EP0554358A4 - Chelating agents - Google Patents

Chelating agents

Info

Publication number
EP0554358A4
EP0554358A4 EP91919986A EP91919986A EP0554358A4 EP 0554358 A4 EP0554358 A4 EP 0554358A4 EP 91919986 A EP91919986 A EP 91919986A EP 91919986 A EP91919986 A EP 91919986A EP 0554358 A4 EP0554358 A4 EP 0554358A4
Authority
EP
European Patent Office
Prior art keywords
chelating agents
chelating
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP91919986A
Other versions
EP0554358A1 (en
Inventor
Wolfgang J Wrasidlo
Michael H Silveira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Brunswick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brunswick Corp filed Critical Brunswick Corp
Publication of EP0554358A1 publication Critical patent/EP0554358A1/en
Publication of EP0554358A4 publication Critical patent/EP0554358A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
EP91919986A 1990-09-27 1991-09-26 Chelating agents Withdrawn EP0554358A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58881690A 1990-09-27 1990-09-27
US588816 1990-09-27

Publications (2)

Publication Number Publication Date
EP0554358A1 EP0554358A1 (en) 1993-08-11
EP0554358A4 true EP0554358A4 (en) 1995-09-06

Family

ID=24355407

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91919986A Withdrawn EP0554358A4 (en) 1990-09-27 1991-09-26 Chelating agents

Country Status (4)

Country Link
EP (1) EP0554358A4 (en)
JP (1) JPH06505795A (en)
CA (1) CA2092434A1 (en)
WO (1) WO1992005804A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476939A (en) * 1993-12-30 1995-12-19 Abbott Laboratories Certain pyridyl and isoquinolyl carbinolamine derivatives
DE4428874A1 (en) * 1994-08-08 1996-02-22 Schering Ag Dimer DTPA derivatives and their metal complexes, pharmaceutical compositions containing these complexes, their use in diagnostics and therapy, and methods for producing the complexes and compositions
JP2004529763A (en) * 2001-04-24 2004-09-30 ティー・エス・コーポレーション Synthesis catalyst for selectively cleaving protein and method for selective cleaving of protein using the same
DE102004022461B4 (en) 2004-05-06 2006-07-06 Forschungszentrum Rossendorf E.V. Metal complexes based on tetrathiol ligands and their application in nuclear medicine diagnostics and endoradione nuclide therapy as well as processes for the preparation of metal complexes
EP3000811B1 (en) * 2014-09-24 2017-11-08 Friedrich-Alexander-Universität Erlangen-Nürnberg Crown Ether Complexes and Methods for Poducing the Same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847949A (en) * 1970-05-12 1974-11-12 Du Pont Macrocyclic hetero imine complexing agents
WO1991010655A1 (en) * 1990-01-16 1991-07-25 Országos 'frederic Joliot-Curie' Sugárbiológiai És Sugáregészségügyi Kutató Intézet 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570703B1 (en) * 1984-09-26 1988-07-08 Commissariat Energie Atomique RARE EARTH MACROPOLYCYCLIC COMPLEXES AND APPLICATION AS FLUORESCENT MARKERS
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US5006643A (en) * 1987-06-24 1991-04-09 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes
US4867951A (en) * 1988-03-31 1989-09-19 The United States Of America As Represented By The United States Department Of Energy Separation of actinides from lanthanides
GB8819375D0 (en) * 1988-08-15 1988-09-14 Ici Plc Composition & use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3847949A (en) * 1970-05-12 1974-11-12 Du Pont Macrocyclic hetero imine complexing agents
WO1991010655A1 (en) * 1990-01-16 1991-07-25 Országos 'frederic Joliot-Curie' Sugárbiológiai És Sugáregészségügyi Kutató Intézet 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
BARTSCH R A ET AL: "Synthesis and metal ion complexing properties of novel chromogenic cryptands", J. INCLUSION PHENOM. MOL. RECOGNIT. CHEM., 1990, VOL. 9, NO. 2, PAGE(S) 113-23 *
CHANG C K: "Stacked double-macrocyclic ligands. 1. Synthesis of a "crowned" porphyrin", J. AM. CHEM. SOC., 1977, VOL. 99, NO. 8, PAGE(S) 2819-22 *
CHEN, SIH JEN ET AL: "The application of Cryptand 22 as a bifunctional stationary phase for ion chromatography", J. CHIN. CHEM. SOC. (TAIPEI), 1991, VOL. 38, PAGE(S) 211-16 *
CHO I ET AL: "Cryptand-containing polymers from N,N'-bis(3-aminopropyl) derivatives of diaza-crown ethers", MAKROMOL. CHEM., RAPID COMMUN., 1981, VOL. 2, NO. 2, PAGE(S) 155-60 *
CHO I ET AL: "Ion-binding properties of N,N'-disubstituted diaza-18-crown-6", BULL. KOREAN CHEM. SOC., 1980, VOL. 1, NO. 4, PAGE(S) 145-6 *
E. KIMURA ET AL.: "A new ditopic receptor molecule for ionic guest molecules.", J.CHEM.SOC.CHEM.COMMUN., 1986, NO. 15, PAGE(S) 1158-9 *
FAGES F ET AL: "Synthesis and fluorescence emission properties of a bisanthracenyl macrotricyclic ditopic receptor. Crystal structure of its dinuclear rubidium cryptate", J. CHEM. SOC., CHEM. COMMUN., 1990, NO. 8, PAGE(S) 655-8 *
HAMILTON A D ET AL: "Mixed substrate supramolecules: binding of organic substrates and of metal ions to heterotopic coreceptors containing porphyrin subunits", J. CHEM. SOC., CHEM. COMMUN., 1984, NO. 5, PAGE(S) 311-13 *
HAMILTON A ET AL: "Coreceptor molecules. Synthesis of metalloreceptors containing porphyrin subunits and formation of mixed substrate supermolecules by binding of organic substrates and of metal ions", J. AM. CHEM. SOC., 1986, VOL. 108, NO. 17, PAGE(S) 5158-67 *
LEHN J M ET AL: "Cryptates. XXIV: structure and stability of mononuclear and binuclear cation inclusion complexes of cylindrical macrotricyclic ligands", HELV. CHIM. ACTA, 1977, VOL. 60, NO. 1, PAGE(S) 141-51 *
PETTIT, WILLIAM A. ET AL: "Synthesis and structure of N1-e-benzo-4,7,13,16,21,26- hexaoxa-1,10-diazabicyclo(8.8.8)hexacos- 23-yl-N2-phenylthiourea. Derivative of a bifunctional complexing agent", J. HETEROCYCL. CHEM., VOL. 29, PAGE(S) 877-81, July 1992 (1992-07-01) *
See also references of WO9205804A1 *
VOEGTLE F ET AL: "Pentamacrocyclic tris-crown hosts: selective binding of cationic, anionic, and neutral guests", J. CHEM. SOC., CHEM. COMMUN., 1990, NO. 2, PAGE(S) 158-61 *
WALLON A ET AL: "Pentamacrocyclic tris-crown hosts. Selective binding of cationic, anionic, and neutral guest compounds", CHEM. BER., 1990, VOL. 123, NO. 4, PAGE(S) 859-67 *

Also Published As

Publication number Publication date
EP0554358A1 (en) 1993-08-11
CA2092434A1 (en) 1992-03-28
JPH06505795A (en) 1994-06-30
WO1992005804A1 (en) 1992-04-16

Similar Documents

Publication Publication Date Title
DE4190756D2 (en) Mikrotom
ZA92888B (en) Complexing agents
HRP921352A2 (en) Detergent
DE4092449D2 (en) Taschenfederkernmatratze
DE4191708D2 (en) Festkoerperlaser
GB9004086D0 (en) Container-cap combination
AU111085S (en) Sunlounger
CS262591A3 (en) Indolonaphthyridines
AU7661991A (en) Chelating agents
EP0554358A4 (en) Chelating agents
DE4092685D2 (en) Mehrkomponenten-kleb- und -werkstoffverarbeitungssystem
EP0481219A3 (en) Connection piece
GB9012847D0 (en) Combination type flush-toilet
CS486190A3 (en) Chelating agents
AU112236S (en) Time piece
AU110900S (en) Facsimilie
EP0478906A3 (en) Intra-sorption agent
DE4191594D2 (en) Sicherheitsgurtverschluss
GB9118591D0 (en) Formold limited
GB9022581D0 (en) Contrast agents
AU109294S (en) Listello
CA65360S (en) Stomatologic electroanesthetizer
CA66168S (en) Récipient
AU157P (en) SUNFLARE Telopea speciosissima
CA65836S (en) Attache-case

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19930427

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: RESEARCH CORPORATION TECHNOLOGIES, INC.

RHK1 Main classification (correction)

Ipc: A61K 51/04

A4 Supplementary search report drawn up and despatched
AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19950401

RHK1 Main classification (correction)

Ipc: A61K 51/00