ATE540976T1 - Antikörper zur inhibierung der blutgerinnung und verfahren zur deren verwendung - Google Patents
Antikörper zur inhibierung der blutgerinnung und verfahren zur deren verwendungInfo
- Publication number
- ATE540976T1 ATE540976T1 AT98910277T AT98910277T ATE540976T1 AT E540976 T1 ATE540976 T1 AT E540976T1 AT 98910277 T AT98910277 T AT 98910277T AT 98910277 T AT98910277 T AT 98910277T AT E540976 T1 ATE540976 T1 AT E540976T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- antibodies
- blood coagulation
- native human
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/814,806 US5986065A (en) | 1997-03-10 | 1997-03-10 | Antibodies for inhibiting blood coagulation and methods of use thereof |
| PCT/US1998/004644 WO1998040408A1 (en) | 1997-03-10 | 1998-03-10 | Antibodies for inhibiting blood coagulation and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540976T1 true ATE540976T1 (de) | 2012-01-15 |
Family
ID=25216046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98910277T ATE540976T1 (de) | 1997-03-10 | 1998-03-10 | Antikörper zur inhibierung der blutgerinnung und verfahren zur deren verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US5986065A (de) |
| EP (1) | EP0975672B1 (de) |
| JP (2) | JP4281852B2 (de) |
| KR (2) | KR20060015702A (de) |
| CN (2) | CN101298479A (de) |
| AT (1) | ATE540976T1 (de) |
| AU (1) | AU745506B2 (de) |
| CA (1) | CA2283746C (de) |
| DK (1) | DK0975672T3 (de) |
| ES (1) | ES2380452T3 (de) |
| PT (1) | PT975672E (de) |
| WO (1) | WO1998040408A1 (de) |
Families Citing this family (65)
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| US20060235209A9 (en) * | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20040229282A1 (en) * | 1997-03-10 | 2004-11-18 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) * | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| EP1115396A4 (de) * | 1998-09-25 | 2002-05-22 | Sunol Molecular Corp | Pharmazeutisch aktive verbindungen und deren verwendungsmethoden |
| US7764130B2 (en) * | 1999-01-22 | 2010-07-27 | Multigig Inc. | Electronic circuitry |
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| US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
| HUP0203486A2 (hu) * | 1999-10-01 | 2003-02-28 | Chugai Seiyaku Kabushiki Kaisha | Véralvadással összefüggő betegségek megelőzése és kezelése |
| EP1829535A3 (de) * | 1999-10-27 | 2007-10-24 | Tanox, Inc. | Gewebefaktor-Antagonisten und Verfahren zu deren Verwendung |
| US6608066B1 (en) | 1999-10-27 | 2003-08-19 | Sunol Molecular Corporation | Tissue factor antagonists and methods of use thereof |
| US6703494B2 (en) | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
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| US7160540B2 (en) * | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
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| JPWO2002078738A1 (ja) * | 2001-03-26 | 2004-10-07 | 鈴木 宏治 | 血液レオロジー改善剤 |
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| TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
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| US20090011991A1 (en) * | 2002-03-08 | 2009-01-08 | Emory University | Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis |
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| KR101080587B1 (ko) * | 2002-05-01 | 2011-11-04 | 바이엘 파마 악티엔게젤샤프트 | 항응고제로서의 신규 조직 인자 표적화된 항체 |
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| US7425328B2 (en) * | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
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| UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
| CN101717447B (zh) * | 2009-12-17 | 2012-06-27 | 山西省生物研究所 | 一种抗人重组组织因子单克隆抗体的制备方法 |
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| CA3055091A1 (en) | 2017-03-14 | 2018-09-20 | The University Of Melbourne | Treatment for gingivitis |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法 |
| CA3099547A1 (en) | 2018-05-07 | 2019-11-14 | Reshma Abdulla RANGWALA | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
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| CA3173263A1 (en) * | 2020-03-30 | 2021-10-07 | Yasuhiro Matsumura | Antibody drug conjugate |
| US20230384330A1 (en) * | 2020-10-23 | 2023-11-30 | The Regents Of The University Of Michigan | Compositions and methods relating to the identification and treatment of immunothrombotic conditions |
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| US6703494B2 (en) * | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
| AU5081401A (en) | 2000-03-16 | 2001-10-03 | Genentech Inc | Anti-tissue factor antibodies with enhanced anticoagulant potency |
| JP2004532642A (ja) * | 2001-06-13 | 2004-10-28 | ジェネンテック・インコーポレーテッド | 動物細胞の培養方法と動物細胞でのポリペプチド産生 |
| IL160998A0 (en) | 2001-10-02 | 2004-08-31 | Novo Nordisk As | Human tissue factor antibodies |
| TWI338009B (en) | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
| AU2004255553B2 (en) * | 2003-06-19 | 2009-08-20 | Genentech, Inc. | Compositions and methods for treating coagulation related disorders |
-
1997
- 1997-03-10 US US08/814,806 patent/US5986065A/en not_active Expired - Lifetime
-
1998
- 1998-03-10 KR KR1020067002062A patent/KR20060015702A/ko not_active Ceased
- 1998-03-10 CN CNA200810082354XA patent/CN101298479A/zh active Pending
- 1998-03-10 AT AT98910277T patent/ATE540976T1/de active
- 1998-03-10 WO PCT/US1998/004644 patent/WO1998040408A1/en not_active Ceased
- 1998-03-10 AU AU64559/98A patent/AU745506B2/en not_active Expired
- 1998-03-10 EP EP98910277A patent/EP0975672B1/de not_active Expired - Lifetime
- 1998-03-10 KR KR1019997007803A patent/KR100585473B1/ko not_active Expired - Lifetime
- 1998-03-10 PT PT98910277T patent/PT975672E/pt unknown
- 1998-03-10 DK DK98910277.7T patent/DK0975672T3/da active
- 1998-03-10 CN CNB988041693A patent/CN100383163C/zh not_active Expired - Lifetime
- 1998-03-10 ES ES98910277T patent/ES2380452T3/es not_active Expired - Lifetime
- 1998-03-10 JP JP53970398A patent/JP4281852B2/ja not_active Expired - Lifetime
- 1998-03-10 CA CA2283746A patent/CA2283746C/en not_active Expired - Lifetime
-
1999
- 1999-04-16 US US09/293,854 patent/US6555319B2/en not_active Expired - Lifetime
-
2002
- 2002-11-12 US US10/293,417 patent/US20030082636A1/en not_active Abandoned
-
2005
- 2005-03-22 US US11/087,528 patent/US20050271664A1/en not_active Abandoned
-
2008
- 2008-06-10 US US12/136,718 patent/US7824677B2/en not_active Expired - Fee Related
- 2008-06-18 JP JP2008159661A patent/JP2009022275A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000075734A (ko) | 2000-12-26 |
| US20030082636A1 (en) | 2003-05-01 |
| US20020168357A1 (en) | 2002-11-14 |
| JP4281852B2 (ja) | 2009-06-17 |
| AU6455998A (en) | 1998-09-29 |
| CA2283746C (en) | 2017-01-17 |
| US6555319B2 (en) | 2003-04-29 |
| CA2283746A1 (en) | 1998-09-17 |
| EP0975672A1 (de) | 2000-02-02 |
| PT975672E (pt) | 2012-02-15 |
| DK0975672T3 (da) | 2012-02-27 |
| US20050271664A1 (en) | 2005-12-08 |
| US5986065A (en) | 1999-11-16 |
| WO1998040408A1 (en) | 1998-09-17 |
| CN100383163C (zh) | 2008-04-23 |
| HK1029123A1 (zh) | 2001-03-23 |
| ES2380452T3 (es) | 2012-05-11 |
| EP0975672A4 (de) | 2005-02-02 |
| US7824677B2 (en) | 2010-11-02 |
| KR20060015702A (ko) | 2006-02-17 |
| US20090041766A1 (en) | 2009-02-12 |
| KR100585473B1 (ko) | 2006-06-02 |
| JP2001516214A (ja) | 2001-09-25 |
| JP2009022275A (ja) | 2009-02-05 |
| EP0975672B1 (de) | 2012-01-11 |
| AU745506B2 (en) | 2002-03-21 |
| CN1252810A (zh) | 2000-05-10 |
| CN101298479A (zh) | 2008-11-05 |
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