ATE520663T1 - Stickstoff atom enthaltenden heteroaryl- harnstoffe als inhibitoren der p38-kinase - Google Patents
Stickstoff atom enthaltenden heteroaryl- harnstoffe als inhibitoren der p38-kinaseInfo
- Publication number
- ATE520663T1 ATE520663T1 AT02725709T AT02725709T ATE520663T1 AT E520663 T1 ATE520663 T1 AT E520663T1 AT 02725709 T AT02725709 T AT 02725709T AT 02725709 T AT02725709 T AT 02725709T AT E520663 T1 ATE520663 T1 AT E520663T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroaryl
- containing nitrogen
- ureases
- kinase
- inhibitors
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- -1 heteroaryl ureas Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Engineering & Computer Science (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/838,286 US20020065296A1 (en) | 1999-01-13 | 2001-04-20 | Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors |
PCT/US2002/012064 WO2002085859A1 (en) | 2001-04-20 | 2002-04-17 | HETEROARYL UREAS CONTAINING NITROGEN HETERO-ATOMS AS p38 KINASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE520663T1 true ATE520663T1 (de) | 2011-09-15 |
Family
ID=25276732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02725709T ATE520663T1 (de) | 2001-04-20 | 2002-04-17 | Stickstoff atom enthaltenden heteroaryl- harnstoffe als inhibitoren der p38-kinase |
Country Status (9)
Country | Link |
---|---|
US (1) | US20020065296A1 (de) |
EP (2) | EP2386545A1 (de) |
JP (1) | JP4359817B2 (de) |
AT (1) | ATE520663T1 (de) |
CA (1) | CA2443952C (de) |
ES (1) | ES2372020T3 (de) |
HK (1) | HK1062440A1 (de) |
MX (1) | MXPA03009649A (de) |
WO (1) | WO2002085859A1 (de) |
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
WO2002085857A2 (en) * | 2001-04-20 | 2002-10-31 | Bayer Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
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EP1423142A1 (de) * | 2001-08-31 | 2004-06-02 | Chiron SRL. | Helicobacter pylori impfung mit einer kombination der proteine caga, vaca und nap |
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DE102005015253A1 (de) | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | Pyrazolderivate |
US7470787B2 (en) | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
US20090068146A1 (en) | 2005-10-31 | 2009-03-12 | Scott Wilhelm | Diaryl ureas and combinations |
DE602006019468D1 (de) * | 2005-11-10 | 2011-02-17 | Bayer Schering Pharma Ag | Diarylharnstoffe zur behandlung von pulmonaler hypertonie |
US20110195110A1 (en) * | 2005-12-01 | 2011-08-11 | Roger Smith | Urea compounds useful in the treatment of cancer |
MY146514A (en) * | 2005-12-05 | 2012-08-15 | Otsuka Pharma Co Ltd | Diarylether derivatives as antitumor agents |
EP1973897B1 (de) * | 2005-12-21 | 2014-05-21 | Bayer Intellectual Property GmbH | Substituierte Pyrimidinderivate zur Behandlung von Krebs und anderen Erkrankungen |
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UA95978C2 (ru) * | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
US20100150863A1 (en) | 2006-12-20 | 2010-06-17 | Bayer Pharmaceuticals Corporation | Hydroxy methyl phenyl pyrazolyl urea compound useful in treatment of cancer |
US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
JP2012525386A (ja) | 2009-05-01 | 2012-10-22 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | 疾患の治療のための二重機構阻害剤 |
EP2595628A1 (de) | 2010-07-19 | 2013-05-29 | Bayer HealthCare LLC | Wirkstoffkombinationen mit fluorsubstituiertem omega-carboxyaryl-diphenylharnstoff zur behandlung und prävention von erkrankungen und zuständen |
CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
EP3039424B1 (de) | 2013-08-28 | 2020-07-29 | Crown Bioscience, Inc. (Taicang) | Prädiktive genexpressionssignaturen für die reaktion einer person auf einen multikinase-inhibitor und verfahren zur verwendung davon |
PE20170189A1 (es) | 2014-05-28 | 2017-03-15 | Novartis Ag | Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1 |
US9638690B2 (en) | 2014-11-07 | 2017-05-02 | The University Of British Columbia | Compounds and compositions for use as alkylating agent sensors and methods of use thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
KR102568082B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
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JP2021519334A (ja) | 2018-03-26 | 2021-08-10 | クリア クリーク バイオ, インコーポレイテッド | ジヒドロオロト酸デヒドロゲナーゼを阻害するための組成物および方法 |
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WO2023091679A1 (en) * | 2021-11-18 | 2023-05-25 | Board Of Regents Of The University Of Nebraska | Novel inhibitors of claudin-1 for therapeutic intervention |
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DE1935388A1 (de) | 1968-07-12 | 1970-01-22 | Kyowa Hakko Kogyo Kk | Derivate von Mitomycin B |
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CH575208A5 (de) | 1973-07-30 | 1976-05-14 | Ciba Geigy Ag | |
JPS5562066A (en) * | 1978-11-03 | 1980-05-10 | Toshihiko Okamoto | N-(2-substituted-4-pyridyl)-urea and thio urea, their preparation and plant growth regulator |
DE59107782D1 (de) | 1990-04-03 | 1996-06-13 | Ciba Geigy Ag | Konzentrierte Farbstofflösungen |
FR2683818B1 (fr) | 1991-11-14 | 1993-12-31 | Adir Cie | Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
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DE1042305T1 (de) * | 1997-12-22 | 2001-04-19 | Bayer Ag | HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN |
ATE556713T1 (de) * | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
MXPA02004594A (es) * | 1999-11-16 | 2002-10-23 | Boehringer Ingelheim Pharma | Derivados de urea como agentes anti-inflamatorios. |
-
2001
- 2001-04-20 US US09/838,286 patent/US20020065296A1/en not_active Abandoned
-
2002
- 2002-04-17 JP JP2002583386A patent/JP4359817B2/ja not_active Expired - Fee Related
- 2002-04-17 AT AT02725709T patent/ATE520663T1/de not_active IP Right Cessation
- 2002-04-17 ES ES02725709T patent/ES2372020T3/es not_active Expired - Lifetime
- 2002-04-17 WO PCT/US2002/012064 patent/WO2002085859A1/en active Application Filing
- 2002-04-17 MX MXPA03009649A patent/MXPA03009649A/es active IP Right Grant
- 2002-04-17 EP EP11170364A patent/EP2386545A1/de not_active Withdrawn
- 2002-04-17 EP EP02725709A patent/EP1379507B1/de not_active Expired - Lifetime
- 2002-04-17 CA CA2443952A patent/CA2443952C/en not_active Expired - Fee Related
-
2004
- 2004-07-14 HK HK04105147.7A patent/HK1062440A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2443952C (en) | 2011-05-24 |
JP2004537511A (ja) | 2004-12-16 |
MXPA03009649A (es) | 2005-10-05 |
EP1379507A1 (de) | 2004-01-14 |
EP1379507B1 (de) | 2011-08-17 |
EP2386545A1 (de) | 2011-11-16 |
JP4359817B2 (ja) | 2009-11-11 |
CA2443952A1 (en) | 2002-10-31 |
ES2372020T3 (es) | 2012-01-13 |
HK1062440A1 (en) | 2004-11-05 |
WO2002085859A1 (en) | 2002-10-31 |
US20020065296A1 (en) | 2002-05-30 |
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