ATE525464T1 - Mutante endoglycoceramidasen mit verbesserter syntheseakivität - Google Patents

Mutante endoglycoceramidasen mit verbesserter syntheseakivität

Info

Publication number
ATE525464T1
ATE525464T1 AT05756329T AT05756329T ATE525464T1 AT E525464 T1 ATE525464 T1 AT E525464T1 AT 05756329 T AT05756329 T AT 05756329T AT 05756329 T AT05756329 T AT 05756329T AT E525464 T1 ATE525464 T1 AT E525464T1
Authority
AT
Austria
Prior art keywords
endoglycoceramidase
mutant
enzyme
improved synthesis
synthesis ability
Prior art date
Application number
AT05756329T
Other languages
English (en)
Inventor
Karl Johnson
Shawn Defrees
Stephen Withers
Mark Vaughan
Original Assignee
Seneb Biosciences Inc
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seneb Biosciences Inc, Univ British Columbia filed Critical Seneb Biosciences Inc
Application granted granted Critical
Publication of ATE525464T1 publication Critical patent/ATE525464T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01123—Endoglycosylceramidase (3.2.1.123)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT05756329T 2004-06-01 2005-06-01 Mutante endoglycoceramidasen mit verbesserter syntheseakivität ATE525464T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57631604P 2004-06-01 2004-06-01
US62679104P 2004-11-10 2004-11-10
US66676505P 2005-03-29 2005-03-29
PCT/US2005/019451 WO2005118798A2 (en) 2004-06-01 2005-06-01 Mutant endoglycoceramidases with enhanced synthetic activity

Publications (1)

Publication Number Publication Date
ATE525464T1 true ATE525464T1 (de) 2011-10-15

Family

ID=35463451

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05756329T ATE525464T1 (de) 2004-06-01 2005-06-01 Mutante endoglycoceramidasen mit verbesserter syntheseakivität

Country Status (6)

Country Link
US (4) US20090170155A1 (de)
EP (1) EP1765998B1 (de)
JP (1) JP2008502329A (de)
AT (1) ATE525464T1 (de)
CA (1) CA2567581C (de)
WO (1) WO2005118798A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120035120A1 (en) 2009-03-25 2012-02-09 Seneb Biosciences, Inc. Glycolipids as treatment for disease
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN108251403B (zh) * 2016-12-29 2021-05-28 上海交通大学 一种新型鞘糖脂内切糖苷酶及其基因工程制备方法和应用
CN108251394B (zh) * 2016-12-29 2021-02-02 上海交通大学 一种新型的鞘糖脂内切糖苷酶
WO2021170620A1 (en) 2020-02-24 2021-09-02 Carbocode S.A. Synthesis of glycosyl fluorides
CN112708687B (zh) * 2021-02-04 2021-11-09 瑞安市人民医院 肠道菌群在肝性脑病检测中的应用
WO2023118378A1 (en) 2021-12-21 2023-06-29 Carbocode S.A. Novel glycosynthase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2832746B2 (ja) * 1990-08-13 1998-12-09 雪印乳業株式会社 スフィンゴ糖脂質の製造方法
US5716812A (en) * 1995-12-12 1998-02-10 The University Of British Columbia Methods and compositions for synthesis of oligosaccharides, and the products formed thereby
US20030138880A1 (en) * 2001-08-24 2003-07-24 University Of British Columbia Solid-phase synthesis of oligosaccharides and glycopeptides using glycosynthases
EP1603932B1 (de) * 2003-03-06 2012-10-03 Seneb Biosciences Inc. Verfahren und zusammensetzungen für die enzymatische synthese von gangliosiden

Also Published As

Publication number Publication date
EP1765998A4 (de) 2008-01-23
EP1765998B1 (de) 2011-09-21
US9068208B2 (en) 2015-06-30
JP2008502329A (ja) 2008-01-31
US20200024628A1 (en) 2020-01-23
WO2005118798A2 (en) 2005-12-15
WO2005118798A3 (en) 2007-05-10
CA2567581A1 (en) 2005-12-15
US10294504B2 (en) 2019-05-21
CA2567581C (en) 2016-08-09
US20140147891A1 (en) 2014-05-29
EP1765998A2 (de) 2007-03-28
US20090170155A1 (en) 2009-07-02
US20160032342A1 (en) 2016-02-04

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