ATE67667T1 - Neue topische metronidazol-formulierungen. - Google Patents
Neue topische metronidazol-formulierungen.Info
- Publication number
- ATE67667T1 ATE67667T1 AT87902908T AT87902908T ATE67667T1 AT E67667 T1 ATE67667 T1 AT E67667T1 AT 87902908 T AT87902908 T AT 87902908T AT 87902908 T AT87902908 T AT 87902908T AT E67667 T1 ATE67667 T1 AT E67667T1
- Authority
- AT
- Austria
- Prior art keywords
- formulations
- drug
- new topical
- topical metronidazole
- topical formulations
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000282 metronidazole Drugs 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 241001303601 Rosacea Species 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000002085 irritant Substances 0.000 abstract 1
- 231100000021 irritant Toxicity 0.000 abstract 1
- 201000004700 rosacea Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Lubrication Of Internal Combustion Engines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1987/000584 WO1988006888A1 (en) | 1987-03-20 | 1987-03-20 | Novel topical metronidazole formulations and therapeutic uses thereof |
| EP87902908A EP0305380B1 (de) | 1987-03-20 | 1987-03-20 | Neue topische metronidazol-formulierungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE67667T1 true ATE67667T1 (de) | 1991-10-15 |
Family
ID=22202320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87902908T ATE67667T1 (de) | 1987-03-20 | 1987-03-20 | Neue topische metronidazol-formulierungen. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0305380B1 (de) |
| JP (1) | JPH0825878B2 (de) |
| KR (1) | KR950003919B1 (de) |
| AT (1) | ATE67667T1 (de) |
| AU (1) | AU610495B2 (de) |
| DE (1) | DE3773383D1 (de) |
| DK (1) | DK173844B1 (de) |
| FI (1) | FI88582C (de) |
| NO (1) | NO175883C (de) |
| WO (1) | WO1988006888A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| US4859694A (en) * | 1988-02-10 | 1989-08-22 | Pavlich Frederick M | Method for treating hoof thrush and hoof rot |
| GB8910076D0 (en) † | 1989-05-03 | 1989-06-21 | Thackray C F Ltd | Sterilisable lubricant |
| SE506509C2 (sv) * | 1992-04-14 | 1997-12-22 | Bioglan Ab | Användning av imidazoler för framställning av en farmaceutisk formulering för behandling av inflammatoriska och/eller infektiösa hudsjukdomar |
| FR2722098B1 (fr) * | 1994-07-06 | 1996-08-23 | Cird Galderma | Nouveaux medicaments a base de metro-nidazole ou d'un melange synergetique de metronidazole et de clindamycine |
| GB9415290D0 (en) | 1994-07-28 | 1994-09-21 | Zeneca Ltd | Gel formation |
| US5972993A (en) * | 1998-03-20 | 1999-10-26 | Avon Products, Inc. | Composition and method for treating rosacea and sensitive skin with free radical scavengers |
| US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| US6387383B1 (en) * | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
| FR2882552B1 (fr) * | 2005-02-25 | 2008-12-26 | Galderma Sa | Gel aqueux de haute stabilite a base de metronidazole et procedes pour leur preparation |
| PL2544532T3 (pl) | 2010-03-12 | 2017-08-31 | Monsanto Technology Llc | Agrochemiczne kompozycje żelowe |
| AU2012275292B2 (en) | 2011-06-28 | 2015-11-12 | Chemo Research, S.L. | High dosage mucoadhesive metronidazole aqueous-based gel formulations their use to treat bacterial vaginosis |
| EP3013368A1 (de) | 2013-06-25 | 2016-05-04 | Mission Pharmacal Company | Neuartige formulierungen zur behandlung von vaginalen erkrankungen |
| EP3641725A1 (de) | 2017-06-23 | 2020-04-29 | The Procter and Gamble Company | Zusammensetzung und verfahren zur verbesserung der erscheinung der haut |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN115843238B (zh) | 2020-06-01 | 2025-06-10 | 宝洁公司 | 改善维生素b3化合物渗透到皮肤中的方法 |
| WO2022269665A1 (ja) * | 2021-06-21 | 2022-12-29 | マルホ株式会社 | 外用剤 |
| CN115350144A (zh) * | 2022-07-28 | 2022-11-18 | 苏州弘森药业股份有限公司 | 一种甲硝唑水凝胶及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3883661A (en) * | 1971-11-09 | 1975-05-13 | Syntex Inc | Acne treatment |
| US4247547A (en) * | 1979-03-19 | 1981-01-27 | Johnson & Johnson | Tretinoin in a gel vehicle for acne treatment |
-
1987
- 1987-03-20 DE DE8787902908T patent/DE3773383D1/de not_active Expired - Lifetime
- 1987-03-20 WO PCT/US1987/000584 patent/WO1988006888A1/en not_active Ceased
- 1987-03-20 KR KR1019880701486A patent/KR950003919B1/ko not_active Expired - Lifetime
- 1987-03-20 AT AT87902908T patent/ATE67667T1/de not_active IP Right Cessation
- 1987-03-20 AU AU72337/87A patent/AU610495B2/en not_active Expired
- 1987-03-20 EP EP87902908A patent/EP0305380B1/de not_active Expired - Lifetime
- 1987-03-20 JP JP62502276A patent/JPH0825878B2/ja not_active Expired - Lifetime
-
1988
- 1988-11-18 FI FI885377A patent/FI88582C/fi not_active IP Right Cessation
- 1988-11-18 DK DK198806454A patent/DK173844B1/da not_active IP Right Cessation
- 1988-11-18 NO NO885172A patent/NO175883C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU610495B2 (en) | 1991-05-23 |
| WO1988006888A1 (en) | 1988-09-22 |
| NO175883B (no) | 1994-09-19 |
| DE3773383D1 (de) | 1991-10-31 |
| DK645488D0 (da) | 1988-11-18 |
| DK173844B1 (da) | 2001-12-10 |
| FI88582B (fi) | 1993-02-26 |
| DK645488A (da) | 1989-01-19 |
| NO175883C (no) | 1994-12-28 |
| FI885377A0 (fi) | 1988-11-18 |
| EP0305380A4 (de) | 1989-06-26 |
| EP0305380B1 (de) | 1991-09-25 |
| FI885377L (fi) | 1988-11-18 |
| KR890701113A (ko) | 1989-12-19 |
| JPH0825878B2 (ja) | 1996-03-13 |
| FI88582C (fi) | 1993-06-10 |
| NO885172D0 (no) | 1988-11-18 |
| JPH01503061A (ja) | 1989-10-19 |
| NO885172L (no) | 1988-11-18 |
| AU7233787A (en) | 1988-10-10 |
| KR950003919B1 (ko) | 1995-04-20 |
| EP0305380A1 (de) | 1989-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |