ATE526320T1 - Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon - Google Patents

Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon

Info

Publication number
ATE526320T1
ATE526320T1 AT06759574T AT06759574T ATE526320T1 AT E526320 T1 ATE526320 T1 AT E526320T1 AT 06759574 T AT06759574 T AT 06759574T AT 06759574 T AT06759574 T AT 06759574T AT E526320 T1 ATE526320 T1 AT E526320T1
Authority
AT
Austria
Prior art keywords
subtype
antagonists
applications
vanilloid receptor
vanilloid
Prior art date
Application number
AT06759574T
Other languages
English (en)
Inventor
Arthur Gomtsyan
Richard Perner
John Koenig
Margaret Chi-Ping Hsu
Dilini Fernando
Chih-Hung Lee
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE526320T1 publication Critical patent/ATE526320T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT06759574T 2005-05-11 2006-05-10 Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon ATE526320T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67970805P 2005-05-11 2005-05-11
PCT/US2006/018256 WO2006122250A2 (en) 2005-05-11 2006-05-10 Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof

Publications (1)

Publication Number Publication Date
ATE526320T1 true ATE526320T1 (de) 2011-10-15

Family

ID=37056909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06759574T ATE526320T1 (de) 2005-05-11 2006-05-10 Antagonisten des vanilloidrezeptors vom subtyp 1 (vr1), und anwendungen davon

Country Status (14)

Country Link
US (3) US7504520B2 (de)
EP (1) EP1885704B1 (de)
JP (1) JP4862042B2 (de)
KR (1) KR20080014024A (de)
CN (2) CN102516192A (de)
AT (1) ATE526320T1 (de)
AU (1) AU2006243987B2 (de)
BR (1) BRPI0608810A2 (de)
CA (1) CA2608091A1 (de)
IL (1) IL187208A0 (de)
MX (1) MX2007014048A (de)
NZ (1) NZ563200A (de)
WO (1) WO2006122250A2 (de)
ZA (1) ZA201102735B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060229305A1 (en) * 2005-03-22 2006-10-12 Markus Berger Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
BRPI0608910A2 (pt) 2005-05-09 2010-02-17 Achillion Pharmaceuticals Inc uso de um composto da fórmula ou um sal ou hidrato farmaceuticamente aceitável desse, composto ou sal ou hidrato do mesmo, composição farmacêutica e composição farmacêutica embalada
MX2008013428A (es) * 2006-04-18 2008-11-04 Abbott Lab Antagonistas del receptor de vanilloides del subtipo (vr1) y usos de los mismos.
CN101801964A (zh) 2007-05-22 2010-08-11 艾其林医药公司 杂芳基取代的噻唑及其作为抗病毒剂的用途
US7998993B2 (en) * 2007-10-25 2011-08-16 Abbott Laboratories TRPV1 antagonists
KR101619341B1 (ko) 2008-01-28 2016-05-11 (주)아모레퍼시픽 바닐로이드 수용체 길항체로서의 신규 화합물, 이의 이성질체 또는 약제학적으로 허용가능한 염, 및 이를 함유하는 약학 조성물
US8106209B2 (en) 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
WO2010002209A2 (en) 2008-07-02 2010-01-07 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
EP2326176B1 (de) * 2008-08-20 2013-09-18 Merck Sharp & Dohme Corp. Nicht-amidische binder mit verzweigten enden als cgrp-rezeptorantagonisten
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
WO2011095450A1 (en) 2010-02-02 2011-08-11 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
MX351165B (es) 2011-03-25 2017-10-04 Abbvie Inc Antagonistas de trpv1.
WO2012166463A2 (en) 2011-05-27 2012-12-06 Neosome Life Sciences, LLC Aminooxazole inhibitors of cyclin dependent kinases
WO2013096223A1 (en) 2011-12-19 2013-06-27 Abbvie Inc. Trpv1 antagonists
WO2013096226A1 (en) 2011-12-19 2013-06-27 Abbvie Inc. Trpv1 antagonists
US8796328B2 (en) 2012-06-20 2014-08-05 Abbvie Inc. TRPV1 antagonists
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
HRP20210431T1 (hr) 2013-11-18 2021-05-14 Forma Therapeutics, Inc. Pripravci tetrahidrokinolina kao inhibitori bet bromodomene
AU2017363145B2 (en) 2016-11-16 2024-02-15 Allele Biotechnology & Pharmaceuticals, Inc. Induction of pancreatic beta cells by stem cell differentiation with RNA
EP3541928A4 (de) * 2016-11-16 2020-11-04 Allele Biotechnology And Pharmaceuticals, Inc. Induktion von hepatozyten durch stammzelldifferenzierung mit rna
GB201704476D0 (en) 2017-03-21 2017-05-03 Antabio Sas Chemical compounds
MA53706A (fr) 2018-09-25 2021-12-29 Antabio Sas Dérivés d'indane destinés à être utilisés dans le traitement d'une infection bactérienne

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151440A (en) * 1990-02-28 1992-09-29 Allergan, Inc. Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenyl-amino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
FR2754258B1 (fr) * 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
CA2425259A1 (en) * 2000-10-11 2002-04-18 Tularik, Inc. Modulation of ccr4 function
US7144903B2 (en) * 2001-05-23 2006-12-05 Amgen Inc. CCR4 antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
US7265138B2 (en) * 2003-02-10 2007-09-04 Amgen Inc. Vanilloid receptor ligands and their use in treatments
BRPI0410348A (pt) * 2003-05-14 2006-05-30 Torreypines Therapeutics Inc compostos e usos dos mesmos na modulação de amilóide-beta
US20050228031A1 (en) * 2004-04-13 2005-10-13 Bilodeau Mark T Tyrosine kinase inhibitors
US7439360B2 (en) * 2004-10-15 2008-10-21 Amgen Inc. Vanilloid receptor ligands and their use in treatments

Also Published As

Publication number Publication date
EP1885704B1 (de) 2011-09-28
JP2008540562A (ja) 2008-11-20
US7504520B2 (en) 2009-03-17
EP1885704A2 (de) 2008-02-13
BRPI0608810A2 (pt) 2010-01-26
US20100010055A1 (en) 2010-01-14
IL187208A0 (en) 2008-02-09
ZA201102735B (en) 2012-12-27
HK1114837A1 (en) 2008-11-14
CA2608091A1 (en) 2006-11-16
WO2006122250A3 (en) 2007-03-29
US7902236B2 (en) 2011-03-08
AU2006243987A8 (en) 2006-11-16
NZ563200A (en) 2011-04-29
WO2006122250A2 (en) 2006-11-16
US20110144057A1 (en) 2011-06-16
CN102516192A (zh) 2012-06-27
AU2006243987B2 (en) 2011-11-24
KR20080014024A (ko) 2008-02-13
AU2006243987A1 (en) 2006-11-16
MX2007014048A (es) 2008-02-05
US20060281799A1 (en) 2006-12-14
CN101248052A (zh) 2008-08-20
JP4862042B2 (ja) 2012-01-25

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