ATE537870T1 - Periphere nervenfeldstimulation und rückenmarksstimulation - Google Patents

Periphere nervenfeldstimulation und rückenmarksstimulation

Info

Publication number
ATE537870T1
ATE537870T1 AT06772757T AT06772757T ATE537870T1 AT E537870 T1 ATE537870 T1 AT E537870T1 AT 06772757 T AT06772757 T AT 06772757T AT 06772757 T AT06772757 T AT 06772757T AT E537870 T1 ATE537870 T1 AT E537870T1
Authority
AT
Austria
Prior art keywords
pnfs
stimulation
therapies
combination
spinal cord
Prior art date
Application number
AT06772757T
Other languages
English (en)
Inventor
Ethan Rooney
Carl Wahlstrand
Gary King
Thomas Cross
Kenneth Heruth
Paul Wacnik
Jeffrey Evanson
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/374,793 external-priority patent/US8244360B2/en
Application filed by Medtronic Inc filed Critical Medtronic Inc
Application granted granted Critical
Publication of ATE537870T1 publication Critical patent/ATE537870T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071Pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0531Brain cortex electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0534Electrodes for deep brain stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0553Paddle shaped electrodes, e.g. for laminotomy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0558Anchoring or fixation means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36021External stimulators, e.g. with patch electrodes for treatment of pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37205Microstimulators, e.g. implantable through a cannula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/375Constructional arrangements, e.g. casings
    • A61N1/3756Casings with electrodes thereon, e.g. leadless stimulators
AT06772757T 2005-06-09 2006-06-09 Periphere nervenfeldstimulation und rückenmarksstimulation ATE537870T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68920405P 2005-06-09 2005-06-09
US70062705P 2005-07-19 2005-07-19
US76182306P 2006-01-25 2006-01-25
US11/374,793 US8244360B2 (en) 2005-06-09 2006-03-14 Regional therapies for treatment of pain
US11/375,492 US7890166B2 (en) 2005-06-09 2006-03-14 Regional therapies for treatment of pain
US11/374,852 US7813803B2 (en) 2005-06-09 2006-03-14 Regional therapies for treatment of pain
PCT/US2006/022565 WO2006135791A2 (en) 2005-06-09 2006-06-09 Peripheral nerve field stimulation and spinal cord stimulation

Publications (1)

Publication Number Publication Date
ATE537870T1 true ATE537870T1 (de) 2012-01-15

Family

ID=37402508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06772757T ATE537870T1 (de) 2005-06-09 2006-06-09 Periphere nervenfeldstimulation und rückenmarksstimulation

Country Status (4)

Country Link
US (2) US8644941B2 (de)
EP (1) EP1904160B1 (de)
AT (1) ATE537870T1 (de)
WO (1) WO2006135791A2 (de)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US9375573B2 (en) * 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
AU2003234385A1 (en) 2002-05-09 2003-11-11 Michael S. Brogan Electrical stimulation unit and waterbath system
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US8340779B2 (en) 2003-08-29 2012-12-25 Medtronic, Inc. Percutaneous flat lead introducer
US8644941B2 (en) 2005-06-09 2014-02-04 Medtronic, Inc. Peripheral nerve field stimulation and spinal cord stimulation
US7792591B2 (en) * 2005-06-09 2010-09-07 Medtronic, Inc. Introducer for therapy delivery elements
US8620435B2 (en) 2005-06-09 2013-12-31 Medtronic, Inc. Combination therapy including peripheral nerve field stimulation
WO2007087626A2 (en) * 2006-01-26 2007-08-02 Advanced Neuromodulation Systems, Inc. Method of neurosimulation of distinct neural structures using single paddle lead
US20080027347A1 (en) * 2006-06-23 2008-01-31 Neuro Vista Corporation, A Delaware Corporation Minimally Invasive Monitoring Methods
US20080091255A1 (en) * 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
US9898656B2 (en) * 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
US20080183097A1 (en) 2007-01-25 2008-07-31 Leyde Kent W Methods and Systems for Measuring a Subject's Susceptibility to a Seizure
US11331488B2 (en) 2007-03-09 2022-05-17 Mainstay Medical Limited Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
US11679261B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention
US9072897B2 (en) 2007-03-09 2015-07-07 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US10925637B2 (en) * 2010-03-11 2021-02-23 Mainstay Medical Limited Methods of implanting electrode leads for use with implantable neuromuscular electrical stimulator
ES2827186T3 (es) 2007-03-09 2021-05-20 Mainstay Medical Ltd Sistema de estimulación eléctrica neuromuscular
US11679262B2 (en) 2007-03-09 2023-06-20 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US20080255582A1 (en) * 2007-04-11 2008-10-16 Harris John F Methods and Template Assembly for Implanting an Electrode Array in a Patient
US9788744B2 (en) * 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US9259591B2 (en) * 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US8260434B2 (en) 2008-01-23 2012-09-04 Boston Scientific Neuromodulation Corporation Paddle lead configurations for electrical stimulation systems and methods of making and using
US9492655B2 (en) 2008-04-25 2016-11-15 Boston Scientific Neuromodulation Corporation Stimulation system with percutaneously deliverable paddle lead and methods of making and using
WO2010011969A1 (en) * 2008-07-24 2010-01-28 Boston Scientific Neuromodulation Corporation System and method for avoiding, reversing, and managing neurological accomodation to electrical stimulation
US8954153B2 (en) * 2008-12-05 2015-02-10 Ndi Medical, Llc Systems and methods to place one or more leads in tissue to electrically stimulate nerves of passage to treat pain
US8700177B2 (en) 2008-08-01 2014-04-15 Ndi Medical, Llc Systems and methods for providing percutaneous electrical stimulation
CA2957010C (en) 2008-09-26 2017-07-04 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
US9289613B2 (en) 2008-10-31 2016-03-22 Medtronic, Inc. Interdevice impedance
US8612020B2 (en) * 2008-10-31 2013-12-17 Medtronic, Inc. Implantable therapeutic nerve stimulator
US8311639B2 (en) 2009-07-08 2012-11-13 Nevro Corporation Systems and methods for adjusting electrical therapy based on impedance changes
US20150105840A1 (en) 2008-12-05 2015-04-16 Spr Therapeutics, Llc Systems and methods to place one or more leads in tissue for providing functional and/or therapeutic stimulation
US9895530B2 (en) 2008-12-05 2018-02-20 Spr Therapeutics, Inc. Systems and methods to place one or more leads in tissue to electrically stimulate nerves of passage to treat pain
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US9370654B2 (en) * 2009-01-27 2016-06-21 Medtronic, Inc. High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation
EP2403589B1 (de) 2009-02-10 2014-01-22 Nevro Corporation Systeme zur verabreichung einer neuralen therapie in korrelation zum patientenstatus
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
US8452417B2 (en) * 2009-07-23 2013-05-28 Rosa M. Navarro System and method for treating pain with peripheral and spinal neuromodulation
US8498710B2 (en) 2009-07-28 2013-07-30 Nevro Corporation Linked area parameter adjustment for spinal cord stimulation and associated systems and methods
EP2461862A4 (de) * 2009-08-06 2013-02-20 Giancarlo Barolat System und verfahren zur stimulation des hinteren tibialnervs und/oder anderer nerven
WO2011019935A1 (en) * 2009-08-12 2011-02-17 Medtronic, Inc. Dorsal column stimulation therapy
US9409013B2 (en) 2009-10-20 2016-08-09 Nyxoah SA Method for controlling energy delivery as a function of degree of coupling
US9415216B2 (en) 2009-10-20 2016-08-16 Nyxoah SA Devices for treatment of sleep apnea
US8577465B2 (en) 2011-09-30 2013-11-05 Nyxoah SA Modulator apparatus configured for implantation
US10806926B2 (en) * 2009-10-20 2020-10-20 Man & Science Sa Implantable electrical stimulator
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
US11684774B2 (en) 2010-03-11 2023-06-27 Mainstay Medical Limited Electrical stimulator for treatment of back pain and methods of use
US9950159B2 (en) 2013-10-23 2018-04-24 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
US11786725B2 (en) 2012-06-13 2023-10-17 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same
CA2792529C (en) 2010-03-11 2018-06-05 Mainstay Medical, Inc. Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use
US9999763B2 (en) 2012-06-13 2018-06-19 Mainstay Medical Limited Apparatus and methods for anchoring electrode leads adjacent to nervous tissue
US8788047B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US8788048B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
US10071240B2 (en) 2010-11-11 2018-09-11 University Of Iowa Research Foundation Floating electrodes that engage and accommodate movement of the spinal cord
WO2012065125A1 (en) 2010-11-11 2012-05-18 University Of Iowa Research Foundation Remotely controlled and/or laterally supported devices for direct spinal cord stimulation
US8788046B2 (en) 2010-11-11 2014-07-22 Spr Therapeutics, Llc Systems and methods for the treatment of pain through neural fiber stimulation
CN103328038A (zh) * 2010-12-01 2013-09-25 史拜诺莫度雷森公司 向神经解剖结构直接递送药剂
US20120296395A1 (en) 2011-05-16 2012-11-22 Hamann Jason J Method and apparatus for neurostimulation with prevention of neural accommodation
WO2013019853A1 (en) 2011-08-02 2013-02-07 Mainstay Medical, Inc. Apparatus for anchoring electrode leads for use with implantable neuromuscular electrical stimulator
AU2012304370B2 (en) 2011-09-08 2016-01-28 Nevro Corporation Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods
US9814884B2 (en) 2011-11-04 2017-11-14 Nevro Corp. Systems and methods for detecting faults and/or adjusting electrical therapy based on impedance changes
AU2012332102B2 (en) 2011-11-04 2017-05-04 Nevro Corporation Medical device communication and charding assemblies for use with implantable signal generators
USD736383S1 (en) 2012-11-05 2015-08-11 Nevro Corporation Implantable signal generator
CA2864473C (en) 2011-11-11 2021-10-19 The Regents Of The University Of California Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry
ES2637383T3 (es) 2011-11-18 2017-10-13 Boston Scientific Neuromodulation Corporation Interfaz de usuario de vinculación de electrodos entre sí durante la programación de un sistema de neuroestimulación
WO2013082022A1 (en) * 2011-11-29 2013-06-06 Cardiac Pacemakers, Inc. Autonomic modulation using peripheral nerve field stimulation
AU2012355384B2 (en) 2011-12-19 2017-03-16 Mainstay Medical Limited Apparatus for rehabilitating a muscle and assessing progress of rehabilitation
WO2013101772A1 (en) 2011-12-30 2013-07-04 Relievant Medsystems, Inc. Systems and methods for treating back pain
EP2809389B1 (de) 2012-01-30 2017-05-24 University of Iowa Research Foundation Behandlung von rückenschmerzen durch anlegen eines hochfrequenten elektrischen stimulus direkt am rückenmark
CA2863372A1 (en) 2012-01-30 2013-08-08 University Of Iowa Research Foundation System that secures an electrode array to the spinal cord for treating back pain
AU2013229854B2 (en) * 2012-03-08 2017-08-17 Spr Therapeutics, Inc. System and method for treatment of pain related to limb joint replacement surgery
EP2822646B1 (de) 2012-03-09 2023-10-18 Mayo Foundation For Medical Education And Research Modulierung afferenter signale zur behandlung medizinischer leiden
US10195419B2 (en) 2012-06-13 2019-02-05 Mainstay Medical Limited Electrode leads for use with implantable neuromuscular electrical stimulator
US9186501B2 (en) 2012-06-13 2015-11-17 Mainstay Medical Limited Systems and methods for implanting electrode leads for use with implantable neuromuscular electrical stimulator
EP2866888B1 (de) 2012-06-30 2018-11-07 Boston Scientific Neuromodulation Corporation System zur vermischung niederfrequenter quellen für hochfrequente neuromodulation
WO2014021926A1 (en) * 2012-07-31 2014-02-06 Abhi Vase System and method for autonimic blood pressure regulation
CN104662787B (zh) 2012-08-31 2017-08-25 艾尔弗雷德·E·曼科学研究基金会 用于感应电力传输的反馈控制线圈驱动器
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
US9002459B2 (en) 2012-09-19 2015-04-07 Boston Scientific Neuromodulation Corporation Method for selectively modulating neural elements in the dorsal horn
WO2014071161A1 (en) 2012-11-05 2014-05-08 Relievant Medsystems, Inc. System and methods for creating curved paths through bone and modulating nerves within the bone
US9895538B1 (en) 2013-01-22 2018-02-20 Nevro Corp. Systems and methods for deploying patient therapy devices
US9731133B1 (en) 2013-01-22 2017-08-15 Nevro Corp. Systems and methods for systematically testing a plurality of therapy programs in patient therapy devices
US9295840B1 (en) 2013-01-22 2016-03-29 Nevro Corporation Systems and methods for automatically programming patient therapy devices
AU2014218716B2 (en) 2013-02-22 2017-10-19 Boston Scientific Neuromodulation Corporation Neurostimulation system having increased flexibility for creating complex pulse trains
US9174053B2 (en) 2013-03-08 2015-11-03 Boston Scientific Neuromodulation Corporation Neuromodulation using modulated pulse train
US9446235B2 (en) 2013-03-14 2016-09-20 Medtronic, Inc. Low frequency electrical stimulation therapy for pelvic floor disorders
JP6174781B2 (ja) 2013-03-15 2017-08-02 アルフレッド イー. マン ファウンデーション フォー サイエンティフィック リサーチ 高電圧モニタリングを行う逐次比較型アナログ・デジタル変換器
CN105164920B (zh) 2013-03-15 2018-02-06 艾尔弗雷德·E·曼科学研究基金会 具有快速开启时间的电流感测多输出电流刺激器
EP3878507A1 (de) 2013-03-15 2021-09-15 The Regents Of The University Of California Transkutane elektrische stimulation an mehreren stellen des rückenmarks zur bewegungserleichterung
ES2874188T3 (es) 2013-03-15 2021-11-04 Boston Scient Neuromodulation Corp Sistemas para administrar terapia de subumbral a un paciente
CA2910943C (en) 2013-05-03 2021-10-26 Alfred E. Mann Foundation For Scientific Research High reliability wire welding for implantable devices
EP2991728B1 (de) 2013-05-03 2020-09-23 Alfred E. Mann Foundation for Scientific Research Handshaking-system und verfahren für implantatauflader
CA2910982C (en) 2013-05-03 2022-07-19 Alfred E. Mann Foundation For Scientific Research Multi-branch stimulation electrode for subcutaneous field stimulation
US9180297B2 (en) 2013-05-16 2015-11-10 Boston Scientific Neuromodulation Corporation System and method for spinal cord modulation to treat motor disorder without paresthesia
WO2014197596A1 (en) 2013-06-06 2014-12-11 Doan Que T System for delivering modulated sub-threshold therapy
US9950173B2 (en) 2013-06-06 2018-04-24 Boston Scientific Neuromodulation Corporation System and method for delivering sub-threshold and super-threshold therapy to a patient
CN105358214B (zh) 2013-06-28 2017-05-17 波士顿科学神经调制公司 用于亚阈值调节治疗的电极选择
JP6181307B2 (ja) 2013-07-26 2017-08-16 ボストン サイエンティフィック ニューロモデュレイション コーポレイション 知覚なしに変調治療を与えるシステム
US20150028805A1 (en) 2013-07-29 2015-01-29 Alfred E. Mann Foundation For Scientific Research Implant charging field control through radio link
AU2014296323B2 (en) 2013-07-29 2019-04-04 Alfred E. Mann Foundation For Scientific Research Microprocessor controlled class E driver
JP6503351B2 (ja) 2013-07-29 2019-04-17 アルフレッド イー. マン ファウンデーション フォー サイエンティフィック リサーチ 埋め込み可能なデバイス用の高効率磁気リンク
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
US9839777B2 (en) 2013-08-14 2017-12-12 Syntilla Medical LLC Implantable neurostimulation lead for head pain
US9042991B2 (en) * 2013-08-14 2015-05-26 Syntilla Medical LLC Implantable head mounted neurostimulation system for head pain
US9427566B2 (en) 2013-08-14 2016-08-30 Syntilla Medical LLC Implantable neurostimulation lead for head pain
EP3782698A1 (de) 2013-09-27 2021-02-24 The Regents Of The University Of California Aktivierung des gebärmutterhals/rückenmark-kreislaufs zur wiederaufnahme der gewollten steuerung einer handfunktion bei tetraplegischen patienten
US9498635B2 (en) 2013-10-16 2016-11-22 Syntilla Medical LLC Implantable head located radiofrequency coupled neurostimulation system for head pain
AU2014338621B2 (en) * 2013-10-23 2019-07-18 Mainstay Medical Limited Systems and methods for restoring muscle function to the lumbar spine
US10258805B2 (en) 2013-10-23 2019-04-16 Syntilla Medical, Llc Surgical method for implantable head mounted neurostimulation system for head pain
US10960215B2 (en) 2013-10-23 2021-03-30 Nuxcel, Inc. Low profile head-located neurostimulator and method of fabrication
WO2015066033A1 (en) 2013-10-30 2015-05-07 Boston Scientific Neuromodulation Corporation Fractional control to avoid dorsal root stimulation
CN105682734B (zh) 2013-10-31 2018-08-17 波士顿科学神经调制公司 用于并入来自图像的引线信息的系统
WO2015066303A1 (en) 2013-11-01 2015-05-07 Boston Scientific Neuromodulation Corporation Systems for delivering sub-threshold therapy at a midline
US10010715B2 (en) 2013-12-04 2018-07-03 Boston Scientific Neuromodulation Corporation Systems and methods for delivering therapy to the dorsal horn of a patient
US9616230B2 (en) 2013-12-12 2017-04-11 Boston Scientific Neuromodulation Corporation Systems and methods for programming a neuromodulation system
US9707391B2 (en) 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Method for modulation of effector organs
US9707390B2 (en) 2013-12-22 2017-07-18 The Research Foundation Of The City University Of New York Apparatus for modulation of effector organs
MX366919B (es) 2013-12-22 2019-07-30 Univ City New York Res Found Sistemas de modulacion de corriente directa trans-espinal.
AU2015214522B2 (en) 2014-02-05 2017-08-31 Boston Scientific Neuromodulation Corporation System and method for delivering modulated sub-threshold therapy to a patient
AU2015214607B2 (en) 2014-02-05 2017-05-18 Boston Scientific Neuromodulation Corporation System and method for delivering modulated sub-threshold therapy to a patient
WO2016004230A1 (en) 2014-07-03 2016-01-07 Boston Scientific Neuromodulation Corporation Neurostimulation system with flexible patterning and waveforms
US9662495B2 (en) 2014-07-24 2017-05-30 Boston Scientific Neuromodulation Corporation Enhanced dorsal horn stimulation using multiple electrical fields
EP3183028A4 (de) 2014-08-21 2018-05-02 The Regents of the University of California Regulierung der autonomen steuerung der blasenentleerung nach einer vollständigen rückenmarksverletzung
EP3662968A1 (de) 2014-08-27 2020-06-10 The Regents Of The University Of California Anordnung aus mehreren elektroden zur epiduralen rückenmarkstimulation
CN106687173A (zh) 2014-09-15 2017-05-17 波士顿科学神经调制公司 用于对神经刺激脉冲模式进行编程的图形用户界面
US10493276B2 (en) 2014-09-23 2019-12-03 Boston Scientific Neuromodulation Corporation Neuromodulation specific to objective function of modulation field for targeted tissue
US10471260B2 (en) 2014-09-23 2019-11-12 Boston Scientific Neuromodulation Corporation Method and apparatus for calibrating dorsal horn stimulation using sensors
WO2016048965A1 (en) 2014-09-23 2016-03-31 Boston Scientific Neuromodulation Corporation Neuromodulation with burst stimulation
CN107073265B (zh) 2014-09-23 2020-11-10 波士顿科学神经调制公司 短脉冲宽度刺激
CN106714901A (zh) 2014-09-23 2017-05-24 波士顿科学神经调制公司 使用场旋转的神经组织的感知校准
US9993646B2 (en) 2014-09-23 2018-06-12 Boston Scientific Neuromodulation Corporation Sub-perception modulation responsive to patient input
US9656085B2 (en) 2014-09-23 2017-05-23 Boston Scientific Neuromodulation Corporation Systems and methods for receiving user-provided selection of electrode lists
US10471268B2 (en) 2014-10-16 2019-11-12 Mainstay Medical Limited Systems and methods for monitoring muscle rehabilitation
AU2015343483B2 (en) 2014-11-04 2018-03-01 Boston Scientific Neuromodulation Corporation Method and apparatus for programming complex neurostimulation patterns
US9849287B2 (en) 2015-02-09 2017-12-26 Boston Scientific Neuromodulation Corporation System and method for determining the neurological position of epidural leads
EP3725225A1 (de) 2015-02-12 2020-10-21 Foundry Innovation & Research 1, Ltd. Implantierbare vorrichtungen zur herzfehlerüberwachung
US9517344B1 (en) 2015-03-13 2016-12-13 Nevro Corporation Systems and methods for selecting low-power, effective signal delivery parameters for an implanted pulse generator
WO2016191055A1 (en) 2015-05-28 2016-12-01 Boston Scientific Neuromodulation Corporation Neuromodulation using stochastically-modulated stimulation parameters
CN107847731B (zh) 2015-07-10 2019-06-28 艾克索尼克斯调制技术股份有限公司 具有无asic的内部电子设备的可植入神经刺激器以及使用方法
CN107921255B (zh) 2015-07-30 2021-02-26 波士顿科学神经调制公司 用于定制模式的电刺激的用户界面
WO2017024051A1 (en) 2015-08-03 2017-02-09 Foundry Innovation & Research 1, Ltd. Devices and methods for measurement of vena cava dimensions, pressure, and oxygen saturation
US10835170B2 (en) * 2015-08-11 2020-11-17 Rhode Island Hospital Methods for detecting neuronal oscillation in the spinal cord associated with pain and diseases or disorders of the nervous system
US11298533B2 (en) 2015-08-26 2022-04-12 The Regents Of The University Of California Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject
RU2612496C1 (ru) * 2015-09-04 2017-03-09 Замил Мустафа Кхалил М.Дауд Аль Способ лечения невропатии локтевого нерва в кубитальном канале
WO2017066187A1 (en) 2015-10-15 2017-04-20 Boston Scientific Neuromodulation Corporation User interface for neurostimulation waveform composition
US11097122B2 (en) 2015-11-04 2021-08-24 The Regents Of The University Of California Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel
US10300277B1 (en) 2015-12-14 2019-05-28 Nevro Corp. Variable amplitude signals for neurological therapy, and associated systems and methods
US9717917B2 (en) 2016-01-06 2017-08-01 Syntilla Medical LLC Charging system incorporating independent charging and communication with multiple implanted devices
ES2862303T3 (es) 2016-01-29 2021-10-07 Axonics Modulation Tech Inc Sistemas de ajuste de frecuencia para optimizar la carga de un neuroestimulador implantable
US10327810B2 (en) 2016-07-05 2019-06-25 Mainstay Medical Limited Systems and methods for enhanced implantation of electrode leads between tissue layers
EP3496606A1 (de) 2016-08-11 2019-06-19 Foundry Innovation & Research 1, Ltd. Systeme und verfahren zum patientenfluidmanagement
US11206992B2 (en) 2016-08-11 2021-12-28 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore
US11701018B2 (en) 2016-08-11 2023-07-18 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore
US10780274B2 (en) 2016-08-22 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for delivering spinal cord stimulation therapy
US11540973B2 (en) 2016-10-21 2023-01-03 Spr Therapeutics, Llc Method and system of mechanical nerve stimulation for pain relief
CA3043228A1 (en) 2016-11-29 2018-06-07 Foundry Innovation & Research 1, Ltd. Wireless resonant circuit and variable inductance vascular implants for monitoring patient vasculature and fluid status and systems and methods employing same
US11135436B2 (en) 2017-05-12 2021-10-05 Cirtec Medical Corporation System, device, and method for generating stimulation waveform having a paresthesia-inducing low-frequency component and a spread-spectrum high-frequency component
US20180333578A1 (en) * 2017-05-17 2018-11-22 Nuvectra Corporation System, device, and method for performing long duration pulse width stimulation without uncomfortable rib stimulation
WO2018220146A1 (en) 2017-05-31 2018-12-06 Foundry Innovation & Research 1, Ltd. Implantable sensors for vascular monitoring
WO2018220143A1 (en) 2017-05-31 2018-12-06 Foundry Innovation And Research 1, Ltd Implantable ultrasonic vascular sensor
DE20168827T1 (de) 2017-06-30 2021-01-21 Gtx Medical B.V. System zur neuromodulierung
US10398899B2 (en) 2017-06-30 2019-09-03 Medtronic, Inc. User interface for identifying midlines of spinal cord
WO2019046658A1 (en) * 2017-08-30 2019-03-07 The Alfred E. Mann Foundation For Scientific Research STIMULATION SYSTEMS AND METHODS FOR SELECTIVELY RECRUITING FASCICLES IN A NERVOUS TRUNK HYPOGLASS
EP3653256B1 (de) 2018-11-13 2022-03-30 ONWARD Medical N.V. Steuerungssystem zur bewegungsrekonstruktion und/oder wiederherstellung für einen patienten
EP3695878B1 (de) 2019-02-12 2023-04-19 ONWARD Medical N.V. System zur neuromodulierung
US11857326B2 (en) * 2019-03-08 2024-01-02 Neuroone Medical Technologies Corporation Agent-delivering neural probe devices and related systems and methods
US11642537B2 (en) 2019-03-11 2023-05-09 Axonics, Inc. Charging device with off-center coil
WO2020242900A1 (en) 2019-05-24 2020-12-03 Axonics Modulation Technologies, Inc. Trainer device for a neurostimulator programmer and associated methods of use with a neurostimulation system
EP4027912A4 (de) 2019-09-12 2023-08-16 Relievant Medsystems, Inc. Systeme und verfahren zur gewebemodulation
EP3827871A1 (de) 2019-11-27 2021-06-02 ONWARD Medical B.V. Neuromodulationssystem
EP3881893A1 (de) * 2020-03-17 2021-09-22 BIOTRONIK SE & Co. KG Implantierbarer impulsgenerator mit einer anordnung von zwei im winkel zueinander angeordneten komponenten

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211151A (en) 1961-11-15 1965-10-12 Foderick Catheters
US3385300A (en) 1965-08-10 1968-05-28 Holter Company Cervical cannula
US3738368A (en) 1970-12-14 1973-06-12 R Avery Implantable electrodes for the stimulation of the sciatic nerve
AR200511A1 (es) 1974-01-25 1974-11-15 Trabucco H Electrodo cateter para estimulacion cardiaca electrica epicardica e intramiocardica
US4058128A (en) 1976-08-26 1977-11-15 Frank Howard A Electrode
US4140131A (en) 1976-11-03 1979-02-20 Medtronic, Inc. Body tissue stimulation apparatus with warning device
AR216293A1 (es) 1976-12-02 1979-12-14 Leon De Pedro F Electrodo de dientecillos autofijable y una pinza para su maniobra
US4142530A (en) 1978-03-06 1979-03-06 Vitatron Medical B. V. Epicardial lead
US4379462A (en) * 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
US4658835A (en) 1985-07-25 1987-04-21 Cordis Corporation Neural stimulating lead with fixation canopy formation
US4759748A (en) 1986-06-30 1988-07-26 Raychem Corporation Guiding catheter
US4862891A (en) 1988-03-14 1989-09-05 Canyon Medical Products Device for sequential percutaneous dilation
US5255691A (en) 1991-11-13 1993-10-26 Medtronic, Inc. Percutaneous epidural lead introducing system and method
US6090072A (en) 1992-10-15 2000-07-18 Scimed Life Systems, Inc. Expandable introducer sheath
US5300110A (en) 1992-10-15 1994-04-05 Angeion Corporation Dirk-based epicardial defibrillation electrode
GB2274995B (en) 1993-02-15 1996-10-09 John Mccune Anderson Biomedical electrode device
US5792187A (en) * 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
US5409469A (en) 1993-11-04 1995-04-25 Medtronic, Inc. Introducer system having kink resistant splittable sheath
EP0928212B1 (de) 1994-07-13 2002-10-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Flexible künstliche nervenplatte
US5545207A (en) 1994-08-24 1996-08-13 Medtronic, Inc. Medical electrical lead having stable fixation system
JP2000508201A (ja) 1996-04-04 2000-07-04 メドトロニック・インコーポレーテッド 生体組織刺激及び記録技術
FR2796562B1 (fr) 1996-04-04 2005-06-24 Medtronic Inc Techniques de stimulation d'un tissu vivant et d'enregistrement avec commande locale de sites actifs
US5713867A (en) 1996-04-29 1998-02-03 Medtronic, Inc. Introducer system having kink resistant splittable sheath
US5843148A (en) 1996-09-27 1998-12-01 Medtronic, Inc. High resolution brain stimulation lead and method of use
US6066126A (en) 1997-12-18 2000-05-23 Medtronic, Inc. Precurved, dual curve cardiac introducer sheath
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
JP3590736B2 (ja) 1999-03-24 2004-11-17 株式会社パイオラックス 体内埋め込み具
US6249707B1 (en) 1999-04-30 2001-06-19 Medtronic, Inc. Apparatus and method for percutaneous implant of a paddle style lead
US20020007168A1 (en) 1999-04-30 2002-01-17 Hamzeh Karami Breathable disposable absorbent articles
US6309401B1 (en) 1999-04-30 2001-10-30 Vladimir Redko Apparatus and method for percutaneous implant of a paddle style lead
US6505075B1 (en) 1999-05-29 2003-01-07 Richard L. Weiner Peripheral nerve stimulation method
US6517477B1 (en) 2000-01-27 2003-02-11 Scimed Life Systems, Inc. Catheter introducer system for exploration of body cavities
US6478777B1 (en) 2000-05-25 2002-11-12 Medtronic, Inc. Introducer system for medical electrical lead
US20020035377A1 (en) 2000-09-18 2002-03-21 Cameron Health, Inc. Subcutaneous electrode for transthoracic conduction with insertion tool
US7120495B2 (en) 2000-09-18 2006-10-10 Cameron Health, Inc. Flexible subcutaneous implantable cardioverter-defibrillator
US20020035378A1 (en) 2000-09-18 2002-03-21 Cameron Health, Inc. Subcutaneous electrode for transthoracic conduction with highly maneuverable insertion tool
US20020035381A1 (en) 2000-09-18 2002-03-21 Cameron Health, Inc. Subcutaneous electrode with improved contact shape for transthoracic conduction
US20030158545A1 (en) 2000-09-28 2003-08-21 Arthrocare Corporation Methods and apparatus for treating back pain
EP1330287B1 (de) 2000-10-26 2009-07-29 Medtronic, Inc. Gerät zur minimierung der wirkungen einer herzverletzung
US7218964B2 (en) 2000-10-26 2007-05-15 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
DE60140072D1 (de) 2000-10-26 2009-11-12 Meditronic Inc Vorrichtung zur minimierung der wirkungen eines herzinsults
CA2426810A1 (en) 2000-10-26 2002-06-13 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions
US7212867B2 (en) 2000-12-07 2007-05-01 Medtronic, Inc. Directional brain stimulation and recording leads
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
GB0104982D0 (en) 2001-02-28 2001-04-18 Gill Steven Electrode
AU2002334749A1 (en) 2001-09-28 2003-04-07 Northstar Neuroscience, Inc. Methods and implantable apparatus for electrical therapy
US20030105501A1 (en) 2001-12-03 2003-06-05 Warman Eduardo N. Shaped lead with electrodes
CA2469080A1 (en) 2001-12-03 2003-06-12 Medtronic, Inc. Shaped lead with electrodes
DE10162508A1 (de) 2001-12-19 2003-07-03 Biotronik Mess & Therapieg Epikardelektrodenleitung, Einführkatheter für eine solche und Elektrodenimplantationsbesteck
US6721603B2 (en) 2002-01-25 2004-04-13 Cyberonics, Inc. Nerve stimulation as a treatment for pain
US7462184B2 (en) 2002-05-06 2008-12-09 Pressure Products Medical Supplies Inc. Introducer for accessing the coronary sinus of a heart
US7123967B2 (en) 2002-05-13 2006-10-17 Pacesetter, Inc. Implantable neural stimulation device providing activity, rest, and long term closed-loop peripheral vascular disease therapy and method
US7860570B2 (en) 2002-06-20 2010-12-28 Boston Scientific Neuromodulation Corporation Implantable microstimulators and methods for unidirectional propagation of action potentials
US7993351B2 (en) 2002-07-24 2011-08-09 Pressure Products Medical Supplies, Inc. Telescopic introducer with a compound curvature for inducing alignment and method of using the same
AU2002322792A1 (en) * 2002-07-31 2004-02-23 Advanced Neuromodulation Systems, Inc. Method and apparatus for providing complex tissue stimulation patterns
US7328069B2 (en) 2002-09-06 2008-02-05 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves
US20050070969A1 (en) * 2002-09-06 2005-03-31 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by electrical stimulation and the delivery of drugs to the sacral and pudendal nerves
US7092765B2 (en) 2002-09-23 2006-08-15 Medtronic, Inc. Non-sheath based medical device delivery system
US20050256452A1 (en) 2002-11-15 2005-11-17 Demarchi Thomas Steerable vascular sheath
US7047084B2 (en) 2002-11-20 2006-05-16 Advanced Neuromodulation Systems, Inc. Apparatus for directionally stimulating nerve tissue
US20040122477A1 (en) 2002-12-19 2004-06-24 Whitehurst Todd K. Fully implantable miniature neurostimulator for spinal nerve root stimulation as a therapy for angina and peripheral vascular disease
WO2004062470A2 (en) 2003-01-03 2004-07-29 Advanced Neuromodulation Systems, Inc. System and method for stimulation of a person’s brain stem
US20040176830A1 (en) 2003-03-06 2004-09-09 Fang H. Kenith Epicardial electrode
US7107104B2 (en) 2003-05-30 2006-09-12 Medtronic, Inc. Implantable cortical neural lead and method
US20060030899A1 (en) * 2004-02-25 2006-02-09 O'keeffe Declan System and method for stimulating peripheral nerves to treat pain
US20050222628A1 (en) 2004-03-31 2005-10-06 Krakousky Alexander A Implantable device for pain control and other medical treatments
GB0409769D0 (en) 2004-04-30 2004-06-09 Algotec Ltd Electrical nerve stimulation device
US20060270978A1 (en) 2005-04-08 2006-11-30 Ken Binmoeller Expandable esophageal access device
US8644941B2 (en) 2005-06-09 2014-02-04 Medtronic, Inc. Peripheral nerve field stimulation and spinal cord stimulation
WO2006133445A2 (en) 2005-06-09 2006-12-14 Medtronic, Inc. Implantable medical lead
US8620435B2 (en) 2005-06-09 2013-12-31 Medtronic, Inc. Combination therapy including peripheral nerve field stimulation
US8244360B2 (en) 2005-06-09 2012-08-14 Medtronic, Inc. Regional therapies for treatment of pain
US7792591B2 (en) 2005-06-09 2010-09-07 Medtronic, Inc. Introducer for therapy delivery elements
EP1904173B8 (de) 2005-06-09 2016-06-08 Medtronic, Inc. Implantierbares medizinprodukt mit elektroden auf mehreren gehäuseoberflächen

Also Published As

Publication number Publication date
US20140114374A1 (en) 2014-04-24
WO2006135791A2 (en) 2006-12-21
US9393416B2 (en) 2016-07-19
EP1904160B1 (de) 2011-12-21
WO2006135791A3 (en) 2007-03-22
US20070073357A1 (en) 2007-03-29
US8644941B2 (en) 2014-02-04
EP1904160A2 (de) 2008-04-02

Similar Documents

Publication Publication Date Title
ATE537870T1 (de) Periphere nervenfeldstimulation und rückenmarksstimulation
WO2006135751A3 (en) Combination therapy including peripheral nerve field stimulation
Mao et al. Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor‐related arthralgia: a randomized trial
Fregni et al. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques
Wintner et al. Quality of life during chemotherapy in lung cancer patients: results across different treatment lines
Sator‐Katzenschlager et al. Subcutaneous target stimulation (STS) in chronic noncancer pain: a nationwide retrospective study
DeGiorgio et al. Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms
Al‐Kaisy et al. Opioid‐sparing effects of 10 kHz spinal cord stimulation: a review of clinical evidence
WO2007127455A3 (en) Tree-based electrical stimulator programming for pain therapy
WO2010002936A3 (en) Systems, methods and devices for paired plasticity
WO2007018787A3 (en) Neurostimulation device for the treating mood disorders
Gupta et al. Treatment of painful diabetic neuropathy—a narrative review of pharmacological and interventional approaches
Tracey Immune cells exploit a neural circuit to enter the CNS
WO2005039688A3 (en) Patient sensory response evaluation for neuromodulation efficacy rating
WO2008027297A3 (en) System for neural stimulation during disordered breathing
WO2008052798A3 (en) Fgfr4 promotes cancer cell resistance in response to chemotherapeutic drugs
Tieppo Francio et al. Management of chronic and neuropathic pain with 10 kHz spinal cord stimulation technology: summary of findings from preclinical and clinical studies
Hagmann et al. Evidence-based palliative care approaches to non-pain physical symptom management in cancer patients
Levy Differentiating the leaves from the branches in the tree of neuromodulation: the state of peripheral nerve field stimulation
Hagedorn et al. Overview of HF10 spinal cord stimulation for the treatment of chronic pain and an introduction to the Senza Omnia™ system
Lang et al. Opioids in rheumatic diseases
De Andrés et al. Neural modulation by stimulation
Herschkowitz et al. A case report of wireless peripheral nerve stimulation for complex regional pain syndrome type-I of the upper extremity: 1 year follow up
EP1898950A4 (de) Galk1s als modifikatoren des pten/akt-wegs und verwendungsverfahren
WO2006138316A3 (en) Methods for delivering molecules to the central nervous system