ATE520665T1 - Asymmetrische katalytische reduktion von oxcarbazepin - Google Patents

Asymmetrische katalytische reduktion von oxcarbazepin

Info

Publication number
ATE520665T1
ATE520665T1 AT06726863T AT06726863T ATE520665T1 AT E520665 T1 ATE520665 T1 AT E520665T1 AT 06726863 T AT06726863 T AT 06726863T AT 06726863 T AT06726863 T AT 06726863T AT E520665 T1 ATE520665 T1 AT E520665T1
Authority
AT
Austria
Prior art keywords
oxcarbazepine
catalytic reduction
asymmetric catalytic
asymmetric
reduction
Prior art date
Application number
AT06726863T
Other languages
English (en)
Inventor
David Learmonth
Gabriela Grasa
Antonio Zanotti-Gerosa
Original Assignee
Bial Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34983785&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE520665(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bial Portela & Ca Sa filed Critical Bial Portela & Ca Sa
Application granted granted Critical
Publication of ATE520665T1 publication Critical patent/ATE520665T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06726863T 2005-07-29 2006-04-21 Asymmetrische katalytische reduktion von oxcarbazepin ATE520665T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0515690.6A GB0515690D0 (en) 2005-07-29 2005-07-29 Asymmetric catalytic reduction
PCT/GB2006/001473 WO2007012793A1 (en) 2005-07-29 2006-04-21 Asymmetric catalytic reduction of oxcarbazepine

Publications (1)

Publication Number Publication Date
ATE520665T1 true ATE520665T1 (de) 2011-09-15

Family

ID=34983785

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06726863T ATE520665T1 (de) 2005-07-29 2006-04-21 Asymmetrische katalytische reduktion von oxcarbazepin

Country Status (23)

Country Link
US (4) US8288532B2 (de)
EP (2) EP2319836B1 (de)
JP (2) JP5295765B2 (de)
KR (1) KR101362281B1 (de)
CN (1) CN101277937B (de)
AR (1) AR055917A1 (de)
AT (1) ATE520665T1 (de)
AU (1) AU2006273874B2 (de)
BR (1) BRPI0615970A8 (de)
CA (1) CA2616984C (de)
CY (1) CY1111988T1 (de)
DK (1) DK1915346T3 (de)
ES (2) ES2371556T3 (de)
GB (1) GB0515690D0 (de)
IL (1) IL189062A0 (de)
MX (1) MX2008001291A (de)
NZ (1) NZ565462A (de)
PL (1) PL1915346T3 (de)
PT (1) PT103467B (de)
RU (1) RU2439060C2 (de)
SI (1) SI1915346T1 (de)
WO (1) WO2007012793A1 (de)
ZA (1) ZA200800986B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
US20120022047A1 (en) 2009-04-02 2012-01-26 Glenmark Generics Ltd Process for the purification of eslicarbazepine acetate
US9855277B2 (en) 2009-07-27 2018-01-02 Bial—Portela & Ca, S.A. Use of 5H-dibenz/b,f/azepine-5-carboxamide derivatives for treating fibromyalgia
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs
EP2383261B1 (de) 2010-04-23 2013-09-04 Euticals GmbH Verfahren zur asymmetrischen Hydrierung von Ketonen
WO2011138795A2 (en) * 2010-05-03 2011-11-10 Msn Laboratories Limited Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide
CN102250005B (zh) * 2010-05-19 2015-04-08 浙江九洲药物科技有限公司 艾利西平的制备方法
US9346760B2 (en) 2011-03-08 2016-05-24 Jubilant Life Sciences Limited Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof
DK2697662T3 (en) 2011-04-13 2018-07-30 Codexis Inc BIOCATALYTIC PROCEDURE FOR PREPARING ESLICARBAZEPIN AND ANALOGUES THEREOF
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
US20150232426A1 (en) 2012-09-26 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
US9896451B2 (en) 2013-09-06 2018-02-20 Nippon Soda Co., Ltd. Method for producing endo-9-azabicyclo[3.3.1]nonan-3-ol derivative
EP3064490A1 (de) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Verbessertes verfahren zur herstellung von eslicarbazepin und eslicarbazepinacetat
PT3554490T (pt) 2016-12-16 2022-03-17 Idorsia Pharmaceuticals Ltd Combinação farmacêutica compreendendo um bloqueador de canais de cálcio de tipo t

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
DE69635874T2 (de) 1995-12-06 2006-12-14 Japan Science And Technology Agency, Kawaguchi Verfahren zur Herstellung von optisch aktiven Alkoholen
AU6448200A (en) 1999-06-15 2001-01-02 Rhodia Chimie Sulphonylamides and carboxamides and their use in asymmetrical catalysis
GB0111566D0 (en) 2001-05-11 2001-07-04 Portela & Ca Sa Method for preparation of (s)-(+)-and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azephine-5-carboxamide
GB0112812D0 (en) 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
JP3504254B2 (ja) 2001-10-31 2004-03-08 関東化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
US6972275B2 (en) 2002-06-28 2005-12-06 Exxonmobil Research And Engineering Company Oil-in-oil emulsion lubricants for enhanced lubrication
GB0223224D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
JP4309686B2 (ja) 2003-01-17 2009-08-05 関東化学株式会社 光学活性化合物の製造方法
GB2401605A (en) 2003-05-12 2004-11-17 Portela & Ca Sa Method for racemisation of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide and optically enriched mixtures thereof
CN1328252C (zh) * 2003-06-12 2007-07-25 中国科学院成都有机化学研究所 新型光学纯水溶性二胺和衍生物及其制备方法和用途
JP4744091B2 (ja) 2003-09-05 2011-08-10 関東化学株式会社 光学活性ニトロ化合物およびシアノ化合物の製造方法
GB2416167A (en) 2004-07-13 2006-01-18 Portela & Ca Sa Chiral inversion and esterification of (S)- and (R)-10-hydroxy-dibenzazepine carboxamides
GB2422149A (en) 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction

Also Published As

Publication number Publication date
PL1915346T3 (pl) 2012-01-31
JP2013173764A (ja) 2013-09-05
EP2319836A1 (de) 2011-05-11
EP2319836B1 (de) 2015-11-25
US20090203902A1 (en) 2009-08-13
EP1915346B1 (de) 2011-08-17
ES2371556T3 (es) 2012-01-05
RU2439060C2 (ru) 2012-01-10
KR101362281B1 (ko) 2014-02-12
WO2007012793A1 (en) 2007-02-01
AU2006273874A8 (en) 2008-03-06
CA2616984A1 (en) 2007-02-01
PT103467B (pt) 2009-03-19
CN101277937B (zh) 2010-12-08
US9643929B2 (en) 2017-05-09
AU2006273874B2 (en) 2013-01-10
US20130041146A1 (en) 2013-02-14
DK1915346T3 (da) 2011-12-05
BRPI0615970A8 (pt) 2017-08-22
JP2009502893A (ja) 2009-01-29
MX2008001291A (es) 2008-03-18
US9206135B2 (en) 2015-12-08
US8288532B2 (en) 2012-10-16
IL189062A0 (en) 2008-08-07
SI1915346T1 (sl) 2011-12-30
GB0515690D0 (en) 2005-09-07
ES2562816T3 (es) 2016-03-08
AR055917A1 (es) 2007-09-12
PT103467A (pt) 2007-01-31
CN101277937A (zh) 2008-10-01
NZ565462A (en) 2010-02-26
KR20080036212A (ko) 2008-04-25
RU2008107718A (ru) 2009-09-10
CY1111988T1 (el) 2015-11-04
BRPI0615970A2 (pt) 2011-05-31
ZA200800986B (en) 2010-02-24
EP1915346A1 (de) 2008-04-30
JP5295765B2 (ja) 2013-09-18
US20160176823A1 (en) 2016-06-23
US20170190668A1 (en) 2017-07-06
AU2006273874A1 (en) 2007-02-01
CA2616984C (en) 2017-09-26

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