ATE98642T1 - 2,2-disubstituierte benzopyran-leukotrien-d4antagonisten. - Google Patents

2,2-disubstituierte benzopyran-leukotrien-d4antagonisten.

Info

Publication number
ATE98642T1
ATE98642T1 AT89108925T AT89108925T ATE98642T1 AT E98642 T1 ATE98642 T1 AT E98642T1 AT 89108925 T AT89108925 T AT 89108925T AT 89108925 T AT89108925 T AT 89108925T AT E98642 T1 ATE98642 T1 AT E98642T1
Authority
AT
Austria
Prior art keywords
hydrogen
chem
straight
carbon atoms
branched chain
Prior art date
Application number
AT89108925T
Other languages
English (en)
Inventor
Francis J Koszyk
James Ronald Deason
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE98642T1 publication Critical patent/ATE98642T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
AT89108925T 1988-05-20 1989-05-18 2,2-disubstituierte benzopyran-leukotrien-d4antagonisten. ATE98642T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/196,996 US4950684A (en) 1988-05-20 1988-05-20 2,2-di-substituted benzopyran leukotriene-D4 antagonists
EP89108925A EP0342664B1 (de) 1988-05-20 1989-05-18 2,2-Disubstituierte Benzopyran-Leukotrien-D4-Antagonisten

Publications (1)

Publication Number Publication Date
ATE98642T1 true ATE98642T1 (de) 1994-01-15

Family

ID=22727590

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89108925T ATE98642T1 (de) 1988-05-20 1989-05-18 2,2-disubstituierte benzopyran-leukotrien-d4antagonisten.

Country Status (6)

Country Link
US (1) US4950684A (de)
EP (1) EP0342664B1 (de)
JP (1) JPH0217182A (de)
AT (1) ATE98642T1 (de)
DE (1) DE68911371T2 (de)
ES (1) ES2061785T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686465A (en) * 1988-10-31 1997-11-11 Endorecherche Inc. Sex steroid activity inhibitors
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
FR2673629B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives du benzopyrane leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5457124A (en) * 1993-12-07 1995-10-10 Hoffmann-La Roche Inc. Carboxylic acid Leukotriene B4 antagonists
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7514461B2 (en) * 2003-09-19 2009-04-07 Edison Pharmaceuticals, Inc. Chroman derivatives
BRPI0519013A2 (pt) * 2004-12-13 2009-11-03 Lilly Co Eli composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto
BRPI0520097A2 (pt) 2005-02-25 2009-08-25 Lilly Co Eli composto ou estereoisÈmeros únicos, misturas de estereoisÈmeros, ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952013A (en) * 1969-02-12 1976-04-20 Fisons Limited 1-Thiachromone-2-carboxylic acids and derivatives
US4006245A (en) * 1971-07-29 1977-02-01 Fisons Limited Chemical compounds
GB1384530A (en) * 1971-07-29 1975-02-19 Fisons Ltd Chromone derivatives
US4133889A (en) * 1971-07-29 1979-01-09 Fisons, Ltd. 2(5-Tetrazolyl)chromones
US3953604A (en) * 1972-01-14 1976-04-27 Miles Laboratories, Inc. 1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
US4238495A (en) * 1976-01-30 1980-12-09 Miles Laboratories, Inc. 1-(4-Cyano-phenoxy)-2-hydroxy-3-[2-(5-1H-tetrazolyl)-chromon-5-yloxy]-propane and salts thereof
GB1583691A (en) * 1977-01-26 1981-01-28 Fisons Ltd Benzopyrans
US4158663A (en) * 1977-07-15 1979-06-19 Warner-Lambert Company Process for the production of 2-substituted chromones
DE3070912D1 (en) * 1979-03-20 1985-09-05 Fisons Plc Pharmaceutical heterocyclic compounds, processes for their preparation and compositions containing them
HU184359B (en) * 1980-12-16 1984-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing substituted acyl-carbamides
DE3275295D1 (en) * 1981-11-12 1987-03-05 Fisons Plc Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them
ZA844519B (en) * 1983-06-24 1985-02-27 Hoffmann La Roche Dihydrobenzopyran derivatives
US4665203A (en) * 1983-08-08 1987-05-12 G. D. Searle & Co. Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
AU548450B2 (en) * 1983-08-08 1985-12-12 G.D. Searle & Co. Substituted dihydrobenzopyrans
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) * 1984-05-29 1985-10-08 G. D. Searle & Co. Substituted chromanon-2-yl alkanols and derivatives thereof
CA1261835A (en) * 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides

Also Published As

Publication number Publication date
EP0342664A2 (de) 1989-11-23
EP0342664A3 (en) 1990-01-10
DE68911371T2 (de) 1994-05-19
ES2061785T3 (es) 1994-12-16
EP0342664B1 (de) 1993-12-15
US4950684A (en) 1990-08-21
DE68911371D1 (de) 1994-01-27
JPH0217182A (ja) 1990-01-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee