ATE526320T1 - Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon - Google Patents

Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon

Info

Publication number
ATE526320T1
ATE526320T1 AT06759574T AT06759574T ATE526320T1 AT E526320 T1 ATE526320 T1 AT E526320T1 AT 06759574 T AT06759574 T AT 06759574T AT 06759574 T AT06759574 T AT 06759574T AT E526320 T1 ATE526320 T1 AT E526320T1
Authority
AT
Austria
Prior art keywords
subtype
antagonists
applications
vanilloid receptor
vanilloid
Prior art date
Application number
AT06759574T
Other languages
English (en)
Inventor
Arthur Gomtsyan
Richard Perner
John Koenig
Margaret Chi-Ping Hsu
Dilini Fernando
Chih-Hung Lee
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE526320T1 publication Critical patent/ATE526320T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT06759574T 2005-05-11 2006-05-10 Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon ATE526320T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67970805P 2005-05-11 2005-05-11
PCT/US2006/018256 WO2006122250A2 (en) 2005-05-11 2006-05-10 Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof

Publications (1)

Publication Number Publication Date
ATE526320T1 true ATE526320T1 (de) 2011-10-15

Family

ID=37056909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06759574T ATE526320T1 (de) 2005-05-11 2006-05-10 Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon

Country Status (14)

Country Link
US (3) US7504520B2 (de)
EP (1) EP1885704B1 (de)
JP (1) JP4862042B2 (de)
KR (1) KR20080014024A (de)
CN (2) CN101248052A (de)
AT (1) ATE526320T1 (de)
AU (1) AU2006243987B2 (de)
BR (1) BRPI0608810A2 (de)
CA (1) CA2608091A1 (de)
IL (1) IL187208A0 (de)
MX (1) MX2007014048A (de)
NZ (1) NZ563200A (de)
WO (1) WO2006122250A2 (de)
ZA (1) ZA201102735B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060229305A1 (en) * 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
EP1879575A2 (de) 2005-05-09 2008-01-23 Achillion Pharmaceuticals, Inc. Thiazolverbindungen und anwendungsverfahren dafür
JP2009534399A (ja) * 2006-04-18 2009-09-24 アボット・ラボラトリーズ バニロイド受容体サブタイプ１型（ｖｒ１）の拮抗薬およびその使用
WO2008147557A2 (en) 2007-05-22 2008-12-04 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles and their use as antiviral agents
US7998993B2 (en) 2007-10-25 2011-08-16 Abbott Laboratories TRPV1 antagonists
CN101925575B (zh) 2008-01-28 2014-06-18 株式会社爱茉莉太平洋 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物
US8106209B2 (en) 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
CN102137851B (zh) 2008-07-02 2014-08-27 株式会社爱茉莉太平洋 作为香草素受体拮抗剂的化合物、其异构体或其药学可接受的盐以及包含它们的药物组合物
JP2012511500A (ja) * 2008-08-20 2012-05-24 メルク・シャープ・エンド・ドーム・コーポレイション Ｃｇｒｐ受容体アンタゴニストとしての分岐末端を有する非アミドリンカー
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
TW201302681A (zh) 2011-03-25 2013-01-16 Abbott Lab Ｔｒｐｖ１拮抗劑
WO2012166463A2 (en) 2011-05-27 2012-12-06 Neosome Life Sciences, LLC Aminooxazole inhibitors of cyclin dependent kinases
US8859584B2 (en) 2011-12-19 2014-10-14 Abbvie, Inc. TRPV1 antagonists
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
US8796328B2 (en) 2012-06-20 2014-08-05 Abbvie Inc. TRPV1 antagonists
KR102007796B1 (ko) 2013-11-18 2019-08-07 포르마 세라퓨틱스 인크. Bet 브로모도메인 저해제로서 테트라하이드로퀴놀린 조성물
WO2015074081A1 (en) 2013-11-18 2015-05-21 Bair Kenneth W Benzopiperazine compositions as bet bromodomain inhibitors
KR102587530B1 (ko) 2016-11-16 2023-10-11 알렐 바이오테크놀로지 앤 파마슈티칼스, 인크. Ｒｎａ를 사용한 줄기 세포 분화에 의한 췌장 베타 세포의 유도
WO2018094111A1 (en) * 2016-11-16 2018-05-24 Allele Biotechnology & Pharmaceuticals, Inc. Induction of hepatocytes by stem cell differentiation with rna
GB201704476D0 (en) 2017-03-21 2017-05-03 Antabio Sas Chemical compounds
MX2021003498A (es) 2018-09-25 2021-09-10 Antabio Sas Derivados de indano para el uso en el tratamiento de infeccion bacteriana.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151440A (en) * 1990-02-28 1992-09-29 Allergan, Inc. Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenyl-amino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
FR2754258B1 (fr) * 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
EP1578341A4 (de) * 2000-10-11 2005-09-28 Tularik Inc Modulation der ccr4-funktion
WO2002094264A1 (en) * 2001-05-23 2002-11-28 Tularik Inc. Ccr4 antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
MXPA05008309A (es) * 2003-02-10 2005-09-20 Amgen Inc Ligandos de receptor vaniloide y su uso en tratamientos.
CA2525547C (en) * 2003-05-14 2012-07-03 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
US20050228031A1 (en) * 2004-04-13 2005-10-13 Bilodeau Mark T Tyrosine kinase inhibitors
EP1802605A1 (de) * 2004-10-15 2007-07-04 Amgen, Inc Imidazol-derivate als vanilloidrezeptor-liganden

Also Published As

Publication number Publication date
WO2006122250A2 (en) 2006-11-16
KR20080014024A (ko) 2008-02-13
IL187208A0 (en) 2008-02-09
US7902236B2 (en) 2011-03-08
US20110144057A1 (en) 2011-06-16
US20060281799A1 (en) 2006-12-14
HK1114837A1 (en) 2008-11-14
BRPI0608810A2 (pt) 2010-01-26
CN102516192A (zh) 2012-06-27
AU2006243987A8 (en) 2006-11-16
JP2008540562A (ja) 2008-11-20
CA2608091A1 (en) 2006-11-16
AU2006243987B2 (en) 2011-11-24
MX2007014048A (es) 2008-02-05
US20100010055A1 (en) 2010-01-14
ZA201102735B (en) 2012-12-27
AU2006243987A1 (en) 2006-11-16
US7504520B2 (en) 2009-03-17
WO2006122250A3 (en) 2007-03-29
EP1885704B1 (de) 2011-09-28
JP4862042B2 (ja) 2012-01-25
CN101248052A (zh) 2008-08-20
EP1885704A2 (de) 2008-02-13
NZ563200A (en) 2011-04-29

Similar Documents

Publication Publication Date Title
ATE526320T1 (de) Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon
ATE451381T1 (de) Prodrugs aus 2,4-pyrimidindiamin-verbindungen und ihre verwendungen
NO20072435L (no) CGRP-reseptorantagonister
ATE466860T1 (de) Cgrp-rezeptorantagonisten
ATE537170T1 (de) Cgrp-rezeptorantagonisten
CY1110398T1 (el) Ενωσεις για την αγωγη της δυσλιπιδαιμιας
NO20071476L (no) Antidiuretiske midler.
ATE463495T1 (de) Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
DE602005020655D1 (de) Carboxamid-spirolactam-cgrp-rezeptor-antagonisten
MX2007011023A (es) 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3.
EA200901124A1 (ru) Соединения формулы (i) в качестве ингибиторов серинпротеазы
ATE376833T1 (de) Chinazolinon-derivate als vanilloid-antagonisten
ATE503755T1 (de) Cgrp-rezeptorantagonisten
HRP20080529T3 (en) Amide prodrug of gemcitabine, compositions and use thereof
EP1802372A4 (de) Cgrp-rezeptorantagonisten
DE602005010421D1 (de) Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen
EA200801365A1 (ru) Замещенные 5-фенил-3,6-дигидро-2-оксо-6h-1,3,4-тиадиазины
ATE466853T1 (de) Cgrp-rezeptorantagonisten
ITMI20041231A1 (it) Antagonisti del recettore dei vanilloidi trpv1
ATE398646T1 (de) Nicht entflammbare zusammensetzung und verwendung davon
SE0303419D0 (sv) New use 11
SE0303488D0 (sv) New use 1X

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties