ATE647T1 - 2-amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidin-6-carbonsaeuren, sie enthaltende arzneimittel sowie verfahren zu ihrer herstellung. - Google Patents

2-amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidin-6-carbonsaeuren, sie enthaltende arzneimittel sowie verfahren zu ihrer herstellung.

Info

Publication number
ATE647T1
ATE647T1 AT80100363T AT80100363T ATE647T1 AT E647 T1 ATE647 T1 AT E647T1 AT 80100363 T AT80100363 T AT 80100363T AT 80100363 T AT80100363 T AT 80100363T AT E647 T1 ATE647 T1 AT E647T1
Authority
AT
Austria
Prior art keywords
cyclopropyl
oxo
amino
pyrido
pyrimidin
Prior art date
Application number
AT80100363T
Other languages
English (en)
Inventor
Klaus Dr. Grohe
Hans-Joachim Dr. Zeiler
Karl Georg Dr. Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE647T1 publication Critical patent/ATE647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
AT80100363T 1979-02-01 1980-01-24 2-amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidin-6-carbonsaeuren, sie enthaltende arzneimittel sowie verfahren zu ihrer herstellung. ATE647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792903850 DE2903850A1 (de) 1979-02-01 1979-02-01 2-amino-8-cyclopropyl-5-oxo-5,8- dihydro-pyrido eckige klammer auf 2,3-d eckige klammer zu -pyrimidin-6-carnonsaeuren, verfahren zu ihrer herstellung sowie ihrer verwendung als antibakterielle mittel
EP80100363A EP0014390B1 (de) 1979-02-01 1980-01-24 2-Amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidin-6-carbonsäuren, sie enthaltende Arzneimittel sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE647T1 true ATE647T1 (de) 1982-02-15

Family

ID=6061940

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80100363T ATE647T1 (de) 1979-02-01 1980-01-24 2-amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidin-6-carbonsaeuren, sie enthaltende arzneimittel sowie verfahren zu ihrer herstellung.

Country Status (12)

Country Link
US (1) US4556709A (de)
EP (1) EP0014390B1 (de)
JP (2) JPS5817758B2 (de)
AT (1) ATE647T1 (de)
AU (1) AU537475B2 (de)
CA (1) CA1142923A (de)
DE (2) DE2903850A1 (de)
DK (1) DK152499C (de)
ES (1) ES488186A1 (de)
FI (1) FI68823C (de)
IL (1) IL59253A (de)
ZA (1) ZA80578B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
IT1200470B (it) * 1985-05-10 1989-01-18 Schering Spa Composti ad attivita' antibatterica,loro preparazione e composizioni farmaceutiche relative
DE3786256T2 (de) * 1986-12-02 1993-10-07 British Tech Group Antifolat-mittel.
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
CN102098918A (zh) * 2008-05-13 2011-06-15 帕纳德制药公司 用于治疗癌症和神经退行性疾病的生物活性化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4837279B1 (de) * 1970-08-29 1973-11-09
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
FR2194420B1 (de) * 1972-08-02 1975-10-17 Bellon Labor Sa Roger
JPS5336478B2 (de) * 1972-08-14 1978-10-03
GB1451912A (en) * 1972-08-14 1976-10-06 Dainippon Pharmaceutical Co 2-1-piperazino-5-oxopyrido-2,3-d-pyridine-6-carboxylic acids their preparation and pharmaceutical compositions thereof
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
US3992380A (en) * 1975-03-03 1976-11-16 Sterling Drug Inc. 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters
JPS5312889A (en) * 1976-07-22 1978-02-04 Dainippon Pharmaceut Co Ltd P-aminobenzylpiperazine dervatives

Also Published As

Publication number Publication date
DK152499B (da) 1988-03-07
IL59253A0 (en) 1980-05-30
EP0014390A1 (de) 1980-08-20
DK41880A (da) 1980-08-02
ES488186A1 (es) 1980-09-16
FI68823B (fi) 1985-07-31
EP0014390B1 (de) 1982-02-03
FI800266A (fi) 1980-08-02
DE3060162D1 (en) 1982-03-11
US4556709A (en) 1985-12-03
FI68823C (fi) 1985-11-11
AU537475B2 (en) 1984-06-28
AU5502380A (en) 1980-08-07
JPS5877816A (ja) 1983-05-11
JPS5817758B2 (ja) 1983-04-09
JPS55104281A (en) 1980-08-09
CA1142923A (en) 1983-03-15
DE2903850A1 (de) 1980-08-07
ZA80578B (en) 1981-01-28
DK152499C (da) 1988-07-25
IL59253A (en) 1983-07-31
JPS6246523B2 (de) 1987-10-02

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