de)
NO (1) NO902176L (de)
NZ (1) NZ230621A (de)
PT (1) PT91719B (de)
WO (1) WO1990002800A1 (de)
YU (1) YU179489A (de)
ZA (1) ZA897020B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5478804A (en) * 1990-09-19 1995-12-26 The Salk Institute For Biological Studies Treatment of tumorigenic pathophysiological conditions with FGF-cytoxic conjugates
JP3135138B2 (ja) * 1990-12-19 2001-02-13 科研製薬株式会社 骨疾患治療剤
US6833354B1 (en) 1990-12-19 2004-12-21 Kaken Pharmaceutical Co., Ltd. Agent for the treatment of bone diseases
DE69205466T2 (de) * 1991-03-21 1996-05-30 Procter & Gamble Mittel zur Kontrolle von Hautfalten, die die Arg-Ser-Arg-Lys-Sequenzen enthalten.
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
TW275068B (de) * 1993-09-24 1996-05-01 American Cyanamid Co
AUPO247496A0 (en) 1996-09-23 1996-10-17 Resmed Limited Assisted ventilation to match patient respiratory need
US6214795B1 (en) 1996-11-12 2001-04-10 Praecis Pharmaceuticals, Inc. Peptide compounds useful for modulating FGF receptor activity
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
JP5704780B2 (ja) 1999-08-13 2015-04-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 脈管形成因子の用量および心筋血流を改善するための投与方法
AU2376000A (en) * 1999-12-22 2001-07-03 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor
JP4212357B2 (ja) 2000-11-27 2009-01-21 株式会社ディナベック研究所 血管新生遺伝子をコードするパラミクソウイルスベクターおよびその利用
US8772460B2 (en) * 2011-12-16 2014-07-08 Wisconsin Alumni Research Foundation Thermostable FGF-2 mutant having enhanced stability
CN106957359B (zh) * 2016-08-31 2020-04-24 黄志锋 Fgf1突变体及其医药应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL81839A0 (en) * 1986-03-14 1987-10-20 Takeda Chemical Industries Ltd Polypeptide,dna and its use
AU1185488A (en) * 1987-01-16 1988-08-10 Amgen, Inc. Production of fibroblast growth factor
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途
AU629176B2 (en) * 1987-07-07 1992-10-01 Scios Nova Inc. Recombinant fibroblast growth factors
EP0326907A1 (de) * 1988-01-26 1989-08-09 Takeda Chemical Industries, Ltd. Polypeptide, DNA und ihre Verwendung

Also Published As

Publication number Publication date
FI902391A0 (fi) 1990-05-14
CA1340834C (en) 1999-11-30
PT91719B (pt) 1995-05-31
EP0396664A1 (de) 1990-11-14
YU179489A (en) 1991-10-31
JP2888575B2 (ja) 1999-05-10
GB8821795D0 (en) 1988-10-19
EP0363675A1 (de) 1990-04-18
HU895573D0 (en) 1990-11-28
JPH03501855A (ja) 1991-04-25
ZA897020B (en) 1990-08-29
NO902176L (no) 1990-07-13
IL91615A0 (en) 1990-04-29
NZ230621A (en) 1992-06-25
KR900702027A (ko) 1990-12-05
AU620925B2 (en) 1992-02-27
HUT53937A (en) 1990-12-28
WO1990002800A1 (en) 1990-03-22
DK120290A (da) 1990-07-16
NO902176D0 (no) 1990-05-15
PT91719A (pt) 1990-03-30
AU4317189A (en) 1990-04-02
DK120290D0 (da) 1990-05-15
EP0363675B1 (de) 1993-12-15
CN1041181A (zh) 1990-04-11
DE68911461D1 (de) 1994-01-27
FI902391A7 (fi) 1990-05-14
MY104910A (en) 1994-06-30
ES2061855T3 (es) 1994-12-16
DE68911461T2 (de) 1994-05-19

Similar Documents

Publication Publication Date Title
ATE98693T1 (de) Derivate des basischen mensch-/rinderfibroblastwachstumsfaktors.
DK0409472T3 (da) Knoglemorfogenetisk protein
DE60125381D1 (de) Zusammensetzungen und verfahren mit analogen von g-csf
NO974812D0 (no) Nytt protein og fremgangsmåte for fremstilling av dette
ATE284954T1 (de) Hyaluronan synthase gen und seine verwendung
DE3851002D1 (de) Lineare und zyklische Analoge von alpha-MSH-Fragmenten mit ausserordentlicher Wirkung.
DK0458959T3 (da) Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf
HU9200548D0 (en) Improved activity process of recombined proteins
DE3850654D1 (de) Immunglobulin-e-kompetitor.
DK38889D0 (da) Onkogen-indkodet polypeptid med vaekstfaktoraktivitet
EP0276778A3 (de) Expression mit hochstufiger Verstärkung von löslichem reifem IL-1beta und Derivate mit geänderter biologischer Aktivität
SE8801723D0 (sv) Fibronectin binding protein as well as its preparation
NO914724D0 (no) Somatotropiner med forandringer i alfa-spiral-1-omraadet ogkombinasjoner med andre mutasjoner
DE69115270D1 (de) Protein mit fibroblasten-wachstumsfaktor-rezeptoraktivität.
DE3856392D1 (de) Klonierung von Malaria-spezifischen DNA-Sequenzen:Isolierung des Gens für das 140 kd Protein
DK0555785T3 (da) Glat-muskel-mitogent stof og DNA, der koder herfor
ATE123056T1 (de) Ancrod-proteine, ihre herstellung und verwendung.
DE3900770A1 (de) Verfahren zur herstellung von pdgf-a und pdgf-aa
DE59106997D1 (de) Ancrod ähnliche proteine, ihre herstellung und verwendung.
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
Bergonzoni et al. Deletion mutant of basic fibroblast growth factor and production thereof

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties