ATE76068T1 - Acridinone als chromogene enzymsubstrate. - Google Patents

Acridinone als chromogene enzymsubstrate.

Info

Publication number
ATE76068T1
ATE76068T1 AT87117548T AT87117548T ATE76068T1 AT E76068 T1 ATE76068 T1 AT E76068T1 AT 87117548 T AT87117548 T AT 87117548T AT 87117548 T AT87117548 T AT 87117548T AT E76068 T1 ATE76068 T1 AT E76068T1
Authority
AT
Austria
Prior art keywords
enzyme
hydroxy
enzyme substrate
acridin
enzymatically
Prior art date
Application number
AT87117548T
Other languages
English (en)
Inventor
Paul F Corey
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of ATE76068T1 publication Critical patent/ATE76068T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/40Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving amylase
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/64Acridine or hydrogenated acridine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/924Hydrolases (3) acting on glycosyl compounds (3.2)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/805Test papers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT87117548T 1986-12-09 1987-11-27 Acridinone als chromogene enzymsubstrate. ATE76068T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93985586A 1986-12-09 1986-12-09
US07/123,537 US4810636A (en) 1986-12-09 1987-11-20 Chromogenic acridinone enzyme substrates

Publications (1)

Publication Number Publication Date
ATE76068T1 true ATE76068T1 (de) 1992-05-15

Family

ID=26821659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87117548T ATE76068T1 (de) 1986-12-09 1987-11-27 Acridinone als chromogene enzymsubstrate.

Country Status (5)

Country Link
US (1) US4810636A (de)
EP (1) EP0270946B1 (de)
AT (1) ATE76068T1 (de)
CA (1) CA1303611C (de)
ES (1) ES2039225T3 (de)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4932871A (en) * 1987-11-20 1990-06-12 Miles Inc. Rapid method for preparing chromogenic alpha-amylase substrate compounds at high preparative yields
US5104980A (en) * 1989-06-12 1992-04-14 Miles Inc. Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates
US5183743A (en) * 1989-06-12 1993-02-02 Miles Inc. Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates
AU7176091A (en) * 1989-12-29 1991-07-24 Symex Corp. Chromogenic 7- or 8-position modified n-acetylneuraminic acid substrates and methods for diagnosing human influenza therewith
US5663055A (en) * 1989-12-29 1997-09-02 Oklahoma Medical Research Foundation Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
DE69131504T2 (de) * 1990-12-31 1999-11-18 Oklahoma Medical Research Foundation, Oklahoma Verfahren zum visuellen nachweis der anwesenheit eines virus in einer klinischen probe
US5252458A (en) * 1990-12-31 1993-10-12 Symex Corp. Method for visually detecting the presence of a virus in a clinical specimen
USRE38723E1 (en) * 1991-08-23 2005-04-12 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5576424A (en) * 1991-08-23 1996-11-19 Molecular Probes, Inc. Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells
US5208326A (en) * 1991-11-08 1993-05-04 Miles Inc. 8-hydroxy-2h-dibenz(b,f)azepin-2-one dyes
US5264577A (en) * 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
JPH07509245A (ja) * 1992-07-20 1995-10-12 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規化学発光化合物およびその使用方法
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
US5393615A (en) * 1994-02-03 1995-02-28 Miles Inc. Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof
US5567624A (en) * 1995-04-27 1996-10-22 Utah Medical Products, Inc. Carbazine dyes and derivatives for pH measurement
JP3169383B2 (ja) * 1996-01-16 2001-05-21 ルミゲン インク ホスファターゼ酵素で化学発光を生成させるための化合物、組成物および方法
US5719020A (en) * 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens
US5773236A (en) * 1997-04-25 1998-06-30 Molecule Probes, Inc. Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules
US6303764B1 (en) 1998-09-24 2001-10-16 Zymetx, Inc. Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
US6420130B1 (en) 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
DE69907962T2 (de) * 1998-12-14 2004-05-19 Vertex Pharmaceuticals (San Diego) Llc, San Diego Optische molekularsensoren für cytochrome p-450 aktivität
DE60001531T2 (de) 1999-04-23 2003-10-02 Molecular Probes, Inc. Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
US6783948B1 (en) * 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
ATE291096T1 (de) * 1999-07-30 2005-04-15 Bayer Ag Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen
US6420552B1 (en) 1999-09-10 2002-07-16 Zymetx, Inc. Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids
US6323337B1 (en) 2000-05-12 2001-11-27 Molecular Probes, Inc. Quenching oligonucleotides
US6448422B1 (en) 2000-07-03 2002-09-10 Eli Lilly And Company Chromogenic compound
US7579463B2 (en) 2000-12-20 2009-08-25 Life Technologies Corporation Crown ether derivatives
US6962992B2 (en) 2000-12-20 2005-11-08 Molecullar Probes, Inc. Crown ether derivatives
US7622446B2 (en) * 2001-04-18 2009-11-24 The Open University Polypeptides, derivatives and uses thereof
US7491702B2 (en) 2001-04-18 2009-02-17 The Open University Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same
US8323903B2 (en) * 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US6972326B2 (en) * 2001-12-03 2005-12-06 Molecular Probes, Inc. Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes
US7186696B2 (en) * 2002-03-07 2007-03-06 Toyama University Reagent and method for measuring amylase
US7183069B2 (en) * 2002-03-07 2007-02-27 Toyama University Reagent, method and apparatus for measuring amylase activity
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
CA2483868A1 (en) * 2002-05-03 2004-05-21 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20050233307A1 (en) * 2002-09-12 2005-10-20 Kyle Gee Site-specific labeling of affinity tags in fusion proteins
US20040101822A1 (en) 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
FR2850378B1 (fr) * 2003-01-29 2005-03-04 Bio Merieux Substrats enzymatiques, milieux de culture les contenant, utilisation pour detecter une activite aminopeptidase et/ou differencier des bacteries a gram+ par rapport a des bacteries a gram-
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
EP1594962B1 (de) 2003-01-31 2014-08-27 Promega Corporation Kovalentes anbinden funktioneller gruppen an proteine
US8445702B2 (en) * 2003-05-05 2013-05-21 Life Technologies Corporation Zinc binding compounds and their method of use
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
CA2445420A1 (en) * 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7619059B2 (en) * 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7727752B2 (en) * 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7271265B2 (en) * 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
JP2007505315A (ja) * 2003-09-12 2007-03-08 インヴィトロジェン コーポレーション 多重結合および活性アッセイ
US7282339B2 (en) * 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
US7446202B2 (en) 2003-12-05 2008-11-04 Molecular Probes, Inc. Cyanine dye compounds
WO2005065241A2 (en) * 2003-12-24 2005-07-21 Argose, Inc. Smmr (small molecule metabolite reporters) for use as in vivo glucose biosensors
US20050227309A1 (en) 2004-01-21 2005-10-13 Corry Schuyler B Optically-detectable enzyme substrates and their method of use
US20060024833A1 (en) 2004-07-27 2006-02-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
EP2395358B1 (de) 2004-07-30 2017-03-29 Promega Corporation Kovalentes Anbinden von Funktionsgruppen an Proteine
CN101258220A (zh) 2004-09-16 2008-09-03 阿普里拉股份有限公司 荧光染料化合物,共轭物及其应用
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
JP5306811B2 (ja) 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
ES2434491T3 (es) * 2005-10-13 2013-12-16 Funda��O D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud An�lisis inmunohistoqu�mico multiplex in situ
US7521577B2 (en) * 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
USD580285S1 (en) 2006-01-13 2008-11-11 Invitrogen Corporation Fluorometer
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
EP2623986B1 (de) 2006-02-10 2017-06-14 Life Technologies Corporation Markierung und Detektion von posttranslational modifizierten Proteinen
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
ES2371039T3 (es) 2006-03-23 2011-12-26 Absorber Ab Antígenos de grupo sanguíneo de diferentes tipos para aplicaciones diagnósticas y terapéuticas.
AU2007240316A1 (en) 2006-04-20 2007-11-01 Becton, Dickinson And Company Thermostable proteins and methods of making and using thereof
WO2008076524A2 (en) 2006-10-27 2008-06-26 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
EP2374875B1 (de) 2006-10-30 2015-09-02 Promega Corporation Mutante Hydrolaseproteine mit verstärkten kinetischen Eigenschaften und funktioneller Expression
US8586743B2 (en) * 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
WO2008151089A2 (en) * 2007-05-30 2008-12-11 Invitrogen Corporation Fluorescent phospholipase a2 indicators
US20090247984A1 (en) * 2007-10-24 2009-10-01 Masimo Laboratories, Inc. Use of microneedles for small molecule metabolite reporter delivery
US10996218B2 (en) 2008-03-11 2021-05-04 Ournextbaby Llc Methods for chemotaxis / redox driven separation of X and Y chromosome bearing sperm and their insemination in gender specific menstrual cycles
JP5774471B2 (ja) 2008-03-27 2015-09-09 プロメガ コーポレイションPromega Corporation シアノベンゾチアゾールコンジュゲートによるタンパク質標識
CN104263816B (zh) * 2008-05-16 2018-10-19 生命技术公司 用于测量细胞增殖的双标记法
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
WO2010135834A1 (en) * 2009-05-29 2010-12-02 Mcmaster University Biosensors utilizing ink jet-printed biomolecule compatible sol gel inks and uses thereof
WO2010141359A2 (en) * 2009-06-01 2010-12-09 Bayer Healthcare Llc Redox molecules and methods of making the same
WO2011003109A1 (en) 2009-07-02 2011-01-06 Sloan-Kettering Institute For Cancer Research Fluorescent silica-based nanoparticles
US12161734B2 (en) 2009-07-02 2024-12-10 Sloan-Kettering Institute For Cancer Research Multimodal silica-based nanoparticles
GB0915664D0 (en) 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
WO2011054731A1 (en) 2009-11-05 2011-05-12 Basf Se Fluorescent materials
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
WO2011150155A1 (en) 2010-05-28 2011-12-01 Bayer Healthcare Llc Polymer bonded redox molecules and methods of making the same
USD653981S1 (en) 2010-08-06 2012-02-14 Life Technologies Corporation Fluorometer
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
EP2619573B1 (de) 2010-09-16 2017-06-14 Urobiologics LLC Verwendung des harns von weiblichen säugetieren zur bestimmung von fetalen geschlechtsspezifischen merkmalen
CN107326073A (zh) 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
AU2013259519B2 (en) * 2012-05-08 2017-07-13 Rutgers, The State University Of New Jersey Methods to detect a fungal cell
US20150246146A1 (en) 2012-10-25 2015-09-03 Life Technologies Corporation Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins
JP6604938B2 (ja) 2013-03-15 2019-11-13 プロメガ コーポレイション タンパク質を官能基または固体表面に共有結合的に係留するための基質
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
EP3733244A1 (de) 2013-10-02 2020-11-04 Medlmmune, LLC Neutralisierende antiinflueanza-a-virus-antikörper und verwendungen davon
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9636034B2 (en) 2013-10-23 2017-05-02 Verily Life Sciences Llc Non-invasive analyte detection system with modulation source
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
CN113082225A (zh) 2014-05-29 2021-07-09 纪念斯隆-凯特琳癌症中心 纳米粒子药物结合物
EP3242690B1 (de) 2015-01-06 2020-09-16 De Haas, Anthony H. Chirurgische nahinfrarot-fluoreszenzfarbstoffmarker
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
JP6974178B2 (ja) 2015-05-29 2021-12-01 メモリアル スローン ケタリング キャンサー センター フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法
EP3304078B1 (de) 2015-06-05 2022-08-31 Promega Corporation Zelldurchlässige, zellkompatible und spaltbare linker zur kovalenten bindung von funktionselementen
JP6967006B2 (ja) 2016-01-15 2021-11-17 クアンタポール, インコーポレイテッド 低減されたバックグラウンドの光学に基づくナノポア分析
WO2017181176A1 (en) 2016-04-15 2017-10-19 Lcahn School Of Medicine At Mount Sinai Tissue profiling using multiplexed immunohistochemical consecutive staining
BR112018073378A2 (pt) 2016-05-20 2019-03-06 Quantum-Si Incorporated composições de nucleotídeos marcados e métodos para sequenciamento de ácidos nucleicos
AU2017312746A1 (en) 2016-08-19 2019-01-31 Quantapore, Inc. Optically-based nanopore sequencing using quenching agents
CN110546273A (zh) 2017-03-30 2019-12-06 生命技术公司 通过衔接子序列定量ngs dna
CA3064253A1 (en) 2017-05-25 2018-11-29 Memorial Sloan Kettering Cancer Center Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof
US11442063B2 (en) 2018-05-30 2022-09-13 Promega Corporation Broad spectrum kinase binding agents
EP3891503A2 (de) 2018-12-04 2021-10-13 Promega Corporation Cpcr-binder mit breitem spektrum
US20210363565A1 (en) 2020-05-22 2021-11-25 Promega Corporation Enhancement of kinase target engagement
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
EP4204808A1 (de) 2020-08-28 2023-07-05 Promega Corporation Zielbindungsassay für ras-proteine
US20250092261A1 (en) 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3378463A (en) * 1965-06-22 1968-04-16 Army Usa Method of measuring enzyme activity
US4279992A (en) * 1978-03-13 1981-07-21 Miles Laboratories, Inc. Specific binding assay employing an enzyme-cleavable substrate as label
DE3411574A1 (de) * 1984-03-29 1985-10-10 Boehringer Mannheim Gmbh, 6800 Mannheim Glycoside von resorufin-derivaten, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der aktivitaet von glycosidasen
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
DE3412939A1 (de) * 1984-04-06 1985-10-17 Behringwerke Ag, 3550 Marburg Substrate fuer hydrolasen, verfahren zu ihrer herstellung und ihre verwendung
US4649108A (en) * 1984-07-26 1987-03-10 Genzyme Corporation Alpha amylase assay
JPS61112092A (ja) * 1984-11-07 1986-05-30 Meiji Seika Kaisha Ltd 新規グルコサミン誘導体及びこれを基質として用いるN−アセチル−β−D−グルコサミニダ−ゼの活性測定試薬

Also Published As

Publication number Publication date
US4810636A (en) 1989-03-07
EP0270946A3 (en) 1988-09-28
EP0270946A2 (de) 1988-06-15
CA1303611C (en) 1992-06-16
EP0270946B1 (de) 1992-05-13
ES2039225T3 (es) 1993-09-16

Similar Documents

Publication Publication Date Title
ATE76068T1 (de) Acridinone als chromogene enzymsubstrate.
ATE113664T1 (de) Zusammensetzung, vorrichtung und verfahren zur untersuchung einer peroxidativ aktiven substanz.
FI832756A0 (fi) Askorbatresistant, pao brett omraode verkande glukostestkomposition, testapparat och -metod
AU623038B2 (en) Improved composition, device and method of assaying for peroxidatively active substances
DK0649535T3 (da) Fremgangsmåde til at forbedre målepræcisionen i optisk biosensor assays med detektering af rumligt dæmpede bølger
DD156295A6 (de) Verfahren zur bestimmung der biologischen aktivitaet von heparin
FR2372798A1 (fr) Substrat chromogene specifique pour des enzymes, son obtention et son application
DE3751896D1 (de) Acridinone als chromogene Enzymsubstrate
CA1265424C (en) FLUOROGENIC INDICATORS BASED ON DIHYDROQUINOLONE AND DIHYDROCOUMARIN FOR HYDROGEN PEROXIDE
DE3663684D1 (de) Determination of prokallikrein
ZA906998B (en) Process and reagent for the specific determination of pancreatic alpha-amylase
SE8402305D0 (sv) Sett att bestemma katepsin b i nervaro av andra proteolytiska enzymer, och dertill anvendbara foreningar
JPS5736997A (ja) Anjiotenshinhenkankosonokatsuseisokuteiho
ES469000A3 (es) Un metodo fluorometrico para la determinacion de la activi- dad de transferasas y proteasas en muestras de fluidos bio- logicos
SU1415692A3 (ru) Способ получения красителя для определения активности фермента

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee