ATE90084T1 - Makropolyzyklische komplexe von seltenen erden und verwendung als fluoreszierende markierungen. - Google Patents

Makropolyzyklische komplexe von seltenen erden und verwendung als fluoreszierende markierungen.

Info

Publication number
ATE90084T1
ATE90084T1 AT85401838T AT85401838T ATE90084T1 AT E90084 T1 ATE90084 T1 AT E90084T1 AT 85401838 T AT85401838 T AT 85401838T AT 85401838 T AT85401838 T AT 85401838T AT E90084 T1 ATE90084 T1 AT E90084T1
Authority
AT
Austria
Prior art keywords
rare earth
fluorescent labels
macropolycyclic
complexes
macropolycyclic complexes
Prior art date
Application number
AT85401838T
Other languages
English (en)
Inventor
Gerard Mathis
Jean Marie Lehn
Original Assignee
Cis Bio Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cis Bio Int filed Critical Cis Bio Int
Application granted granted Critical
Publication of ATE90084T1 publication Critical patent/ATE90084T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/08Luminescent materials, e.g. electroluminescent or chemiluminescent containing inorganic luminescent materials
    • C09K11/77Luminescent materials, e.g. electroluminescent or chemiluminescent containing inorganic luminescent materials containing rare earth metals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/40Rare earth chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
AT85401838T 1984-09-26 1985-09-23 Makropolyzyklische komplexe von seltenen erden und verwendung als fluoreszierende markierungen. ATE90084T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8414799A FR2570703B1 (fr) 1984-09-26 1984-09-26 Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
EP85401838A EP0180492B1 (de) 1984-09-26 1985-09-23 Makropolyzyklische Komplexe von seltenen Erden und Verwendung als fluoreszierende Markierungen

Publications (1)

Publication Number Publication Date
ATE90084T1 true ATE90084T1 (de) 1993-06-15

Family

ID=9308106

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85401838T ATE90084T1 (de) 1984-09-26 1985-09-23 Makropolyzyklische komplexe von seltenen erden und verwendung als fluoreszierende markierungen.

Country Status (9)

Country Link
US (1) US4927923A (de)
EP (1) EP0180492B1 (de)
JP (3) JPH0655741B2 (de)
KR (1) KR930008210B1 (de)
AT (1) ATE90084T1 (de)
CA (1) CA1329593C (de)
DE (1) DE3587380T2 (de)
ES (3) ES8706792A1 (de)
FR (1) FR2570703B1 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220012A (en) * 1984-09-26 1993-06-15 Compagnie Oris Industrie Sa Macropolycyclic rare earth complexes and application as fluorescent tracers
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
FR2624862B1 (fr) * 1987-12-18 1990-06-08 Oris Ind Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents
US5134232A (en) * 1988-11-14 1992-07-28 The Regents Of The University Of California Fluorescent indicator dyes for alkali metal cations
US5094759A (en) * 1989-03-17 1992-03-10 The University Of Southern Mississippi Method of water treatment using 2,6-substituted aminopyridines and polymer derived therefrom
US5216134A (en) * 1989-10-23 1993-06-01 Wallac Oy Spectrofluorometric method and compounds that are of value for the method
FR2664699B1 (fr) * 1990-07-13 1995-08-18 Cis Bio Int Procede d'amplification du signal d'emission d'un compose luminescent.
EP0554358A4 (en) * 1990-09-27 1995-09-06 Brunswick Corp Chelating agents
EP0493745A1 (de) * 1990-12-21 1992-07-08 Dojindo Laboratories Fluoreszierende Verbindung, Komplex, Reagenz und spezifische Bindungtest
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
FR2680787B1 (fr) * 1991-08-30 1994-11-04 Cis Bio Int Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.
WO1993011433A1 (en) * 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
WO1995020353A1 (en) * 1994-01-28 1995-08-03 Mallinckrodt Medical, Inc. Functionalized aza-bimacrocyclic ligands for imaging applications
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5792330A (en) * 1995-05-31 1998-08-11 Board Of Regents, The University Of Texas System Lanthanide metal cations for concurrent detection and separation in capillary electrophoresis
FR2768817B1 (fr) * 1997-09-19 1999-12-10 Cis Bio Int Methode homogene pour la detection et/ou la determination de l'activite phosphorylante d'un materiel biologique
FR2769315B1 (fr) * 1997-10-03 2001-06-08 Cis Bio Int Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation
EP1064360B1 (de) 1998-03-27 2008-03-05 Prolume, Ltd. Luciferase, gfp fluoreszenzproteine, kodierende nukleinsaüre und ihre verwendung in der diagnose
EP1925320A3 (de) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme
US7109315B2 (en) * 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
FR2809817B1 (fr) 2000-06-02 2003-08-15 Cis Bio Int Procede de detection de presence d'un liquide dans un melange
FR2810406B1 (fr) * 2000-06-15 2002-09-20 Cis Bio Int Nouveaux cryptates de terre rare peu sensibles a l'extinction de fluorescence
AU2003291677A1 (en) * 2002-10-30 2004-05-25 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
WO2004071641A2 (en) * 2003-02-10 2004-08-26 Pointilliste, Inc. Self-assembling arrays and uses thereof
US7018851B2 (en) 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
DE602004025592D1 (de) * 2003-09-12 2010-04-01 Life Technologies Corp Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
US8916692B2 (en) * 2003-11-07 2014-12-23 Robert C. Leif Reagent system and method for modifying the luminescence of lanthanide(III) macrocyclic complexes
WO2005067980A2 (en) * 2004-01-12 2005-07-28 Pointilliste, Inc. Design of therapeutics and therapeutics
CA2575675A1 (en) 2004-07-30 2006-03-09 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin
FR2878850B1 (fr) * 2004-12-02 2008-10-31 Cis Bio Internat Sa Derives de l'inositol-1-phosphate
DE102005020384A1 (de) * 2005-05-02 2006-11-09 Therainvention Gmbh Spektroskopisches Verfahren zum Nachweis von Analyten
JP4559922B2 (ja) 2005-06-21 2010-10-13 株式会社東芝 蛍光性錯体及びそれを用いた照明装置
FR2890174B1 (fr) 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
FR2890446B1 (fr) 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
WO2007051207A2 (en) 2005-10-28 2007-05-03 Invitrogen Corporation Kinase and ubiquination assays
US7482444B2 (en) * 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
DE102006021406B4 (de) 2006-05-08 2008-08-07 B.R.A.H.M.S Aktiengesellschaft In vitro Verfahren zur Früherkennung von arznei- und suchtmittelinduzierten Leberschäden und zur Erkennung der bereits erreichten Stufe der Leberschädigung
JP5237949B2 (ja) 2006-08-18 2013-07-17 アバクス ディアグノスティカ オイ 発光性ランタノイド標識試薬及びその用途
KR20090094303A (ko) * 2006-11-27 2009-09-04 스미또모 가가꾸 가부시키가이샤 다핵 착체
DE102007009751A1 (de) 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
DE102007022367A1 (de) 2007-05-07 2008-11-20 B.R.A.H.M.S Ag Verfahren zur Bestimmung von aminoterminalen pro-ANP bei übergewichtigen Patienten
EP2316035A2 (de) * 2008-07-16 2011-05-04 Radiometer Medical ApS Thrombinsubstrat und testverfahren zur bestimmung des spiegels von biologisch aktivem thrombin in einer probe
FR2934684B1 (fr) 2008-07-31 2012-11-16 Cis Bio Int Methode de detection de l'internalisation de proteines membranaires.
FR2936245B1 (fr) 2008-09-23 2012-07-06 Cis Bio Int Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants.
FR2940286B1 (fr) 2008-12-19 2011-04-08 Cis Bio Int Nouveaux cryptates de terres rares comportant un motif tetraazatriphenylene
FI20090100A0 (fi) 2009-03-16 2009-03-16 Wallac Oy Biotinidaasimääritys
CA2759885A1 (fr) 2009-04-30 2010-11-04 Etienne Doumazane Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft
FR2949156B1 (fr) 2009-08-13 2016-04-15 Cis-Bio Int Methode de determination de la liaison d'un compose donne a un recepteur membranaire
FR2977674B1 (fr) 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
FR2978149B1 (fr) 2011-07-18 2014-01-10 Cisbio Bioassays Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents
FR2980271B1 (fr) 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
WO2013042120A2 (en) 2011-09-19 2013-03-28 Proteologics Ltd Synthetic ubiquitins and use thereof in drug screening assays
EP2817614A1 (de) 2012-02-22 2014-12-31 Cisbio Bioassays Verfahren zur normalisierung der von einem messmedium emittierten lumineszenz
FR2988174B1 (fr) 2012-03-19 2014-04-25 Cisbio Bioassays Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre
WO2014136115A1 (en) 2013-03-07 2014-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Non-selfabsorbing luminescent solar concentrator
FR3004189B1 (fr) 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
FR3032797B1 (fr) 2015-02-13 2017-03-03 Cisbio Bioassays Procede de quantification d'une proteine d'interet presente dans un echantillon biologique
JP6944449B2 (ja) 2015-11-27 2021-10-06 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 対象の細胞外液量状態のマーカーとしてのMR−proADM
FR3045053B1 (fr) 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants
US9834808B2 (en) 2016-01-21 2017-12-05 SeLux Diagnostics, Inc. Methods for rapid antibiotic susceptibility testing
ES2862345T3 (es) 2016-01-21 2021-10-07 Selux Diagnostics Inc Métodos rápidos para probar la susceptibilidad antimicrobiana
JP7104689B2 (ja) 2016-08-09 2022-07-21 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 有害事象を示すマーカーとしてのヒストンおよび/またはproADM
US20190178897A1 (en) 2016-08-09 2019-06-13 B.R.A.H.M.S Gmbh Histones and/or proadm as markers indicating organ dysfunction
BR112018016717A2 (pt) 2016-12-16 2018-12-26 H Lundbeck As agentes, usos e métodos
JP7146765B2 (ja) 2016-12-23 2022-10-04 セルックス・ダイアグノスティクス・インコーポレイテッド 改善された迅速な抗菌薬感受性試験のための方法
EP4220175A1 (de) 2017-02-02 2023-08-02 B.R.A.H.M.S GmbH Proadm als marker zur anzeige eines unerwünschten ereignisses
US12385926B2 (en) 2017-05-31 2025-08-12 B.R.A.H.M.S Gmbh MMP-8 as a marker for identifying infectious disease
FR3067349B1 (fr) 2017-06-12 2020-12-04 Cisbio Bioassays Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants
FR3067712B1 (fr) 2017-06-14 2019-08-02 Cisbio Bioassays Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants
FR3069644B1 (fr) 2017-07-28 2024-07-12 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
EP3682246A1 (de) 2017-09-13 2020-07-22 B.R.A.H.M.S GmbH Verfahren zur leitung einer flüssigkeitstherapie auf basis von proadrenomedullin
EP3502691A1 (de) 2017-12-20 2019-06-26 B.R.A.H.M.S GmbH Proadrenomedullin als indikator für nierenersatztherapie bei kritisch kranken patienten
US11327082B2 (en) 2017-09-13 2022-05-10 B.R.A.H.M.S Gmbh Proadrenomedullin as a marker for abnormal platelet levels
CN111094981B (zh) 2017-09-13 2024-04-16 B.R.A.H.M.S有限公司 Pct和pro-adm作为监测抗生素治疗的标记物
US20200271666A1 (en) 2017-09-13 2020-08-27 B.R.A.H.M.S Gmbh Proadrenomedullin as indicator for renal replacement therapy in critically ill patients
CN111630381B (zh) 2017-12-20 2025-08-01 B.R.A.H.M.S有限公司 基于pro-adm的抗生素疗法指导
CN111656189A (zh) 2017-12-20 2020-09-11 B.R.A.H.M.S有限公司 基于合并症患者的降钙素原的抗生素疗法指导
US20200309796A1 (en) 2017-12-21 2020-10-01 H. Lundbeck A/S Assay, method and treatment of alpha-synucleinopathies
EP3578989A1 (de) 2018-06-06 2019-12-11 B.R.A.H.M.S GmbH Pro-adm zur prognose von traumabedingten komplikationen bei polytraumapatienten
FR3084365B1 (fr) 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
EP3608673A1 (de) 2018-08-08 2020-02-12 B.R.A.H.M.S GmbH Pro-adm zur prognose des risikos einer erkrankung, die einen krankenhausaufenthalt bei patienten mit symptomen einer infektionskrankheit erfordert
EP3918343B1 (de) 2019-01-28 2025-06-11 B.R.A.H.M.S GmbH Verfahren zur vorhersage der behandlung bei patienten mit enuresis nocturna
FR3092172B1 (fr) 2019-01-30 2021-02-12 Cisbio Bioassays Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP
EP3928099A1 (de) 2019-02-21 2021-12-29 B.R.A.H.M.S GmbH Diagnose oder prognose postoperativer nebenwirkungen
AU2020253042B2 (en) 2019-03-29 2025-10-02 B.R.A.H.M.S Gmbh Prescription of remote patient management based on biomarkers
EP3715851A1 (de) 2019-03-29 2020-09-30 B.R.A.H.M.S GmbH Verschreibung von fernpatientenmanagement auf der basis von biomarkern
WO2021041710A1 (en) 2019-08-27 2021-03-04 SeLux Diagnostics, Inc. Systems and methods for performing antimicrobial susceptibility testing
JP7579353B2 (ja) 2020-04-06 2024-11-07 ベー.エル.アー.ハー.エム.エス ゲゼルシャフト ミット ベシュレンクテル ハフツング 重症急性呼吸器症候群(sars)における疾患進行を予後診断するためのプロアドレノメデュリン
CN115136009A (zh) 2020-04-09 2022-09-30 B.R.A.H.M.S有限公司 用于呼吸道感染诊断的生物标志物
AU2022405688A1 (en) 2021-12-08 2024-06-06 B.R.A.H.M.S Gmbh Biomarkers for prognosis of early onset preeclampsia
US20250327816A1 (en) 2021-12-13 2025-10-23 UNIVERSITé LAVAL Biomarkers for the prediction of preterm birth
AU2023390798A1 (en) 2022-12-08 2025-06-12 B.R.A.H.M.S Gmbh Multiple sflt-1 measurements for prognosis of early onset preeclampsia
EP4710108A1 (de) 2023-05-12 2026-03-18 B.R.A.H.M.S GmbH Mittelregionaler pro-adrenomedullin-immuntest mit monoklonalen antikörpern
WO2025078420A1 (en) 2023-10-09 2025-04-17 B.R.A.H.M.S Gmbh Biomarkers for therapy management and/or prognosing disease progression, severity and/or outcome for respiratory virus infections
WO2026013199A1 (en) 2024-07-12 2026-01-15 Cezanne S.A.S. Clinical immunoassay with early signal measurement

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888877A (en) * 1969-06-11 1975-06-10 Schering Corp Macrocyclic compounds and complexes thereof
US3847949A (en) * 1970-05-12 1974-11-12 Du Pont Macrocyclic hetero imine complexing agents
CA966127A (en) * 1970-05-12 1975-04-15 Marilyn H. Bromels Macrocyclic hetero imine complexing agents
US4156683A (en) * 1973-03-26 1979-05-29 Schering Corporation Complexes of macrocyclic compounds
US3966766A (en) * 1973-03-26 1976-06-29 Schering Corporation Monocyclic macrocyclic compounds and complexes thereof
US4058732A (en) * 1975-06-30 1977-11-15 Analytical Radiation Corporation Method and apparatus for improved analytical fluorescent spectroscopy
SE428332B (sv) * 1979-03-08 1983-06-20 Wallac Oy Forfarande for fluorescensspektroskopisk bestemning av biologiskt aktivt emne, sasom hapten, antikropp eller antigen
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
CA1205028A (en) * 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
DE3202779A1 (de) * 1982-01-28 1983-08-04 Merck Patent Gmbh, 6100 Darmstadt Kaliumreagens und verfahren zur bestimmung von kaliumionen
US4631119A (en) * 1983-11-23 1986-12-23 W. R. Grace & Co. Reversible, electrochemically-switched lariat ethers
US4659815A (en) * 1985-02-04 1987-04-21 The President And Trustees Of The Miami University Chromogenic aza-12-crown-4 ethers and method of using same for the detection of lithium
US4734376A (en) * 1985-02-04 1988-03-29 The President & Trustees Of The Miami University Process for the spectrophotometric measurement of lithium ion employing a chromogenic aza-12-crown-4- ether
GB8528804D0 (en) * 1985-11-22 1985-12-24 Amersham Int Plc Compounds

Also Published As

Publication number Publication date
EP0180492B1 (de) 1993-06-02
ES557485A0 (es) 1988-02-16
JPH06184151A (ja) 1994-07-05
DE3587380T2 (de) 1994-01-05
EP0180492A1 (de) 1986-05-07
FR2570703A1 (fr) 1986-03-28
ES8801695A1 (es) 1988-02-16
ES557486A0 (es) 1988-03-01
JPH0714935B2 (ja) 1995-02-22
JPH06199858A (ja) 1994-07-19
US4927923A (en) 1990-05-22
JPH0715471B2 (ja) 1995-02-22
DE3587380D1 (de) 1993-07-08
JPH0655741B2 (ja) 1994-07-27
FR2570703B1 (fr) 1988-07-08
ES547294A0 (es) 1987-07-01
ES8706792A1 (es) 1987-07-01
JPS6187680A (ja) 1986-05-06
KR930008210B1 (ko) 1993-08-26
CA1329593C (en) 1994-05-17
KR860002553A (ko) 1986-04-26
ES8801938A1 (es) 1988-03-01

Similar Documents

Publication Publication Date Title
ATE90084T1 (de) Makropolyzyklische komplexe von seltenen erden und verwendung als fluoreszierende markierungen.
DE69333062D1 (de) 4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
DE3785312D1 (de) Substituierte tetrahydropyridinoxime und ihre verwendung als cholinergische heilmittel.
DE3783478D1 (de) Zurueckgewinnung von argon.
DE3772748D1 (de) Selbstausrichtung von raumfahrzeugsbeschleunigungsmessern.
DE3751179D1 (de) Peptide, die die Bindung des Von-Willebrand-Faktors inhibieren.
DE3578923D1 (de) Verwendung von aryloxy-verbindungen als antidots.
BR8406485A (pt) Selos de seguranca
DE69326474D1 (de) Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren
DE69310092D1 (de) Wiedergewinnung von Molybdän
ATA57485A (de) Kanalartiges leuchtensystem
DE3881270D1 (de) Verwendung von pyrrolidon-derivaten als antiamnetikum.
ATE154098T1 (de) Verwendung kohlenwasserstoffreicher gele als fracturing-flüssigkeiten
DE3669550D1 (de) Stabilisierung von pechfasern.
DE68905075D1 (de) Herstellung von tris(2-zyanaethyl)amin.
ATE72112T1 (de) Verwendung von 1-benzyl-amino-alkylpyrrolidinonen als antidepressiva.
DE3768834D1 (de) Spannungsregler.
DE59003265D1 (de) Verwendung von nor-verapamil und nor-gallopamil als antiarteriosklerotica.
DE3777432D1 (de) Verwendung von 2-aminoalkyl-5-pyridinol-verbindungen als nootropika und antidepressiva.
DE3779211D1 (de) Verwendung von dihydrobenzopyranderivaten.
NO173566C (no) Symmetrisk doerlaas
IT8410502V0 (it) Travellers identification systemin sigla t.i.s.
DE3579479D1 (de) Neue verwendung von somatostatin.
DE58907992D1 (de) Verwendung von Polyurethanmischungen als Klebstoffe.
ATE41310T1 (de) Verwendung von hexamethylcyclotrisiloxan als riechstofftraegermaterial.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties