ES2061785T3 - Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4. - Google Patents
Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4.Info
- Publication number
- ES2061785T3 ES2061785T3 ES89108925T ES89108925T ES2061785T3 ES 2061785 T3 ES2061785 T3 ES 2061785T3 ES 89108925 T ES89108925 T ES 89108925T ES 89108925 T ES89108925 T ES 89108925T ES 2061785 T3 ES2061785 T3 ES 2061785T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- chem
- straight
- carbon atoms
- branched chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Pretreatment Of Seeds And Plants (AREA)
Abstract
ESTA SE REFIERE A COMPUESTOS DE BENZOPIRANO 2,2 - DISUSTITUIDOS QUE POSEEN ACTIVIDAD ANTAGONISTA DE LEUCOTRIENO - D4, (LTD4). EN ESPECIAL SE REFIERE A ANTAGONISTAS DE LTD4 DE LA FORMULA(I) O UNA SAL DE ESTO, DONDE X1 Y X2 PUEDEN SER LOS MISMOS O DIFERENTES Y SON MIEMBROS DEL GRUPO QUE COMPRENDE H, - CL, - BR - CF3, NH2, NO2 O ALQUILO DE CADENA RECTA O RAMIFICADA DE 1 A 3 C, SIENDO M UN ENTERO DE 1 A 9, N ES DE 1 A 5, Y V = C = O, - CH(OH) - O CH2 -, W ES H O ALQUILO DE 1 A 6 C DE CADENA RECTA O RAMIFICADA, Y ES H O - COCH3, Z ES - CHO, - COOR2, - COR3, Y R2, R3, R4, R5, R6, R7 Y R8 TIENEN EL SIGNIFICADO DADO EN LA ESPECIFICACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/196,996 US4950684A (en) | 1988-05-20 | 1988-05-20 | 2,2-di-substituted benzopyran leukotriene-D4 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2061785T3 true ES2061785T3 (es) | 1994-12-16 |
Family
ID=22727590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89108925T Expired - Lifetime ES2061785T3 (es) | 1988-05-20 | 1989-05-18 | Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4950684A (es) |
EP (1) | EP0342664B1 (es) |
JP (1) | JPH0217182A (es) |
AT (1) | ATE98642T1 (es) |
DE (1) | DE68911371T2 (es) |
ES (1) | ES2061785T3 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
US5686465A (en) * | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
FR2673629B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives du benzopyrane leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
US6060503A (en) * | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
US5457124A (en) * | 1993-12-07 | 1995-10-10 | Hoffmann-La Roche Inc. | Carboxylic acid Leukotriene B4 antagonists |
ITTO20030140U1 (it) * | 2003-09-16 | 2005-03-17 | Interfila Srl | Matita cosmetica |
CA2583087C (en) | 2003-09-19 | 2012-07-10 | Galileo Pharmaceuticals, Inc. | Chroman derivatives |
BRPI0519013A2 (pt) * | 2004-12-13 | 2009-11-03 | Lilly Co Eli | composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto |
MX2007010328A (es) | 2005-02-25 | 2008-03-13 | Lilly Co Eli | Cromanos, tiocromanos y dihidroquinolinas espiro-heterociclicos. |
US8093253B2 (en) * | 2008-03-06 | 2012-01-10 | Hoffmann-La Roche Inc. | Leukotriene B4 inhibitors |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3952013A (en) * | 1969-02-12 | 1976-04-20 | Fisons Limited | 1-Thiachromone-2-carboxylic acids and derivatives |
US4133889A (en) * | 1971-07-29 | 1979-01-09 | Fisons, Ltd. | 2(5-Tetrazolyl)chromones |
GB1384530A (en) * | 1971-07-29 | 1975-02-19 | Fisons Ltd | Chromone derivatives |
US4006245A (en) * | 1971-07-29 | 1977-02-01 | Fisons Limited | Chemical compounds |
US3953604A (en) * | 1972-01-14 | 1976-04-27 | Miles Laboratories, Inc. | 1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes |
US4156726A (en) * | 1974-12-07 | 1979-05-29 | Fisons Limited | 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds |
GB1493998A (en) * | 1975-06-03 | 1977-12-07 | Beecham Group Ltd | Propanolamine derivatives |
US4238495A (en) * | 1976-01-30 | 1980-12-09 | Miles Laboratories, Inc. | 1-(4-Cyano-phenoxy)-2-hydroxy-3-[2-(5-1H-tetrazolyl)-chromon-5-yloxy]-propane and salts thereof |
GB1583691A (en) * | 1977-01-26 | 1981-01-28 | Fisons Ltd | Benzopyrans |
US4158663A (en) * | 1977-07-15 | 1979-06-19 | Warner-Lambert Company | Process for the production of 2-substituted chromones |
ATE14579T1 (de) * | 1979-03-20 | 1985-08-15 | Fisons Plc | Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen. |
HU184359B (en) * | 1980-12-16 | 1984-08-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing substituted acyl-carbamides |
EP0079637B1 (en) * | 1981-11-12 | 1987-01-28 | FISONS plc | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them |
ZA844519B (en) * | 1983-06-24 | 1985-02-27 | Hoffmann La Roche | Dihydrobenzopyran derivatives |
US4665203A (en) * | 1983-08-08 | 1987-05-12 | G. D. Searle & Co. | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors |
AU548450B2 (en) * | 1983-08-08 | 1985-12-12 | G.D. Searle & Co. | Substituted dihydrobenzopyrans |
US4565882A (en) * | 1984-01-06 | 1986-01-21 | G. D. Searle & Co. | Substituted dihydrobenzopyran-2-carboxylates |
US4546194A (en) * | 1984-05-29 | 1985-10-08 | G. D. Searle & Co. | Substituted chromanon-2-yl alkanols and derivatives thereof |
CA1261835A (en) * | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
-
1988
- 1988-05-20 US US07/196,996 patent/US4950684A/en not_active Expired - Fee Related
-
1989
- 1989-05-18 EP EP89108925A patent/EP0342664B1/en not_active Expired - Lifetime
- 1989-05-18 JP JP1123040A patent/JPH0217182A/ja active Pending
- 1989-05-18 AT AT89108925T patent/ATE98642T1/de not_active IP Right Cessation
- 1989-05-18 DE DE68911371T patent/DE68911371T2/de not_active Expired - Fee Related
- 1989-05-18 ES ES89108925T patent/ES2061785T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0217182A (ja) | 1990-01-22 |
EP0342664B1 (en) | 1993-12-15 |
ATE98642T1 (de) | 1994-01-15 |
EP0342664A2 (en) | 1989-11-23 |
US4950684A (en) | 1990-08-21 |
DE68911371D1 (de) | 1994-01-27 |
EP0342664A3 (en) | 1990-01-10 |
DE68911371T2 (de) | 1994-05-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO2011026I2 (no) | Eribulin eller et farmasøytisk akseptabelt salt derav | |
UA26427A (uk) | Похідhі ксаhтиhу у вигляді суміші ізомерів або іhдивідуальhих ізомерів, що мають властивість аhтагоhіста адеhозиhу | |
EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
ATE214393T1 (de) | Bis(3,4-dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen | |
DK0378518T3 (da) | Adenosinderivater med farmaceutisk aktivitet som antihypertensiva | |
BRPI9908319B8 (pt) | composto amino cíclico, composição farmacêutica, medicamento contendo um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo, e, uso de um composto amino cíclico ou um sal farmacologicamente aceitável do mesmo. | |
HUT59663A (en) | Process for producing new d vitamine analogues and pharmaceutical compositions containing them as active components | |
DK0956855T3 (da) | Immunhæmmende effekter af 8-substituerede xanthin-derivater | |
ES2090048T3 (es) | Derivados de xantina. | |
DE69733308D1 (de) | Aktivsauerstoffaufnehmer enthaltende pterinderivate | |
NO992259D0 (no) | Ny anvendelse for 1,3-propandiolderivater | |
ES2061785T3 (es) | Benzopiranos 2,2-disustituidos de utilidad como antagonistas de leucotrieno-d4. | |
EA200000614A1 (ru) | 2,3-замещенные соединения индола в качестве ингибиторов сох-2 | |
NO20004295D0 (no) | Nye pyridinforbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem | |
ATE153664T1 (de) | Imidazoacridine und ihre antineoplastische anwendung | |
DE69127691D1 (de) | Be-13793c-derivat mit antitumorwirkung | |
ES535281A0 (es) | Un procedimiento para la preparacion de nuevos derivados de cefalosporina | |
ES2188481T3 (es) | Derivados de polinalbufina. | |
DK0420121T3 (da) | Antitumormiddel | |
DE69617909D1 (de) | 2-substituierte vitamin-d3-derivate | |
ES2056194T3 (es) | Compuestos tetraciclicos antidepresivos. | |
EP0335979A4 (en) | Thienopyrimidine derivatives | |
ATE202103T1 (de) | 6-azaindole-hemmer der tromboxan-synthetase | |
NO900732D0 (no) | Arylalkylaminforbindelser. | |
ATE146476T1 (de) | Cephalosporinverbindungen und verfahren zu ihrer herstellung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 342664 Country of ref document: ES |