ATE78053T1 - Vereinfachtes verfahren zur herstellung von menschlichen lymphokinaktivierten killerzellen. - Google Patents

Vereinfachtes verfahren zur herstellung von menschlichen lymphokinaktivierten killerzellen.

Info

Publication number
ATE78053T1
ATE78053T1 AT88106566T AT88106566T ATE78053T1 AT E78053 T1 ATE78053 T1 AT E78053T1 AT 88106566 T AT88106566 T AT 88106566T AT 88106566 T AT88106566 T AT 88106566T AT E78053 T1 ATE78053 T1 AT E78053T1
Authority
AT
Austria
Prior art keywords
production
killer cells
inactivated
simplified procedure
human lymphokine
Prior art date
Application number
AT88106566T
Other languages
English (en)
Inventor
George Franks Dunn Jr
Joseph David Irr
Lise Nadine Halpern
Original Assignee
Terumo Corp
Haemonetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp, Haemonetics Corp filed Critical Terumo Corp
Application granted granted Critical
Publication of ATE78053T1 publication Critical patent/ATE78053T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT88106566T 1987-04-27 1988-04-23 Vereinfachtes verfahren zur herstellung von menschlichen lymphokinaktivierten killerzellen. ATE78053T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/042,998 US4808151A (en) 1987-04-27 1987-04-27 Simplified method for the preparation of human lymphokine activated killer cells

Publications (1)

Publication Number Publication Date
ATE78053T1 true ATE78053T1 (de) 1992-07-15

Family

ID=21924902

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88106566T ATE78053T1 (de) 1987-04-27 1988-04-23 Vereinfachtes verfahren zur herstellung von menschlichen lymphokinaktivierten killerzellen.

Country Status (17)

Country Link
US (1) US4808151A (de)
EP (1) EP0289896B1 (de)
JP (1) JPH0657147B2 (de)
KR (1) KR900004422B1 (de)
AT (1) ATE78053T1 (de)
AU (1) AU612086B2 (de)
CA (1) CA1304306C (de)
DE (1) DE3872588T2 (de)
DK (1) DK226288A (de)
ES (1) ES2051790T3 (de)
FI (1) FI881952L (de)
HU (1) HU205380B (de)
IL (1) IL86177A0 (de)
NO (1) NO881819L (de)
NZ (1) NZ224379A (de)
PT (1) PT87335B (de)
ZA (1) ZA882948B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000970A2 (en) * 1986-08-08 1988-02-11 Regents Of The University Of Minnesota Method of culturing leukocytes
WO1990004633A1 (en) * 1988-10-21 1990-05-03 Brigham And Women's Hospital ACTIVATION AND GROWTH OF HUMAN TUMOR-INFILTRATING LYMPHOCYTES USING ANTIBODIES TO CD3 OR TcR
AU4525589A (en) * 1988-10-27 1990-05-14 Regents Of The University Of Minnesota Liposome immunoadjuvants containing il-2
US5484396A (en) * 1988-11-17 1996-01-16 Naficy; Sadeque S. Method and device for treatment of HIV infections and AIDS
DE69012105T2 (de) * 1989-02-21 1994-12-22 Terumo Corp Proliferation von cd4-lymfocyten.
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US6004811A (en) 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US5843728A (en) * 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5725855A (en) * 1991-04-05 1998-03-10 The United States Of America As Represented By The Department Of Health And Human Services Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations
WO1992017567A1 (en) * 1991-04-05 1992-10-15 Regents Of The University Of Minnesota Method of enhancing the immunotherapeutic activity of immune cells by depletion/positive selection of cell subsets
IE922233A1 (en) * 1991-07-10 1993-01-13 Augusto C Ochoa Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity
JPH07502734A (ja) * 1991-12-31 1995-03-23 ザイモジェネティクス，インコーポレイティド 血液損失を減少する方法および組成物
DE69634860T2 (de) * 1995-04-18 2006-05-11 Gambro Inc., Lakewood Vorrichtung und Verfahren zur Teilchentrennung
US5951877A (en) * 1995-04-18 1999-09-14 Cobe Laboratories, Inc. Particle filter method
US5674173A (en) * 1995-04-18 1997-10-07 Cobe Laboratories, Inc. Apparatus for separating particles
US6022306A (en) * 1995-04-18 2000-02-08 Cobe Laboratories, Inc. Method and apparatus for collecting hyperconcentrated platelets
US6053856A (en) * 1995-04-18 2000-04-25 Cobe Laboratories Tubing set apparatus and method for separation of fluid components
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US6051146A (en) * 1998-01-20 2000-04-18 Cobe Laboratories, Inc. Methods for separation of particles
US6153113A (en) 1999-02-22 2000-11-28 Cobe Laboratories, Inc. Method for using ligands in particle separation
US6334842B1 (en) 1999-03-16 2002-01-01 Gambro, Inc. Centrifugal separation apparatus and method for separating fluid components
US6354986B1 (en) 2000-02-16 2002-03-12 Gambro, Inc. Reverse-flow chamber purging during centrifugal separation
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US7201848B2 (en) * 2001-12-05 2007-04-10 Gambro Bct, Inc. Methods and apparatus for separation of particles
US20030173274A1 (en) * 2002-02-01 2003-09-18 Frank Corbin Blood component separation device, system, and method including filtration
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
CA2642653A1 (en) 2002-04-16 2003-10-30 Gambro Bct, Inc. Blood component processing system, apparatus and method
CN1291231C (zh) 2003-12-08 2006-12-20 胡军 活化淋巴细胞特异性的检测方法
WO2008021623A1 (en) * 2006-08-10 2008-02-21 Gambro Bct, Inc. Method and apparatus for recirculating elutriation fluids
DE102011106914B4 (de) 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
WO2014127122A1 (en) 2013-02-18 2014-08-21 Terumo Bct, Inc. System for blood separation with a separation chamber having an internal gravity valve
KR102181610B1 (ko) * 2016-06-03 2020-11-23 주식회사 젬백스앤카엘 항암 치료용 사이토카인 유도 살해세포의 생산 방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3145713A (en) * 1963-09-12 1964-08-25 Protein Foundation Inc Method and apparatus for processing blood
US4197847A (en) * 1977-03-31 1980-04-15 Isaac Djerassi Method and apparatus for collecting transfusable granulocytes
US4185629A (en) * 1977-10-18 1980-01-29 Baxter Travenol Laboratories, Inc. Method and apparatus for processing blood
US4151844A (en) * 1977-11-11 1979-05-01 Baxter Travenol Laboratories, Inc. Method and apparatus for separating whole blood into its components and for automatically collecting one component
US4285464A (en) * 1979-01-22 1981-08-25 Haemonetics Corporation Apparatus for separation of blood into components thereof
US4401756A (en) * 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
US4464166A (en) * 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US4464167A (en) * 1981-09-03 1984-08-07 Haemonetics Corporation Pheresis apparatus
US4416654A (en) * 1981-09-03 1983-11-22 Haemonetics Corporation Pheresis apparatus
JPS5998015A (ja) * 1982-11-27 1984-06-06 Microbial Chem Res Found 免疫賦活剤
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US4683889A (en) * 1983-03-29 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4675383A (en) * 1983-11-15 1987-06-23 The Salk Institute For Biological Studies Purification of T-cell growth factor
US4578056A (en) * 1984-10-29 1986-03-25 Extracorporeal Medical Specialties, Inc. Patient photopheresis treatment apparatus and method
US4690915A (en) * 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans

Also Published As

Publication number Publication date
AU1520088A (en) 1988-10-27
CA1304306C (en) 1992-06-30
HU205380B (en) 1992-04-28
ZA882948B (en) 1989-12-27
NO881819D0 (no) 1988-04-26
JPH0657147B2 (ja) 1994-08-03
DK226288D0 (da) 1988-04-26
US4808151A (en) 1989-02-28
PT87335A (pt) 1988-05-01
ES2051790T3 (es) 1994-07-01
NO881819L (no) 1988-10-28
EP0289896A1 (de) 1988-11-09
KR880012751A (ko) 1988-11-29
FI881952A0 (fi) 1988-04-26
DE3872588T2 (de) 1992-12-03
FI881952A7 (fi) 1988-10-28
NZ224379A (en) 1990-12-21
PT87335B (pt) 1992-08-31
JPS63295510A (ja) 1988-12-01
EP0289896B1 (de) 1992-07-08
IL86177A0 (en) 1988-11-15
FI881952L (fi) 1988-10-28
DE3872588D1 (de) 1992-08-13
KR900004422B1 (ko) 1990-06-25
DK226288A (da) 1988-10-28
AU612086B2 (en) 1991-06-27

Similar Documents

Publication Publication Date Title
DE3872588D1 (de) Vereinfachtes verfahren zur herstellung von menschlichen lymphokinaktivierten killerzellen.
AU7262691A (en) Anabolic activity modulator and uses thereof
ATE77960T1 (de) Verwendung von interleukin-1 zur induzierung der bildung von multipotenten haemopoietischen zellpopulationen.
NL194909B (nl) Werkwijze voor de bereiding van gepolymeriseerd hemoglobine en celvrij vervangingsmiddel voor rode bloedlichaampjes op basis daarvan.
AU641488B2 (en) Human hematopoietic stem cell
AU574350B2 (en) Human nerve growth factor by recombinant technology
DE69224124D1 (de) Verfahren zur Herstellung von Dihomo-Gamma-Linolensäure und das in dieser enthaltende Lipid
AU2290988A (en) Process for obtaining concentrates having a high alpha-lactalbumin content from whey
DE69023160D1 (de) Herstellung von Copolymeren.
NZ223221A (en) Separation of leucocytes and erythrocytes by sedimentation
DE3864512D1 (de) Verfahren zur herstellung von kandis mit gepressten gaszellen.
ATE56430T1 (de) Verfahren zur herstellung von alkylthioalkansaeuresalzen.
ATE127842T1 (de) Megakaryocytopoietin, seine herstellung und benutzung.
EP0257962A3 (de) Verfahren zur Behandlung von Umkreisblut für die Verbesserung der lymphokinaktivierten Töterzell-Immuntherapie
ATE60780T1 (de) Verfahren zur herstellung von alkyloligoglycosiden.
MY103370A (en) A simplified method for the preparation of human lymphokine activated killer cells
AU5279093A (en) Process for production of cell cultures with elevated content of endogenous cytokines
DE3585416D1 (de) Verfahren zur herstellung eines biologischen stoffes.
ATE95569T1 (de) Verfahren zur herstellung von pregnenooxazolinen.
SU1082422A1 (ru) Способ определени активности интерферона в сыворотке и плазме крови
DE3671441D1 (de) Verfahren zur herstellung von cyclohexylhydroperoxid.
DE3786134D1 (de) Verfahren zur herstellung von polyamidsaeure mit siloxanbindungen und von polyimid mit siloxanbindungen und isoindolochinazolindion-ringen.
DE68908843D1 (de) Verfahren zur Herstellung von 4,6-Dimethyl-7-hydroxynonan-3-on.
ATE81530T1 (de) Verfahren zur fermentativen herstellung von laminos|uren aus alpha-ketocarbonsaeuren.
ATE11568T1 (de) Verfahren zur herstellung von 11-alpha-hydroxy-20-alpha-hydroxymethyl-1,4-pre nadien-3-on.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee