ATE79870T1 - 2-thiomethyl-substituierte pyridine, verfahren zu deren herstellung und diese enthaltende arzneimittel. - Google Patents

2-thiomethyl-substituierte pyridine, verfahren zu deren herstellung und diese enthaltende arzneimittel.

Info

Publication number
ATE79870T1
ATE79870T1 AT88103777T AT88103777T ATE79870T1 AT E79870 T1 ATE79870 T1 AT E79870T1 AT 88103777 T AT88103777 T AT 88103777T AT 88103777 T AT88103777 T AT 88103777T AT E79870 T1 ATE79870 T1 AT E79870T1
Authority
AT
Austria
Prior art keywords
thiomethyl
preparation
substituted pyridines
pharmaceuticals containing
pyridines
Prior art date
Application number
AT88103777T
Other languages
English (en)
Inventor
Marco Frigerio
Carmelo A Gandolfi
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of ATE79870T1 publication Critical patent/ATE79870T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT88103777T 1987-03-13 1988-03-10 2-thiomethyl-substituierte pyridine, verfahren zu deren herstellung und diese enthaltende arzneimittel. ATE79870T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8719700A IT1204948B (it) 1987-03-13 1987-03-13 2-tiometil-sostituite-piridine, metodo per la loro preparazione e composizioni farmaceutiche che le contengono.
EP88103777A EP0282904B1 (de) 1987-03-13 1988-03-10 2-Thiomethyl-substituierte Pyridine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ATE79870T1 true ATE79870T1 (de) 1992-09-15

Family

ID=11160490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88103777T ATE79870T1 (de) 1987-03-13 1988-03-10 2-thiomethyl-substituierte pyridine, verfahren zu deren herstellung und diese enthaltende arzneimittel.

Country Status (6)

Country Link
US (1) US4918087A (de)
EP (1) EP0282904B1 (de)
JP (1) JPS63243073A (de)
AT (1) ATE79870T1 (de)
DE (1) DE3873939D1 (de)
IT (1) IT1204948B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8905526D0 (en) * 1989-03-10 1989-04-19 Fujisawa Pharmaceutical Co N-containing heterocyclic compounds,processes for the preparation thereof and composition comprising the same
ES2065234B1 (es) * 1992-10-27 1995-09-01 Smithkline Beecham Corp Compuestos para tratar enfermedades relacionadas con los leucotrienos.
US5380734A (en) * 1993-04-15 1995-01-10 American Home Products Corporation N-cyanoamidine derivatives as anti-influenza agents
DE19532320A1 (de) * 1995-09-01 1997-03-06 Bayer Ag Verfahren zur Herstellung von optisch aktiven ortho-substituierten 4-Aryl-Dihydropyridinen
AU771033B2 (en) * 1999-06-14 2004-03-11 Ortho-Mcneil Pharmaceutical, Inc. Dithiepino(6,5-b)pyridines, and related compositions and methods
DE10115945A1 (de) * 2001-03-30 2002-10-02 Bayer Ag Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3209274A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Pyridincarbonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
US4572908A (en) * 1982-12-21 1986-02-25 Pfizer Inc. Dihydropyridines
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite

Also Published As

Publication number Publication date
EP0282904A3 (en) 1988-10-05
IT8719700A0 (it) 1987-03-13
EP0282904A2 (de) 1988-09-21
IT1204948B (it) 1989-03-10
US4918087A (en) 1990-04-17
EP0282904B1 (de) 1992-08-26
DE3873939D1 (de) 1992-10-01
JPS63243073A (ja) 1988-10-07

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