EA201190269A1 - 2'-фторарабинонуклеозиды и их применение - Google Patents

2'-фторарабинонуклеозиды и их применение

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Publication number
EA201190269A1
EA201190269A1 EA201190269A EA201190269A EA201190269A1 EA 201190269 A1 EA201190269 A1 EA 201190269A1 EA 201190269 A EA201190269 A EA 201190269A EA 201190269 A EA201190269 A EA 201190269A EA 201190269 A1 EA201190269 A1 EA 201190269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
arabicono
nucleoside
fluoro
application
compounds
Prior art date
Application number
EA201190269A
Other languages
English (en)
Inventor
Джон А. Секрист
Анита Т. Фоулер
Камал Н. Тивари
Original Assignee
Саузерн Рисерч Инститьют
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Саузерн Рисерч Инститьют filed Critical Саузерн Рисерч Инститьют
Publication of EA201190269A1 publication Critical patent/EA201190269A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Предложен способ лечения рака посредством использования некоторых 2'-фторарабинонуклеозидов. Кроме того, предложены соединения формул (I и А), в которых R представляет собой алкил; а также фармацевтически приемлемые соли таких соединений; и фармацевтические композиции, содержащие эти соединениягде А представляет собой
EA201190269A 2009-05-12 2010-05-12 2'-фторарабинонуклеозиды и их применение EA201190269A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17743609P 2009-05-12 2009-05-12
PCT/US2010/034463 WO2010132513A1 (en) 2009-05-12 2010-05-12 2'-fluoro arabino nucleosides and use thereof

Publications (1)

Publication Number Publication Date
EA201190269A1 true EA201190269A1 (ru) 2012-07-30

Family

ID=43085308

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190269A EA201190269A1 (ru) 2009-05-12 2010-05-12 2'-фторарабинонуклеозиды и их применение

Country Status (11)

Country Link
US (1) US20120149657A1 (ru)
EP (1) EP2430034A4 (ru)
JP (1) JP2012526831A (ru)
KR (1) KR20120007077A (ru)
CN (1) CN102459297A (ru)
AU (1) AU2010249119A1 (ru)
BR (1) BRPI1010809A2 (ru)
CA (1) CA2761880A1 (ru)
EA (1) EA201190269A1 (ru)
MX (1) MX2011012068A (ru)
WO (1) WO2010132513A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014014740B1 (pt) 2011-12-22 2021-08-24 Alios Biopharma, Inc Compostos de nucleosídeos, nucleotídeos e análogos destes, seu uso e composição farmacêutica
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
TW202400134A (zh) * 2022-03-15 2024-01-01 美商羅米醫療公司 用於治療疾病之化合物及方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
JP2002504558A (ja) * 1998-02-25 2002-02-12 エモリー ユニバーシテイ ２’−フルオロヌクレオシド
CN101240001B (zh) * 1998-02-25 2013-10-16 埃莫里大学 2'-氟代核苷
CN100532388C (zh) * 2007-07-16 2009-08-26 郑州大学 2’-氟-4’-取代-核苷类似物、其制备方法及应用

Also Published As

Publication number Publication date
JP2012526831A (ja) 2012-11-01
BRPI1010809A2 (pt) 2015-10-13
CN102459297A (zh) 2012-05-16
US20120149657A1 (en) 2012-06-14
WO2010132513A1 (en) 2010-11-18
MX2011012068A (es) 2012-06-08
EP2430034A4 (en) 2013-05-15
EP2430034A1 (en) 2012-03-21
AU2010249119A1 (en) 2011-12-01
KR20120007077A (ko) 2012-01-19
CA2761880A1 (en) 2010-11-18

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