ATE528307T1 - Imidazopyridin-2-onderivate als inhibitoren von endothellipase - Google Patents
Imidazopyridin-2-onderivate als inhibitoren von endothellipaseInfo
- Publication number
- ATE528307T1 ATE528307T1 AT07723584T AT07723584T ATE528307T1 AT E528307 T1 ATE528307 T1 AT E528307T1 AT 07723584 T AT07723584 T AT 07723584T AT 07723584 T AT07723584 T AT 07723584T AT E528307 T1 ATE528307 T1 AT E528307T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- bicyclic
- ocoa
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- JXXWJMUPNZDILL-UHFFFAOYSA-N imidazo[4,5-b]pyridin-2-one Chemical class C1=CC=NC2=NC(=O)N=C21 JXXWJMUPNZDILL-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 6
- -1 Bicyclic imidazolone derivatives Chemical class 0.000 abstract 4
- 102100031375 Endothelial lipase Human genes 0.000 abstract 3
- 101710087274 Endothelial lipase Proteins 0.000 abstract 3
- 241000972349 Ocoa Species 0.000 abstract 3
- 125000002619 bicyclic group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- QWRBIGGBOGLFFP-UHFFFAOYSA-N n-hexyl-1-methyl-2-oxoimidazo[4,5-b]pyridine-3-carboxamide Chemical compound C1=CC=C2N(C)C(=O)N(C(=O)NCCCCCC)C2=N1 QWRBIGGBOGLFFP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006014685A DE102006014685A1 (de) | 2006-03-28 | 2006-03-28 | Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen |
| PCT/EP2007/002637 WO2007110215A1 (en) | 2006-03-28 | 2007-03-26 | Imidazopyridin-2-one derivatives as inhibitors of endothelial lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528307T1 true ATE528307T1 (de) | 2011-10-15 |
Family
ID=38179814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07723584T ATE528307T1 (de) | 2006-03-28 | 2007-03-26 | Imidazopyridin-2-onderivate als inhibitoren von endothellipase |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7897616B2 (de) |
| EP (1) | EP2001878B1 (de) |
| JP (1) | JP2009531356A (de) |
| KR (1) | KR20080104341A (de) |
| CN (1) | CN101405288A (de) |
| AT (1) | ATE528307T1 (de) |
| AU (1) | AU2007229708A1 (de) |
| BR (1) | BRPI0709211A2 (de) |
| CA (1) | CA2647422A1 (de) |
| DE (1) | DE102006014685A1 (de) |
| MX (1) | MX2008012126A (de) |
| NO (1) | NO20084419L (de) |
| TW (1) | TW200815434A (de) |
| WO (1) | WO2007110215A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010044441A1 (ja) | 2008-10-17 | 2010-04-22 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| WO2011034741A1 (en) * | 2009-09-15 | 2011-03-24 | Merck Sharp & Dohme Corp. | Imidazopyridin-2-one derivatives |
| WO2011059839A1 (en) * | 2009-10-29 | 2011-05-19 | Sirtris Pharmaceuticals, Inc. | Bicyclic pyridines and analogs as sirtuin modulators |
| CA2784710A1 (en) * | 2009-12-15 | 2011-06-23 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| CN103298469A (zh) | 2010-08-31 | 2013-09-11 | 首尔大学校产学协力财团 | PPARδ激动剂的胎儿重编程的用途 |
| US9249096B2 (en) | 2011-09-27 | 2016-02-02 | Bristol-Myers Squibb Company | Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors |
| WO2013048928A1 (en) | 2011-09-27 | 2013-04-04 | Bristol-Myers Squibb Company | Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors |
| EP2760829B1 (de) | 2011-09-27 | 2016-05-18 | Bristol-Myers Squibb Company | Pyrrolinon-carboxamid-derivate als inhibitoren von endothellipase |
| US8993557B2 (en) | 2011-09-30 | 2015-03-31 | Bristol-Myers Squibb Company | Pyridinedione carboxamide inhibitors of endothelial lipase |
| US8946430B2 (en) | 2011-09-30 | 2015-02-03 | Bristol-Myers Squibb Company | Quinolinone carboxamide inhibitors of endothelial lipase |
| US8933235B2 (en) | 2011-09-30 | 2015-01-13 | Bristol-Myers Squibb Company | Pyridinedione carboxamide inhibitors of endothelial lipase |
| US9199946B2 (en) | 2012-04-03 | 2015-12-01 | Bristol-Myers Squibb Company | Pyrimidinone carboxamide inhibitors of endothelial lipase |
| EP2847174B1 (de) | 2012-04-03 | 2017-05-17 | Bristol-Myers Squibb Company | Pyrimidinon carboxamide als inhibitoren der endothellipase |
| US9139578B2 (en) | 2012-07-09 | 2015-09-22 | Bristol-Myers Squibb Company | Amide or urea containing benzothiazole inhibitors of endothelial lipase |
| EP2870153B1 (de) | 2012-07-09 | 2016-11-02 | Bristol-Myers Squibb Company | Sulfonylhaltige benzothiazolinhibitoren der endothellipase |
| US8987314B2 (en) | 2012-07-19 | 2015-03-24 | Bristol-Myers Squibb Company | Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| WO2014042939A1 (en) | 2012-09-11 | 2014-03-20 | Bristol-Myers Squibb Company | Ketone linked benzothiazole inhibitors of endothelial lipase |
| US10173991B2 (en) | 2014-01-07 | 2019-01-08 | Bristol-Myers Squibb Company | Sulfone amide linked benzothiazole inhibitors of endothelial lipase |
| WO2017214005A1 (en) | 2016-06-06 | 2017-12-14 | Bristol-Myers Squibb Company | 2-(benzothiazol-2-yl)-2-cyano-acetamide derivatives and their use as endothelial lipase inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE422799B (sv) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner |
| WO2002030886A2 (en) * | 2000-10-12 | 2002-04-18 | Matthews Barry R | Heterocyclic angiogenesis inhibitors |
| DE102004005172A1 (de) * | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| EP1753423A4 (de) * | 2004-05-28 | 2009-10-21 | Merck & Co Inc | Benzoharnstoffe mit antidiabetischer wirkung |
| EP1861377B1 (de) * | 2005-03-15 | 2010-12-29 | Pfizer, Inc. | Benzimidazolonderivate als cb2-rezeptor-liganden |
| DE102005026762A1 (de) * | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
-
2006
- 2006-03-28 DE DE102006014685A patent/DE102006014685A1/de not_active Withdrawn
-
2007
- 2007-03-26 MX MX2008012126A patent/MX2008012126A/es not_active Application Discontinuation
- 2007-03-26 TW TW096110266A patent/TW200815434A/zh unknown
- 2007-03-26 EP EP07723584A patent/EP2001878B1/de not_active Not-in-force
- 2007-03-26 WO PCT/EP2007/002637 patent/WO2007110215A1/en not_active Ceased
- 2007-03-26 CA CA002647422A patent/CA2647422A1/en not_active Abandoned
- 2007-03-26 KR KR1020087023444A patent/KR20080104341A/ko not_active Withdrawn
- 2007-03-26 CN CNA2007800101778A patent/CN101405288A/zh active Pending
- 2007-03-26 BR BRPI0709211-3A patent/BRPI0709211A2/pt not_active IP Right Cessation
- 2007-03-26 AT AT07723584T patent/ATE528307T1/de not_active IP Right Cessation
- 2007-03-26 AU AU2007229708A patent/AU2007229708A1/en not_active Abandoned
- 2007-03-26 JP JP2009501922A patent/JP2009531356A/ja not_active Abandoned
-
2008
- 2008-09-22 US US12/235,053 patent/US7897616B2/en not_active Expired - Fee Related
- 2008-10-21 NO NO20084419A patent/NO20084419L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE102006014685A1 (de) | 2007-10-04 |
| US7897616B2 (en) | 2011-03-01 |
| EP2001878A1 (de) | 2008-12-17 |
| CA2647422A1 (en) | 2007-10-04 |
| KR20080104341A (ko) | 2008-12-02 |
| NO20084419L (no) | 2008-11-26 |
| CN101405288A (zh) | 2009-04-08 |
| US20090076068A1 (en) | 2009-03-19 |
| JP2009531356A (ja) | 2009-09-03 |
| BRPI0709211A2 (pt) | 2011-06-28 |
| AU2007229708A1 (en) | 2007-10-04 |
| WO2007110215A1 (en) | 2007-10-04 |
| MX2008012126A (es) | 2008-10-03 |
| EP2001878B1 (de) | 2011-10-12 |
| TW200815434A (en) | 2008-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |