ATE542806T1 - Diarylmethylpiperazinderivate, deren herstellung und deren verwendung - Google Patents

Diarylmethylpiperazinderivate, deren herstellung und deren verwendung

Info

Publication number
ATE542806T1
ATE542806T1 AT05762524T AT05762524T ATE542806T1 AT E542806 T1 ATE542806 T1 AT E542806T1 AT 05762524 T AT05762524 T AT 05762524T AT 05762524 T AT05762524 T AT 05762524T AT E542806 T1 ATE542806 T1 AT E542806T1
Authority
AT
Austria
Prior art keywords
diarylmethylpiperazine
derivatives
production
diarylmethylpiperazine derivatives
Prior art date
Application number
AT05762524T
Other languages
German (de)
English (en)
Inventor
William Brown
Andrew Griffin
Thomas Hudzik
Carla Maciag
Gennady Smagin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32906880&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE542806(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE542806T1 publication Critical patent/ATE542806T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05762524T 2004-08-02 2005-07-27 Diarylmethylpiperazinderivate, deren herstellung und deren verwendung ATE542806T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0401968A SE0401968D0 (sv) 2004-08-02 2004-08-02 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
US60236304P 2004-08-18 2004-08-18
PCT/SE2005/001186 WO2006014133A1 (en) 2004-08-02 2005-07-27 Diarylmethyl piperazine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
ATE542806T1 true ATE542806T1 (de) 2012-02-15

Family

ID=32906880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05762524T ATE542806T1 (de) 2004-08-02 2005-07-27 Diarylmethylpiperazinderivate, deren herstellung und deren verwendung

Country Status (22)

Country Link
US (2) US20070249619A1 (enExample)
EP (1) EP1781631B1 (enExample)
JP (1) JP5006785B2 (enExample)
CN (1) CN1993338B (enExample)
AR (1) AR050260A1 (enExample)
AT (1) ATE542806T1 (enExample)
AU (1) AU2005267929B2 (enExample)
BR (1) BRPI0514014A (enExample)
CA (1) CA2576067C (enExample)
ES (1) ES2379364T3 (enExample)
NZ (1) NZ553539A (enExample)
PL (1) PL1781631T3 (enExample)
PT (1) PT1781631E (enExample)
RS (1) RS52315B (enExample)
RU (1) RU2404172C2 (enExample)
SE (1) SE0401968D0 (enExample)
SG (1) SG155181A1 (enExample)
SI (1) SI1781631T1 (enExample)
TW (1) TWI370124B (enExample)
UA (1) UA87146C2 (enExample)
WO (1) WO2006014133A1 (enExample)
ZA (1) ZA200700680B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319876T3 (es) 2001-05-18 2009-05-14 Astrazeneca Ab Derivados de 4 (fenil-piperazinil-metil) benzamida y su uso para el tratamiento de la ansiedad o trastornos gastrointestinales.
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
CA2707105C (en) 2007-12-11 2013-02-12 F. Hoffmann-La Roche Ag Inhibitors of stearoyl-coa desaturase
US20090291966A1 (en) * 2008-05-20 2009-11-26 Astrazeneca Ab Method Of Treating Anxious Major Depressive Disorder
US8314250B2 (en) 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
US20110207745A1 (en) * 2009-11-25 2011-08-25 Astrazeneca Ab Solid forms of 4--n,n-diethylbenzamide, compositions thereof, and uses therewith
US9073881B2 (en) 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH585209A5 (enExample) * 1973-06-29 1977-02-28 Cermol Sa
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US5840896A (en) * 1989-11-22 1998-11-24 Janssen Pharmaceutica, N.V. Method of preventing or limiting reperfusion damage
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
DK0711289T3 (da) * 1993-07-30 2000-11-06 Delta Pharmaceuticals Inc Piperazinforbindelser til anvendelse i terapi
SE9504661D0 (sv) * 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0001209D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101766D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
ES2319876T3 (es) * 2001-05-18 2009-05-14 Astrazeneca Ab Derivados de 4 (fenil-piperazinil-metil) benzamida y su uso para el tratamiento de la ansiedad o trastornos gastrointestinales.
JP4892654B2 (ja) * 2001-10-29 2012-03-07 マウント クック ファーマ，インコーポレーテッド デルタレセプターアゴニスト化合物によるうつ病の治療方法
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
SE0203302D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203300D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0400027D0 (sv) * 2004-01-09 2004-01-09 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
SE0401968D0 (sv) * 2004-08-02 2004-08-02 Astrazeneca Ab Diarylmethyl piperazine derivatives, preparations thereof and uses thereof

Also Published As

Publication number Publication date
AU2005267929B2 (en) 2010-04-08
UA87146C2 (ru) 2009-06-25
EP1781631A1 (en) 2007-05-09
NZ553539A (en) 2010-09-30
PT1781631E (pt) 2012-05-07
PL1781631T3 (pl) 2012-07-31
JP2008508350A (ja) 2008-03-21
ES2379364T3 (es) 2012-04-25
JP5006785B2 (ja) 2012-08-22
US20070249619A1 (en) 2007-10-25
EP1781631B1 (en) 2012-01-25
SE0401968D0 (sv) 2004-08-02
TWI370124B (en) 2012-08-11
ZA200700680B (en) 2008-09-25
AR050260A1 (es) 2006-10-11
SI1781631T1 (sl) 2012-05-31
CN1993338B (zh) 2011-07-06
RS52315B (sr) 2012-12-31
BRPI0514014A (pt) 2008-05-27
US20060030569A1 (en) 2006-02-09
CA2576067A1 (en) 2006-02-09
AU2005267929A1 (en) 2006-02-09
CA2576067C (en) 2011-05-03
TW200612930A (en) 2006-05-01
RU2007101522A (ru) 2008-09-10
SG155181A1 (en) 2009-09-30
RU2404172C2 (ru) 2010-11-20
CN1993338A (zh) 2007-07-04
WO2006014133A1 (en) 2006-02-09

Similar Documents

Publication Publication Date Title
ATE372998T1 (de) 1-aminophthalazinderivate, deren herstellung und deren therapeutische verwendung
DE602005006815D1 (de) 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung
ATE430150T1 (de) 8-ä3-amino-piperidin-1-ylü-xanthine, deren herstellung und deren verwendung als dpp-iv hemmer
ATE467633T1 (de) 2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung
DE502005010912D1 (de) Dihydropteridinonderivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE60336907D1 (de) Spirobifluorenderivate, deren herstellung und deren verwendung
EP1900430A4 (en) HYDROCRACKING CATALYST, ITS PREPARATION AND USE
DE502005002105D1 (de) 4-benzimidazol-2-yl-pyridazin-3-on-derivative, ihre herstellung und verwendung in arzneimitteln
ATE316966T1 (de) Benzoxazinonderivate, deren herstellung und deren verwendung als medikamente
ATE409184T1 (de) Dioxan-2-alkylkarbamaten derivaten, deren herstellung und deren therapeutischen verwendung
ATE420072T1 (de) Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel
ATE519727T1 (de) 4-chlor-4-alkoxy-1,1,1-trifluor-2-butanone, deren herstellung und deren verwendung bei der herstellung von 4-alkoxy-1,1,1-trifluor-3-buten-2-onen
ATE502035T1 (de) 2-amido-4-phenylthiazol-derivate, ihre herstellung und ihre therapeutische verwendung
DE602005019743D1 (de) Oxopiperidinderivate, ihre herstellung und therapeutische verwendung
ATE396994T1 (de) 3-phenylpyridoindolderivate, ihre herstellung und verwendung
ATE542806T1 (de) Diarylmethylpiperazinderivate, deren herstellung und deren verwendung
ATE520654T1 (de) Polypyrrol-derivate, ihre herstellung und ihre therapeutische verwendung
ATE403649T1 (de) Neue imidazolderivative, deren herstellung und deren verwendung als medikament
ATE451923T1 (de) N-(arylalkyl)-1h-pyrrolopyridin-2-carboxamid- derivate, ihre herstellung und verwendung
DE602005002424D1 (de) Polyhydrosiloxanverbindungen, Erzeugnisse und deren Verwendung
ATE417846T1 (de) Aminotropanderivate, deren herstellung und deren therapeutische verwendung
EP1968616A4 (en) DERIVATIVES OF SULINDAC, USE AND PREPARATION THEREOF
ATE423119T1 (de) Pyridoä2,3-düpyrimidin-derivate sowie deren herstellung und therapeutische anwendung
ATE473971T1 (de) (4-phenylpiperazin-1-yl)acylpiperidinderivate, deren herstellung und deren verwendung in therapeutka
ATE555097T1 (de) 4-cycloalkyl-substituierte tetrahydrochinolinderivate und deren verwendung als medikamente