ATE555084T1 - Neue aminosäurederivate, verfahren zu deren herstellung und deren therapeutische verwendung - Google Patents
Neue aminosäurederivate, verfahren zu deren herstellung und deren therapeutische verwendungInfo
- Publication number
- ATE555084T1 ATE555084T1 AT09745768T AT09745768T ATE555084T1 AT E555084 T1 ATE555084 T1 AT E555084T1 AT 09745768 T AT09745768 T AT 09745768T AT 09745768 T AT09745768 T AT 09745768T AT E555084 T1 ATE555084 T1 AT E555084T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- phenyl
- formula
- hydrogen
- benzyl radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0853092A FR2931151A1 (fr) | 2008-05-13 | 2008-05-13 | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
PCT/EP2009/055787 WO2009138436A1 (fr) | 2008-05-13 | 2009-05-13 | Nouveaux dérivés d'amino-acides, leur procédé de préparation et leur utilisation thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE555084T1 true ATE555084T1 (de) | 2012-05-15 |
Family
ID=40225670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09745768T ATE555084T1 (de) | 2008-05-13 | 2009-05-13 | Neue aminosäurederivate, verfahren zu deren herstellung und deren therapeutische verwendung |
Country Status (16)
Country | Link |
---|---|
US (1) | US8466309B2 (de) |
EP (1) | EP2297095B9 (de) |
JP (1) | JP5642664B2 (de) |
KR (1) | KR20110008325A (de) |
CN (2) | CN103739531B (de) |
AT (1) | ATE555084T1 (de) |
AU (1) | AU2009248056A1 (de) |
BR (1) | BRPI0912398A2 (de) |
CA (1) | CA2722840C (de) |
EA (1) | EA201071272A1 (de) |
FR (1) | FR2931151A1 (de) |
IL (1) | IL209214A (de) |
MX (1) | MX2010012273A (de) |
NZ (1) | NZ588955A (de) |
WO (1) | WO2009138436A1 (de) |
ZA (1) | ZA201008029B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2934267B1 (fr) | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
FR2997081B1 (fr) | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine |
FR2997080B1 (fr) * | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs de neprilysine |
TWI712582B (zh) * | 2015-10-14 | 2020-12-11 | 法商領先藥物公司 | 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法 |
FR3077201B1 (fr) * | 2018-01-26 | 2020-01-17 | Pharmaleads | Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
FR2488253A1 (fr) | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
FR2518088B1 (fr) | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
US4426391A (en) * | 1982-09-15 | 1984-01-17 | Merck & Co., Inc. | [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa |
DE3475065D1 (en) * | 1983-06-23 | 1988-12-15 | Merck & Co Inc | (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives |
US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
FR2605004B1 (fr) | 1986-09-25 | 1989-01-13 | Centre Nat Rech Scient | Nouveaux derives d'amino-acides, leur procede de preparation et composition pharmaceutiques les contenant |
FR2611722B1 (fr) | 1987-03-02 | 1989-08-11 | Inst Nat Sante Rech Med | Nouveaux peptides derives de la cck8, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2634763B1 (fr) | 1988-08-01 | 1991-07-12 | Inst Nat Sante Rech Med | Amino-acides et peptides presentant un residu tyrosine modifiee, leur preparation et leur application comme medicaments |
FR2651229B1 (fr) | 1989-08-24 | 1991-12-13 | Inst Nat Sante Rech Med | Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique. |
FR2679564A1 (fr) | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
FR2729668A1 (fr) | 1995-01-23 | 1996-07-26 | Adir | Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2745571B1 (fr) | 1996-03-04 | 1998-06-19 | Inst Nat Sante Rech Med | Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant |
FR2755135B1 (fr) | 1996-10-25 | 2002-12-27 | Inst Nat Sante Rech Med | Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent |
FR2773712B1 (fr) | 1998-01-16 | 2000-06-02 | Inst Nat Sante Rech Med | Composition pharmaceutique comprenant au moins un inhibiteur de l'aminopeptidase a |
FR2777780B1 (fr) | 1998-04-22 | 2001-05-04 | Inst Nat Sante Rech Med | Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent |
US20020055463A1 (en) | 1998-12-24 | 2002-05-09 | Christiane Garbay | Pseudopeptide compounds having an inhibiting activity with respect to paths activated by proteins with active tyrosine kinase activity and pharmaceutical compositions containing same |
FR2788526B1 (fr) | 1999-01-20 | 2002-07-05 | Inst Nat Sante Rech Med | Composes tripeptidiques utiles a titre d'hinhibiteurs selectifs de l'aminopeptidase a et compositions pharmaceutiques correspondantes |
FR2805259B1 (fr) | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | Nouveaux derives d'aminoacides n-mercaptoacyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2807523B1 (fr) | 2000-04-07 | 2002-08-30 | Inst Nat Sante Rech Med | UTILISATION D'UN RESTE PyA-(Z)x-pNF A DES FINS DE DETECTION, IDENTIFICATION ET/OU DOSAGE PAR FLUORESCENCE |
GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
FR2809733B1 (fr) | 2000-06-02 | 2004-04-30 | Inst Nat Sante Rech Med | Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants |
ES2369256T3 (es) * | 2000-06-26 | 2011-11-28 | Helen Of Troy Limited | Sistema de lámpara recargable. |
GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
WO2002020570A2 (en) | 2000-09-11 | 2002-03-14 | Institut Pasteur | Mitochondrial membrane permeabilization bv hiv-1 vpr and methods of screening |
FR2823212B1 (fr) | 2001-04-10 | 2005-12-02 | Inst Nat Sante Rech Med | Inhibiteurs de la toxine botulique de type b |
ATE400552T1 (de) | 2002-07-16 | 2008-07-15 | Inst Nat Sante Rech Med | 4,4' -dithiobis- (3-aminobutane-1-sulfonate)- derivate und sie enthaltende zusammensetzungen |
FR2858617A1 (fr) | 2003-08-06 | 2005-02-11 | Inst Nat Sante Rech Med | Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant |
CA2565678C (fr) | 2004-05-05 | 2013-07-09 | Pharmaleads | Substrats peptidiques reconnus par la toxine botulique de type a, bont/a et leurs utilisations |
US20070049627A1 (en) * | 2005-08-23 | 2007-03-01 | Tran Pierre V | Treating vulvodynia using prodrugs of GABA analogs |
EP1940818B1 (de) * | 2005-10-25 | 2011-08-24 | Pharmaleads | Eine disulfanylgruppe enthaltende aminosäurederivate als gemischte inhibitoren von neprilysin und aminopeptidase n |
US8247609B2 (en) * | 2005-10-25 | 2012-08-21 | Pharamleads | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors |
-
2008
- 2008-05-13 FR FR0853092A patent/FR2931151A1/fr not_active Withdrawn
-
2009
- 2009-05-13 KR KR1020107028001A patent/KR20110008325A/ko not_active Application Discontinuation
- 2009-05-13 EA EA201071272A patent/EA201071272A1/ru unknown
- 2009-05-13 NZ NZ588955A patent/NZ588955A/en not_active IP Right Cessation
- 2009-05-13 US US12/991,999 patent/US8466309B2/en active Active
- 2009-05-13 AU AU2009248056A patent/AU2009248056A1/en not_active Abandoned
- 2009-05-13 WO PCT/EP2009/055787 patent/WO2009138436A1/fr active Application Filing
- 2009-05-13 CA CA2722840A patent/CA2722840C/fr active Active
- 2009-05-13 MX MX2010012273A patent/MX2010012273A/es not_active Application Discontinuation
- 2009-05-13 JP JP2011508908A patent/JP5642664B2/ja active Active
- 2009-05-13 CN CN201310736987.9A patent/CN103739531B/zh active Active
- 2009-05-13 EP EP09745768A patent/EP2297095B9/de active Active
- 2009-05-13 CN CN200980116831.2A patent/CN102026966B/zh active Active
- 2009-05-13 BR BRPI0912398A patent/BRPI0912398A2/pt not_active IP Right Cessation
- 2009-05-13 AT AT09745768T patent/ATE555084T1/de active
-
2010
- 2010-11-09 ZA ZA2010/08029A patent/ZA201008029B/en unknown
- 2010-11-09 IL IL209214A patent/IL209214A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2722840C (fr) | 2017-04-11 |
ZA201008029B (en) | 2011-08-31 |
JP2011522797A (ja) | 2011-08-04 |
EP2297095A1 (de) | 2011-03-23 |
CN103739531B (zh) | 2016-09-14 |
US20110071218A1 (en) | 2011-03-24 |
EA201071272A1 (ru) | 2011-04-29 |
JP5642664B2 (ja) | 2014-12-17 |
EP2297095B9 (de) | 2013-01-09 |
CA2722840A1 (fr) | 2009-11-19 |
IL209214A (en) | 2014-08-31 |
NZ588955A (en) | 2012-07-27 |
BRPI0912398A2 (pt) | 2016-03-15 |
CN102026966B (zh) | 2014-02-12 |
US8466309B2 (en) | 2013-06-18 |
FR2931151A1 (fr) | 2009-11-20 |
CN102026966A (zh) | 2011-04-20 |
IL209214A0 (en) | 2011-01-31 |
KR20110008325A (ko) | 2011-01-26 |
EP2297095B1 (de) | 2012-04-25 |
WO2009138436A1 (fr) | 2009-11-19 |
MX2010012273A (es) | 2010-12-02 |
CN103739531A (zh) | 2014-04-23 |
AU2009248056A1 (en) | 2009-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR080865A1 (es) | Derivados de espirotetrahidronaftaleno, composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos para tratar enfermedades neurodegenerativas,tal como alzheimer. | |
PE20141075A1 (es) | 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina | |
ECSP11011561A (es) | Derivados aminobutíricos sustituidos como inhibidores de neprilisina | |
DK2091948T3 (da) | Nye inhibitorer af glutaminylcyclase | |
AR086357A1 (es) | Derivados de indazol sustituidos activos como inhibidores de quinasas | |
ECSP056016A (es) | Nuevos derivados de 2-piridinacarboxamida | |
AR083953A1 (es) | Compuestos para tratar enfermedades neurodegenerativas | |
BR112014015363A8 (pt) | derivados de ácido alfa-amino borônico, inibidores de imunoproteassoma seletivos | |
CR10383A (es) | Derivados triazolopirazina. | |
EA201490445A1 (ru) | Циклопропанаминовое соединение | |
CO6540001A2 (es) | Derivados del ácido carbamoil-metil-amino -acçetico sustituido como inhibidores de nep novedosos. | |
MY173930A (en) | Crystalline solvates and complexes of (is)-1,5-anhydro-1-c-(3-((phenyl)methyl)phenyl)-d-glucitol derivatives with amino acids as sglt2 inhibitors for the treatment of diabetes | |
ATE514692T1 (de) | Phenothiazin derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
AR076765A1 (es) | Compuestos antivirales | |
ATE555084T1 (de) | Neue aminosäurederivate, verfahren zu deren herstellung und deren therapeutische verwendung | |
RU2009143926A (ru) | Производные пиридина, замещенные гетероциклическим циклом и фосфоноаминогруппой, и содержащее их противогрибковое средство | |
EA201070442A1 (ru) | НОВЫЕ ИНГИБИТОРЫ sEH И ИХ ПРИМЕНЕНИЕ | |
EA201071012A1 (ru) | Производные азетидинов, способ их получения и применение их в терапии | |
AR084864A1 (es) | Proceso de preparacion de girasa e inhibidores de topoisomerasa iv y compuestos intermediarios de dicho proceso | |
AR072802A1 (es) | Derivados piperidinicos de esteres de acido bifenil-2-il-carbamico, antagonistas de receptores muscarinicos m3, composiciones farmaceuticas que los contienen y usos de los mismos para el tratamiento de trastornos digestivos,respiratorios y/o urinarios. | |
EA201190269A1 (ru) | 2'-фторарабинонуклеозиды и их применение | |
MX2009013775A (es) | Sustituto novedoso de piperidones sustituidas como inductor de hsp. | |
ATE500219T1 (de) | Neue dipeptidylpeptidase-iv-inhibitoren und verfahren zur ihrer herstellung und pharmazeutische zusammensetzung, die diese enthalten | |
AR045548A1 (es) | Derivados de imidazol | |
MXPA05012096A (es) | Derivados de amina ciclica, procedimientos para su preparacion y composiciones farmaceuticas que los contienen. |