ES2051790T3 - Un metodo simplificado para la preparacion de celulas asesinas humanas activadas por linfoquinas. - Google Patents
Un metodo simplificado para la preparacion de celulas asesinas humanas activadas por linfoquinas.Info
- Publication number
- ES2051790T3 ES2051790T3 ES88106566T ES88106566T ES2051790T3 ES 2051790 T3 ES2051790 T3 ES 2051790T3 ES 88106566 T ES88106566 T ES 88106566T ES 88106566 T ES88106566 T ES 88106566T ES 2051790 T3 ES2051790 T3 ES 2051790T3
- Authority
- ES
- Spain
- Prior art keywords
- killer cells
- lymphocines
- preparation
- simplified method
- cells activated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000005119 centrifugation Methods 0.000 abstract 2
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000003714 granulocyte Anatomy 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
UNA FRACCION DE LEUCOCITOS QUE CONTIENEN LINFOCITOS OBTENIDA POR LEUCOFORESIS CONVENCIONAL, LEUCOFORESIS POR ELUTRIACION O CENTRIFUGACION NORMAL, PUEDE SER USADA PARA LA PRODUCCION DE CELULAS ASESINAS ACTIVADAS CON LINFOQUINA POR INCUBACION CON IL-2. NO ES NECESAROA LA SEPARACION DE LOS GLOBULOS ROJOS Y LOS GRANULOCITOS POR CENTRIFUGACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/042,998 US4808151A (en) | 1987-04-27 | 1987-04-27 | Simplified method for the preparation of human lymphokine activated killer cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2051790T3 true ES2051790T3 (es) | 1994-07-01 |
Family
ID=21924902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88106566T Expired - Lifetime ES2051790T3 (es) | 1987-04-27 | 1988-04-23 | Un metodo simplificado para la preparacion de celulas asesinas humanas activadas por linfoquinas. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4808151A (es) |
EP (1) | EP0289896B1 (es) |
JP (1) | JPH0657147B2 (es) |
KR (1) | KR900004422B1 (es) |
AT (1) | ATE78053T1 (es) |
AU (1) | AU612086B2 (es) |
CA (1) | CA1304306C (es) |
DE (1) | DE3872588T2 (es) |
DK (1) | DK226288A (es) |
ES (1) | ES2051790T3 (es) |
FI (1) | FI881952A (es) |
HU (1) | HU205380B (es) |
IL (1) | IL86177A0 (es) |
NO (1) | NO881819L (es) |
NZ (1) | NZ224379A (es) |
PT (1) | PT87335B (es) |
ZA (1) | ZA882948B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988000970A2 (en) * | 1986-08-08 | 1988-02-11 | Regents Of The University Of Minnesota | Method of culturing leukocytes |
AU4485089A (en) * | 1988-10-21 | 1990-05-14 | Brigham And Women's Hospital | Activation and growth of human tumor-infiltrating lymphocytes using antibodies to cd3 or tcr |
JP2955314B2 (ja) * | 1988-10-27 | 1999-10-04 | リージェンツ・オブ・ザ・ユニバーシティー・オブ・ミネソタ | Il―2含有リポソーム免疫アジュバント |
US5484396A (en) * | 1988-11-17 | 1996-01-16 | Naficy; Sadeque S. | Method and device for treatment of HIV infections and AIDS |
WO1990010059A1 (en) * | 1989-02-21 | 1990-09-07 | Terumo Corporation | A process for the generation of proliferating cd4 lymphocytes |
US5912170A (en) | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US6004811A (en) * | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
US6753162B1 (en) | 1991-03-07 | 2004-06-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US5843728A (en) * | 1991-03-07 | 1998-12-01 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
WO1992017567A1 (en) * | 1991-04-05 | 1992-10-15 | Regents Of The University Of Minnesota | Method of enhancing the immunotherapeutic activity of immune cells by depletion/positive selection of cell subsets |
US5725855A (en) * | 1991-04-05 | 1998-03-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations |
IE922233A1 (en) * | 1991-07-10 | 1993-01-13 | Augusto C Ochoa | Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity |
CA2127107C (en) * | 1991-12-31 | 2007-06-19 | Bruce L. A. Carter | Methods and compositions for reducing blood loss |
DE69638219D1 (de) * | 1995-04-18 | 2010-08-26 | Caridianbct Inc | Teilchentrennverfahren |
US6022306A (en) * | 1995-04-18 | 2000-02-08 | Cobe Laboratories, Inc. | Method and apparatus for collecting hyperconcentrated platelets |
US5951877A (en) * | 1995-04-18 | 1999-09-14 | Cobe Laboratories, Inc. | Particle filter method |
US5674173A (en) * | 1995-04-18 | 1997-10-07 | Cobe Laboratories, Inc. | Apparatus for separating particles |
US6053856A (en) * | 1995-04-18 | 2000-04-25 | Cobe Laboratories | Tubing set apparatus and method for separation of fluid components |
US20020182730A1 (en) * | 1995-07-26 | 2002-12-05 | Micheal L. Gruenberg | Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease |
US6051146A (en) * | 1998-01-20 | 2000-04-18 | Cobe Laboratories, Inc. | Methods for separation of particles |
US6153113A (en) | 1999-02-22 | 2000-11-28 | Cobe Laboratories, Inc. | Method for using ligands in particle separation |
US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
US6354986B1 (en) | 2000-02-16 | 2002-03-12 | Gambro, Inc. | Reverse-flow chamber purging during centrifugal separation |
FR2821947B1 (fr) * | 2001-03-12 | 2003-05-16 | Canon Kk | Procede et dispositif de validation de parametres definissant une image |
US20030134415A1 (en) * | 2001-09-19 | 2003-07-17 | Gruenberg Micheal L. | Th1 cell adoptive immunotherapy |
US20030134341A1 (en) * | 2001-09-19 | 2003-07-17 | Medcell Biologics, Llc. | Th1 cell adoptive immunotherapy |
CA2455964A1 (en) * | 2001-12-05 | 2003-06-19 | Gambro, Inc. | Methods and apparatus for separation of blood components |
US20030173274A1 (en) * | 2002-02-01 | 2003-09-18 | Frank Corbin | Blood component separation device, system, and method including filtration |
US20030175272A1 (en) * | 2002-03-07 | 2003-09-18 | Medcell Biologics, Inc. | Re-activated T-cells for adoptive immunotherapy |
EP1920792B1 (en) | 2002-04-16 | 2010-03-17 | CaridianBCT, Inc. | Blood components processing method |
CN1291231C (zh) | 2003-12-08 | 2006-12-20 | 胡军 | 活化淋巴细胞特异性的检测方法 |
WO2008021623A1 (en) * | 2006-08-10 | 2008-02-21 | Gambro Bct, Inc. | Method and apparatus for recirculating elutriation fluids |
DE102011106914B4 (de) | 2011-07-08 | 2015-08-27 | Zellwerk Gmbh | Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen |
WO2014127122A1 (en) | 2013-02-18 | 2014-08-21 | Terumo Bct, Inc. | System for blood separation with a separation chamber having an internal gravity valve |
WO2017209498A1 (ko) * | 2016-06-03 | 2017-12-07 | 주식회사 젬백스앤카엘 | 항암 치료용 사이토카인 유도 살해세포의 생산 방법 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3145713A (en) * | 1963-09-12 | 1964-08-25 | Protein Foundation Inc | Method and apparatus for processing blood |
US4197847A (en) * | 1977-03-31 | 1980-04-15 | Isaac Djerassi | Method and apparatus for collecting transfusable granulocytes |
US4185629A (en) * | 1977-10-18 | 1980-01-29 | Baxter Travenol Laboratories, Inc. | Method and apparatus for processing blood |
US4151844A (en) * | 1977-11-11 | 1979-05-01 | Baxter Travenol Laboratories, Inc. | Method and apparatus for separating whole blood into its components and for automatically collecting one component |
US4285464A (en) * | 1979-01-22 | 1981-08-25 | Haemonetics Corporation | Apparatus for separation of blood into components thereof |
US4401756A (en) * | 1981-04-14 | 1983-08-30 | Immunex Corporation | Process for preparing human interleukin 2 |
US4464166A (en) * | 1981-06-12 | 1984-08-07 | Frederic A. Bourke, Jr. | Method for externally treating the blood |
US4464167A (en) * | 1981-09-03 | 1984-08-07 | Haemonetics Corporation | Pheresis apparatus |
US4416654A (en) * | 1981-09-03 | 1983-11-22 | Haemonetics Corporation | Pheresis apparatus |
JPS5998015A (ja) * | 1982-11-27 | 1984-06-06 | Microbial Chem Res Found | 免疫賦活剤 |
US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
US4683889A (en) * | 1983-03-29 | 1987-08-04 | Frederic A. Bourke, Jr. | Method and system for externally treating the blood |
US4675383A (en) * | 1983-11-15 | 1987-06-23 | The Salk Institute For Biological Studies | Purification of T-cell growth factor |
US4578056A (en) * | 1984-10-29 | 1986-03-25 | Extracorporeal Medical Specialties, Inc. | Patient photopheresis treatment apparatus and method |
US4690915A (en) * | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
-
1987
- 1987-04-27 US US07/042,998 patent/US4808151A/en not_active Expired - Fee Related
-
1988
- 1988-03-22 CA CA000562097A patent/CA1304306C/en not_active Expired - Lifetime
- 1988-04-23 ES ES88106566T patent/ES2051790T3/es not_active Expired - Lifetime
- 1988-04-23 DE DE8888106566T patent/DE3872588T2/de not_active Expired - Lifetime
- 1988-04-23 AT AT88106566T patent/ATE78053T1/de not_active IP Right Cessation
- 1988-04-23 EP EP88106566A patent/EP0289896B1/en not_active Expired - Lifetime
- 1988-04-26 PT PT87335A patent/PT87335B/pt not_active IP Right Cessation
- 1988-04-26 NZ NZ224379A patent/NZ224379A/en unknown
- 1988-04-26 JP JP63101509A patent/JPH0657147B2/ja not_active Expired - Lifetime
- 1988-04-26 ZA ZA882948A patent/ZA882948B/xx unknown
- 1988-04-26 NO NO881819A patent/NO881819L/no unknown
- 1988-04-26 DK DK226288A patent/DK226288A/da not_active Application Discontinuation
- 1988-04-26 IL IL86177A patent/IL86177A0/xx unknown
- 1988-04-26 FI FI881952A patent/FI881952A/fi not_active Application Discontinuation
- 1988-04-27 HU HU882123A patent/HU205380B/hu not_active IP Right Cessation
- 1988-04-27 KR KR1019880004761A patent/KR900004422B1/ko not_active IP Right Cessation
- 1988-04-27 AU AU15200/88A patent/AU612086B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL86177A0 (en) | 1988-11-15 |
FI881952A (fi) | 1988-10-28 |
KR880012751A (ko) | 1988-11-29 |
DE3872588T2 (de) | 1992-12-03 |
DK226288D0 (da) | 1988-04-26 |
NZ224379A (en) | 1990-12-21 |
PT87335B (pt) | 1992-08-31 |
DE3872588D1 (de) | 1992-08-13 |
AU612086B2 (en) | 1991-06-27 |
JPS63295510A (ja) | 1988-12-01 |
CA1304306C (en) | 1992-06-30 |
ZA882948B (en) | 1989-12-27 |
HU205380B (en) | 1992-04-28 |
US4808151A (en) | 1989-02-28 |
PT87335A (pt) | 1988-05-01 |
KR900004422B1 (ko) | 1990-06-25 |
DK226288A (da) | 1988-10-28 |
NO881819L (no) | 1988-10-28 |
EP0289896B1 (en) | 1992-07-08 |
EP0289896A1 (en) | 1988-11-09 |
AU1520088A (en) | 1988-10-27 |
JPH0657147B2 (ja) | 1994-08-03 |
ATE78053T1 (de) | 1992-07-15 |
NO881819D0 (no) | 1988-04-26 |
FI881952A0 (fi) | 1988-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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