DK1140888T3 - Optiske molekylære sensorer for cytochrom P450-aktivitet - Google Patents

Optiske molekylære sensorer for cytochrom P450-aktivitet

Info

Publication number
DK1140888T3
DK1140888T3 DK99965226T DK99965226T DK1140888T3 DK 1140888 T3 DK1140888 T3 DK 1140888T3 DK 99965226 T DK99965226 T DK 99965226T DK 99965226 T DK99965226 T DK 99965226T DK 1140888 T3 DK1140888 T3 DK 1140888T3
Authority
DK
Denmark
Prior art keywords
sub
substituted
unsaturated
sup
saturated
Prior art date
Application number
DK99965226T
Other languages
English (en)
Inventor
Lewis Makings
Gregor Zlokarnik
Original Assignee
Vertex Pharma San Diego Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/301,525 external-priority patent/US6420130B1/en
Priority claimed from US09/301,395 external-priority patent/US6143492A/en
Application filed by Vertex Pharma San Diego Llc filed Critical Vertex Pharma San Diego Llc
Application granted granted Critical
Publication of DK1140888T3 publication Critical patent/DK1140888T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
DK99965226T 1998-12-14 1999-12-10 Optiske molekylære sensorer for cytochrom P450-aktivitet DK1140888T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11225298P 1998-12-14 1998-12-14
US09/301,525 US6420130B1 (en) 1998-12-14 1999-04-28 Optical molecular sensors for cytochrome P450 activity
US09/301,395 US6143492A (en) 1998-12-14 1999-04-28 Optical molecular sensors for cytochrome P450 activity
PCT/US1999/029439 WO2000035900A1 (en) 1998-12-14 1999-12-10 Optical molecular sensors for cytochrome p450 activity

Publications (1)

Publication Number Publication Date
DK1140888T3 true DK1140888T3 (da) 2003-08-25

Family

ID=27381127

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99965226T DK1140888T3 (da) 1998-12-14 1999-12-10 Optiske molekylære sensorer for cytochrom P450-aktivitet

Country Status (11)

Country Link
US (1) US20070072256A1 (da)
EP (1) EP1140888B1 (da)
JP (1) JP2002532487A (da)
AT (1) ATE240310T1 (da)
AU (1) AU3119000A (da)
CA (1) CA2352631A1 (da)
DE (1) DE69907962T2 (da)
DK (1) DK1140888T3 (da)
ES (1) ES2199605T3 (da)
PT (1) PT1140888E (da)
WO (1) WO2000035900A1 (da)

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US6420130B1 (en) 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6420131B1 (en) 1999-08-19 2002-07-16 Gentest Corporation Use of fluorescein aryl ethers in high throughput cytochrome P450 inhibition assays
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
AU2001271985A1 (en) * 2000-07-12 2002-01-21 American Home Products Corporation Method for testing for inhibition of drug-metabolizing cytochrome p450 isozymes
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
AU2003267245C1 (en) * 2002-09-20 2008-05-29 Promega Corporation Luminescence-based methods and probes for measuring cytochrome P450 activity
WO2006034036A1 (en) * 2004-09-16 2006-03-30 Applera Corporation Fluorescent dye compounds, conjugates and uses thereof
EP2277872B1 (en) 2005-05-31 2016-03-23 Promega Corporation Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
WO2010021686A1 (en) 2008-08-18 2010-02-25 Promega Corporation Luminogenic compounds and methods to detect cytochrome p450 3a enzymes
US20120288885A1 (en) * 2009-09-01 2012-11-15 National Institute Of Advanced Industrial Science And Technolgoy Method and kit for measuring enzymatic activities of various cytochrome p450 molecule species comprehensively and with high efficiency
US8788046B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US8788047B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US8788048B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
EP2913408A1 (en) 2010-12-29 2015-09-02 Life Technologies Corporation Ddao compounds as fluorescent reference standards
JP6703484B2 (ja) 2014-01-29 2020-06-03 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ
JP6360345B2 (ja) * 2014-04-22 2018-07-18 五稜化薬株式会社 キサンテン化合物及びその用途
WO2017068612A1 (ja) * 2015-10-21 2017-04-27 住友化学株式会社 キサンテン化合物及びその用途
US11540973B2 (en) 2016-10-21 2023-01-03 Spr Therapeutics, Llc Method and system of mechanical nerve stimulation for pain relief
CN109608427B (zh) * 2018-12-29 2020-06-30 山东师范大学 一种用于定性检测一氧化氮浓度的双光子荧光探针及其合成方法、应用

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US6514687B1 (en) * 1998-12-14 2003-02-04 Vertex Pharmaceuticals (San Diego), Llc Optical molecular sensors for cytochrome P450 activity
US6143492A (en) * 1998-12-14 2000-11-07 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6420130B1 (en) * 1998-12-14 2002-07-16 Aurora Biosciences Corporation Optical molecular sensors for cytochrome P450 activity
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays

Also Published As

Publication number Publication date
EP1140888A1 (en) 2001-10-10
ATE240310T1 (de) 2003-05-15
CA2352631A1 (en) 2000-06-22
EP1140888B1 (en) 2003-05-14
PT1140888E (pt) 2003-09-30
DE69907962T2 (de) 2004-05-19
JP2002532487A (ja) 2002-10-02
US20070072256A1 (en) 2007-03-29
DE69907962D1 (de) 2003-06-18
WO2000035900A1 (en) 2000-06-22
AU3119000A (en) 2000-07-03
ES2199605T3 (es) 2004-02-16

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