ATE73803T1 - Imidazo(1,2-b>pyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. - Google Patents
Imidazo(1,2-b>pyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.Info
- Publication number
- ATE73803T1 ATE73803T1 AT88402199T AT88402199T ATE73803T1 AT E73803 T1 ATE73803 T1 AT E73803T1 AT 88402199 T AT88402199 T AT 88402199T AT 88402199 T AT88402199 T AT 88402199T AT E73803 T1 ATE73803 T1 AT E73803T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl group
- imidazo
- pyridazine
- denotes hydrogen
- manufacture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000001054 cortical effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000004942 imidazo[1,2-b]pyridazines Chemical class 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8712167A FR2619818B1 (fr) | 1987-09-01 | 1987-09-01 | Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| EP88402199A EP0306408B1 (de) | 1987-09-01 | 1988-09-01 | Imidazo[1,2-b]pyridazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE73803T1 true ATE73803T1 (de) | 1992-04-15 |
Family
ID=9354553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88402199T ATE73803T1 (de) | 1987-09-01 | 1988-09-01 | Imidazo(1,2-b>pyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4910199A (de) |
| EP (1) | EP0306408B1 (de) |
| JP (1) | JPS6471877A (de) |
| AT (1) | ATE73803T1 (de) |
| CA (1) | CA1310318C (de) |
| DE (1) | DE3869286D1 (de) |
| FR (1) | FR2619818B1 (de) |
| PT (1) | PT88373B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601011B1 (fr) * | 1986-07-03 | 1988-10-28 | Sanofi Sa | Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant |
| FR2625201B1 (fr) * | 1987-12-24 | 1990-06-15 | Sanofi Sa | Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant |
| US5912246A (en) * | 1995-02-15 | 1999-06-15 | Pharmacia & Upjohn Company | Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases |
| US6013654A (en) * | 1997-08-14 | 2000-01-11 | Pharmacia & Upjohn Company | Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases |
| TWI312347B (en) * | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
| US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| CN101981033B (zh) | 2008-02-06 | 2015-02-04 | 百时美施贵宝公司 | 用作激酶抑制剂的取代的咪唑并哒嗪化合物 |
| JP5576802B2 (ja) * | 2008-02-28 | 2014-08-20 | ノバルティス アーゲー | Ｃ−Ｍｅｔチロシンキナーゼ介在疾患の治療用のイミダゾ［１，２−ｂ］ピリダジン誘導体 |
| US8431603B2 (en) * | 2008-04-15 | 2013-04-30 | Eisai R&D Management Co., Ltd. | 3-phenylpyrazolo[5,1-b]thiazole compounds |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| EP2487177A1 (de) * | 2009-10-08 | 2012-08-15 | Eisai R&D Management Co., Ltd. | Pyrazoloxazolverbindung |
| AR078521A1 (es) * | 2009-10-08 | 2011-11-16 | Eisai R&D Man Co Ltd | Compuesto pirazolotiazol |
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| JP2015537017A (ja) | 2012-11-19 | 2015-12-24 | バイエル ファーマ アクチエンゲゼルシャフト | アミノイミダゾピリダジン類 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489755A (en) * | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
| US3828041A (en) * | 1971-02-24 | 1974-08-06 | American Cyanamid Co | 6-substituted 3-nitroimidazo(1,2-b)pyridazines and method of preparing same |
| FR2473522A1 (fr) * | 1980-01-16 | 1981-07-17 | Synthelabo | Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent |
| US4464372A (en) * | 1982-08-16 | 1984-08-07 | Schering Corporation | Imidazo[1,2-b]pyridazines |
| US4569934A (en) * | 1984-10-09 | 1986-02-11 | American Cyanamid Company | Imidazo[1,2-b]pyridazines |
-
1987
- 1987-09-01 FR FR8712167A patent/FR2619818B1/fr not_active Expired - Fee Related
-
1988
- 1988-08-30 PT PT88373A patent/PT88373B/pt not_active IP Right Cessation
- 1988-08-31 CA CA000576243A patent/CA1310318C/en not_active Expired - Fee Related
- 1988-08-31 US US07/238,488 patent/US4910199A/en not_active Expired - Fee Related
- 1988-09-01 DE DE8888402199T patent/DE3869286D1/de not_active Expired - Fee Related
- 1988-09-01 JP JP63219591A patent/JPS6471877A/ja active Pending
- 1988-09-01 AT AT88402199T patent/ATE73803T1/de not_active IP Right Cessation
- 1988-09-01 EP EP88402199A patent/EP0306408B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4910199A (en) | 1990-03-20 |
| PT88373A (pt) | 1989-07-31 |
| FR2619818A1 (fr) | 1989-03-03 |
| EP0306408A1 (de) | 1989-03-08 |
| JPS6471877A (en) | 1989-03-16 |
| EP0306408B1 (de) | 1992-03-18 |
| PT88373B (pt) | 1992-10-30 |
| FR2619818B1 (fr) | 1990-01-12 |
| CA1310318C (en) | 1992-11-17 |
| DE3869286D1 (de) | 1992-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |