ATE66211T1 - 4(5)-substituierte imidazol-derivate und zwischenverbindungen und verfahren zu ihrer herstellung. - Google Patents
4(5)-substituierte imidazol-derivate und zwischenverbindungen und verfahren zu ihrer herstellung.Info
- Publication number
- ATE66211T1 ATE66211T1 AT87304304T AT87304304T ATE66211T1 AT E66211 T1 ATE66211 T1 AT E66211T1 AT 87304304 T AT87304304 T AT 87304304T AT 87304304 T AT87304304 T AT 87304304T AT E66211 T1 ATE66211 T1 AT E66211T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- alkyl
- processes
- preparation
- imidazole derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 101100448208 Human herpesvirus 6B (strain Z29) U69 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Dental Preparations (AREA)
- Golf Clubs (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Epoxy Resins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI862039A FI862039A0 (fi) | 1986-05-15 | 1986-05-15 | Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat. |
| FI870462A FI870462A0 (fi) | 1987-02-04 | 1987-02-04 | Foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat. |
| EP87304304A EP0247764B1 (de) | 1986-05-15 | 1987-05-14 | 4(5)-Substituierte Imidazol-Derivate und Zwischenverbindungen und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE66211T1 true ATE66211T1 (de) | 1991-08-15 |
Family
ID=26157963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87304304T ATE66211T1 (de) | 1986-05-15 | 1987-05-14 | 4(5)-substituierte imidazol-derivate und zwischenverbindungen und verfahren zu ihrer herstellung. |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4933359A (de) |
| EP (1) | EP0247764B1 (de) |
| JP (1) | JP2561272B2 (de) |
| KR (1) | KR950002158B1 (de) |
| AT (1) | ATE66211T1 (de) |
| AU (1) | AU600725B2 (de) |
| CA (1) | CA1299186C (de) |
| DE (1) | DE3772104D1 (de) |
| DK (1) | DK172422B1 (de) |
| ES (1) | ES2037712T3 (de) |
| FI (1) | FI81092C (de) |
| GR (1) | GR3002928T3 (de) |
| HU (1) | HU197314B (de) |
| IE (1) | IE59609B1 (de) |
| IL (1) | IL82541A (de) |
| NO (1) | NO166940C (de) |
| NZ (1) | NZ220306A (de) |
| PT (1) | PT84881B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2225782A (en) * | 1988-12-09 | 1990-06-13 | Farmos Group Limited | Imidazole derivatives useful for treatment of diabetes |
| CA1321751C (en) * | 1989-02-21 | 1993-08-31 | Eugene C. Crichlow | Mechanism mediating ruminal stasis in ruminal lactic acidosis |
| GB2244431A (en) * | 1990-05-31 | 1991-12-04 | Farmos Oy | Treatment of age related memory impairment and other cognitive disorders |
| FR2669030B1 (fr) * | 1990-11-14 | 1992-12-31 | Adir | Nouveaux derives d'imidazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB9127050D0 (en) * | 1991-12-20 | 1992-02-19 | Orion Yhtymae Oy | Substituted imidazole derivatives and their preparation and use |
| GB9312669D0 (en) | 1993-06-18 | 1993-08-04 | Orion Yhtymae Oy | New opticla isomers |
| FR2735776B1 (fr) * | 1995-06-22 | 1997-07-18 | Synthelabo | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique |
| GB9520150D0 (en) * | 1995-10-03 | 1995-12-06 | Orion Yhtymae Oy | New imidazole derivatives |
| EP1147092A1 (de) * | 1999-01-18 | 2001-10-24 | Novo Nordisk A/S | Substituierte imidazole, ihre herstellung und verwendung |
| US6388090B2 (en) * | 2000-01-14 | 2002-05-14 | Orion Corporation | Imidazole derivatives |
| PE20011321A1 (es) * | 2000-05-08 | 2002-01-03 | Orion Corp | Indanilimizadoles policiclicos nuevos con actividad adrenergica alfa 2 |
| US8188126B2 (en) | 2002-05-16 | 2012-05-29 | Pierre Fabre Medicament | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors |
| FR2839719B1 (fr) * | 2002-05-16 | 2004-08-06 | Pf Medicament | Nouveaux composes imidazoliques, leur procede de preparation et leur utilisation a titre de medicaments |
| AU2006287070A1 (en) * | 2005-08-30 | 2007-03-08 | Queen's University At Kingston | Potentiation of the therapeutic action of an opioid receptor agonist and/or inhibition or reversal of tolerance to an opioid receptoi agonists using an ultralow dose of an alpha-2 receptor antagonist |
| CL2008003553A1 (es) * | 2007-12-05 | 2009-11-27 | Grindeks Jsc | Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso |
| CN106316812A (zh) * | 2009-07-24 | 2017-01-11 | Dpx精细化学奥地利两合公司 | 作为中间体的二氢化茚衍生物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908922A (nl) * | 1979-12-12 | 1981-07-16 | Akzo Nv | Carboximidamide derivaten. |
| US4480118A (en) * | 1981-01-13 | 1984-10-30 | Sumitomo Chemical Company, Limited | Carboxylic acid ester and an insecticidal and/or acaricidal composition containing the same |
| EP0077122B1 (de) * | 1981-09-15 | 1986-05-07 | Imperial Chemical Industries Plc | Aminosubstituierte Tetraline und verwandte homocyclische Verbindungen |
| US4661522A (en) * | 1984-05-24 | 1987-04-28 | Akzo N.V. | Cycloalkane-indene-carboximidamide derivatives |
| GB2167408B (en) * | 1984-11-23 | 1988-05-25 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
-
1987
- 1987-04-15 FI FI871655A patent/FI81092C/fi not_active IP Right Cessation
- 1987-04-24 DK DK198702082A patent/DK172422B1/da not_active IP Right Cessation
- 1987-05-14 HU HU872181A patent/HU197314B/hu unknown
- 1987-05-14 DE DE8787304304T patent/DE3772104D1/de not_active Expired - Lifetime
- 1987-05-14 NO NO872004A patent/NO166940C/no unknown
- 1987-05-14 IE IE125887A patent/IE59609B1/en not_active IP Right Cessation
- 1987-05-14 KR KR1019870004746A patent/KR950002158B1/ko not_active Expired - Lifetime
- 1987-05-14 AT AT87304304T patent/ATE66211T1/de not_active IP Right Cessation
- 1987-05-14 ES ES198787304304T patent/ES2037712T3/es not_active Expired - Lifetime
- 1987-05-14 NZ NZ220306A patent/NZ220306A/xx unknown
- 1987-05-14 US US07/049,882 patent/US4933359A/en not_active Expired - Lifetime
- 1987-05-14 JP JP62118077A patent/JP2561272B2/ja not_active Expired - Lifetime
- 1987-05-14 EP EP87304304A patent/EP0247764B1/de not_active Expired - Lifetime
- 1987-05-15 AU AU73102/87A patent/AU600725B2/en not_active Ceased
- 1987-05-15 CA CA000537323A patent/CA1299186C/en not_active Expired - Lifetime
- 1987-05-15 IL IL82541A patent/IL82541A/xx not_active IP Right Cessation
- 1987-05-15 PT PT84881A patent/PT84881B/pt unknown
-
1989
- 1989-11-06 US US07/431,959 patent/US5026868A/en not_active Expired - Lifetime
-
1991
- 1991-10-17 GR GR91401554T patent/GR3002928T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR950002158B1 (ko) | 1995-03-14 |
| FI81092C (fi) | 1990-09-10 |
| FI871655A7 (fi) | 1987-11-16 |
| IE871258L (en) | 1987-11-15 |
| ES2037712T3 (es) | 1993-07-01 |
| NZ220306A (en) | 1990-02-26 |
| NO872004D0 (no) | 1987-05-14 |
| IE59609B1 (en) | 1994-03-09 |
| NO166940B (no) | 1991-06-10 |
| GR3002928T3 (en) | 1993-01-25 |
| IL82541A0 (en) | 1987-11-30 |
| DK208287A (da) | 1987-11-16 |
| US4933359A (en) | 1990-06-12 |
| PT84881B (pt) | 1990-02-08 |
| EP0247764B1 (de) | 1991-08-14 |
| DK172422B1 (da) | 1998-06-08 |
| JP2561272B2 (ja) | 1996-12-04 |
| HU197314B (en) | 1989-03-28 |
| DE3772104D1 (de) | 1991-09-19 |
| US5026868A (en) | 1991-06-25 |
| DK208287D0 (da) | 1987-04-24 |
| FI871655A0 (fi) | 1987-04-15 |
| CA1299186C (en) | 1992-04-21 |
| HUT45234A (en) | 1988-06-28 |
| NO872004L (no) | 1987-11-16 |
| AU600725B2 (en) | 1990-08-23 |
| KR880009941A (ko) | 1988-10-06 |
| AU7310287A (en) | 1987-11-19 |
| NO166940C (no) | 1991-09-25 |
| IL82541A (en) | 1992-06-21 |
| EP0247764A1 (de) | 1987-12-02 |
| JPS62289566A (ja) | 1987-12-16 |
| FI81092B (fi) | 1990-05-31 |
| PT84881A (en) | 1987-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |