ATE540673T1 - Verwendung von a3-adenosin-rezeptor-agonisten bei der behandlung von osteoarthritis - Google Patents
Verwendung von a3-adenosin-rezeptor-agonisten bei der behandlung von osteoarthritisInfo
- Publication number
- ATE540673T1 ATE540673T1 AT06821594T AT06821594T ATE540673T1 AT E540673 T1 ATE540673 T1 AT E540673T1 AT 06821594 T AT06821594 T AT 06821594T AT 06821594 T AT06821594 T AT 06821594T AT E540673 T1 ATE540673 T1 AT E540673T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- osteoarthritis
- a3ar
- agonist
- adenosine receptor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74063105P | 2005-11-30 | 2005-11-30 | |
PCT/IL2006/001374 WO2007063538A1 (en) | 2005-11-30 | 2006-11-29 | Use of a3 adenosine receptor agonist in osteoarthritis treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540673T1 true ATE540673T1 (de) | 2012-01-15 |
Family
ID=37872156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06821594T ATE540673T1 (de) | 2005-11-30 | 2006-11-29 | Verwendung von a3-adenosin-rezeptor-agonisten bei der behandlung von osteoarthritis |
Country Status (12)
Country | Link |
---|---|
US (2) | US20080300213A1 (de) |
EP (1) | EP1959939B1 (de) |
JP (2) | JP5339916B2 (de) |
KR (1) | KR101101252B1 (de) |
CN (1) | CN101330909B (de) |
AT (1) | ATE540673T1 (de) |
AU (1) | AU2006321165B2 (de) |
BR (1) | BRPI0619395A2 (de) |
CA (1) | CA2622879C (de) |
DK (1) | DK1959939T3 (de) |
ES (1) | ES2379591T3 (de) |
WO (1) | WO2007063538A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
PT2013211E (pt) | 2006-04-21 | 2012-06-21 | Novartis Ag | Derivados de purina para utilização como agonistas de receptores a2a de adenosina |
GB0607953D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
GB0607944D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
EP1889846A1 (de) | 2006-07-13 | 2008-02-20 | Novartis AG | Purinderivate als A2a Agonisten |
EP1903044A1 (de) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosinderivate als Agonisten des A2A-Rezeptors |
JP2010508835A (ja) * | 2006-11-10 | 2010-03-25 | ノバルティス アーゲー | シクロペンテンジオールモノアセテート誘導体 |
HUE034474T2 (en) | 2007-03-14 | 2018-02-28 | Can Fite Biopharma Ltd | Method for the synthesis of IB-meca |
IL184620A0 (en) * | 2007-07-15 | 2008-01-20 | Can Fite Biopharma Ltd | Composition for the treatment of inflammation |
ES2531828T3 (es) | 2008-03-31 | 2015-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Derivados de purina como agonistas selectivos de los receptores A3 de adenosina |
US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
AU2009276411B2 (en) | 2008-08-01 | 2014-08-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists and partial agonists |
US10441541B2 (en) * | 2015-09-14 | 2019-10-15 | New York University | Methods and compositions for treating osteoarthritis and promoting cartilage formation |
IL254535A0 (en) * | 2017-09-17 | 2017-11-30 | Can Fite Biopharma Ltd | Adenosine a3 receptor ligand for use in the management of cytokine release syndrome |
IL272078A (en) | 2020-01-16 | 2021-07-29 | Can Fite Biopharma Ltd | Cannabinoids for use in therapy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7331094A (en) * | 1993-07-13 | 1995-02-13 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | A3 adenosine receptor agonists |
US5688774A (en) | 1993-07-13 | 1997-11-18 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
JP2004135657A (ja) * | 2002-08-21 | 2004-05-13 | Kyowa Hakko Kogyo Co Ltd | ヒトa3アデノシン受容体を発現するトランスジェニック非ヒト哺乳動物 |
AU2003282359A1 (en) * | 2002-11-19 | 2004-06-15 | Can-Fite Biopharma Ltd. | A3ar agonists for the treatment of inflammatory arthritis |
GB0305150D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
GB0305153D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Identification of therapeutic compounds |
WO2005000331A2 (en) * | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
US7807675B2 (en) * | 2004-04-02 | 2010-10-05 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid-methotrexate conjugate |
BRPI0517639A (pt) * | 2004-11-08 | 2008-10-14 | Can Fite Biopharma Ltd | método para o tratamento de ressorção óssea acelerada, composição farmacêutica, e, uso de um agonista de a3ar |
JP4842964B2 (ja) * | 2004-12-02 | 2011-12-21 | キャン−ファイト・バイオファーマ・リミテッド | 炎症用生体マーカー |
US20080051365A1 (en) * | 2004-12-02 | 2008-02-28 | Can-Fite Biopharma Ltd. | Treatment of Inflammation |
-
2006
- 2006-11-29 AT AT06821594T patent/ATE540673T1/de active
- 2006-11-29 CA CA2622879A patent/CA2622879C/en active Active
- 2006-11-29 EP EP06821594A patent/EP1959939B1/de active Active
- 2006-11-29 KR KR1020087015391A patent/KR101101252B1/ko active IP Right Grant
- 2006-11-29 BR BRPI0619395-1A patent/BRPI0619395A2/pt not_active Application Discontinuation
- 2006-11-29 US US11/632,897 patent/US20080300213A1/en not_active Abandoned
- 2006-11-29 DK DK06821594.6T patent/DK1959939T3/da active
- 2006-11-29 JP JP2008542938A patent/JP5339916B2/ja active Active
- 2006-11-29 AU AU2006321165A patent/AU2006321165B2/en active Active
- 2006-11-29 ES ES06821594T patent/ES2379591T3/es active Active
- 2006-11-29 WO PCT/IL2006/001374 patent/WO2007063538A1/en active Application Filing
- 2006-11-29 CN CN2006800448083A patent/CN101330909B/zh active Active
-
2013
- 2013-05-29 JP JP2013113299A patent/JP2013166789A/ja not_active Withdrawn
-
2016
- 2016-05-20 US US15/160,462 patent/US10265337B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2006321165B2 (en) | 2010-04-22 |
CN101330909A (zh) | 2008-12-24 |
EP1959939B1 (de) | 2012-01-11 |
ES2379591T3 (es) | 2012-04-27 |
US10265337B2 (en) | 2019-04-23 |
JP2013166789A (ja) | 2013-08-29 |
DK1959939T3 (da) | 2012-04-23 |
KR101101252B1 (ko) | 2012-01-04 |
JP2009517458A (ja) | 2009-04-30 |
CN101330909B (zh) | 2012-09-26 |
WO2007063538A1 (en) | 2007-06-07 |
CA2622879A1 (en) | 2007-06-07 |
US20080300213A1 (en) | 2008-12-04 |
CA2622879C (en) | 2011-07-05 |
EP1959939A1 (de) | 2008-08-27 |
JP5339916B2 (ja) | 2013-11-13 |
BRPI0619395A2 (pt) | 2011-10-04 |
KR20080071609A (ko) | 2008-08-04 |
AU2006321165A1 (en) | 2007-06-07 |
US20160263142A1 (en) | 2016-09-15 |
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