ATE548656T1 - Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür - Google Patents

Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür

Info

Publication number
ATE548656T1
ATE548656T1 AT07717460T AT07717460T ATE548656T1 AT E548656 T1 ATE548656 T1 AT E548656T1 AT 07717460 T AT07717460 T AT 07717460T AT 07717460 T AT07717460 T AT 07717460T AT E548656 T1 ATE548656 T1 AT E548656T1
Authority
AT
Austria
Prior art keywords
identifying patients
occurring
biomarkers
biomarker
expression
Prior art date
Application number
AT07717460T
Other languages
English (en)
Inventor
Timothy Fischer
Douglas Malinowski
Qin He
Clark Whitehead
Robert Cheek
John Groelke
Original Assignee
Tripath Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tripath Imaging Inc filed Critical Tripath Imaging Inc
Application granted granted Critical
Publication of ATE548656T1 publication Critical patent/ATE548656T1/de

Links

Classifications

    • G01N33/57545—
    • G01N33/575—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07717460T 2006-01-27 2007-01-29 Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür ATE548656T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76276006P 2006-01-27 2006-01-27
PCT/US2007/061205 WO2007090076A2 (en) 2006-01-27 2007-01-29 Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor

Publications (1)

Publication Number Publication Date
ATE548656T1 true ATE548656T1 (de) 2012-03-15

Family

ID=38328113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07717460T ATE548656T1 (de) 2006-01-27 2007-01-29 Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür

Country Status (11)

Country Link
US (3) US20070212721A1 (de)
EP (2) EP1987360B1 (de)
JP (1) JP2009524438A (de)
KR (1) KR20080094803A (de)
CN (1) CN101410715A (de)
AT (1) ATE548656T1 (de)
AU (1) AU2007211085A1 (de)
BR (1) BRPI0707249A2 (de)
CA (1) CA2637446A1 (de)
MX (1) MX2008009592A (de)
WO (1) WO2007090076A2 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002213720A1 (en) * 2000-11-01 2002-05-15 Mount Sinai Hospital Detection of ovarian cancer
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1984738A2 (de) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und kontrolle von nanoreaktoren
JP2009526519A (ja) * 2006-01-17 2009-07-23 セルーメン、インコーポレイテッド 生物学的システム応答の予測方法
EP2047910B1 (de) 2006-05-11 2012-01-11 Raindance Technologies, Inc. Mikrofluidische Vorrichtung und Verfahren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
IL282783B2 (en) 2006-05-18 2023-09-01 Caris Mpi Inc A system and method for determining a personalized medical intervention for a disease stage
US20100009352A1 (en) * 2006-05-24 2010-01-14 Gough Albert H Method for Modeling a Disease
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
WO2008060483A2 (en) * 2006-11-10 2008-05-22 Cellumen, Inc. Protein-protein interaction biosensors and methods of use thereof
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
WO2008112514A1 (en) * 2007-03-09 2008-09-18 Tripath Imaging, Inc. He4 monoclonal antibodies and methods for their use
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2009032974A2 (en) * 2007-09-06 2009-03-12 Tripath Imaging, Inc. Nucleic acid-based methods for the detection of ovarian cancer
US20090130195A1 (en) 2007-10-17 2009-05-21 Mildred Acevedo-Duncan Prostate carcinogenesis predictor
EP2088204A1 (de) * 2008-02-05 2009-08-12 Adnagen AG Verfahren und Kit zur Diagnose bzw. Kontrolle der Behandlung von Ovarialkarzinomen
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
CA2737004A1 (en) * 2008-10-06 2010-04-15 Somalogic, Inc. Ovarian cancer biomarkers and uses thereof
US20100221752A2 (en) * 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
US20110251099A1 (en) * 2008-12-30 2011-10-13 Sudha Visvanathan SERUM MARKERS PREDICTING CLINICAL RESPONSE TO ANTI-TNFa ANTIBODIES IN PATIENTS WITH ANKYLOSING SPONDYLITIS
US20100227335A1 (en) * 2009-03-05 2010-09-09 Becton, Dickinson And Company Matrix metalloproteinase-7 (mmp-7) monoclonal antibodies and methods for their use in the detection of ovarian cancer
US8252904B2 (en) 2009-03-06 2012-08-28 Tripath Imaging, Inc. Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer
EP3415235B1 (de) 2009-03-23 2025-11-12 Bio-Rad Laboratories, Inc. Manipulation von mikrofluidiktröpfchen
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US9718878B2 (en) 2010-02-10 2017-08-01 Maine Medical Center Kit for detecting Cthrc1 in a sample
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
KR101870123B1 (ko) 2010-07-09 2018-06-25 소마로직, 인크. 폐암 바이오마커 및 그것의 용도
CA2804857C (en) 2010-08-13 2021-07-06 Somalogic, Inc. Pancreatic cancer biomarkers and uses thereof
EP2622103B2 (de) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwichassays in tröpfchen
EP2659005A4 (de) * 2010-12-28 2016-08-24 Caris Mpi Inc Molekulare profilierung von krebs
EP2673614B1 (de) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
ES2834617T3 (es) * 2011-02-17 2021-06-18 Fujirebio Diagnostics Inc Composiciones y métodos de uso para la determinación de HE4a
EP2675819B1 (de) 2011-02-18 2020-04-08 Bio-Rad Laboratories, Inc. Zusammensetzungen und verfahren für molekulare etikettierung
GB2503148A (en) * 2011-02-24 2013-12-18 Vermillion Inc Biomarker panels diagnostic methods and test kits for ovarian cancer
CA3212002A1 (en) 2011-03-17 2012-09-20 Cernostics, Inc. Systems and compositions for diagnosing barrett's esophagus and methods of using the same
CN102735840B (zh) * 2011-04-13 2014-06-04 中国医学科学院肿瘤研究所 用于诊断或筛查卵巢癌的试剂
WO2012142330A1 (en) * 2011-04-15 2012-10-18 Brown University Micro rnas as diagnostic biomarkers and therapeutics for ovarian cancer and metastatic tumors that disseminate within the peritoneal cavity
CA2838086A1 (en) * 2011-06-02 2012-12-06 Almac Diagnostics Limited Molecular diagnostic test for cancer
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US9556470B2 (en) 2011-06-02 2017-01-31 Raindance Technologies, Inc. Enzyme quantification
EP2721417A4 (de) * 2011-06-17 2015-05-06 Univ Arkansas Neue marker zur frühdiagnose von eierstockkrebs, überwachung während der entsprechenden therapie und neue therapieoptionen während und nach der entsprechenden chemotherapie
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP3495817B1 (de) 2012-02-10 2024-10-16 Bio-Rad Laboratories, Inc. Molekulardiagnostischer screeningtest
EP3524693A1 (de) 2012-04-30 2019-08-14 Raindance Technologies, Inc. Digitale analytanalyse
CN103575902B (zh) * 2012-08-03 2015-07-29 河南生生医疗器械有限公司 一种时间分辨荧光法四项综合检测卵巢癌试剂盒及其应用
CN105102631A (zh) 2012-12-03 2015-11-25 阿尔玛克诊断有限公司 用于癌症的分子诊断测试
EP3633369A1 (de) * 2013-03-27 2020-04-08 Theranos IP Company, LLC Verfahren, vorrichtungen und systeme zur probenanalyse
WO2014172288A2 (en) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Digital analyte analysis
CN105745543B (zh) * 2013-09-18 2018-02-02 阿德莱德研究及创新控股有限公司 卵巢癌的自身抗体生物标志物
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US11221327B2 (en) * 2013-10-10 2022-01-11 Mcmaster University Method for diagnosing and monitoring inflammatory disease progression
CN103525941A (zh) * 2013-10-29 2014-01-22 上海市奉贤区中心医院 Cthrc1基因在制备检测/治疗宫颈癌药物中的应用
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
CN106290892A (zh) * 2015-06-26 2017-01-04 上海市肿瘤研究所 Cthrc1在肝硬化诊断和治疗中的应用
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2017091658A1 (en) 2015-11-25 2017-06-01 Cernostics, Inc. Methods of predicting progression of barrett's esophagus
US20190064172A1 (en) * 2016-04-20 2019-02-28 Eisai Inc. Prognosis of serous ovarian cancer using biomarkers
US11136581B2 (en) * 2016-06-24 2021-10-05 University Of South Carolina Inhibin as targetable regulators of angiogenesis
TWI823836B (zh) 2016-07-08 2023-12-01 美商建南德克公司 人類副睪蛋白４（ｈｅ４）用於評定癌症治療反應性之用途
WO2018029690A1 (en) 2016-08-10 2018-02-15 Memed Diagnostics Ltd. System and method for analysis of biological data
CN106520924A (zh) * 2016-10-14 2017-03-22 浙江大学 一种用于检测卵巢癌的引物组及检测方法
US10998178B2 (en) 2017-08-28 2021-05-04 Purdue Research Foundation Systems and methods for sample analysis using swabs
CN109480771B (zh) * 2018-10-17 2021-09-07 江西惠肽生物科技有限公司 一种卵巢肿块良恶的确定方法及确定装置
CN112946290A (zh) * 2019-12-10 2021-06-11 上海交通大学医学院附属仁济医院 细胞外基质底物反应蛋白1在制备诊断和预测卵巢癌试剂中的应用
KR102316178B1 (ko) * 2020-04-14 2021-10-22 서울대학교병원 난소암 환자의 암 재발율 또는 생존율 예측용 조성물
CN111693703B (zh) * 2020-07-17 2023-07-21 北京信诺卫康科技有限公司 Spondin 1和HE4联合用作早期卵巢癌生物标志物以及试剂盒
KR102472050B1 (ko) * 2022-03-29 2022-11-30 주식회사 아이엠비디엑스 환자 맞춤형 패널을 이용한 암의 재발을 예측하는 방법

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
EP0138854B1 (de) 1983-03-08 1992-11-04 Chiron Mimotopes Pty. Ltd. Antigen aktive aminosäuresequenzen
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
US4921790A (en) * 1987-04-24 1990-05-01 Research Corporation Tumor specific assay for CA125 ovarian cancer antigen
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP1892296A1 (de) 1988-09-02 2008-02-27 Dyax Corporation Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE185601T1 (de) 1990-07-10 1999-10-15 Cambridge Antibody Tech Verfahren zur herstellung von spezifischen bindungspaargliedern
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
CA2105300C (en) 1991-03-01 2008-12-23 Robert C. Ladner Process for the development of binding mini-proteins
IE921169A1 (en) 1991-04-10 1992-10-21 Scripps Research Inst Heterodimeric receptor libraries using phagemids
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
DE69233501T2 (de) 1991-11-22 2006-02-23 Affymetrix, Inc. (n.d.Ges.d.Staates Delaware), Santa Clara Kombinatorische Strategien für die Polymersynthese
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5976818A (en) * 1991-12-16 1999-11-02 The Board Of Trustees Of The University Of Arkansas Monoclonal antibodies which identify the glycoprotein carrying the CA 125 epitope
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
CA2306501C (en) 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
EP1027456B1 (de) 1997-10-31 2005-03-16 Affymetrix, Inc. (a Delaware Corporation) Expressionsprofile in adulten und fötalen organen
CA2318779C (en) 1998-01-22 2009-08-25 Luminex Corporation Microparticles with multiple fluorescent signals
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
US7223727B2 (en) * 1998-04-09 2007-05-29 Serono Genetics Institute S.A. GSSP4 polynucleotides and polypeptides and uses thereof
US6783961B1 (en) * 1999-02-26 2004-08-31 Genset S.A. Expressed sequence tags and encoded human proteins
WO1999058955A1 (en) 1998-05-14 1999-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US20020052308A1 (en) * 1999-03-12 2002-05-02 Rosen Craig A. Nucleic acids, proteins and antibodies
US20030064072A9 (en) * 1999-03-12 2003-04-03 Rosen Craig A. Nucleic acids, proteins and antibodies
US20020151681A1 (en) * 1999-03-12 2002-10-17 Rosen Craig A. Nucleic acids, proteins and antibodies
US20020039764A1 (en) * 1999-03-12 2002-04-04 Rosen Craig A. Nucleic, acids, proteins, and antibodies
US20030040617A9 (en) * 1999-03-12 2003-02-27 Rosen Craig A. Nucleic acids, proteins and antibodies
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
US20020019330A1 (en) * 1999-08-11 2002-02-14 Richard Murray Novel methods of diagnosis of angiogenesis, compositions, and methods of screening for angiogenesis modulators
US20020015970A1 (en) * 1999-08-11 2002-02-07 Richard Murray Novel methods of diagnosis of angiogenesis, compositions, and methods of screening for angiogenesis modulators
US20040009494A1 (en) * 1999-08-11 2004-01-15 Richard Murray Novel methods of diagnosis of angiogenesis and other conditions, compositions, and the methods of screening for modulators
US20030152926A1 (en) * 1999-08-11 2003-08-14 Eos Biotechnology, Inc. Novel methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
US20020155468A1 (en) * 1999-09-23 2002-10-24 Corixa Corporation Ovarian tumor antigen and methods of use therefor
US20020058292A1 (en) * 2000-12-08 2002-05-16 Dillon Davin C. Ovarian tumor antigen and methods of use therefor
AU7832700A (en) * 1999-09-23 2001-04-24 Corixa Corporation Ovarian tumor antigen and methods of use therefor
US20030171252A9 (en) * 2000-01-31 2003-09-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20030125246A9 (en) * 2000-01-31 2003-07-03 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020077270A1 (en) * 2000-01-31 2002-06-20 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020094953A1 (en) * 2000-01-31 2002-07-18 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020090674A1 (en) * 2000-01-31 2002-07-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020132753A1 (en) * 2000-01-31 2002-09-19 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20040101927A9 (en) * 2000-01-31 2004-05-27 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020086330A1 (en) * 2000-01-31 2002-07-04 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020086823A1 (en) * 2000-01-31 2002-07-04 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20030092611A9 (en) * 2000-01-31 2003-05-15 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020090615A1 (en) * 2000-01-31 2002-07-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20020061521A1 (en) * 2000-01-31 2002-05-23 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20040259152A1 (en) * 2000-02-22 2004-12-23 Richard Murray Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases
US6773883B2 (en) * 2000-07-31 2004-08-10 The Brigham & Women's Hospital, Inc. Prognostic classification of endometrial cancer
US20020045230A1 (en) * 2000-08-14 2002-04-18 Rosen Craig A. Nucleic acids, proteins, and antibodies
US20070037165A1 (en) * 2000-09-08 2007-02-15 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
AU2001289036A1 (en) * 2000-09-13 2002-03-26 Zymogenetics Inc. Use of human phermone polypeptides
WO2002046765A2 (en) * 2000-11-08 2002-06-13 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
WO2002071928A2 (en) * 2001-03-14 2002-09-19 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US7309760B2 (en) * 2001-04-17 2007-12-18 The Board Of Trustees Of The University Of Arkansas Repeat sequences of the CA125 gene and their use for diagnostic and therapeutic interventions
WO2002083866A2 (en) * 2001-04-17 2002-10-24 The Board Of Trustees Of The University Of Arkansas Repeat sequences of the ca125 gene and their use for diagnostic and therapeutic interventions
CA2445990A1 (en) * 2001-04-18 2002-10-24 Genset S.A. Full-length human cdnas encoding potentially secreted proteins
WO2002092836A2 (en) * 2001-05-11 2002-11-21 Sloan-Kettering Institute For Cancer Research Nucleic acid sequence encoding ovarian antigen, ca125, and uses thereof
US7205142B2 (en) * 2001-05-11 2007-04-17 Sloan-Kettering Institute For Cancer Research Nucleic acid sequence encoding ovarian antigen, CA125, and uses thereof
IL159015A0 (en) * 2001-05-25 2004-05-12 Genset Sa Polypeptides, their preparation and use
US20070015144A9 (en) * 2001-05-25 2007-01-18 Genset, S.A. Human cDNAs and proteins and uses thereof
US7189507B2 (en) * 2001-06-18 2007-03-13 Pdl Biopharma, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
AU2002322280A1 (en) * 2001-06-21 2003-01-21 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
US20040076955A1 (en) * 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
US20040033495A1 (en) * 2001-08-03 2004-02-19 Eos Biotechnology, Inc. Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US20030124579A1 (en) * 2001-09-05 2003-07-03 Eos Biotechnology, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
US20070042360A1 (en) * 2001-09-17 2007-02-22 Eos Biotechnology, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
US20030232350A1 (en) * 2001-11-13 2003-12-18 Eos Biotechnology, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
CN101692090B (zh) * 2002-08-06 2014-06-25 约翰霍普金斯大学 用于检测卵巢癌的生物标记的用途
US20060183120A1 (en) * 2002-10-04 2006-08-17 Teh Bin T Molecular sub-classification of kidney tumors and the discovery of new diagnostic markers
WO2004063355A2 (en) * 2003-01-10 2004-07-29 Protein Design Labs, Inc. Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer
WO2004075713A2 (en) * 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
WO2004079014A2 (en) * 2003-03-04 2004-09-16 Arcturus Bioscience, Inc. Signatures of er status in breast cancer
US20050255114A1 (en) * 2003-04-07 2005-11-17 Nuvelo, Inc. Methods and diagnosis for the treatment of preeclampsia
KR20060013425A (ko) * 2003-05-29 2006-02-09 밀레니엄 파머슈티컬스 인코퍼레이티드 유방암의 확인, 평가, 예방 및 요법에 대한 조성물, 키트및 방법
FR2855832B1 (fr) * 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
US20070037204A1 (en) * 2003-08-08 2007-02-15 Hiroyuki ABURANTAI Gene overexpressed in cancer
AU2004264948A1 (en) * 2003-08-15 2005-02-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Multifactorial assay for cancer detection
EP1668149A4 (de) * 2003-09-05 2007-01-03 Royal Women S Hospital Diagnostischer marker für ovarialkarzinom
CA2761987A1 (en) * 2003-10-07 2005-04-21 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
EP2026071B1 (de) * 2004-02-19 2013-07-31 Yale University Identifizierung von Krebsprotein-Biomarkern unter Verwendung von Proteomtechniken
JP2008506123A (ja) * 2004-07-09 2008-02-28 トリパス イメージング， インコーポレイテッド 卵巣癌の検出のための方法および組成物
EP1969136A4 (de) * 2006-01-04 2009-04-15 Fujirebio America Inc Verwendung von he4 und anderen biochemischen markern zur beurteilung von endometrium- und gebärmutterkrebs

Also Published As

Publication number Publication date
KR20080094803A (ko) 2008-10-24
CA2637446A1 (en) 2007-08-09
JP2009524438A (ja) 2009-07-02
MX2008009592A (es) 2008-09-08
US20090068690A1 (en) 2009-03-12
EP1987360B1 (de) 2012-03-07
US20090075307A1 (en) 2009-03-19
EP1987360A2 (de) 2008-11-05
WO2007090076A2 (en) 2007-08-09
AU2007211085A1 (en) 2007-08-09
EP2363711A1 (de) 2011-09-07
CN101410715A (zh) 2009-04-15
US20070212721A1 (en) 2007-09-13
WO2007090076A3 (en) 2007-11-08
WO2007090076A8 (en) 2011-03-03
BRPI0707249A2 (pt) 2011-04-26

Similar Documents

Publication Publication Date Title
ATE548656T1 (de) Verfahren zur identifizierung von patienten mit erhöhter wahrscheinlichkeit des auftretens eines ovarialkarzinoms und zusammensetzungen dafür
ATE536553T1 (de) Verfahren zum nachweis grösserer ungünstiger kardiovaskulärer und zerebrovaskulärer ereignisse
WO2006036788A3 (en) Methods and compositions for evaluating breast cancer prognosis
ATE408828T1 (de) Verfahren zur erkennung eines ovarialkarzinoms
ATE457362T1 (de) Mrna-verhältnisse in harnsedimenten und/oder harn als prognostische und/oder theranostische marker für prostatakrebs
WO2008154098A3 (en) Reagents and methods for mirna expression analysis and identification of cancer biomarkers
WO2008095152A3 (en) Methods and materials for identifying the origin of a carcinoma of unknown primary origin
NZ593514A (en) p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer
WO2007035690A3 (en) Methods for diagnosing pancreatic cancer
IL181132A0 (en) Use of transthyretin as a biomarker for colorectal adenoma and/or carcinoma; method for detection and test system
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
CA2701341A1 (en) Method of assessing colorectal cancer from a stool sample by use of the marker combination calprotectin and hemoglobin/haptoglobin complex
RU2011140471A (ru) Способ диагностики эндометриоза и диагностический набор для эндометриоза
EP2074427A4 (de) Diagnostik-biomolekül(e)
ATE546550T1 (de) Verfahren zum nachweis von hpv sowie sonden, primer und kits
ATE462803T1 (de) Kit und verfahren zum nachweis von urothelkarzinom
ATE545867T1 (de) I-plastin-testverfahren zur in-vitro-diagnose von kolorektalkarzinom
PL1721162T3 (pl) Sposób oceny reumatoidalnego zapalenia stawów przez pomiar anty-CCP oraz amyloidu A w surowicy
Allison Ancillary prognostic and predictive testing in breast cancer: focus on discordant, unusual, and borderline results
WO2006122053A3 (en) Biomarkers for evaluating likelihood of tumor sensitivity to an mtor inhibitor
WO2021211969A3 (en) Fluorescence quenching immunossay
CA2798441A1 (en) Methods for predicting sensitivity to treatment with a targeted tyrosine kinase inhibitor
ATE479778T1 (de) Verfahren zur diagnose nicht-kleinzelliger lungenkarzinome über die trna-dihydrouridin- synthaseaktivität von urlc8
DE602005026587D1 (de) Verwendung eines endoplasmin-fragments und von derivaten davon als biomarker für kolorektaladenom und/oder -karzinom; nachweisverfahren und testsystem
JP2017529074A (ja) 治療剤に対する抵抗性の診断に使用するためのＥＲＣＣ１アイソフォーム３のｍＲＮＡおよび／またはタンパク質ならびにこのｍＲＮＡおよび／またはタンパク質を使用する治療剤に対する抵抗性を診断するための方法