ATE528410T1 - Verfahren und zusammensetzungen zur diagnose von altersbedingter maculadegeneration - Google Patents
Verfahren und zusammensetzungen zur diagnose von altersbedingter maculadegenerationInfo
- Publication number
- ATE528410T1 ATE528410T1 AT05851755T AT05851755T ATE528410T1 AT E528410 T1 ATE528410 T1 AT E528410T1 AT 05851755 T AT05851755 T AT 05851755T AT 05851755 T AT05851755 T AT 05851755T AT E528410 T1 ATE528410 T1 AT E528410T1
- Authority
- AT
- Austria
- Prior art keywords
- macular degeneration
- related macular
- compositions
- methods
- amd
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1725—Complement proteins, e.g. anaphylatoxin, C3a or C5a
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Plant Pathology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62936304P | 2004-11-18 | 2004-11-18 | |
US64947905P | 2005-02-02 | 2005-02-02 | |
US67234605P | 2005-04-18 | 2005-04-18 | |
PCT/US2005/041664 WO2006062716A2 (en) | 2004-11-18 | 2005-11-18 | Methods and compositions for treating ocular disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE528410T1 true ATE528410T1 (de) | 2011-10-15 |
Family
ID=36578383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05851755T ATE528410T1 (de) | 2004-11-18 | 2005-11-18 | Verfahren und zusammensetzungen zur diagnose von altersbedingter maculadegeneration |
Country Status (15)
Country | Link |
---|---|
US (3) | US20090017029A1 (de) |
EP (1) | EP1836312B1 (de) |
JP (2) | JP2008520242A (de) |
KR (1) | KR101290621B1 (de) |
CN (2) | CN102618644A (de) |
AT (1) | ATE528410T1 (de) |
AU (1) | AU2005314461B2 (de) |
BR (1) | BRPI0518289A2 (de) |
CA (1) | CA2588270A1 (de) |
CY (1) | CY1112579T1 (de) |
DK (1) | DK1836312T3 (de) |
ES (1) | ES2375490T3 (de) |
HK (1) | HK1113690A1 (de) |
IL (1) | IL183284A (de) |
WO (1) | WO2006062716A2 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE426043T1 (de) | 2002-11-25 | 2009-04-15 | Sequenom Inc | Verfahren zur identifizierung des brustkrebsrisikos |
PT1713503E (pt) | 2004-02-10 | 2013-11-14 | Nat Jewish Health | Inibição do factor b, a via alternativa do complemento e métodos relacionados |
WO2006088950A2 (en) * | 2005-02-14 | 2006-08-24 | University Of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
ES2548700T3 (es) | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
WO2007056227A2 (en) * | 2005-11-04 | 2007-05-18 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
US8012683B2 (en) | 2006-02-13 | 2011-09-06 | University Of Iowa Research Foundation | Variants in complement regulatory genes predict age-related macular degeneration |
WO2007120975A2 (en) * | 2006-02-13 | 2007-10-25 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Variants in complement regulatory genes predict age-related macular degeneration |
CN101421409A (zh) * | 2006-02-13 | 2009-04-29 | 爱荷华大学研究基金会 | 补体调控基因中预测年龄相关性黄斑变性的变体 |
CN101563363B (zh) | 2006-06-21 | 2013-01-02 | 南卡罗来纳医疗大学研究发展基金会 | 用于治疗疾病的靶向补体因子h |
AU2016204271B2 (en) * | 2006-07-13 | 2018-04-19 | University Of Iowa Research Foundation | Methods and reagents for the treatment and diagnosis of vascular disorders and age-related macular degeneration |
NZ574046A (en) * | 2006-07-13 | 2012-09-28 | Univ Iowa Res Found | Methods and reagents for treatment and diagnosis of vascular disorders and age-related macular degeneration |
CA2658853A1 (en) * | 2006-07-26 | 2008-01-31 | Yale University | Diagnosis and treatment of age related macular degeneration |
CN101173314B (zh) * | 2006-10-18 | 2010-12-01 | 四川省医学科学院(四川省人民医院) | 检测老年黄斑变性疾病的试剂盒 |
EP2097455B1 (de) | 2006-11-02 | 2014-10-22 | Genentech, Inc. | Humanisierte anti-faktor d-antikörper |
GB0701213D0 (en) * | 2007-01-23 | 2007-02-28 | Univ Cardiff | Factor H polymorphisms in the diagnosis and therapy of inflammatory diseases such as age-related macular degeneration |
WO2008103299A2 (en) | 2007-02-16 | 2008-08-28 | Massachusetts Eye & Ear Infirmary | Methods and compositions for prognosing, detecting, and treating age-related macular degeneration |
EP2236518B1 (de) | 2007-03-14 | 2014-08-06 | Alexion Cambridge Corporation | Humanisierter Antikörper gegen Faktor B |
JP5226256B2 (ja) * | 2007-07-26 | 2013-07-03 | ニプロ株式会社 | 加齢黄斑変性症の発症リスクの予測方法 |
US20100324154A1 (en) * | 2007-11-01 | 2010-12-23 | Hageman Gregory S | Assessing susceptibility to vascular disorders |
US8114592B2 (en) | 2008-03-18 | 2012-02-14 | Cambridge Enterprise Limited | Genetic markers associated with age-related macular degeneration, methods of detection and uses thereof |
WO2009121065A2 (en) * | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
US20120003641A1 (en) | 2008-11-05 | 2012-01-05 | Graham Robert R | Genetic polymorphisms in age-related macular degeneration |
WO2010075519A2 (en) * | 2008-12-23 | 2010-07-01 | Massachusetts Eye & Ear Infirmary | Allelic variants associated with advanced age-related macular degeneration |
KR100937720B1 (ko) * | 2009-04-20 | 2010-01-20 | 전남대학교산학협력단 | CFH 또는 ApoH를 급성골수성백혈병 관해 진단용 생화학적 마커로 사용하는 방법 |
RS20120461A1 (en) | 2009-07-02 | 2013-06-28 | Musc Foundation For Research Development | METHODS FOR STIMULATION OF LIVER REGENERATION |
AU2010314931A1 (en) | 2009-11-05 | 2012-06-21 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
WO2011113641A1 (en) | 2010-02-12 | 2011-09-22 | Cemm Forschungszentrum Für Molekulare Medizin Gmbh | Complement factor h for oxidative stress disease conditions |
JP5986990B2 (ja) | 2010-05-14 | 2016-09-06 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド,ア ボディ コーポレート | 改善された補体レセプター2(cr2)ターゲティング基 |
WO2011153234A2 (en) * | 2010-06-01 | 2011-12-08 | University Of Kentucky Research Foundation | Methods of inhibiting alu rna and therapeutic uses thereof |
US9421240B2 (en) | 2010-06-22 | 2016-08-23 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
WO2011163412A1 (en) | 2010-06-22 | 2011-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the c3d fragment of complement component 3 |
JP2014502953A (ja) | 2010-08-16 | 2014-02-06 | ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク | 細胞透過性治療薬の鼻腔内送達 |
FR2983212A1 (fr) * | 2011-11-28 | 2013-05-31 | Lfb Biotechnologies | Aptameres anti-fh, procede pour leur obtention et utilisations |
FR2988298A1 (fr) * | 2012-03-23 | 2013-09-27 | Lfb Biotechnologies | Facteur h pour son utilisation comme molecule antioxydante |
EP2855529A4 (de) | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | Humanisierte anti-faktor-b-antikörper |
CN102707068B (zh) * | 2012-05-31 | 2015-03-18 | 北京大学 | 补体h因子用作甲基苯丙胺成瘾患者的基因表达产物中的应用 |
AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
EP3660033B9 (de) | 2012-11-15 | 2022-06-22 | Apellis Pharmaceuticals, Inc. | Langwirkende compstatin-analoga sowie verwandte zusammensetzungen und verfahren |
LT2968457T (lt) | 2013-03-14 | 2018-10-25 | Baxalta Incorporated | Transplantacijos veiksnys h |
JP6484215B2 (ja) | 2013-03-14 | 2019-03-13 | バクスアルタ インコーポレイテッド | 関節リウマチの治療のためのh因子 |
JP5721150B2 (ja) * | 2013-03-14 | 2015-05-20 | 学校法人 埼玉医科大学 | 加齢黄斑変性症の発症リスクの予測方法 |
AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
US10308687B2 (en) | 2013-03-15 | 2019-06-04 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
KR20160042438A (ko) | 2013-08-12 | 2016-04-19 | 제넨테크, 인크. | 보체-연관 상태의 치료를 위한 조성물 및 방법 |
US20150093331A1 (en) * | 2013-10-01 | 2015-04-02 | OncoLock Co., Ltd. | Biomarkers for breast cancer |
KR102131973B1 (ko) * | 2013-12-30 | 2020-07-08 | 주식회사 케이티 | 개인 건강관리 방법 및 시스템 |
KR20220164083A (ko) * | 2014-02-26 | 2022-12-12 | 알러간, 인코포레이티드 | 보체 성분 c5 항체 |
US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
US10179821B2 (en) | 2014-05-01 | 2019-01-15 | Genentech, Inc. | Anti-factor D antibodies |
KR102314785B1 (ko) * | 2015-04-21 | 2021-10-19 | 인제대학교 산학협력단 | 신규한 황반변성 진단용 마커 및 황반변성 진단방법 |
BR112018006810A2 (pt) | 2015-10-07 | 2018-10-23 | Apellis Pharmaceuticals Inc | regimes de dosagem |
US10654932B2 (en) | 2015-10-30 | 2020-05-19 | Genentech, Inc. | Anti-factor D antibody variant conjugates and uses thereof |
WO2017075173A2 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
CN106018838A (zh) * | 2015-11-01 | 2016-10-12 | 李倩 | 一种用于检测眼科疾病的试剂盒及其检测方法 |
ES2956007T3 (es) * | 2015-12-03 | 2023-12-11 | Regeneron Pharma | Métodos de asociación de variantes genéticas con un resultado clínico en pacientes que padecen degeneración macular asociada a la edad tratados con anti-VEGF |
KR102011182B1 (ko) * | 2016-10-07 | 2019-08-16 | 단국대학교 천안캠퍼스 산학협력단 | 익상편 과발현 유전자 및 이의 용도 |
CN110831544B (zh) | 2017-04-07 | 2022-11-18 | 阿佩利斯制药有限公司 | 长效坎普他汀类似物、其组合物的给药方案及其医药用途 |
US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
EP3824095A4 (de) * | 2018-07-20 | 2022-04-20 | University of Utah Research Foundation | Gentherapie für makuladegeneration |
US20220146530A1 (en) * | 2019-03-07 | 2022-05-12 | Reti Mark Co., Ltd. | A combination of biomarkers for diagnosing of age-related macular degeneration and use thereof |
KR102333953B1 (ko) * | 2020-07-10 | 2021-12-02 | 인제대학교 산학협력단 | 신규한 황반변성 진단용 유전자 마커 |
CN113293206A (zh) * | 2021-07-23 | 2021-08-24 | 西安医臻生物医药科技有限公司 | 一种快速鉴别老年黄斑病变风险的方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
NZ509797A (en) * | 1998-07-10 | 2003-11-28 | Univ Sydney | Prophylactic treatments of neovascularisation in macular degeneration using a steroid |
US20020032319A1 (en) * | 2000-03-07 | 2002-03-14 | Whitehead Institute For Biomedical Research | Human single nucleotide polymorphisms |
ATE412185T1 (de) * | 2000-04-29 | 2008-11-15 | Univ Iowa Res Found | Diagnostika und therapeutika für makula degeneration erkrankungen |
CN1466953A (zh) * | 2003-01-15 | 2004-01-14 | 哈佛东方生物医药(云南)有限公司 | 预防治疗老年黄斑变性的复合制剂 |
WO2006088950A2 (en) * | 2005-02-14 | 2006-08-24 | University Of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
-
2005
- 2005-11-18 AU AU2005314461A patent/AU2005314461B2/en not_active Ceased
- 2005-11-18 JP JP2007543226A patent/JP2008520242A/ja not_active Withdrawn
- 2005-11-18 ES ES05851755T patent/ES2375490T3/es active Active
- 2005-11-18 WO PCT/US2005/041664 patent/WO2006062716A2/en active Application Filing
- 2005-11-18 CN CN2012100868621A patent/CN102618644A/zh active Pending
- 2005-11-18 CN CN2005800467319A patent/CN101142321B/zh not_active Expired - Fee Related
- 2005-11-18 CA CA002588270A patent/CA2588270A1/en not_active Abandoned
- 2005-11-18 DK DK05851755.8T patent/DK1836312T3/da active
- 2005-11-18 BR BRPI0518289-1A patent/BRPI0518289A2/pt not_active IP Right Cessation
- 2005-11-18 KR KR1020077013736A patent/KR101290621B1/ko not_active IP Right Cessation
- 2005-11-18 AT AT05851755T patent/ATE528410T1/de active
- 2005-11-18 US US11/791,025 patent/US20090017029A1/en not_active Abandoned
- 2005-11-18 EP EP05851755A patent/EP1836312B1/de not_active Not-in-force
-
2007
- 2007-05-17 IL IL183284A patent/IL183284A/en not_active IP Right Cessation
-
2008
- 2008-03-05 HK HK08102583.1A patent/HK1113690A1/xx not_active IP Right Cessation
-
2011
- 2011-09-16 US US13/235,289 patent/US20120135000A1/en not_active Abandoned
-
2012
- 2012-01-04 JP JP2012000185A patent/JP2012080900A/ja active Pending
- 2012-01-11 CY CY20121100030T patent/CY1112579T1/el unknown
-
2013
- 2013-09-26 US US14/038,602 patent/US20140018306A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0518289A2 (pt) | 2008-11-11 |
IL183284A0 (en) | 2007-09-20 |
US20120135000A1 (en) | 2012-05-31 |
KR101290621B1 (ko) | 2013-07-29 |
ES2375490T3 (es) | 2012-03-01 |
CN101142321B (zh) | 2012-06-06 |
CY1112579T1 (el) | 2016-02-10 |
JP2012080900A (ja) | 2012-04-26 |
CN101142321A (zh) | 2008-03-12 |
HK1113690A1 (en) | 2008-10-10 |
EP1836312B1 (de) | 2011-10-12 |
IL183284A (en) | 2014-09-30 |
US20140018306A1 (en) | 2014-01-16 |
WO2006062716A2 (en) | 2006-06-15 |
JP2008520242A (ja) | 2008-06-19 |
CA2588270A1 (en) | 2006-06-15 |
KR20070105969A (ko) | 2007-10-31 |
AU2005314461A1 (en) | 2006-06-15 |
WO2006062716A3 (en) | 2006-10-05 |
DK1836312T3 (da) | 2012-03-12 |
EP1836312A2 (de) | 2007-09-26 |
CN102618644A (zh) | 2012-08-01 |
AU2005314461B2 (en) | 2012-02-02 |
US20090017029A1 (en) | 2009-01-15 |
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