ATE89276T1 - ((aryl-4-piperazinyl-1)-2-ethoxy>-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten derivate, das verfahren zu deren herstellung und die als aktives prinzip diese verbindungen enthaltenden arzneimittel. - Google Patents

((aryl-4-piperazinyl-1)-2-ethoxy>-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten derivate, das verfahren zu deren herstellung und die als aktives prinzip diese verbindungen enthaltenden arzneimittel.

Info

Publication number
ATE89276T1
ATE89276T1 AT89401640T AT89401640T ATE89276T1 AT E89276 T1 ATE89276 T1 AT E89276T1 AT 89401640 T AT89401640 T AT 89401640T AT 89401640 T AT89401640 T AT 89401640T AT E89276 T1 ATE89276 T1 AT E89276T1
Authority
AT
Austria
Prior art keywords
cymole
monosubstituted
piperazinyl
ortho
para
Prior art date
Application number
AT89401640T
Other languages
English (en)
Inventor
Patrick Houziaux
Jean-Yves Lacolle
Jean-Pierre Riffaud
Bernard Danree
Original Assignee
Inst Rech Chim Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Rech Chim Biolog filed Critical Inst Rech Chim Biolog
Application granted granted Critical
Publication of ATE89276T1 publication Critical patent/ATE89276T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT89401640T 1988-06-13 1989-06-13 ((aryl-4-piperazinyl-1)-2-ethoxy>-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten derivate, das verfahren zu deren herstellung und die als aktives prinzip diese verbindungen enthaltenden arzneimittel. ATE89276T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8807864A FR2632641B1 (fr) 1988-06-13 1988-06-13 ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
EP89401640A EP0347305B1 (de) 1988-06-13 1989-06-13 [(Aryl-4-piperazinyl-1)-2-ethoxy]-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten Derivate, das Verfahren zu deren Herstellung und die als aktives Prinzip diese Verbindungen enthaltenden Arzneimittel

Publications (1)

Publication Number Publication Date
ATE89276T1 true ATE89276T1 (de) 1993-05-15

Family

ID=9367221

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89401640T ATE89276T1 (de) 1988-06-13 1989-06-13 ((aryl-4-piperazinyl-1)-2-ethoxy>-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten derivate, das verfahren zu deren herstellung und die als aktives prinzip diese verbindungen enthaltenden arzneimittel.

Country Status (8)

Country Link
US (1) US5110816A (de)
EP (2) EP0445116A1 (de)
JP (1) JPH03505456A (de)
AT (1) ATE89276T1 (de)
DE (1) DE68906466T2 (de)
DK (1) DK168071B1 (de)
FR (1) FR2632641B1 (de)
WO (1) WO1989012634A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
ES2160158T3 (es) 1994-03-30 2001-11-01 Zeria Pharm Co Ltd Derivados de 4-indol-1-il acido butirico, su preparacion y su utilizacion como inhibidores de receptores alfa1-adrenergicos y testosterona 5alfa-reductasas.
ES2239766T3 (es) * 1995-01-23 2005-10-01 Daiichi Suntory Pharma Co., Ltd. Alivio o remedio para sintomas causados por enfermedades isquemicas y compuestos de fenilpiperidina utilizados para ello.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1349636A (fr) * 1962-02-26 1964-01-17 Soc Ind Fab Antibiotiques Sifa Nouveaux dérivés de la pipérazine, et procédé de préparation
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
FR2515647A1 (fr) * 1981-11-03 1983-05-06 Cortial Nouvelles imines derivees de (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique
FR2515648A1 (fr) * 1981-11-03 1983-05-06 Cortial Nouvelles (phenyl-4 piperazinylethyl)-2 anilines, leur methode de preparation et leur application therapeutique
FR2568878B1 (fr) * 1984-08-07 1986-11-21 Cortial Nouveaux derives de (phenylpiperazinylethylamine ethoxy)-4 phenol, leur methode de preparation et leur application therapeutique
EP0173634B1 (de) * 1984-08-07 1988-08-31 Cortial S.A. 4-(Arylpiperazinylethylaminoethoxy)-phenolderivate, Verfahren zu deren Herstellung und deren therapeutische Verwendung
EP0179009A1 (de) * 1984-09-19 1986-04-23 Cortial S.A. N-1(Aminoalcoxy)-4-isopropyl-5 phenoxy)-2 ethyl-N-4-phenylpiperazine, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung
DE3604941A1 (de) * 1986-02-17 1987-08-20 Heumann Pharma Gmbh & Co Phenylpiperazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2595357B1 (fr) * 1986-03-04 1988-07-08 Irceba (piperidino-3 propoxy)-5 p.cymene, les derives acetyl, acetoxy et hydroxy dudit produit, les sels de ces produits, un procede de preparation desdits produits et les medicaments contenant au moins un de ces produits comme principe actif

Also Published As

Publication number Publication date
WO1989012634A1 (fr) 1989-12-28
DE68906466T2 (de) 1993-09-09
DK293890D0 (da) 1990-12-11
DK168071B1 (da) 1994-01-31
EP0347305A1 (de) 1989-12-20
EP0347305B1 (de) 1993-05-12
FR2632641A1 (fr) 1989-12-15
DE68906466D1 (de) 1993-06-17
FR2632641B1 (fr) 1990-10-12
DK293890A (da) 1990-12-11
EP0445116A1 (de) 1991-09-11
JPH03505456A (ja) 1991-11-28
US5110816A (en) 1992-05-05

Similar Documents

Publication Publication Date Title
FR2382441A1 (fr) Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides utiles en tant que medicaments et procedes pour leur preparation
PT77110B (fr) Procede de preparation de nouveaux derives de la xanthine
ATE8144T1 (de) Indolobenzoxazine, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
ATE89276T1 (de) ((aryl-4-piperazinyl-1)-2-ethoxy>-3p-cymole, die ortho-, meta-, para-monosubstituierten oder disubstituierten derivate, das verfahren zu deren herstellung und die als aktives prinzip diese verbindungen enthaltenden arzneimittel.
ATE73445T1 (de) 1,2,5,6-tetrahydropyridinoxim-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel und diese enthaltende zusammensetzungen.
DE68912263D1 (de) 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl]-Thiazolderivate, ihre Herstellung und Zusammenstellungen, die sie enthalten.
ATE25849T1 (de) Tricyclophosphazen-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE71938T1 (de) 1,2,5,6-tetrahydropyridin-3-carboxaldehydoximderivate, verfahren zu deren herstellung, deren verwendung als arzneimittel und diese enthaltende zusammensetzungen.
ATE417831T1 (de) Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel
ATE214375T1 (de) Piperazinylalkylthiopyrimidin derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung
ATE19244T1 (de) 2-piperazinyl-4-phenyl-quinazolin-derivate mit antidepressiven eigenschaften, verfahren zu deren herstellung und diese enthaltende arzneimitteln.
ES8407023A1 (es) Un procedimiento para la preparacion de 4-(3-trifluormetilfenil-1,2,3,6-tetrahidropiridinas
DE3381892D1 (de) 4-(1-(phenyl)-1-(hydroxy)-prop-1-yl)-resorcinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE55611T1 (de) 2,2;6,6-diethylen-3-oxo-17alpha-pregn-4-en-21, 17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharm. praeparate.
DE69006338D1 (de) Neue Derivate substituierter Verfahren zu deren Herstellung und pharmazeutische Zubereitungen, die sie enthalten.
OA08813A (fr) Nouveaux dérivés de l'acide (dihydro-2,3, oxo-2 benzofurannyl-3)-2 acétique, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DK0865422T3 (da) Anvendelse af aminoalkoholderivater som lægemidler, hidtil ukendte derivater og fremgangsmåde til fremstilling deraf
DE3860117D1 (de) 2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
BG50776A1 (en) Derivatives of n- (2- phenylmorpholinomethyl)- succinamide and method for their preparation
KR890014535A (ko) 인돌화합물 및 이들의 제조방법, 및 이들 화합물을 함유하는 약학적 조성물
GB2316406A (en) Free radical scavenger molecules