ATE84029T1 - Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit. - Google Patents

Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit.

Info

Publication number
ATE84029T1
ATE84029T1 AT87101246T AT87101246T ATE84029T1 AT E84029 T1 ATE84029 T1 AT E84029T1 AT 87101246 T AT87101246 T AT 87101246T AT 87101246 T AT87101246 T AT 87101246T AT E84029 T1 ATE84029 T1 AT E84029T1
Authority
AT
Austria
Prior art keywords
substituted
benzylpyrimidines
diamino
antimicrobial activity
medications
Prior art date
Application number
AT87101246T
Other languages
German (de)
English (en)
Inventor
Joachim K Prof Dr Seydel
Rolf Prof Dr Haller
Manfred Kansy
Gerd Hachtel
Original Assignee
Fatol Arzneimittel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fatol Arzneimittel Gmbh filed Critical Fatol Arzneimittel Gmbh
Application granted granted Critical
Publication of ATE84029T1 publication Critical patent/ATE84029T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT87101246T 1986-02-06 1987-01-29 Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit. ATE84029T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863603577 DE3603577A1 (de) 1986-02-06 1986-02-06 Neue substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antibakterieller wirksamkeit
EP87101246A EP0231888B1 (de) 1986-02-06 1987-01-29 Substituierte 2,4-Diamino-5-benzylpyrimidine, deren Herstellung und deren Verwendung als Arzneimittel mit antimikrobieller Wirksamkeit

Publications (1)

Publication Number Publication Date
ATE84029T1 true ATE84029T1 (de) 1993-01-15

Family

ID=6293457

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87101246T ATE84029T1 (de) 1986-02-06 1987-01-29 Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit.

Country Status (6)

Country Link
US (1) US4912112A (show.php)
EP (1) EP0231888B1 (show.php)
JP (1) JPH0826007B2 (show.php)
AT (1) ATE84029T1 (show.php)
DE (2) DE3603577A1 (show.php)
IN (1) IN167562B (show.php)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831445C2 (de) * 1988-09-13 1998-09-10 Joachim K Prof Dr Seydel Verwendung von substituierten 2,4-Diamino-5-benzylpyrimidinen gegebenenfalls in Kombination mit 4,4'-Diaminodiphenylsulfonen zur Behandlung von Malaria
US5622954A (en) * 1994-05-11 1997-04-22 Fmc Corporation 5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides
US20030157036A1 (en) * 2002-02-20 2003-08-21 Osborne David W. Topical dapsone for the treatment of acne
WO2000071160A1 (en) 1999-05-24 2000-11-30 Sankyo Company, Limited MEDICINAL COMPOSITIONS CONTAINING ANTI-Fas ANTIBODY
AU2005229331B2 (en) 2004-03-05 2011-10-13 F. Hoffmann-La Roche Ag Diaminopyrimidines as P2X3 and P2X2/3 antagonists
CA2559036C (en) 2004-03-26 2013-08-20 Dainippon Sumitomo Pharma Co., Ltd. 9-substituted 8-oxoadenine compound
EP1924566B1 (en) * 2005-09-01 2016-01-13 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
WO2007025899A1 (en) * 2005-09-01 2007-03-08 F. Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
EP1924565B1 (en) * 2005-09-01 2016-09-14 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p3x2/3 modulators
EP1986637A1 (en) * 2006-02-13 2008-11-05 Laboratoires Serono SA Sulfonamide derivatives for the treatment of bacterial infections
US8138172B2 (en) * 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
ES2373616T3 (es) * 2007-03-19 2012-02-07 Astrazeneca Ab Compuestos de 8-oxo-adenina 9 sustituidos como moduladores del receptor de tipo toll (tlr7).
JP5480637B2 (ja) * 2007-03-19 2014-04-23 アストラゼネカ・アクチエボラーグ Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
WO2008114819A1 (ja) * 2007-03-20 2008-09-25 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
ES2775825T3 (es) 2008-02-27 2020-07-28 Allergan Inc Dapsona para tratar la rosácea
EA201101650A1 (ru) 2009-05-21 2012-07-30 Астразенека Аб Новые производные пиримидина и их применение в лечении злокачественных новообразований и последующих заболеваний
GB0908772D0 (en) * 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
WO2012080728A1 (en) 2010-12-16 2012-06-21 Astrazeneca Ab Imidazo [4, 5 -c] quinolin- 1 -yl derivative useful in therapy
DK2651943T3 (en) 2010-12-17 2017-06-06 Sumitomo Dainippon Pharma Co Ltd purine derivatives
RU2636146C2 (ru) 2012-05-18 2017-11-21 Сумитомо Дайниппон Фарма Ко., Лтд. Соединения карбоновых кислот

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB920412A (en) * 1958-04-18 1963-03-06 Wellcome Found Pyrimidine derivatives and the manufacture thereof
DE1303727B (de) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
FR94837E (fr) * 1966-02-19 1969-11-28 Wellcome Found Procédé de préparation de dérivés de la pyrimidine.
GB1261455A (en) * 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles
US4143227A (en) * 1973-02-26 1979-03-06 Hoffmann-La Roche Inc. Process for substituted 5-benzyl-2,4-diamino-pyrimidines
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2720771C3 (de) * 1977-05-09 1979-11-29 Ludwig Heumann & Co Gmbh, 8500 Nuernberg 2,4-Diamino-5-(33-dimethoxy-4thioalkyl-benzyD-pyrimidine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
GR71725B (show.php) * 1977-11-10 1983-06-22 Hoffmann La Roche
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
DK523781A (da) * 1980-11-27 1982-05-28 Wellcome Found Fremgangsmaade til fremstilling af benzylpyrimidiner samt mellemprodukt for disse

Also Published As

Publication number Publication date
DE3603577A1 (de) 1987-08-13
EP0231888A3 (en) 1988-10-19
IN167562B (show.php) 1990-11-17
US4912112A (en) 1990-03-27
JPS62265272A (ja) 1987-11-18
DE3783238D1 (de) 1993-02-11
EP0231888B1 (de) 1992-12-30
JPH0826007B2 (ja) 1996-03-13
EP0231888A2 (de) 1987-08-12

Similar Documents

Publication Publication Date Title
ATE84029T1 (de) Substituierte 2,4-diamino-5-benzylpyrimidine, deren herstellung und deren verwendung als arzneimittel mit antimikrobieller wirksamkeit.
ATE175669T1 (de) Sulfonylaminopyrimidine, ihre herstellung und verwendung als heilmittel
DE59009351D1 (de) Neue arylpyridazine, ihre herstellung, verwendung und sie enthaltende arzneimittel.
JPS6470457A (en) Local remedy for skin damaged by beam
RU94031102A (ru) Сульфамиды в качестве антагонистов эндотелина и способ лечения соответствующих заболеваний
IT8419543A0 (it) Derivati di 3-cefem-4-carbossilati e loro sali, esteri e solvati aventi proprieta' antibatteriche.
ATE198708T1 (de) Verwendung von makrolid-verbindungen gegen augenerkrankungen
FR2393039A1 (fr) Revetement siloxane-etain
FI925734A0 (fi) Polyaspartamidderivat som adsorptionsmedel foer gallsyra, polyaspartamidderivat innehaollande gallsyror och foerfarande foer framstaellning av dessa samt anvaendning av dessa som laekemedel
FI944770A0 (fi) Neurotensiiniin vaikuttavia substituoituja 1-naftyylipyratsoli-3-karboksiamideja, niiden valmistus ja niitä sisältäviä farmaseuttisia koostumuksia
DE69311541D1 (de) Kosmetische oder pharmazeutische zusammensetzungen zur topischen anwendung die deacylierten glycerophospholipide enthalten
ATE246509T1 (de) Bakterien-stämme mit verändertem gallensäuren- stoffwechsel und deren verwendung
DE59200244D1 (de) Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung als Herbizide.
NO911674D0 (no) Biocid blanding og anvendelse derav.
DK0465581T3 (da) Erythromycinderivater
DE59203924D1 (de) Substituierte Aminosäureamid-Derivate deren Herstellung und Verwendung als Fungizide.
ES2125309T3 (es) Derivados de tiomarinol y procedimientos para su preparacion.
DE3876114D1 (de) Benzodioxol-derivate, diese enthaltende zusammensetzungen und deren verwendung zur herstellung von medikamenten.
ATE232723T1 (de) Verwendung von allylaminderivaten wie terbinafin zur herstellung eines medikaments zur behandlung von mit einer helicobacter pylori infektion zusammenhängenden erkrankungen
DE59207380D1 (de) Glykolaldehyd- und Milchsäurederivate, deren Herstellung und herbizide Verwendung
ITTO940823A0 (it) Composizione per regolare la crescita di insetti.
DK296186D0 (da) Tetramethylcyclopropancarboxylsyreestere, deres fremstilling og anvendelse
NO305556B1 (no) Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
DE59102802D1 (de) Lösung und ihre Verwendung zur Herstellung supraleitender Fäden und Beschichtungen.
ES2055700T3 (es) Mezclas bactericidas.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee