ATE555785T1 - Triazolderivate als smo-antagonisten - Google Patents

Triazolderivate als smo-antagonisten

Info

Publication number
ATE555785T1
ATE555785T1 AT08742913T AT08742913T ATE555785T1 AT E555785 T1 ATE555785 T1 AT E555785T1 AT 08742913 T AT08742913 T AT 08742913T AT 08742913 T AT08742913 T AT 08742913T AT E555785 T1 ATE555785 T1 AT E555785T1
Authority
AT
Austria
Prior art keywords
triazole derivatives
smo antagonists
smo
antagonists
triazole
Prior art date
Application number
AT08742913T
Other languages
German (de)
English (en)
Inventor
James Balkovec
Rolf Thieringer
Sherman Waddell
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE555785T1 publication Critical patent/ATE555785T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08742913T 2007-04-18 2008-04-15 Triazolderivate als smo-antagonisten ATE555785T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92501807P 2007-04-18 2007-04-18
PCT/US2008/004862 WO2008130552A1 (en) 2007-04-18 2008-04-15 Triazole derivatives which are smo antagonists

Publications (1)

Publication Number Publication Date
ATE555785T1 true ATE555785T1 (de) 2012-05-15

Family

ID=39433852

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08742913T ATE555785T1 (de) 2007-04-18 2008-04-15 Triazolderivate als smo-antagonisten

Country Status (12)

Country Link
US (1) US7691887B2 (OSRAM)
EP (1) EP2136803B1 (OSRAM)
JP (1) JP5498936B2 (OSRAM)
CN (1) CN101663033B (OSRAM)
AR (1) AR066063A1 (OSRAM)
AT (1) ATE555785T1 (OSRAM)
AU (1) AU2008241527B2 (OSRAM)
CA (1) CA2683946C (OSRAM)
CL (1) CL2008001074A1 (OSRAM)
PE (1) PE20090806A1 (OSRAM)
TW (1) TW200901987A (OSRAM)
WO (1) WO2008130552A1 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
EP2225254A4 (en) * 2007-12-27 2011-03-30 Infinity Pharmaceuticals Inc THERAPEUTIC CARE TREATMENTS
CA2710858A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
GB0813740D0 (en) * 2008-07-28 2008-09-03 Angeletti P Ist Richerche Biologica Therapeutic compounds
AU2009286528B2 (en) * 2008-08-29 2014-07-17 Msd Italia S.R.L. Saturated bicyclic heterocyclic derivatives as Smo antagonists
EP2462115B1 (en) 2009-08-05 2016-01-06 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
WO2011063309A1 (en) * 2009-11-20 2011-05-26 Infinity Pharmaceuticals, Inc. Methods and compositions for treating hedgehog-associated cancers
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
AU2014251038A1 (en) 2013-04-08 2015-11-26 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
CN104324039A (zh) * 2014-10-20 2015-02-04 付茜 一种治疗人身体表面脂肪瘤的药剂及使用方法
BR112017026103B1 (pt) 2015-06-04 2023-10-03 Sol-Gel Technologies Ltd Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos
CN108623446A (zh) * 2017-03-24 2018-10-09 北京艾德旺科技发展有限公司 一种合成3，3-二氟环丁烷甲酸的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
JP4368683B2 (ja) 2002-02-01 2009-11-18 メルク エンド カムパニー インコーポレーテッド 糖尿病、肥満症および脂質代謝異常の治療に有用な１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
US8026264B2 (en) 2003-05-29 2011-09-27 Merck Sharp And Dohme Corp. Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1
US8067608B2 (en) 2003-09-29 2011-11-29 The Johns Hopkins University Hedgehog pathway antagonists
US8273743B2 (en) 2004-04-30 2012-09-25 Curis, Inc. Quinoxaline inhibitors of the hedgehog signalling
WO2006017542A1 (en) 2004-08-06 2006-02-16 Merck & Co., Inc. Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
EP1817308B1 (en) 2004-08-27 2014-10-08 Infinity Pharmaceuticals, Inc. Cyclopamine analogues and methods of use thereof
PT1789390E (pt) 2004-09-02 2012-02-08 Genentech Inc Inibidores de piridilo da sinalização de hedgehog
CN101083996A (zh) 2004-10-28 2007-12-05 Irm责任有限公司 作为hedgehog途径调节剂的化合物和组合物
CA2587489C (en) 2004-11-03 2013-12-31 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
EP1940393B1 (en) * 2005-10-20 2012-07-25 Merck Sharp & Dohme Corp. Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Also Published As

Publication number Publication date
CN101663033B (zh) 2013-01-16
WO2008130552A1 (en) 2008-10-30
AU2008241527A1 (en) 2008-10-30
AU2008241527B2 (en) 2014-02-13
US7691887B2 (en) 2010-04-06
JP5498936B2 (ja) 2014-05-21
CA2683946C (en) 2013-01-22
AR066063A1 (es) 2009-07-22
JP2010524937A (ja) 2010-07-22
EP2136803A1 (en) 2009-12-30
PE20090806A1 (es) 2009-06-27
EP2136803B1 (en) 2012-05-02
CA2683946A1 (en) 2008-10-30
CL2008001074A1 (es) 2009-06-05
CN101663033A (zh) 2010-03-03
TW200901987A (en) 2009-01-16
US20080262051A1 (en) 2008-10-23

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