EA201071272A1 - Новые производные аминокислот, способ их получения и применение - Google Patents

Новые производные аминокислот, способ их получения и применение

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Publication number
EA201071272A1
EA201071272A1 EA201071272A EA201071272A EA201071272A1 EA 201071272 A1 EA201071272 A1 EA 201071272A1 EA 201071272 A EA201071272 A EA 201071272A EA 201071272 A EA201071272 A EA 201071272A EA 201071272 A1 EA201071272 A1 EA 201071272A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
phenyl
formula
hydrogen
benzyl radical
Prior art date
Application number
EA201071272A
Other languages
English (en)
Inventor
Мари-Клод Фурнье-Залуски
Эрве Пора
Бернар Рок
Original Assignee
Фармалидс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармалидс filed Critical Фармалидс
Publication of EA201071272A1 publication Critical patent/EA201071272A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение относится к новым соединениям формулы (I) RNH-CH(R)-CH-S-S-CH-C(R)(R)-CONH-C(R)(R)-COOR, в которых Rпредставляет собой (ацилокси)алкилкарбаматную группу -C(O)-O-C(R)(R)-OC(O)-R; Rпредставляет собой углеводородную цепь, метиленовый радикал, замещенный гетероциклом; Rпредставляет собой атом водорода и Rпредставляет собой фенильный или бензильный радикал, гетероарил, метиленовую группу, замещенную гетероциклом, либо Rи Rобразуют вместе насыщенный цикл; Rи Rпредставляют собой атом водорода, углеводородную цепь, фенильный или бензильный радикал, либо Rи Rобразуют вместе насыщенный цикл; Rпредставляет собой атом водорода, фенильный или бензильный радикал, группу формулы CR(R)C(O)ORили OCR(R)OC(O)Rили OCR(R)OC(O)OR. Изобретение также относится к применению этих соединений в качестве лекарства и к фармацевтической композиции, содержащей эти соединения и фармацевтически приемлемый носитель. Далее изобретение относится к комбинированному применению по меньшей мере одного производного каннабиноидов и/или морфина или одного его производного и/или производных ГАМК для усиления анальгезирующего и антидепрессивного эффекта новых соединений формулы (I).
EA201071272A 2008-05-13 2009-05-13 Новые производные аминокислот, способ их получения и применение EA201071272A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0853092A FR2931151A1 (fr) 2008-05-13 2008-05-13 Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
PCT/EP2009/055787 WO2009138436A1 (fr) 2008-05-13 2009-05-13 Nouveaux dérivés d'amino-acides, leur procédé de préparation et leur utilisation thérapeutique

Publications (1)

Publication Number Publication Date
EA201071272A1 true EA201071272A1 (ru) 2011-04-29

Family

ID=40225670

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071272A EA201071272A1 (ru) 2008-05-13 2009-05-13 Новые производные аминокислот, способ их получения и применение

Country Status (16)

Country Link
US (1) US8466309B2 (ru)
EP (1) EP2297095B9 (ru)
JP (1) JP5642664B2 (ru)
KR (1) KR20110008325A (ru)
CN (2) CN103739531B (ru)
AT (1) ATE555084T1 (ru)
AU (1) AU2009248056A1 (ru)
BR (1) BRPI0912398A2 (ru)
CA (1) CA2722840C (ru)
EA (1) EA201071272A1 (ru)
FR (1) FR2931151A1 (ru)
IL (1) IL209214A (ru)
MX (1) MX2010012273A (ru)
NZ (1) NZ588955A (ru)
WO (1) WO2009138436A1 (ru)
ZA (1) ZA201008029B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2997080B1 (fr) * 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs de neprilysine
FR2997081B1 (fr) * 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
TWI712582B (zh) * 2015-10-14 2020-12-11 法商領先藥物公司 用來製備(5s,10s)-10-苄基-16-甲基-11,14,18-三側氧基-15,17,19-三氧雜-2,7,8-三噻基-12-氮二十一烷基-5-銨基(e)-3-羧基丙烯酸鹽的工業方法
FR3077201B1 (fr) 2018-01-26 2020-01-17 Pharmaleads Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau

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FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
FR2488253A1 (fr) * 1980-08-08 1982-02-12 Roques Bernard Nouveaux peptides et leur application en therapeutique
FR2518088B1 (fr) 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
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Also Published As

Publication number Publication date
MX2010012273A (es) 2010-12-02
EP2297095B9 (fr) 2013-01-09
US20110071218A1 (en) 2011-03-24
CA2722840A1 (fr) 2009-11-19
JP5642664B2 (ja) 2014-12-17
ATE555084T1 (de) 2012-05-15
US8466309B2 (en) 2013-06-18
CN103739531B (zh) 2016-09-14
KR20110008325A (ko) 2011-01-26
AU2009248056A1 (en) 2009-11-19
CA2722840C (fr) 2017-04-11
IL209214A (en) 2014-08-31
ZA201008029B (en) 2011-08-31
JP2011522797A (ja) 2011-08-04
IL209214A0 (en) 2011-01-31
FR2931151A1 (fr) 2009-11-20
CN103739531A (zh) 2014-04-23
EP2297095A1 (fr) 2011-03-23
CN102026966B (zh) 2014-02-12
NZ588955A (en) 2012-07-27
WO2009138436A1 (fr) 2009-11-19
CN102026966A (zh) 2011-04-20
EP2297095B1 (fr) 2012-04-25
BRPI0912398A2 (pt) 2016-03-15

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